• The Korean Journal of Nuclear Medicine
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• v.38 no.4
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• pp.311-317
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• 2004

Purpose: The purpose of this study was to determine the utility of tumor marker CA 15-3 in the following: the diagnosis of breast cancer relapse after curative mastectomy, and the differentiation or the value of tumor marker by site of metastases. Materials and Methods: Two hundred two patients (median age 48 years) with breast cancer included in the follow-up after curative mastectomy. The tumor marker CA 15-3 was determined by IRMA (CIS BIO INTERNATIONAL, France). Test values > 30 U/ml were considered elevated (positive). Results: Among 202 patients, recurrent diseases were found in 16 patients. CA 15-3 was elevated in 5 of 16 patients with recurrences. There was no false-positive patient who had elevated CA 15-3. Sensitivity and specificity of CA 15-3 for detection of breast cancer recurrence were 31%, and 100%. CA 15-3 was elevated in all of the 4 patients with liver metastases. CA 15-3 was elevated in none of the patients who relapsed with metastasis to bone-only or contralateral breast-only. Conclusion: The tumor marker CA 15-3 in the detection of breast cancer relapse after curative mastectomy is specific, but not sensitive. However, it is useful to rule out liver metastases of breast cancer, which indicates bad prognosis.

• Applied Biological Chemistry
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• v.31 no.3
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• pp.241-248
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• 1988

In order to determine the approptiate usage of insecticides to honeybee(Apis mellifera L.), median effective dose to seven insecticides were studied. $LC_(50)$ value of DDT was the highest as being 58 ppm, and that of EPN was the lowest as being 1.61ppm. Various detoxifying enzymes from the midget cf adult worker bee, including microsomal oxidases, glutathione Stransferases, esterases, and DDT-dehydrochlorinase were assayed. Effects of various insecticides on microsomal enzyme activities were as follows: Aldrin epoxidase activity was inhibited by malathione and permethrin treatment. N-demethylase activity was induced by diazinon and EPN treatment and O-demethlase activity was induced by diazinon treatment. Of the glutathione S-transferases, aryltransferase(DCNB conjugation) activity was significantly induced by diazinon, and moderately induced by permethrin. Of the esterases, ${\alpha}-NA$ esterase activity was moderately inhibited by malatjione and permethrin. Acetylcholinesterase activity was not affected by the sublethal exposure of honeybee to the insecticides. Sublethal exposure of honeybee to the insecticides had no effect on DDT-dehydrochlorinase activity, except carbaryl and permethrin were significantly induced.

• Journal of Preventive Medicine and Public Health
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• v.25 no.1 s.37
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• pp.26-33
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• 1992

The carpal tunnel syndrome is one of the most common peripheral nerve entrapment syndromes. The typical symptoms are pain, numbness and paresthesia in the median nerve territory of the hand. Recently, it is widely recognized that occupational factor is regarded as the important cause of the carpal tunnel syndrome. Clinical study is performed in the 42 female workers who is repetitively working at packing department in a rayon manufacturing factory from November 1991 till March 1992. The study included a questionnaire, physical examinations, and the neurophysiological test. The summary of the results obtained was as follows : 1. Among 42 packing workers, 9 workers(21.4%) were diagnosed as carpal tunnel syndrome by electromyography. The affected side was bilateral in 4 workers(9.5%), right in 4 workers(9.5%), and left in one worker(2.4%). 2. Among 42 subjects, 28 workers(66.7%) complained the clinical symptoms related to carpal tunnel syndrome, 11 workers(26.2%) showed positive Phalen sign, and 7 workers(16.7%) showed positive Tinel sign. 3. Researchers regard electromyographic finding as the gold standard for diagnosis of carpal tunnel syndrome. The sensitivity and specificity of the clinical symptoms to diagnose the carpal tunnel syndrome were 0.89, 0.39 respectively. If the carpal tunnel syndrome is diagnosed by the combination of the positive findings of the symptoms and the physical examinations, either Tinel or Phalen sign, the sensitivity and specificity were 0.67 and 0.76 respectively. Considering above results, though this small number of workers is not adequate for epidemiologic conclusions, carpal tunnel syndrome seems to be an important occupational disorder among packing workers in a rayon manufacturing factory.

