• 대한화학회지
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• 제55권1호
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• pp.57-62
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• 2011

가끔 먼 지역 거주자들은 현대 의약품이나 의학 서비스에 있어서 불충분하거나 접근할 수 없다. 그들은 개똥쑥의 선택된 품종을 경작하고 차 제조의 적절한 방법에 따라 식물로부터 차나 달인즙을 만드는 것에 의해 말라리아에 대항한 치료의 관점에서 이익을 얻을 수 있다. 아르테미시닌에 대한 최대 추출 효율을 위해, 개똥쑥의 차제조의 다른 방법들은 발달된 DPP방법을 적용하여 연구되었고 이 논문에 서술되었다. 차는 시간을 다르게 하여 3가지 다른 방법으로 제조된다(굽기, 섞거나 섞지 않으면서 굽지 않기 그리고 마이크로 웨이브 오븐). 결과로부터, 아르테미시닌의 더 높은 농도(84.7%)는 15분 동안 섞으면서 굽지 않는 차 제조법에 의해 도달될 수 있다는 것을 발견했다(R.S.D. 2.34%). 아르테미시닌의 농도는 마이크로 웨이브 오븐에서 1.5분 이상 구울 때 감소한다. 최대한도의 추출(88.9%)은 증류수에서 5%에탄올과 함께 섞는 추출방법에서 가능했다(R.S.D. 2.28%).

• 대한약침학회지
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• 제18권1호
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• pp.79-85
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• 2015

Objectives: A vertebral compression fracture (VCF) is characterized by back pain and fracture of a vertebral body on spinal radiography. VCFs of the thoraco lumbar spine are common in the elderly. In general, appropriate analgesics should be prescribed to reduce pain and, thus, promote early mobilization. The ideal treatment approach for VCFs has not been determined. In Korea, acupuncture and herbal medication have been used to treat VCFs for many years. There is empirical evidence that acupuncture might benefit patients with a VCF. However, no randomized, controlled, clinical trials evaluating the efficacy and the safety of acupuncture for treating a VCF have been published. Therefore, we designed a randomized, controlled, pilot, clinical trial to obtain information for the design of a further full scale trial. Methods: A five week protocol for a randomized, controlled, pilot, clinical trial is presented. Fourteen patients will be recruited and randomly allocated to two groups: a control group receiving interlaminar epidural steroid injections once a week for three weeks, and an experimental group receiving interlaminar epidural steroid injections plus acupuncture treatment (three acupuncture sessions per week for three weeks, nine sessions in total). The primary outcomes will be the pain intensity (visual analogue scale and PainVision$^{TM}$ system). The secondary outcome measurements will be the answers on the short form McGill pain questionnaire and the oswestry disability index. Assessments will be made at baseline and at one, three, and five weeks. The last assessment (week five) will take place two weeks after treatment cessation. This study will provide both an indication of feasibility and a clinical foundation for a future large scale trial. The outcomes will provide additional resources for incorporating acupuncture into existing treatments, such as nonsteroidal anti-inflammatory medications, narcotics and vertebral augmentation. This article describes the protocol.

• Radiation Oncology Journal
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• 제16권4호
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• pp.399-408
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• 1998

