• International Journal of CAD/CAM
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• v.8 no.1
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• pp.1-10
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• 2009

This paper presents a topology optimization approach using element-free Galerkin method (EFGM) for the optimal design of compliant mechanisms with geometrically non-linearity. Meshless method has an advantage over the finite element method(FEM) because it is more capable of handling large deformation resulted from geometrical nonlinearity. Therefore, in this paper, EFGM is employed to discretize the governing equations and the bulk density field. The sensitivity analysis of the optimization problem is performed by incorporating the adjoint approach with the meshless method. The Lagrange multipliers method adjusted for imposition of both the concentrated and continuous essential boundary conditions in the EFGM is proposed in details. The optimization mathematical formulation is developed to convert the multi-criteria problem to an equivalent single-objective problem. The popularly applied interpolation scheme, solid isotropic material with penalization (SIMP), is used to indicate the dependence of material property upon on pseudo densities discretized to the integration points. A well studied numerical example has been applied to demonstrate the proposed approach works very well and the non-linear EFGM can obtain the better topologies than the linear EFGM to design large-displacement compliant mechanisms.

• Korean Journal of Agricultural Science
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• v.44 no.1
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• pp.1-15
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• 2017

In major field crops, synthetic herbicides have been used to control weeds worldwide. Globally, herbicide resistance in weeds should be minimized because it is a major limiting factor for food security. Cross resistance can occur with herbicides within the same or in different herbicide families and with the same or different sites of action. Multiple resistance refers to evolved mechanisms of resistance to more than one herbicide (e.g., resistance to both ALS-inhibitors and ACCase-inhibitors) and this resistance was brought about by separate selection processes. Target site resistance could occur from changes at the biochemical site of action of one herbicide. Non target site resistance occurs through mechanisms which reduce the number of herbicide molecules that reach the herbicide target site. There are currently 480 unique cases (species ${\times}$ site of action) of herbicide resistance globally in 252 plant species (145 dicots and 105 monocots). To date, resistance in weeds has been reported to 161 different herbicides, involving 23 of the 26 known herbicide sites of action. Finally, it can be concluded that we can protect crops associated to herbicide resistant weeds by applications of biochemical, genetic and crop control strategies.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.3
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• pp.360-371
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• 1998

In this paper, output precision characteristics of a planar 6 degree-of-freedom parallel mechanisms are investigated, where the 6 degree-of-freedom mechanism is formed by adding an additional link along with an actuated joint in each serial subchain of the planar 3 degree-of-freedom parallel mechanism. Kinematic analysis for the parallel mechanism is performed, and its first-order kinematic characteristics are examined via kinematic isotropic index, maximum and minimum input-output velocity transmission ratios of the mechanisms. Based on this analysis, two types of planar 6 degrees-of-freedom parallel manipulators are selected. Then, dynamic characteristics of the two selected planar 6 degree-of-freedom parallel mechanisms, via Frobenius norms of inertia matrix and power modeling array, are investigated to compare the magnitudes of required control efforts of both three large actuators and three small actuators when the link lengths of three additional links are changed. It can be concluded from the analysis results that each of these two planar 6 degrees-of-freedom parallel mechanisms has an excellent control-in-the-small characteristics and therefore, it can be very effectively employed as a high-precision macro-micro manipulator when both its link lengths and locations of small and large actuators are properly chosen.

• Molecules and Cells
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• v.37 no.4
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• pp.286-294
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• 2014

Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key regulator of various cell cycle events that are critical for proper M-phase progression. The polobox domain (PBD) present in Plk1's C-terminal noncatalytic region has been shown to play a central role in targeting the N-terminal kinase domain of Plk1 to specific subcellular locations. Subsequent studies reveal that PBD binds to a phosphorylated motif generated by one of the two mechanisms - self-priming by Plk1 itself or non-self-priming by a Pro-directed kinase, such as Cdc2. Here, we comparatively review the differences in the biochemical steps of these mechanisms and discuss their physiological significance. Considering the diverse functions of Plk1 during the cell cycle, a better understanding of how the catalytic activity of Plk1 functions in concert with its cisacting PBD and how this coordinated process is intricately regulated to promote Plk1 functions will be important for providing new insights into different mechanisms underlying various Plk1-mediated biological events that occur at the multiple stages of the cell cycle.

• The Korean Journal of Ecology
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• v.28 no.2
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• pp.105-112
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• 2005

Environmental factors such as light and low $CO_2$ concentrations trigger events which may result in stomatal opening. Stomatal aperature is largely controlled by the solute contents of guard cells, but not exclusively, by through changes in their content of potassium salts, with $K^+$ balanced either by $Cl^-$ or malate, depending on the species and conditions. However, how these signals are sensed and how they are transduced into driving the ion fluxes that control stomatal movements is not still fully understood. The basic role of stomata is regulating transpiration and photosynthesis. Photosynthesis plays a central role in the physiology of plants and an understanding of its response to light is, therefore, critical to any discussion of how plants sense and respond to light. It had been proposed that the evidences pointed three possible mechanisms for the light response. Firstly, there is a direct response of stomata to light. Secondly. there is an indirect response of stomata to light through the effect of $CO_2$. Lastly, there are some evidences for a third effect of light on stomata. However, attempts to investigate how these three possible mechanisms explained in detail in response to light have not been made. Therefore, this study is examined the differences among these three possible mechanisms.

