• The Journal of Information Systems
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• v.30 no.2
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• pp.165-188
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• 2021

Purpose This study was conducted to identify the multidimensional role of institutional mechanisms in the linear relationship of satisfaction, trust and repurchase intention, which are used as an important concept in the research of e-commerce. To this end, a research model was proposed by combining concepts which are the concept of perceived effectiveness of institutional mechanisms for overall e-commerce environment(e.g., PEEIM) and the concep of perceived effectiveness of institutional structures(e.g., PEIS) of a specific marketplace based on the social cognitive theory. Design/methodology/approach This study was conducted by dividing the data into two groups to identify institutional mechanisms and trust-building relationships according to the institutional contexts inherent in e-commerce. The institutional contexts were set up for the top two online companies and the bottom two online companies according to the results of the open market brand assessment from 2018 to 2019 in South Korea. Findings The result of this study found that PEIS had a direct impact on trust in both high and low groups respectively whereas PEEIM presented different paradoxical results in high and low groups. In the relationship between the satisfaction and the trust in the vendor of the high group, PEEIM showed negative moderating effects but in the relationship between the trust and the repurchase intention of the low group PEEIM showed positive moderating effects.

• Genomics & Informatics
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• v.19 no.1
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• pp.2.1-2.10
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• 2021

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in the majority of cases. Although secondary mutations in the mitogen-activated protein kinase signaling pathway are known to be responsible for this phenomenon, the molecular mechanisms governing acquired resistance are not known in more than half of patients. Here we report a genome- and transcriptome-wide study investigating the molecular mechanisms of acquired resistance to BRAF inhibitors. A microfluidic chip with a concentration gradient of vemurafenib was utilized to rapidly obtain therapy-resistant clones from two melanoma cell lines with the BRAF V600E mutation (A375 and SK-MEL-28). Exome and transcriptome data were produced from 13 resistant clones and analyzed to identify secondary mutations and gene expression changes. Various mechanisms, including phenotype switching and metabolic reprogramming, have been determined to contribute to resistance development differently for each clone. The roles of microphthalmia-associated transcription factor, the master transcription factor in melanocyte differentiation/dedifferentiation, were highlighted in terms of phenotype switching. Our study provides an omics-based comprehensive overview of the molecular mechanisms governing acquired resistance to BRAF inhibitor therapy.

• The Journal of Industrial Distribution & Business
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• v.13 no.9
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• pp.11-26
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• 2022

Purpose: Manufacturers rely on interfirm governance mechanisms to reduce the risks inherent in uncertain environments; however, it is unclear which governance mechanisms are developed to manage relationships with suppliers. This study sought to enhance knowledge of how environmental uncertainty affects interfirm governance mechanisms under conditions reflecting varying levels of structural holes. To this end, the study investigated the relationships between manufacturers and major first-tier and sub-suppliers. In particular, the moderating effect of structural holes is examined. Research design, data and methodology: A questionnaire survey was conducted with a major first-tier supplier of a Korean engineering firm. Proposed hypotheses were tested using structural equation modeling. Results: The results show that while the relationship between environmental uncertainty and unilateral governance is positive but statistically insignificant, with bilateral governance is negative and statistically significant. The study also demonstrates that when structural holes are considered, the effects between environmental uncertainty and governance mechanisms are attenuated. Conclusions: This study suggests some theoretical and managerial contributions between exchange partners, especially, the results suggest that structural holes have a critical competitive advantage in uncertain environments. Therefore, manufacturers should carefully consider how they deal with environmental uncertainty when they make a business decision under structural holes situations.

• The Plant Pathology Journal
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• v.40 no.3
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• pp.235-250
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• 2024

During the infection process, plant pathogenic fungi encounter plant-derived oxidative stress, and an appropriate response to this stress is crucial to their survival and establishment of the disease. Plant pathogenic fungi have evolved several mechanisms to eliminate oxidants from the external environment and maintain cellular redox homeostasis. When oxidative stress is perceived, various signaling transduction pathways are triggered and activate the downstream genes responsible for the oxidative stress response. Despite extensive research on antioxidant systems and their regulatory mechanisms in plant pathogenic fungi, the specific functions of individual antioxidants and their impacts on pathogenicity have not recently been systematically summarized. Therefore, our objective is to consolidate previous research on the antioxidant systems of plant pathogenic fungi. In this review, we explore the plant immune responses during fungal infection, with a focus on the generation and function of reactive oxygen species. Furthermore, we delve into the three antioxidant systems, summarizing their functions and regulatory mechanisms involved in oxidative stress response. This comprehensive review provides an integrated overview of the antioxidant mechanisms within plant pathogenic fungi, revealing how the oxidative stress response contributes to their pathogenicity.

