• Title/Summary/Keyword: Mediating Effect

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Regulatory Mechanisms of Angiotensin II on the $Na^+/H^+$ Antiport System in Rabbit Renal Proximal Tubule Cells. II. Inhibitory Effects of ANG II on $Na^+$ Uptake

  • Han, Ho-Jae;Park, Soo-Hyun;Koh, Hyun-Ju
    • The Korean Journal of Physiology and Pharmacology
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    • v.1 no.4
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    • pp.425-434
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    • 1997
  • Many reports represent that angiotensin II (ANG II) caused a dose dependent biphasic effects on fluid transport in the proximal tubule. However, respective roles of different signaling pathways in mediating these effects remain unsettled. The aim of the present study was to examine signaling pathways at high doses of ANG II on the $Na^+$ uptake of primary cultured rabbit renal proximal tubule cells(PTCs) in hormonally defined serum-free medium. High concentrations of ANG II $(>10^{-9}\;M)$ inhibited $Na^+$ uptake and increased $[Ca^{2+}]_i\;level$ in the PTCs. However, low concentrations of $(<10^{-11}\;ANG\;II)$ stimulated $Na^+$ uptake and did not affect $[Ca^{2+}]_i\;level$. 8-(N, N-diethylamino)-octyl-3,3,5- trimethoxybenzoate (TMB-8), ethylene glycol-bis$({/beta}-amino\;ethyl ether)-N,N,N'$, N'-tetra acetic acid (EGTA), and nifedifine partially blocked the inhibitory effects of ANG II on $Na^+$ uptake. When ANG II and bradykinin (BK) were treated together, $Na^+$ uptake was further reduced $(88.47{\pm}1.98%\;of\;that\;of\;ANG\;II,\;81.85{\pm}1.84%\;of\;that\;of\;BK)$. In addition, W-7 and KN-62 blocked the ANG II-induced inhibition of $Na^+$ uptake. Arachidonic acid reduced $Na^+$ uptake in a dose-dependent manner. When ANG II and arachidonic acid were treated together, inhibitory effects on $Na^+$ uptake significantly exhibited greater reduction than that of each group, respectively. When PTCs were treated by mepacrine $(10^{-6}\;M)$ and AACOCF3 $(10^{-5}\;M)$ for 1 hr before the addition of $(<10^{-9}\;ANG\;II)$, the inhibitory effect of ANG II was reversed. In addition, econazole $(>10^{-6}\;M)$ blocked ANG II-induced inhibition of $Na^+$ uptake. In conclusion, the $[Ca^{2+}]_i$ (calcium-calmodulin-dependent kinase) and phospholipase $A_2\;(PLA_2)$ metabolites are involved in the inhibitory effects of ANG II on $Na^+$ uptake in the PTCs.

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A Structural Analysis on University Students' Consciousness of Lifelong Education, Leadership and Life Core Competencies (대학생의 평생교육의식과 리더십 및 생애핵심능력 간의 구조적 분석)

  • Park, Myeung-sin;Han, Sang-hoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.8
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    • pp.5212-5222
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    • 2015
  • The purpose of this study is to analyze the structural relation among consciousness of lifelong education, leadership and life core competencies. The subjects were 607 university students who participated in the courses of the lifelong educator in Daejeon, Chungnam and Chungbuk province. As the results of the study, first, university students' consciousness of lifelong education had positive effects on their life core competencies. Second, university students' consciousness of lifelong education had positive effects on their leadership. Third, university students' leadership had positive effects on their life core competencies. Forth, university students' leadership had mediating effect between consciousness of lifelong education and life core competencies. In other words, university students' consciousness of lifelong education influences their leadership, and then it influences their life core competencies positively. These results can be used to change university students' consciousness of lifelong education and to develop their leadership and life core competencies. In addition, the results present that their participation rate can be increased through continuous interest and participation after their graduation. The study has a realistic point to operate lifelong educator training courses and lifelong education of university, so it is meaningful to provide the theoretical and practical implications for developing lifelong education.

