• BMB Reports
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• 제52권1호
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• pp.70-85
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• 2019

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.

• BMB Reports
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• 제56권12호
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• pp.625-632
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• 2023

Nonsense-mediated mRNA decay (NMD) is both a quality control mechanism and a gene regulation pathway. It has been studied for more than 30 years, with an accumulation of many mechanistic details that have often led to debate and hence to different models of NMD activation, particularly in higher eukaryotes. Two models seem to be opposed, since the first requires intervention of the exon junction complex (EJC) to recruit NMD factors downstream of the premature termination codon (PTC), whereas the second involves an EJC-independent mechanism in which NMD factors concentrate in the 3'UTR to initiate NMD in the presence of a PTC. In this review we describe both models, giving recent molecular details and providing experimental arguments supporting one or the other model. In the end it is certainly possible to imagine that these two mechanisms co-exist, rather than viewing them as mutually exclusive.

• Molecules and Cells
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• 제46권11호
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• pp.664-671
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• 2023

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of Caenorhabditis elegans, an outstanding model for aging research. We discuss the recently discovered functions of the proper regulation of nonsense-mediated mRNA decay, ribosome-associated quality control, and mRNA splicing in the aging of C. elegans. We describe how mRNA quality control contributes to longevity conferred by various regimens, including inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling, dietary restriction, and reduced mechanistic target of rapamycin signaling. This review provides valuable information regarding the relationship between the mRNA quality control and aging in C. elegans, which may lead to insights into healthy longevity in complex organisms, including humans.

• 에너지공학
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• 제25권1호
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• pp.69-75
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• 2016

기포크기는 다차원 이상유동에서 정확한 기포거동의 예측을 위해 중요한 인자이다. 현재 CFD 코드인 STAR CCM+에서는 유동채널에서 기포크기예측을 위해 역학적인 기포크기모델인 $S{\gamma}$ 모델을 제공하고 있다. 기포크기 예측을 위한 또 다른 모델로써 고압조건의 과냉 비등 실험인 DEBORA 실험을 바탕으로 개발된 Yun 모델이 있다. 본 연구에서는 상용 CFD 코드인 STAR CCM+ ver. 10.02를 이용하여 물-공기 이상유동에 대한 수치해석을 통해 $S{\gamma}$ 모델과 Yun 모델의 성능을 확인하고 평가하였다. 이를 위해 두 모델은 수직관에서의 물-공기 실험인 DEDALE 실험과 Hibiki 등의 실험에 대하여 평가되었다. 해석 결과 $S{\gamma}$ 모델은 이상유동 인자들을 합리적으로 예측하였으며, Yun 모델은 저압조건의 물-공기 유동에는 적합하지 않음을 확인하였다.

• 한국압력기기공학회 논문집
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• 제12권2호
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• pp.40-49
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• 2016

Flow accelerated corrosion (FAC) of the carbon steel piping has been a significant problem in nuclear power plants. FAC occurs under certain hydrodynamic, environmental, and material conditions, and extensive research into the factors of FAC has been conducted. The basic process of FAC is now relatively well understood; however, a full mechanistic model has not yet been established. Recently, the Korea Atomic Energy Research Institute (KAERI) has built a large experiment loop system for FAC. To produce significant experimental results using this system, the factors affecting on FAC should be analyzed quantitatively, and a model needs to be developed. In this work, a statistical modeling methodology to develop an empirical model is described in detail, and a preliminary model is suggested. Firstly, FAC data were collected from the research literature in Japan and the results of domestic experiments. The flow rate, water temperature, pH at room temperature, and the Cr content are selected as major factors, and nonlinear regression is used to find the best fit of the available data. An iterative procedure between suggesting and evaluating a model is used until an optimum model is obtained. The developed model gives the FAC rate comparable to the measured FAC rate. The developed model is going to be refined using additional laboratory data in the future.

• 한국도로학회논문집
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• 제6권3호
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• pp.27-35
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• 2004

공용중인 공항 콘크리트 포장의 잔존수명을 추정하는 방법은 크게 과거의 누적 교통량을 고려하는 방법, 이론적 해석을 통한 역학적 방법 등 두 가지로 구분할 수 있다. 단순히 과거의 누적교통량을 이용하는 방법은 노후포장의 잔존수명을 추정하기에는 현실과 많은 차이가 있기 때문에 최근들어 많은 연구자들은 역학적 해석에 의한 방법을 많이 채택하고 있다. 역학적 방법에서 피로식은 잔존수명산출의 핵심을 이루는 것으로서 그 역할은 매우 중요하다고 할 수 있다. 본 연구는 국내 공항 콘크리트 포장의 피로식을 개발하기 위한 연구이다. 이를 위하여 재령이 10년된 공항을 선정하여 30개의 코어시료를 채취하여 피로시험을 실시하였다. 피로실험은 쪼갬인장 모드를 이용하여 수행하였으며 응력비 산정을 위한 기준 강도도 코어시료의 쪼갬인장 강도를 통해 얻었다. 본 연구에서 얻은 피로식의 상관계수값은 0.5였으며, 이 모델을 검증하기 위해 다른 공항에서 채취한 시료를 이용하여 실험을 수행하였으며 실험결과는 본 연구에서 제시된 피로식에 크게 벗어나지 않는 것을 확인하였다. 본 피로식을 기존의 외국 연구와 비교한 결과 응력비가 80%이상인 구간에서는 피로수명이 약간 큰 것으로 나타났다.

