• 정보처리학회논문지C
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• 제9C권4호
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• pp.505-512
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• 2002

사용자가 요구하는 서비스들은 그들의 QoS에 따라 다양하게 분류되어질 수 있으며, 이렇게 각기 다른 특성을 갖는 서비스들이 네트워크 상에 발생할 수 있는 장애 상황에 대처하여 안전하고 효율적인 서비스를 제공하기 위해서는 이들 연결에 대한 재라우팅(rerouting) 기법이 사용되어야 한다. 본 논문은 장애가 발생할 수 있는 IP 네트워크 상에서 차별화 된 서비스 제공을 위해 각 서비스들의 QoS에 따라 이들의 우선순위를 분류하고 이에 맞는 재라우팅 기법을 연구하고자 한다. 이를 위해서 재라우팅을 시작하는 시작점에 따라 Source Rerouting, Link Rerouting 기법을, 재라우팅을 수행하는 시간에 따라 Immediate Rerouting, Random Rerouting을 연구하여 이들에 대한 효과적인 orthogonal 관계에 대한 연구를 통해 서비스의 우선순위에 따라 보다 높은 성능을 갖는 DRIT와 DRDT 재라우팅 기법을 연구하고자 한다 결과적으로 차별화 된 서비스를 지원하기 위해 각 재라우팅 기법을 차별적으로 적용한 DRDT 보다 높은 성능을 보이고 있다.

• 한방안이비인후피부과학회지
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• 제36권2호
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• pp.1-9
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• 2023

Objectives : This study used a network pharmacology approach to analyze the treatment mechanisms of Yijin-tang on Meniere's disease, and comparative analysis the treatment mechanisms of drugs recommended in the Meniere's disease treatment guidelines. Methods : We collected information on the recommended drugs from the Meniere's disease treatment guidelines and their target proteins were screened via the STITCH database. The intersection targets were obtained through Venny 2.1.0. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis were performed using ClueGO. Results : The 7 proteins(TNF, CASP9, PARP1, CCL2, CFTR, NOS2, NOS1) were associated with both Yijin-tang and Meniere's disease related genes. The 10 proteins(AQP2, KCNE1, AQP1, AVP, ACE, HRH1, HRH3, NOS1, CA1, CFTR) were associated with both the recommended drugs in the guidelines and Meniere's disease related genes. The 2 proteins(CFTR, NOS1) were common across all three groups. Further, GO/KEGG pathway analysis of the collected proteins revealed that the common mechanisms of action between Yijin-tang and the recommended drugs in the guidelines were related to pathways involving immune dysfunction and disturbances in lymphatic fluid homeostasis. In addition, the recommended drugs in the guidelines appeared to act through mechanisms that improve blood flow through vasodilation. Conclusions : Pharmacological network analysis can help to explain the treatment mechanisms of Yijin-tang on Meniere's disease.

• Journal of Ginseng Research
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• 제48권4호
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• pp.373-383
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• 2024

Background: Network pharmacology has emerged as a powerful tool to understand the therapeutic effects and mechanisms of natural products. However, there is a lack of comprehensive evaluations of network-based approaches for natural products on identifying therapeutic effects and key mechanisms. Purpose: We systematically explore the capabilities of network-based approaches on natural products, using Panax ginseng as a case study. P. ginseng is a widely used herb with a variety of therapeutic benefits, but its active ingredients and mechanisms of action on chronic diseases are not yet fully understood. Methods: Our study compiled and constructed a network focusing on P. ginseng by collecting and integrating data on ingredients, protein targets, and known indications. We then evaluated the performance of different network-based methods for summarizing known and unknown disease associations. The predicted results were validated in the hepatic stellate cell model. Results: We find that our multiscale interaction-based approach achieved an AUROC of 0.697 and an AUPR of 0.026, which outperforms other network-based approaches. As a case study, we further tested the ability of multiscale interactome-based approaches to identify active ingredients and their plausible mechanisms for breast cancer and liver cirrhosis. We also validated the beneficial effects of unreported and top-predicted ingredients, in cases of liver cirrhosis and gastrointestinal neoplasms. Conclusion: our study provides a promising framework to systematically explore the therapeutic effects and key mechanisms of natural products, and highlights the potential of network-based approaches in natural product research.