A Study on the Mediating Role of Mathematics Anxiety in the Influence of Self Efficacy on Mathematics Skills of College Students Majoring in Hospitality Management (호텔.레스토랑 전공 대학생들의 자기효능감과 수학실력의 관계에서 수학불안의 매개역할에 관한 연구)

  • Kim, Min-Jung;Kim, Hyun-Jung;Kim, Dong-Jin
    • Culinary science and hospitality research
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    • v.18 no.4
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    • pp.59-69
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    • 2012
  • This study examines the role of mathematics anxiety as a mediator between self efficacy and mathematics skills using a series of regression analyses suggested by Baron RM & Kenny DA(1986). The participants include college students who enrolled in the Food Service Production and Operation course in a department of hotel and restaurant management at a college in the United States. Descriptive analysis, principal component analysis, reliability test, and a series of regression analyses were used for data analysis using SPSS 19.0. In order to collect data for the study, General Self Efficacy Scale(GSES) and Math Anxiety Rating Scale(MARS) were utilized, and they turned out to be reliable(${\alpha}$=.906 and ${\alpha}$=.890, respectively). A significant negative relationship was found between self efficacy and mathematics anxiety. In addition, it was found that self-efficacious students performed better mathematics skills than those who had lower level of self efficacy. However, the relationship was no longer significant when the concept of mathematics anxiety was added, which satisfies the condition of mediation.

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The Impact of Environmental CSR on Trust and Corporate Reputation : The Moderating Effect of Authenticity (기업의 환경적 사회적책임 활동이 신뢰와 기업평판에 미치는 영향: 진정성의 조절효과를 중심으로)

  • Bae, JeongHo
    • Journal of Service Research and Studies
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    • v.9 no.2
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    • pp.17-29
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    • 2019
  • So far, there has been a lot of research on CSR, however, not much on the relationship between environmental CSR and corporate reputation and authenticity, The purpose of this study is to empirically examine the relation between Environmental CSR, Trust and Corporate Reputation as well as a moderating role of Authenticity between Environmental CSR and Trust. To achieve the purpose of the study, the hypothesis was established based on prior research and theoretical background regarding environmental CSR, trust, corporate reputation, and authenticity. Samples of this study were collected from 479 general consumers respondents across the country and analyzed based on quantative datas using the SPSS and AMOS statistical models. We find that First, Environmental CSR is positively related with both corporate reputation and trust. Secondly, we find that trust play a mediating role in the relationship between environmental CSR and Corporate Reputation, Thirdly, we also find that Authenticity does not moderate the enfluence relationship between environmental CSR and trust. The study will contribute to both CSR research and marketing strategy.

The Effect of Leader Emotional Labor on Followers' Work Engagement : Examining the Role of Followers' PsyCap and Quality of LMX (리더의 감정노동이 부하의 직무몰입에 미치는 영향 : 심리적 자본과 상사-부하관계의 효과 연구)

  • Kong, Joon-Seo;Woo, Jung
    • The Journal of the Korea Contents Association
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    • v.16 no.12
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    • pp.422-445
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    • 2016
  • Almost all research on emotional labor has focused on how services workers use emotional labor. However, this study examined that leaders' emotional labor influence follower's outcomes. Especially, this study tested how the leader emotional labor influence followers' work engagement and mediating role of PsyCap between leader emotional labor and followers' work engagement. In addition, this study investigated the quality of LMX as moderator the relationship between leader emotional labor and followers' work engagement. The SPSS 24.0 and AMOS 24.0 was used in this study. The results collected from 469 employees in domestic large Telecom and their related companies revealed that leader emotional labor positively influence followers' work engagement and PsyCap. Especially, leader deep acting and surface acting positively influence followers' work engagement, but not display of genuine emotion, and leader deep acting only positively influence followers' PsyCap. Furthermore, followers' PsyCap partially mediated the relationship between leader emotional labor and followers' work engagement. Finally, the quality of LMX as moderator in link between leader emotional labor and followers' work engagement showed when followers in high-quality LMX. Implication and suggestion for future study are discussed.

The Impact of Entrepreneurship of Franchisees on Their Business Performance : Mediation Effects of Market Orientation and Relationship Commitment (프랜차이즈 가맹점의 창업정신이 경영성과에 미치는 영향 : 본사의 시장지향성과 가맹점 관계몰입의 매개효과)

  • Yoon, Sung-Wook;Park, Sung-Il
    • Journal of Distribution Research
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    • v.13 no.3
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    • pp.101-125
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    • 2008
  • This research suggests an ideal role between franchisee and franchisee for survival and development of the Korean franchise business by identifying causal relationships between entrepreneurship of franchisees and their business performance. Besides, when considering multi-dimensional features of a franchise system, this study aims to show that the market orientation of the franchisee and the relationship commitment between franchisee and franchisee will play an important mediating role to achieve a better business performance. Thus specific causal relationships among sub-dimensional constructs of entrepreneurship and market orientations were investigated. They are innovativeness, risk-taking propensity, pro-activeness, information creation, intelligence generation, intelligence dissemination, response design, response implementation. The results demonstrate that pro-activeness of franchisee plays a crucial role for franchisee's business performance. It was noted that franchisor's market orientation and innovativeness is also important for high market orientation of franchisor. The higher the market orientation of franchisor was, the higher relationship commitment of franchisee was formed. By identifying the mediation effect of relationship commitment and market orientation of franchisor, this paper showed that relationship commitment positively affect the improvement of franchisee's business performance. Above all, it should be noted that this research empirically identified the relationship between franchisee's entrepreneurship and business performance that most of the previous researchers have ignored. Furthermore, the analysis was conducted at sub-dimensional construct level. It is expected that empirical results from this study will be able to provide a meaningful framework and theoretical basis for future research on franchise, entrepreneurship and market orientation.