• 한국환경복원기술학회지
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• 제19권6호
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• pp.19-30
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• 2016

The projection of climate-related range shift is critical information for conservation planning of Korean fir (Abies koreana E. H. Wilson). We first modeled the distribution of Korean fir under current climate condition using five single-model species distribution models (SDMs) and the pre-evaluation weighted ensemble method and then predicted the distributions under future climate conditions projected with HadGEM2-AO under four $CO_2$ emission scenarios, the Representative Concentration Pathways (RCP) 2.6, 4.5, 6.0 and 8.5. We also investigated the predictive uncertainty stemming from five individual algorithms and four $CO_2$ emission scenarios for better interpretation of SDM projections. Five individual algorithms were Generalized linear model (GLM), Generalized additive model (GAM), Multivariate adaptive regression splines (MARS), Generalized boosted model (GBM) and Random forest (RF). The results showed high variations of model performances among individual SDMs and the wide range of diverging predictions of future distributions of Korean fir in response to RCPs. The ensemble model presented the highest predictive accuracy (TSS = 0.97, AUC = 0.99) and predicted that the climate habitat suitability of Korean fir would increase under climate changes. Accordingly, the fir distribution could expand under future climate conditions. Increasing precipitation may account for increases in the distribution of Korean fir. Increasing precipitation compensates the negative effects of increasing temperature. However, the future distribution of Korean fir is also affected by other ecological processes, such as interactions with co-existing species, adaptation and dispersal limitation, and other environmental factors, such as extreme weather events and land-use changes. Therefore, we need further ecological research and to develop mechanistic and process-based distribution models for improving the predictive accuracy.

• 한국도로학회논문집
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• 제7권4호
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• pp.1-8
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• 2005

아스팔트 포장에서 소성변형은 교통하중에 의해 발생하는 가장 심각한 파손중의 하나이다. 현재 개발중인 한국형 포장 설계법은 역학적-경험적 설계법으로 다양한 포장 파손 예측모델을 필요로 한다. 이 연구는 포장설계시 아스팔트층에서 발생하는 소성 변형량을 예측할 수 있는 모델을 개발하여 포장의 공용성을 규명하고자 하였다. 본 논문은 아스팔트 혼합물의 소성변형에 영향을 미치는 인자를 규명하고, 소성변형 예측 모델을 개발하고자 한다. 이를 위하여 3단계 온도, 공극률을 조합한 19mm 밀입도 혼합물에 대하여 삼축압축 반복재하시험을 수행하였다. 그 결과 혼합물의 온도와 공극률이 소성변형 예측 모델 계수에 영향을 미치는 것으로 확인되었다. 이에 근거하여 19mm밀입도 아스팔트 혼합물에 대한 소성변형 예측식을 다중 회귀분석을 통하여 개발하였으며, 개발된 모델을 검증하였다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.1404-1414
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• 2008

In the mechanistic-empirical trackbed design of railways, the resilient modulus is the key input parameter. This study focused on the resilient modulus prediction model, which is the functions of mean effective principal stress and axial strain, for three types of railroad trackbed materials such as crushed stone, weathered soil, and crushed-rock soil mixture. The model is composed with the maximum Young's modulus and nonlinear values for higher strain in parallel with dynamic shear modulus. The maximum values is modeled by model parameters, $A_E$ and the power of mean effective principal stress, $n_E$. The nonlinear portion is represented by modified hyperbolic model, with the model parameters of reference strain, ${\varepsilon}_r$ and curvature coefficient, a. To assess the performance of the prediction models proposed herein, the elastic response of a test trackbed near PyeongTaek, Korea was evaluated using a 3-D nonlinear elastic computer program (GEOTRACK) and compared with measured elastic vertical displacement during the passages of freight and passenger trains. The material types of sub-ballasts are crushed stone and weathered granite soil, respectively. The calculated vertical displacements within the sub-ballasts are within the order of 0.6mm, and agree well with measured values with the reasonable margin. The prediction models are thus concluded to work properly in the preliminary investigation.

• 한국태양에너지학회 논문집
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• 제33권5호
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• pp.9-17
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• 2013

Hourly horizontal global solar radiation has been used as one of significant parameters in a weather file for building energy simulations, which determines the quality of building thermal performance. However, as about twenty two weather stations in Korea have actually measured the horizontal global sola radiation, the weather files collected in other stations requires solar data simulation from the other meteorological parameters. Thus, finding the reliable complicated method that can be used in various weather conditions in Korea is critically important. In this paper, three solar simulation models were selected and evaluated through the reliability test with the simulated hourly horizontal global solar radiation against the actually measured solar data to find the most suitable model for the south east area of Korea. Three selected simulation models were CRM, ZHM, and MRM. The first two models are regression type models using site-fitted coefficients which are derived from the correlation between measured solar data and local meteorological parameters from the previous years, and the last model is a mechanistic type model using the meteorological data to calculate conditions of atmospheric constituents that cause absorption and scattering of the extraterrestrial radiation on the way to the surface on the Earth. The evaluation results show that ZHM is the most reliable model in this area, yet a complicated hybrid simulation methods applying the advantages of each simulation method with the monthly-based weather data is needed.