• Journal of Korean Biological Nursing Science
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• 제2권1호
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• pp.1-19
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• 2000

The purpose of this study was to define the content of the requisite knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for clinical knowledge for nursing practice. Contents of knowlege on pathological physiology, clinical microbiology, and mechanisms and effects of drugs were constructed from syllabus of basic nursing subjects in 4 colleges of nursing, and textbooks. The degree of need of 72 items was measured with a 4 point scale. The subjects of this study were college-graduated 136 nurses from seven university hospital in Seoul and three in Chonnam Province, Kyungbook Province, and Inchon. They have been working at internal medicine ward, surgical ward, intensive care unit, obstetrics and gynecology ward, pediatrics ward, opthalmology ward, ear, nose, and throat ward, emergency room, rehabilitation ward, cancer ward, and hospice ward. The results were as follows : 1. The highest scored items of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice were side effects of drugs, anticoagulants, mechanisms of drugs, antihypertensive drugs, tolerance and addiction of drugs, interactions among drugs, hospital infection in the order of importance. The lowest scored item was structure of microorganisms. 2. The highest order of need according to unit was repair in tissue injury unit, definition etiology classification of inflammation in inflammation unit, transplantation and immunologic response in alterations in immunity unit, thrombus and thrombosis in disorders of cardiovascular function unit, gene disorders in genetic disorders unit, hospital infection in infection unit, virus in microorganisms unit, side reactions of drugs in introduction unit, anticonvulsants in drugs for central nervous system unit, local anesthesia in anesthesia unit, anticoagulants in drugs for cardiovascular system unit, anti-inflammatory drugs in antibiotics unit, anti-ulcer drugs in drugs for digestive system unit, and bronchodilators in drugs for respiratory system unit. 3. The common content of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs needed for all clinical areas in nursing were side effects of drugs, anticoagulants, interactions among drugs, and hospital infection. However, the degree of need of each pathological physiology, clinical microbiology, clinical microbiology, and mechanisms and effects of drugs was different depending on clinical areas. 4. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as tissue changes due to injurious stimuli, degenerative changes of tissue, alterations in metabolism of carbohydrates, ischemia, hyperemia and congestion, hospital infection, structure of microorganism, classification of microorganism, bacteria, virus, antidepressants, antipsychotic drugs, antiemetic drugs, antiparkinsonism drugs, antianxiety drugs, antibiotics, tuberculostatics, antiviral drugs, antifungal drugs, parasiticides, antiulcer drugs, antidiarrheais, and anti constipation drugs were shown according to the work area. 5. Significant differences in the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs necessary for nursing practice such as transplantation and immunologic response, alterations in the metabolism of uric acid, structure of microorganism, classification of microorganism, immunosuppressants, drugs for congestive heart failure were demonstrated according to the duration of work. Based on these findings, all the 72 items constructed by Korean Academic Society of Basic Nursing science should be included as contents of the knowledge of pathophysiology, clinical microbiology, and mechanisms and effects of drugs.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.64.1-64.1
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• 2008

• 한국전자거래학회지
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• 제21권2호
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• pp.1-22
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• 2016

최근 온라인 뉴스 포탈의 뉴스 추천 메커니즘이 뉴스 콘텐츠를 수집, 선택, 편집 및 왜곡하는 일이 일어나고 있다. 선행연구들은 뉴스의 가치에 대한 일관된 정의를 내리지도, 뉴스의 가치가 독자의 반응에 어떤 영향을 미치는지 실증적으로 검증하지도 못했다. 본 연구는 선행연구의 뉴스 가치 개념을 종합하고, 뉴스 가치를 아우를 수 있는 개념으로 대표성의 개념을 도입하였으며, 대표성 기반 정보발견법 및 정보 수용 모델을 활용하여, 대표성이 인지된 뉴스 품질, 신뢰, 인지된 유용성, 서비스 만족도, 충성도, 지속사용의도, 구전의도 등 독자 반응에 어떠한 영향을 미치는 지를 실증적으로 검증하였다. 시나리오 설문 법을 통해 총 357개의 유효한 자료가 수집되었다. 각 집단들은 1) 시간 순서기반 뉴스 추천 메커니즘, 2) 조회수 기반 뉴스 추천 메커니즘, 3) 편집자에 의해 선택된 주요 뉴스를 다시 조회수 기반으로 정렬한 뉴스 추천 메커니즘의 세 종류의 메커니즘에 각각 노출되었다. MANOVA 분석결과에 따르면, 편집자에 의해 선택된 주요 뉴스를 다시 조회수 기반으로 정렬한 뉴스 추천 메커니즘만이 여타 집단에 비해 인지된 뉴스 품질과 신뢰에서 유의한 차이를 보였다. PLS 분석 결과에 따르면, 이렇게 형성된 인지된 뉴스 품질과 신뢰는 인지된 유용성, 서비스 만족도, 충성도, 지속사용의도, 구전의도 등 독자 반응을 유의하게 증가시키는 것으로 조사되었다. 본 연구의 학술적 기여는 언론 영역에서 정보기술의 역할을 강조하고, 편집자와 독자 모두가 인정하는 뉴스가 가치 있는 뉴스라고 개념화 하였으며, 뉴스 추천 메커니즘의 효과를 실증한 가치를 가진다. 실무적 측면에서 본 연구는 온라인 뉴스 포탈이 편집자와 독자의 시각이 모두 반영된 절충안의 뉴스 추천 메커니즘을 활용하는 것이 독자를 유인하기 위해 도움이 될 것이라고 제안한다.