목적 : 본 연구는 비인강암 환자의 방사선치료에서 기존의 2차원적 치료계획과 3차원 입체조형 치료계획을 비교 분석하여 3차원적 치료계획의 우월성을 입증하고자 하였다. 대상 및 방법 : 병기가 T4인 환자를 대상으로 하였으며, 두 치료계획 모두 기존의 2차원적 치료방법으로 50.4Gy가 조사된 후 추가조사하는 과정을 2차원적 치료계획과 3차원적 치료계획으로 구분하여 수립하였다. 치료계획의 비교는 선량통계, 선량체적히스토그람, 국소제어율, 그리고 정상조직손상확률을 이용하여 시행하였다. 결과 : 3차원적 치료계획에서 2차원적 치료계획과 비교하여 계획용표적체적의 선량균일성이 더욱 향상되었으며 평균선량도 15.2$\%$의 증가를 보였다. 또한 종양 주위의 정상 장기인 측두엽, 뇌간, 이하선 및 측두하악골관절에 조사되는 평균선량은 3차원적 치료계획에서 낮았다. 종양제어확률은 3차원적 치료계획에서 2차원적 치료계획에서보다도 6$\%$ 증가하였으나 정상조직손상확률은 측두엽, 뇌간, 이하선, 측두하악골관절, 그리고 시신경교차 등 대부분의 정상장기에서 낮았다. 결론 : 3차원 입체조형치료계획은 2차원적 치료계획에 비교하여 종양의 국소제어율을 증가시킬수 있는 우월한 치료법임이 증명되었으나 임상적으로도 같은 결과를 가져올 지는 향후 전향적인 임상 연구가 요구된다.

• Journal of Preventive Medicine and Public Health
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• 제40권2호
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• pp.150-154
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• 2007

Objectives : The aim of this study is to identify factors determining the purchase of private health insurance under the mandatory National Health Insurance(NHI) system in Korea. Methods : The data were collected by the National Cancer Center in Korea. It includes cancer patients who were newly diagnosed with stomach (ICD code, C16), lung(C33-C34), liver (C22), colorectal cancer(C18-C20) or breast(C50) cancer. Data were gathered from the hospital Order Communication System (OCS), medical records, and face-to-face interviews, using a structured questionnaire. Clinical, socio-demographic and private health insurance related factors were also gathered. Results : Overall, 43.9% of patients had purchased one or more private health insurance schemes related to cancer, with an average monthly premium of \65,311 and an average benefit amount of \19million. Females, younger aged, high income earners, national health insurers and metropolitan citizens were more likely to purchase private health insurance than their counterparts. Conclusions : About half of Korean people have supple-mentary private health insurance and their benefits are sufficient to cover the out-of-pocket fees required for cancer treatment, but inequality remains in the purchase of private health insurance. Further studies are needed to investigate the impacts of private health insurance on NHI, and the relationship between cancer patients' burden and benefits.

• Journal of Ginseng Research
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• 제43권2호
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• pp.272-281
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• 2019

Background: Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment of various diseases, including diabetes mellitus; however, there is little research about its benefit for treating sensorineural damage. Therefore, we aim to evaluate RG efficacy in alloxan-induced diabetic neuromast (AIDN) zebrafish. Methods: In this study, we developed and validated an AIDN zebrafish model. To assess RG effectiveness, we observed morphological changes in live neuromast zebrafish. Also, zebrafish has been observed to have an ultrastructure of hair-cell cilia under scanning electron microscopy. Thus, we recorded these physiological traits to assess hair cell function. Finally, we confirmed that RG promoted neuromast recovery via nerve growth factor signaling pathway markers. Results: First, we established an AIDN zebrafish model. Using this model, we showed via live neuromast imaging that RG fostered recovery of sensorineural damage. Damaged hair cell cilia were recovered in AIDN zebrafish. Furthermore, RG rescued damaged hair cell function through cell membrane ion balance. Conclusion: Our data suggest that RG potentially facilitates recovery in AIDN zebrafish, and its mechanism seems to be promotion of the nerve growth factor pathway through increased expression of topomyosin receptor kinase A, transient receptor potential channel vanilloid subfamily type 1, and mitogen-activated protein kinase phosphorylation.