• Journal of Communications and Networks
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• v.6 no.1
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• pp.60-67
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• 2004

With the fast growth of Internet and a new widespread interest in optical networks, the unparalleled potential of Multi-Protocol Label Switching (MPLS) is leading to further research and development efforts. One of those areas of research is Path Protection Mechanism. It is widely accepted that layer three protection and recovery mechanisms are too slow for today’s reliability requirements. Failure recovery latencies ranging from several seconds to minutes, for layer three routing protocols, have been widely reported. For this reason, a recovery mechanism at the MPLS layer capable of recovering from failed paths in 10’s of milliseconds has been sought. In light of this, several MPLS based protection mechanisms have been proposed, such as end-to-end path protection and local repair mechanism. Those mechanisms are designed for intra-domain recoveries and little or no attention has been given to the case of non-homogenous independent inter-domains. This paper presents a novel solution for the setup and maintenance of independent protection mechanisms within individual domains and merged at the domain boundaries. This innovative solution offers significant advantages including fast recovery across multiple nonhomogeneous domains and high scalability. Detailed setup and operation procedures are described. Finally, simulation results using OPNET are presented showing recovery times of a few milliseconds.

• The Korean Journal of Pain
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• v.27 no.2
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• pp.103-111
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• 2014

Nefopam (NFP) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the nonsedative benzoxazocine, developed and known in 1960s as fenazocine. Although the mechanisms of analgesic action of NFP are not well understood, they are similar to those of triple neurotransmitter (serotonin, norepinephrine, and dopamine) reuptake inhibitors and anticonvulsants. It has been used mainly as an analgesic drug for nociceptive pain, as well as a treatment for the prevention of postoperative shivering and hiccups. Based on NFP's mechanisms of analgesic action, it is more suitable for the treatment of neuropathic pain. Intravenous administration of NFP should be given in single doses of 20 mg slowly over 15-20 min or with continuous infusion of 60-120 mg/d to minimize adverse effects, such as nausea, cold sweating, dizziness, tachycardia, or drowsiness. The usual dose of oral administration is three to six times per day totaling 90-180 mg. The ceiling effect of its analgesia is uncertain depending on the mechanism of pain relief. In conclusion, the recently discovered dual analgesic mechanisms of action, namely, a) descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and b) inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.3
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• pp.225-234
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• 2018

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of $K_{ATP}$ channels, an increase in the levels of antioxidant enzymes, functional interaction with opioid receptors; increase in nitric oxide production; decrease in inflammation; activation of transient receptor potential vanilloid (TRPV) channels; activation of kinases such as protein kinase B (Akt), protein kinase C, tyrosine kinase, mitogen activated protein (MAP) kinases such as ERK 1/2, p38 MAP kinases and MAP kinase kinase (MEK 1) MMP. The present review discusses the role and mechanisms involved in adenosine preconditioning-induced cardioprotection.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.4
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• pp.1947-1953
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• 2011

OSEK/VDX is a joint project aiming at an industry standard for ECUs in vehicles and OSEK OS is a real-time operating system that meets OSEK/VDX specifications. In this paper, we suggest an implementation of task switching and interrupt handling mechanisms of OSEK operating system based on ARM processors. Considering the requirements of OSEK OS and characteristics of ARM processor, we have designed task switching and interrupt handling mechanisms. For evaluating the validation of the suggested mechanisms, we have checked the functional correctness on an experimental embedded board with ARM processor and calculated the time of task switching and interrupt handling.

• Hwankyungkyoyuk
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• v.25 no.1
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• pp.105-116
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• 2012

The most necessary thing for education now, is an ecological approach to look at and be conscious of the uncertainty of nature and the structural contradiction of society. In brief, we need to make a judgment on what standard and value are required for a forming righteous relation between nature and human being, and include it in the notion of citizenship. Based on this point of view, this study extracted moral virtues, skills and agreement mechanisms of new citizenship from ecologism, environmental justice and the ecological community, and systematized them. From ecologism and environmental justice, virtues that are inner values to lead ecological citizen's act and skills as capabilities required for correcting environmental injustice, were derived. Then, workings of citizens in a community and directions of each society and education were considered from the ecological community as an utopia where ecological citizens ultimately aim for. As the result, the ecological sensitivity, freedom, creativity, a sense of justice, a sense of responsibility, caring were found to be moral virtues that ecological citizens have to have. Next, ecological thinking skills like systemic thinking, quantitative thinking and empathetic thinking, and principles of deliberation and perturbation as mechanisms to improve communication skill and environmental injustice which have been considered importantly as components of democratic citizenship, were selected as skills of ecological citizens.