• Journal of Ginseng Research
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• 제46권6호
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• pp.759-770
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• 2022

Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD⁺-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.

• Clinical and Experimental Pediatrics
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• 제55권6호
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• pp.185-192
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• 2012

The prevalence of allergic diseases has increased worldwide, a phenomenon that can be largely attributed to environmental effects. Among environmental factors, air pollution due to traffic is thought to be a major threat to childhood health. Residing near busy roadways is associated with increased asthma hospitalization, decreased lung function, and increased prevalence and severity of wheezing and allergic rhinitis. Recently, prospective cohort studies using more accurate measurements of individual exposure to air pollution have been conducted and have provided definitive evidence of the impact of air pollution on allergic diseases. Particulate matter and ground-level ozone are the most frequent air pollutants that cause harmful effects, and the mechanisms underlying these effects may be related to oxidative stress. The reactive oxidative species produced in response to air pollutants can overwhelm the redox system and damage the cell wall, lipids, proteins, and DNA, leading to airway inflammation and hyper-reactivity. Pollutants may also cause harmful effects via epigenetic mechanisms, which control the expression of genes without changing the DNA sequence itself. These mechanisms are likely to be a target for the prevention of allergies. Further studies are necessary to identify children at risk and understand how these mechanisms regulate gene-environment interactions. This review provides an update of the current understanding on the impact of air pollution on allergic diseases in children and facilitates the integration of issues regarding air pollution and allergies into pediatric practices, with the goal of improving pediatric health.

• Genomics & Informatics
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• 제12권3호
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• pp.87-97
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• 2014

Although the number of protein-coding genes is not highly variable between plant taxa, the DNA content in their genomes is highly variable, by as much as 2,056-fold from a 1C amount of 0.0648 pg to 132.5 pg. The mean 1C-value in plants is 2.4 pg, and genome size expansion/contraction is lineage-specific in plant taxonomy. Transposable element fractions in plant genomes are also variable, as low as ~3% in small genomes and as high as ~85% in large genomes, indicating that genome size is a linear function of transposable element content. Of the 2 classes of transposable elements, the dynamics of class 1 long terminal repeat (LTR) retrotransposons is a major contributor to the 1C value differences among plants. The activity of LTR retrotransposons is under the control of epigenetic suppressing mechanisms. Also, genome-purging mechanisms have been adopted to counter-balance the genome size amplification. With a wealth of information on whole-genome sequences in plant genomes, it was revealed that several genome-purging mechanisms have been employed, depending on plant taxa. Two genera, Lilium and Fritillaria, are known to have large genomes in angiosperms. There were twice times of concerted genome size evolutions in the family Liliaceae during the divergence of the current genera in Liliaceae. In addition to the LTR retrotransposons, non-LTR retrotransposons and satellite DNAs contributed to the huge genomes in the two genera by possible failure of genome counter-balancing mechanisms.

• 대한기계학회논문집A
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• 제26권8호
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• pp.1495-1505
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• 2002

As combining the functions of a 2K-H B type differential gear unit and a V-belt type continuously variable unit(CVU), 16 different mechanisms are presented. Some useful theoretical formula related to speed ratio, power flow and efficiency are derived and analyzed. Continuously variable transmission(CVT) mechanisms are proposed, which can of ffr a backward mode, a geared neutral, an underdrive mode and an overdrive mode. They are not required of a starting device as a torque converter. CVT mechanisms developed here present two distinct operating modes which are a power circulation mode and a power split mode. The transition of two modes takes place at the particular CVU speed ratio. For these CVT mechanisms, performance analysis related to speed ratio, power ratio and theoretical efficiency are executed.