• 보건행정학회지
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• 제30권4호
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• pp.438-443
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• 2020

The digital treatment technology industry is one of the core fostering industries of the Moon Jae-in government along with the global trend. The purpose of this study is to compare and analyze the investment and economic ripple effect on the related industries. To this end, we used the industry-related table, which is the actual measurement data for 2015 that the Bank of Korea actually measured and released every 5 years in 2019. The digital treatment technology industry was not clearly classified within Korea's industrial classification system, so the contents of the industry-related survey were analyzed, and the digital treatment technology industry was reclassified and then analyzed. As a result of the analysis, it was analyzed that the production induction effect of the digital treatment technology-related industry in 2015 was 1.770, the value-added induction effect was 0.875, and the employment induction effect was 19.128, which was higher than that of other industries in Korea. As a result of the analysis of the economic ripple effect (scenario 1), the production inducing effect was about 370 billion won, the added value inducing effect was about 185 billion won, and the employment inducing effect was 4,044 people. The results of this study are expected to play a large role in economic revitalization as the effect of inducing production, increasing employment, and creating added value through fostering the digital treatment technology industry is expected to play a large role in activating the economy. It is expected to play a large role in providing central medical services. Therefore, it is expected that policy support for revitalizing the digital treatment technology industry through active investment support and tax benefits from the government to foster the digital treatment technology industry is necessary.

• 의료법학
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• 제23권1호
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• pp.121-148
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• 2022

유전자가위 CRISPR-Cas9은 유전자편집을 위한 생명과학기술 가운데 하나로서 무한한 잠재력을 지니고 있다. 이는 인류에게 많은 혜택을 줄 수도 있으며, 또는 예측하기 어려운 도전과제를 남겨줄 수도 있다. 유전자편집의 표준 또는 규제를 위한 거버넌스는 이러한 기술로부터 발생할 수 있는 연구자의 과학 발전을 위한 목적과 윤리적 책무 사이의 충돌을 합리적으로 해결해기 위한 절차적 방식이다. 관련 연구자들을 비롯한 그의 연구로부터 영향을 받을 수 있는 당사자들이 거버넌스 절차를 통해서 연구자들의 유전자가위 CRISPR-Cas9을 남용한 연구를 경계하기 위한 그들의 책임의식 향상에 기여하여야 한다. 이러한 거버넌스 절차는 연구자들의 책임의식을 어떻게 효과적이고 실효적으로 고양시켜줄 것인지 확인시켜줄 수 있다. 즉 세계적으로 논의되고 있는 유전자가위를 활용한 인간 배아에 대한 연구가 누구를 위해서 진행되는지 명확히 하여야 한다. 연구를 통한 과학적 호기심의 해결이 유전자가위를 활용한 인간 배아 연구의 목적이 될 수도 있다. 하지만 이러한 연구의 목적인 인간 배아는 단순한 연구의 도구로 취급되어서는 안된다. 그러므로 거버넌스는 유전자치료에 관한 연구를 장려하는 것과 더불어 연구자들의 책임의식을 고양하여야 한다. 그렇지 않으면, 과학 발전만을 위한 연구만 남을 것이고, 이러한 연구는 인류에게 기술을 통한 혜택보다 오히려 불행을 초래할 수 있다. 그러므로 이 글은 연구자의 책임의식을 고양하기 위한 거버넌스를 중심으로 연구하는 것을 내용으로 한다.

• 대한통합의학회지
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• 제10권4호
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• pp.121-136
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• 2022