• International Journal of Highway Engineering
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• v.8 no.4 s.30
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• pp.125-133
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• 2006

In this study, the Korean Industrial Standard(KS) penetration grade system was examined to evaluate its statistical validity. It was found from this limited study that the system has no gap between each grade, the binder falling out of limit trespasses into other binder grade. Therefore, many products can have similar property level with an adjacent grade even though the mean value is within the specification limit. It was also found out that the equal range setup of each grade, such as 20 for 40-60, 60-80, 80-100, has no statistical foundation. Since KS penetration grade is defined without gap between each grade, the producer must maintain the coefficient of variation below the level by the ASTM system to satisfy the normal quality control limit of products. Due to its lack of a gap between grades, higher percentage of products will be duplicated even if the mean is at the median of the specification limits due to material's quality uncertainty. Especially if the mean moves toward the upper limit, a half or more of the binder grade will be overlapped with the upper binder grade. Therefore, KS penetration specification should be immediately modified by statistically valid methodologies.

• Journal of Korean Society of Transportation
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• v.21 no.1
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• pp.77-90
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• 2003

This paper explores the way and the extent to which drivers' route choice was influenced by uncertain information. In particular, this paper investigates the effect of qualitative information on route choice when drivers face a choice with different degrees of uncertain information. The SP survey was conducted and route choice legit models were estimated. We also applied Prospect Theory to the analysis of drivers' decision making under uncertain information. The main findings are firstly, drivers tend to prefer a route with information than(to) one without information. This indicated that providing charge information encouraged drivers to choose the routes for which information is provided in preference to those for which it is not provided. Secondly, drivers also prefer a route with a certain and precise information over one with uncertain and imprecise information. Thirdly, when the information is given as a range, the size of the range of the information influenced route choice slightly and as the range of the charge increases, the route becomes slightly less unattractive. Fourthly, when the information is given as a range, drivers' route choices are influenced more by the median value of the ranges than by the size of the overall ranges of the information. Application of Prospect Theory to the results explains the way drivers may be interpreting the choice situation and how they make a route choice in response to uncertain information. The results of this paper implicate that drivers' decision making under uncertainty seem to be very complicated and flexible, depending on the way drivers interpret the choice situation. Therefore, it is recommended to apply wider related theories to the analysis of the drivers' behaviour.

• Korean Journal of Agricultural Science
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• v.40 no.2
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• pp.155-162
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• 2013

Genome-wide association study was performed on data from 266 Hanwoo steers derived from 66 sire using bovine 10K mapping chip in Hanwoo (Korean Cattle). SNPs were excluded from the analysis if they failed in over 5% of the genotypes, had median GC scores below 0.6, had GC scores under 0.6 in less than 90% of the samples, deviated in heterozygosity more than 3 standard deviations from the other SNPs and were out of Hardy-Weinberg equilibrium for a cutoff p-value of $1^{-15}$. Unmapped and SNPs on sex chromosomes were also excluded. A total of 4,522 SNPs were included in the analysis. To test an association between SNP and QTL, GWAS for five genetic mode (additive, dominant, overdominant, recessive and codominant) was implemented in this study. Three SNPs (rs29018694, ss46526851 and rs29018222) at a threshold p< $1.11{\times}10^{-5}$ were detected on BTA12 and BTA21 for dressing percentages in codominant and recessive genetic mode. The G allele for rs29018694 has 4.9% higher dressing percentage than A allele, while the T allele for ss46526851 has 2.57 % higher dressing percentage than C allele. Therefore, rs29018694 SNP showed a bigger effect than the other two SNPs (ss46526851 and rs29018222) in this study. In conclusion, this study identifies three loci with moderate effects and many loci with infinitesimally small effect across genome in Hanwoo.

