• 한국세라믹학회지
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• 제37권4호
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• pp.332-337
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• 2000

Forming mechanism of fibrous TiC during self-propagating high temperature synthetic reaction was analyzed and suggested. It was revealed that critical temperature for the stable fiber formation was not the melting point of TiC, but the eutectic reaction temperature of TiC and C. Minimum amount of TiC diluent addition required to form fibers was calculated to be 25.6%, which was consistent with the experimental result. Synthesized fibers were found hollow tube-like. The morphology was explained by the diffusion rates of C and Ti in TiC, and by the molar volume chnage of C during the reaction. Expanding shell model was suggested for the hollow fiber formation mechanism.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1995년도 춘계학술대회 논문집
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• pp.525-530
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• 1995

The main objective of this study is to develop a gripper mechanism that can be employed for assembly and removal tasks of a nozzle-dam of steam gererator which is one of the nuclear reactor maintenance process. Brief description of the open-close type gripper mechanism, its postion analysis, and its kinematic amalysis are given. The optimal design of the gripper mechanism with slipping on its two gripping surfaces is considered. As an optimaldesign index, the ratio of the actuator force of prismatic cylinder to gripping load is proposed. Then, based on this index the optimal design synthesis is careied out to identify values of optimal design parameters for the gripper mechanism.

• 대한기계학회논문집A
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• 제21권7호
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• pp.1127-1140
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• 1997

With the study for identifying the transmission characteristics of vibration and noise generated by operating engine system of a vehicle, recently many engineers have studied actively the reduction of vibration and noise inducing uncomfortableness to the passenger. In this study, output noise was analyzed by multi-dimensional spectral analysis and vector synthesis method. The multi-dimensional analysis method is very effective in case of identification of primary source, but this method has little effect on suggestion for interior noised reduction. For compensation of this, vector synthesis method was used to obtain effective method for interior noise reduction, after identifying primary source for output noise. In this paper, partial coherence function of each input was calculated to know which input was most coherent to output noise, then with simulation of changes for input magnitude and phase by vector synthesis diagram, the trends of synthesized output vector was obtained. As a result, the change of synthesized output vector could be estimated.

• BMB Reports
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• 제31권2호
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• pp.201-208
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• 1998

Amino acid analogs, like other inducers of stress response, induce the synthesis of stress proteins in mammalian cells. In this study, Drosophila Kc cells, in which translation is tightly controlled during stress response, was treated with proline analogs, L-azetidine-2-carboxylic acid (AzC) and 3,4-dehydro-L-proline (dh-P). Kc cells exposed to AzC or dh-P induced the synthesis of several proteins which had the same molecular weights as known heat shock proteins. However, in Kc cells, normal protein synthesis still continued in the presence of amino acids analogs unlike in heat-shocked cells. For the induction of stress response, the incorporation of dh-P into the protein was not essential, but the incorporation of AzC was. The stress protein synthesis was regulated mainly at the transcriptional level by AzC, whereas it was regulated by dh-P at the transcription level and possibly posttranscription level. During recovery, the stress protein synthesis stopped sooner in analog-treated cells than in heat-shocked cells even though the accumulated amount of Hsp70 was much less in proline analogstreated cells. It could be concluded that the proline analogs, AzC and dh-P, induced stress response through a different mechanism from heat shock.

• Molecules and Cells
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• 제39권5호
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• pp.410-417
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• 2016

During the lactation cycle of the bovine mammary gland, autophagy is induced in bovine mammary epithelial cells (BMECs) as a cellular homeostasis and survival mechanism. Interferon gamma ($IFN-{\gamma}$) is an important antiproliferative and apoptogenic factor that has been shown to induce autophagy in multiple cell lines in vitro. However, it remains unclear whether $IFN-{\gamma}$ can induce autophagy and whether autophagy affects milk synthesis in BMECs. To understand whether $IFN-{\gamma}$ affects milk synthesis, we isolated and purified primary BMECs and investigated the effect of $IFN-{\gamma}$ on milk synthesis in primary BMECs in vitro. The results showed that $IFN-{\gamma}$ significantly inhibits milk synthesis and that autophagy was clearly induced in primary BMECs in vitro within 24 h. Interestingly, autophagy was observed following $IFN-{\gamma}$ treatment, and the inhibition of autophagy can improve milk protein and milk fat synthesis. Conversely, upregulation of autophagy decreased milk synthesis. Furthermore, mechanistic analysis confirmed that $IFN-{\gamma}$ mediated autophagy by depleting arginine and inhibiting the general control nonderepressible-2 kinase (GCN2)/eukaryotic initiation factor $2{\alpha}$ ($eIF2{\alpha}$) signaling pathway in BMECs. Then, it was found that arginine supplementation could attenuate $IFN-{\gamma}$-induced autophagy and recover milk synthesis to some extent. These findings may not only provide a novel measure for preventing the $IFN-{\gamma}$-induced decrease in milk quality but also a useful therapeutic approach for $IFN-{\gamma}$-associated breast diseases in other animals and humans.