Purpose : Marine therapy is an activity that promotes public health such as constitution improvement, immunity improvement, and anti-aging by utilizing marine therapeutic resources such as seawater, mud, seaweed, salt and sea climate. In Europe developed countries, the marine therapy industry has been developing for centuries, with France, Germany, and Israel leading the way. Currently, it has achieved great industrial achievements and is of great help in improving the human health. The purpose of this study is to investigate how marine therapeutic resources benefit to human health, as well as how to study and utilize their efficacy. We analyzed previous research articles related to the effects of marine therapeutic resources. Methods : The study included a total of 830 published literatures in the last 20 years from the Republic of Korea and other contries. PubMed and Google Scholar were utilized to collect the foreign source while the local scientific publications were accessed through the Korean Education and research Information Service (KERIS) and Korean studies Information Service System (KISS). The keywords used to search foreign literature were "marine therapy", "Thalassotherapy", "seawater", "deep seawater", "saline groundwater", "sand therapy", "mud therapy", "hydrotherapy", "seaweed", "Sun light", "sea salt", "marine animal", and "marine microorganisms" were combined, and for the domestic literature, the keywords were "marine therapy", "marine therapeutic resources", "seawater", and "sand". Results : A total of 830 research papers were found as a result of searching for domestic and international papers related to marine therapeutic resources. The collected documents were classified into 175 seawater resources, 259 marine mineral resources, 41 marine environment, and 355 marine organisms. The efficacy of each marine therapeutic resources was analyzed. By resources type, there were about 213 papers on the efficacy of seaweed, followed by about 175 papers on seawater, 142 on microorganisms, 124 on mud/peat, and sand, salt, minerals and others are appeared in order (Table 1). Conclusion : Korea has the highest marine biodiversity index, excellent tidal flats, four distinct seasons, and various sea environments of the East sea, Yellow sea, South sea and Jeju sea. For this reason, Korea has a much more diverse marine therapeutic resources than other advanced countries in the marine therapy industry. prebiously, we thought that the sea was only valuable as a shipping port and fishery industry. But now, it been shown that the ocean can become a new industrial field which can contribute to human health and well-being by providing healing and therapy to people through the gift of marine resources.

• 스마트미디어저널
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• 제11권10호
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• pp.30-35
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• 2022

의학 전공분야의 학회의 초록이 출판으로 이어지는 비율은 50% 이하라는 이전의 연구들이 있었지만, 소아치과 분야에서는 이에 대한 연구가 거의 없었다. 이번 연구의 목적은 2001년에서 2011년까지의 개최된 대한소아치과 춘추계 학술대회의 초록들 중 어느 정도가 논문으로 출판되는지에 관한 것이다. 구연과 포스터를 위한 초록들을 모두 조사했다. 이 초록들의 제목을 이용해서 학술연구정보서비스에서 논문들을 검색하였다. 총 24번의 학회에서 706개의 초록 (477개의 구연, 229개의 포스터)가 있었고, 이 중 2011년 45.2%(319)에서 2022년 82.9%(585)가 논문으로 출판되었다. 구연은 52.2%(249)에서 86.6%(413), 포스터는 30.6%(70)에서 75.1%(172)의 출판율을 보였다. 우리는 최근 12년 간의 출판율 변화 결과가 전자 문헌검색과 전자 출판 등 디지털화 된 환경에서 기인한다고 생각한다.

• 보건행정학회지
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• 제33권2호
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• pp.141-156
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• 2023

Background: As the population rapidly ages, older adults are increasingly likely to experience mobility problems. This study aims to explore the characteristics related to an elderly person's willingness to live in a nursing home if they have mobility problems Methods: This study analyzed data from 9,917 older adults (5,976 young-old and 3,941 old-old) obtained from the 2020 National Survey of Older Koreans. The dependent variable was the intended place of residence for older adults with mobility problems. Independent variables included various characteristics: (1) sociodemographic and social support, (2) health and functional status, and (3) residential environment. Rao-Scott chi-square tests and survey logistic regression analyses were performed for the young-old and old-old, respectively. Results: The intention to live in a nursing home was significantly different between the young-old (30.4%) and the old-old (34.7%) (p=0.009). According to fully adjusted multivariable analyses, for the young-old, the odds ratio of intending to live in a nursing home was significantly higher in social security benefit recipients (1.45; 95% confidence interval [CI], 1.06-1.97) compared to other individuals. The odds ratio was higher in unmarried (divorced, separated, widowed, or never-married) individuals for both young-old (1.41; 95% CI, 1.22-1.63) and old-old (1.34; 95% CI, 1.09-1.65) age groups, compared to their respective married counterparts. Conclusion: The results of this study suggest that in an aging society, health and social policies should be designed considering the different characteristics of the elderly to improve their health, function, and quality of life.