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The Effect of Trust and Justice on Relation Satisfaction and Long-term Commitment in Franchise Business (가맹본부에 대한 신뢰와 공정성이 관계만족과 장기적 결속에 미치는 영향)

  • Lyu, Myoung-Keun;Yang, Hoe-Chang
    • Journal of Distribution Science
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    • v.11 no.1
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    • pp.25-34
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    • 2013
  • Purpose - This study examines the adverse press coverage that has increased in proportion to the remarkable growth of various kinds of franchise businesses in the food service industry. Today, the trust of franchisees in relation to their franchisor, and the maintenance of good relations between the two, has become a significant social issue. This study investigates relationship satisfaction and the long-term commitment between the franchisor and franchisee. Research design, data, methodology - We used a path analysis to investigate the relationship between justice and trust, trust and relationship satisfaction, justice and relationship satisfaction, trust and long-term commitment, and relationship satisfaction and long-term commitment. Structural Equation Modeling and a Sobel test were used to investigate the mediating effects of trust and relationship satisfaction. Data were collected from 237 Food Franchisees in Seoul and Gyeonggi Province in order to test the theoretical model and its hypotheses. Two research methodologies are generally used in the distribution management field. For this study, an empirical method was used. Results - A causal analysis was carried out to test if the research model has a sufficient fit index (for instance, χ2 = 46.694, df = 10, p = .000, GFI = 0.946, AGFI = 0.850, RMR = 0.034, NFI = 0.966, CFI = 0.973), and the results showed that the model was sufficient, thus demonstrating the suitability of the research model. Each hypothesis had a positive influence, both on long-term commitment and relationship satisfaction. Justice with the franchisor had a positive influence on trust. Relation satisfaction cognized by franchisees was found to positively influence long-term commitment. The franchisee perception of justice in relation to the franchisor had no significant influence on long-term commitment. The study investigated the hypothesis that trust could mediate justice and long-term commitment, and that relationship satisfaction could also mediate long-term commitment Both trust and relationship satisfaction were found to be important for long-term commitment. Specifically, trust sub-factors and justice sub-factors influenced long-term commitment. Identification-based and knowledge-based trust were more important than calculus-based trust. Distributive justice was deemed more important than procedural justice; distributive justice should thus be strengthened. Conclusions - Both franchisor and franchisee were independent businesses. Evidently however, the franchisor could not ensure profit without long-term commitment from the franchisee. As for the success of the franchise business, the franchisor should carry out appropriate strategies leading to a satisfactory relationship. For example, transparency makes it possible to maintain and enhance trust and to improve relationship satisfaction. Just relations between franchisor and franchisee should make it possible to maintain and enhance the franchisee's trust. The franchisor should provide a variety of information with respect to the franchisee's business success. Finally, in order to improve the franchisee's long-term commitment, the franchisor should ensure a just approach with trust and relationship satisfaction among their strategies.

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Impact of Conflict and Nurturing Factors for the Divorced Parents on the Behavioral Adaptation of their Children (이혼가정자녀의 행동적응문제에 영향을 미치는 부모요인과 아동의 이혼지각 분석)

  • Joo, So-Hee;Cho, Sung-Woo
    • Korean Journal of Social Welfare
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    • v.56 no.4
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    • pp.215-238
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    • 2004
  • The purpose of this paper is to examine the impact of conflict and nurturing factors for the divorced parent on the behavioral adaptation of their children. The participants in this study include 216 children in divorced families nationwide. Structural Equation Modeling with LISREL8 was used for statistical method. In order to achieve the purpose, researchers firstly tried to test a construct validity of conceptual variables(parental conflict, negative attitude of parental nurturing, child's belief about parental divorce, child's aggression and child's delinquence) by employing exploratory factor analysis(EFA) and confirmatory factor analysis(CFA). Result showed that all the five conceptual variables were discriminated. It was identified as the fit index of path structure was good(CFI=.955, NNFI=.947, RMSEA=.046). The specific result were as follows: 1. the parental conflict(${\xi}1$) was directly related to the negative attitude of parental nurturing(${\eta}1$) and the child's belief about parental divorce(${\eta}2$). 2. the parental conflict(${\xi}1$) was indirectly related to child's belief about parental divorce(${\eta}2$), the child's aggression(${\eta}3$) and delinquence(${\eta}4$). 3. the negative attitude of parental nurturing(${\eta}1$) was directly related to the child's belief about parental divorce(${\eta}2$). 4. the negative attitude of parental nurturing(${\eta}1$) was indirectly related to the child's aggression(${\eta}3$) and delinquence(${\eta}4$). Lastly, and, the child's belief about parental divorce(${\eta}2$) was directly related to the child's aggression(${\eta}3$) and delinquence(${\eta}4$). Researchers also identified the mediating effect of the parental nurturing between parental conflict and child's belief about parental divorce. On the basis of these results, this article provided some suggestions for promoting of children welfare.