• 한국항공우주학회지
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• 제41권10호
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• pp.827-832
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• 2013

극초소형 위성으로 분류되는 큐브위성의 경우, 1U를 기준으로 $10cm{\times}10cm{\times}10cm$의 크기, 1kg 이하의 중량제한을 비롯해 폭발식 구속분리장치의 적용이 불가한 설계요구조건으로 인하여 열선 작동시 나일론선의 절단과 함께 구속을 해제하는 구속분리 방식이 일반적으로 적용되고 있으나 낮은 체결력과 다수 구조물의 구속 시 다수의 열선 적용을 필요로 하는 등 시스템 복잡화의 단점이 존재한다. 본 논문에서는 기존의 큐브위성에 적용되는 열선 절단방식의 단점을 극복하기 위하여 열선절단방식을 적용한 분리너트형 비폭발식 구속분리장치를 고안하였으며, 인증모델의 기능시험, 정하중시험 및 충격시험을 통해 설계 유효성을 입증하였다.

• 한국항공우주학회지
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• 제44권3호
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• pp.274-280
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• 2016

2015년 발사예정인 우주기반기술 검증용 큐브위성 STEP Cube Lab.의 주요 탑재체인 열선절단방식 힌지구동형 구속분리장치는 높은 체결력 및 저충격 구현의 장점으로 초소형위성 전개구조물의 구속/분리에 적용이 용이하며, 기존 나일론선 절단방식의 낮은 체결력 및 복수구조물 적용에 따른 시스템 복잡화의 단점을 극복가능하다. 본 논문에서는 인증모델 검증시험이 완료된 구속분리장치의 궤도검증 임무수행을 목적으로 체결력 검증 및 전개 확인 신호 획득이 가능한 비행모델을 설계/제작하였으며, 탑재체 레벨에서의 발사 및 궤도환경 검증시험을 수행하여 설계 유효성을 입증하였다.

• 한국세라믹학회지
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• 제35권12호
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• pp.1336-1336
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• 1998

2단계 열탄소환원법으로 탄화규소 휘스커를 Ar과 H2분위기에서 기상-고상, 2단계, 기상-액상-고상 성장기구를 통해 각각 합성하였다. Ar분위기에서 탄화규소 휘스커는 다음과 같은 반응기구로 성장하였다. SiO2(S)+C(s)-SiO(v)+CO(v) SiO(v)3CO(v)=SiC(s)whisker+2CO2(v) 2C(s)+2CO2(v)=4CO(v) 이때 전체 반응속도는 세번째 반응에 참여하는 탄소에 의해 지배되었다. 따라서 이 반응이 휘스커 합성의 율속반응으로 판단되었다. 한편 H2 분위기에서 탄화규소 휘스커는 다음과 같은 반응기구로 성장하였다.SiO2(s)+C(s)=SiO(v)+CO(v) 2C(s)+4H2(v)=2CH4(v) SiO(v)+2CH4(v)=SiC(s)whisker+CO(v)+4H2(v) 이때 전체 반응속도는 SiO(v) 기체의발생 속도에 의해 지배되었다. 따라서 첫번째 반응이 휘스커 합성의 율속 반응인 것으로 판단되었다.

• Bulletin of the Korean Chemical Society
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• 제32권spc8호
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• pp.3022-3030
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• 2011

Since the discovery of the fact that compounds bearing a vinylic fluoride moiety often exhibit remarkable biological activities such as enzyme inhibitors, many synthetic methods for fluorine-substituted vinylic compounds have been developed. The synthesis of selectively fluorinated building blocks, such as arylsubstituted fluoro-alkenes, also has become an area of interest in recent years. Herein we describe a novel and practical method for the synthesis of 1,1-difluoro- and 1-fluoroalkenes starting from easily accessible trifluoroacetophenone derivatives. Various 1,1-difluoro- and 1-fluoroalkenes were prepared by the reaction of the corresponding tosyl hydrazones that were derived from trifluoroacetophenone derivatives by treating with alkyl or aryllithium reagents via addition-elimination and single electron transfer (SET) mechanism.

• 대한기계학회논문집A
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• 제24권1호
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• pp.225-231
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• 2000

Dimensional synthesis of planar and spatial mechanisms mostly requires solution-finding, procedure for a system of polynomial equations. In case the system is nonlinear, numerical techniques like Newton-Raphson are often used. But there are no logical ways for finding all possible solutions in such iterative methods. In this paper, algebraic elimination is used to get all solutions for the synthesis of 5-SS spatial mechanism with seven prescribed positions. The proposed algorithm is more suitable for computer implementation and takes less time than existing one. Two numerical examples are given to demonstrate the implemented algorithm.