• Journal of Life Science
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• v.17 no.7 s.87
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• pp.937-943
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• 2007

The fish fauna and weight-length relationship in Andong reservoir were investigated from May 2005 to March 2006. During surveyed period, 2,540 individuals 20 species belonging to 7 families were collected. Dominant species were Hemibarbus labeo(19.6%) and sub-dominant species were Carassius cuvieri (19.2%). The korea endemic species were Hemiculter eigenmanni(7.1%), Squalidus chankaensis tsuchigae (0.1 %), Corroperca herzi (0.1 %) and introduced fishes were Carassius cuvieri (19.21 %) Lepomis macrochirus (4.2%), Micropterus salmoides (0.2%). Dominace, species diversity, species richness, species even-ness were 0.39, 3.16, 2.42, 0.73 respectively. The values of the exponent b in the weight-length relation-ship $W=aL^{b}$ ranged from 2.9162(H. labeo, $R^{2}$=0.9567) to 3.2509(Zacco pla쇼pus, $R^{2}$=0.9928) and the median value was 3.1079, whereas 50% of the values ranged between about 3.05 to 3.20. The Condition factor(K) showed good state of health in the surveyed species (excepts H. labeo and Cyprinus carpio).

• Journal of Korean Society of Environmental Engineers
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• v.36 no.10
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• pp.711-718
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• 2014

Investigated the processing characteristics of the pollutants and runoff due to storm events in the actual application of the road fields and a Non-Point Sources (NPS) pilot scale equipment. This phenomenon has occurred in the influent bypass the blockage occurs after 90 min the expended polymeric media was filled with filtered column. When entering a treatment tank SS 200 mg/L or more high concentration of effluent treatment efficiency was reduced from the reaction time 60 min. Influent concentration less then SS 180 mg/L was stable handling. The $COD_{Cr}/SS$ ratio were analyzed with 0.67, median value. Showed 92.1% and 82.3% respectively with an average removal rate of the SS and the $COD_{Cr}$. If the influent concentration of TP is the 0.5 mg/L or less, the quality of the treated water is 0.1 mg/L levels were expressed in a stable process. And when entering the 1.0 mg/L or more of the treated water, had a greater than average 0.2 mg/L. If the influent concentration of TN is 4~10 mg/L, the treatment water quality level was kept a 1.5~3.0 mg/L. The average removal efficiency of TP and TN respectively 73.9%, 50.4%.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.42 no.6
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• pp.67-76
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• 2005

This paper proposes a compact-sized surface myoelectric sensor for the myoelectric hand prosthesis. To fit the surface myoelectric sensor in the socket for the myoelectric hand prosthesis, the sensor should be a compact size. The surface myoelectric sensor is. composed of a skin interface and a single processing circuit that are mounted on a single package. The skin interface has one reference and two input electrodes, and the reference electrode is located in the center of two input electrodes. In this paper we propose two types of sensors with the circle- and bar-shaped reference electrode, but all input electrodes are the bar-shaped. The metal material of the electrodes is the stainless steel (SUS440) that endures sweat and wet conditions. Considering the conduction velocity and the median frequency of the myoelectric signal, we select the inter-electrode distance (IED) between two input electrodes as 18mm, 20mm, and 22 mm. The signal processing circuit consists of a differential amplifier with a band pass filter, a band rejection filter for rejecting 60Hz power-line noise, amplifiers, and a mean absolute value circuit. We evaluate the proposed sensor from the output characteristics according to the IED and the shape of the reference electrode. From the experimental results we show the surface myoelectric sensor with the 18mm IED and the bar-shaped reference electrode is suitable for the myoelectric hand prosthesis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.18 no.3
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• pp.255-264
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• 1989

The results of toxicity test using mice and rats for ethanol extract of Bracken Fern collected in Kwang Ju area were shown as follows ; Up to the dose of 10g per kg of mice administered intraperitoneally there was no lethal toxicity so that it was impossible to calculate the median lethal dose $(LD_{50})$. For the first 7 days experiment all rats administered frond extract grouping in 40mg, 400mg, and 1200mg per kg of rat as the daily oral doses did not show any characterized sign in the weight gain rate, anatomical findings, and biochemical studies. For 3 weeks following the first week the weight gain rates of all test group were reduced to $4.2{\sim}7%$ below the weight gain rate of control. In this period serum GPT, GOT, and Alkaline phosphatase value were increased significantly indicating the symptoms of Bracken Fern poisonings. The pathological findings of all test groups for 28 days showed acute and chronic intestinal lesion and liver damage with steatosis especially in 1200g/kg rat groups. In this experiment the Bracken poisonings appeared slowly in rats of 400mg/kg and 1200mg/kg for two weeks and in rats of 40mg/kg for 3 weeks, showing the symptoms of lowering of weight gain rate, subacute hepatitis, hepatic steatosis and enteritis in 28 days experiment.