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Mediating Effects of Perceived Risk and Usefulness between Online Information Credibility and Intention to Use (온라인 정보의 신뢰성 및 정보 활용의도 사이의 지각된 위험과 유용성의 매개효과에 관한 연구)

  • Sun, Jonghak;Yoon, Jung-Hyeon
    • Management & Information Systems Review
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    • v.33 no.4
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    • pp.99-118
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    • 2014
  • Using the theory of attribution, this study investigates the determinants if controllability and explores underlying dimensions of online information credibility, and then investigates if the credibility of online information influences the users' intention to use the online information for evaluating or judging the involved products. Moreover, as a research attempt to investigate the impacts of online information credibility, this study examines whether the main effect of perceived online information credibility on the intention of using online information to make a decision of purchase is mediated by both perceived risk and perceived usefulness. A total of 287 survey forms were collected from online consumers. We examined reliability by exploring internal consistency of the multiple item scales in the overall sample. Convergent and discriminant validity were also examined for evidence of construct validity. Then, PLS technique was employed to test the research model. As a result of analyzing data from a dataset of 287 responses via PLS technique, it is found that (1) both sources (controllability and stability) of perceived credibility are significantly associated with both perceived risk and perceived usefulness, and (2) perceived risk as well as perceived usefulness partially mediate the link between the two sources of credibility and intention to use. The findings of this study also suggest that the two dimensions of online information credibility influence information recipient's intention to use. Moreover, the online information including descriptions about controllability and stability can trigger potential consumers to perceive risk about consumption of the informed products and services. Therefore, providing online information with highly described controllability and stability can increase not only the credibility of the online information itself, but also the intention to use the online information through perceived risk and usefulness.

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An Impact of Empathy on the Job Satisfaction and Turnover Intention - Focused on the Mediating Effect of Job Stress - (조직구성원의 공감이 직무만족과 이직의도에 미치는 영향 - 직무스트레스의 매개효과 -)

  • Choi, Su-Heyong
    • Management & Information Systems Review
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    • v.35 no.4
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    • pp.229-250
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    • 2016
  • This research was conducted to examine the effects of cognitive and emotional empathy amongst employees, and its contribution to the enhancement of the effectiveness of an organization. Further, 'job stress' was used as the moderating value. For this purpose, examination procedures were based on theoretical ground drawn from previous research papers, and an appropriate hypothesis established. Statistical methods were also employed to obtain empirical evidence. This study consisted of four variables. The independent variable is categorised into the factors of cognitive and emotional empathy. Job stress as the moderating value as well as job satisfaction and turnover intention as members of the dependent variable. A survey was carried out targeting employees of numerous firms working in teams, and a total of 324 samples were collected and processed by the software package SPSS 21 for windows as a means to verify the set study model and hypothesis. The results of the study are as follows: The two factor of cognitive and emotional empathy did not present with any significant effects. However, cognitive empathy in relation to job stress was found to inflict negative effects. The study also found the two factors to play a significant role in asserting positive effects on an individual's level of satisfaction on his/her job. While the study further explained that cognitive understanding had the tendency to impose negative effects on the turnover intention, emotional empathy did not demonstrate significant effects. Job related stress negatively effects the level of satisfaction of an individual's given task or a job and positive relation with turnover intention. It was confirmed that job stress had a degree of intermediary role upon other factors such as empathy, job satisfaction and turnover intention. The results of the study purported that empathy can raise the level of an individual's job satisfaction and kerb turnover intention. In order to accomplish depreciated levels of job related stress, it is vital that firms consistently input fervent endeavours to be subserved. It must be able to create an environment wherein employees may enjoy the improved structure of the company to empathies with each other. These transitions would allow firms to achieve maximum efficiency and improvements on the effectiveness of an organization.

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