• Journal of Distribution Research
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• v.1 no.2
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• pp.53-84
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• 1996

This paper is to develop a conceptual framework regarding the choice among dispute-resolution mechanisms in channels of distribution. These mechanisms are characterized by the division of labor in resolving disputes. The choice of the mechanism depends on dispute environments. These environments concern culture and stratification. Six propositions are addressed with respect to how the environments affect the choice of the mechanism.

• Structural Engineering and Mechanics
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• v.4 no.2
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• pp.125-138
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• 1996

This paper deals with the application of certain active and passive control mechanisms to control the dynamic response of a steel jacket platform due to wave-induced forces. The forces are estimated using the nonlinear Morison equation which provides nonlinear self-excited hydrodynamic forces. The influence of these forces on the response of a structure without and with vibration control mechanisms is demonstrated using a steel jacket platform as a simple example.

• Korean Management Science Review
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• v.28 no.3
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• pp.31-45
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• 2011

This study aims to analyze determinants and complementarities of the technological innovation protection mechanisms of Korean manufacturing firms. The results of the inter-industry comparison show that there are differentiations of the determinants among industries. Independence between legal and strategic protection mechanisms is found in the high technology industry, whereas complementarities exist between them in the low technology industry. It implies that the firms should take into account their endogenous and exogenous factors to choose appropriate combinations of the mechanisms when they build up their innovation protection strategies. This study expects to contribute to establishing technological innovation protection strategies in manufacturing industry.

• Journal of Distribution Science
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• v.12 no.1
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• pp.5-12
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• 2014

Purpose - The general objective of this study is to explain the governance mechanisms of relational exchanges by considering both economic and relational factors. As regards the relationship between opportunism and governance mechanisms, opportunism was hypothesized as being positively related to the use of the authority mechanism, and negatively related with use of the trust mechanism. Research design, data, and methodology - Purchasing relationships between original equipment manufacturers (OEMs) and their component suppliers were chosen as the empirical setting. Purchasing specialists in each company, who interact regularly with suppliers and have the major responsibility for managing the exchange relationships with suppliers, were used as the respondents for this study. A mail survey methodology was employed to collect data in the final field survey. Results - As predicted, opportunistic behavior is found to be negatively related to the use of the trust mechanism and positively related to the use of the authority mechanism. Therefore, the result supports the proposed hypotheses. Conclusions - By integrating research streams, this study contributes to the marketing discipline by improving our understanding of when and why different mixtures of governance mechanisms are used.

• Structural Engineering and Mechanics
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• v.67 no.5
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• pp.545-553
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• 2018

Mode II delamination propagation is an important damage mode in laminated composites and this paper aims to investigate the behavior of this damage in laminated composite materials using acoustic emission (AE) technique. Three different lay-ups of glass/epoxy composites were subjected to mode II delamination propagation and generated AE signals were recorded. In order to investigate the propagation of delamination behavior of these specimens, AE signals were analyzed using Wavelet Packet Transforms (WPT) and Fast Fourier Transform (FFT). In addition, conventional AE analyses were used to enhance understanding of the propagation of delamination damage. The results indicate that different fracture mechanisms were the main cause of the AE signals. The dominant mechanisms in all the specimens were matrix cracking, fiber/matrix debonding and fiber breakage, with varying percentage of the damage mechanisms for each lay-up. Scanning Electron Microscopy (SEM) observations were in accordance to the AE results.

• 한국경영정보학회:학술대회논문집
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• 2008.06a
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• pp.428-433
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• 2008

The online advertising industry's business model undertakes the change from CPM (cost-per-mille)-based to CPC (cost-per-click)-based. However, due to the problem of 'Click Fraud', CPA (cost-per-action) has been regarded as a new step. For CPA, publishers need to get information after a user clicks an advertisement. Therefore, in CPA, the key is to get Conversion Action Data (CAD). This paper introduces two existing mechanisms for getting CAD, compare their characteristics, and analyze their limitations. Then the two new mechanisms are introduced and their requirements and feasibility are analyzed. Lastly, we compare the existing two and the new two mechanisms, and point out each mechanism's business possibility, value and Application Area. This paper will help publishers choose the most appropriate mechanism on the basis of their situation.