• Journal of Ginseng Research
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• v.14 no.2
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• pp.162-166
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• 1990

The climacterium is that phase in the aging precess during which a woman passes from the reproductive to the non-reporductive stage. The signals, such as hot flashes, vaso-motoric disturbances, perspiration, stiff shoulders, emotinal symptoms, are refered to as climacteric disturbances. Treatment of climacteric symptoms centers around estrogen replacement and transfuilizers, but there are many problems to be solved to use these hormones/drugs as far as dossage, duration and complications are concerned. The care of women during the climacteric years should provide relief of distressing symptoms with as high a degree of safety as possible. From this view point, we used red ginseng powder to those patients with high menopausal index successfully. We studied its mechanism of action and proved that red ginseng improved the micro-circulation system via improvement of erythrocyte reformability which enhanced sex steroidgensis consequently.

• Microbiology and Biotechnology Letters
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• v.18 no.3
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• pp.260-267
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• 1990

The mechanism of enzymatic hydrolysis of raw corn starch by the purified glucoamylase and a - amylase in an agitated bead reaction system was studied by investigating the changes of sugar profiles produced by each enzyme, the granular structure of raw corn starch, the amount of enzyme adsorption on residual starch, and the amylose content in residual raw starch. The sugar profiles produced by the action of exo-type glucoamylase or endo-type $\alpha$ -amylase in an agitated bead system were not recognizably differed with those produced in reaction system without bead. Without enzyme the intergenic microcrystalline structure of starch granule was not changed by the simple mechanical impact of solid media, but it was cleaved. However, starch granule was fragment into large number of small particles by the synergistic action of enzyme and attrition-milling media, identified to be the major saccharification enhancing mechanism along with the increased amount of enzyme adsorption. The amylose content decreased more readily in an agitated bead reaction system, especially by $\alpha$ -amylase.

• Archives of Pharmacal Research
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• v.22 no.2
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• pp.173-178
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• 1999

Remarks on polyphenolic compounds has been arisen since past few years. the flavonoids appears to be the important groups of compounds with their capability to inhibit DNA damage, lipid peroxidation, to quench free radicals and, at least, anticarcinogenic and antiproliferative effects. On the other hand, their mechanism of action is still unexplained. Apigenin and luteolin are the most wide-spread flavones and they exhibited to be useful in chemoprevention. UV spectrometric and DC polarographic studies on these two compounds have been carried out with regard to changing pH. The most significant changes were observed at basic pH. These results could aid to elucidation of their mechanism of action as pH is one of the important factors for bioprocesses passing in living organisms.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.88.2-88.2
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• 2003

Ascorbic acid (vitamin C) has been shown to have anti-cancer actions. However, the exact mechanism of this action is not fully understood. In this study we investigated the possible mechanism of anti-cancer action of ascorbic acid in HepG2 human hepatoblastoma cells. Ascorbic acid induced apoptotic cell death in a dose-dependent manner in the HepG2 cells, assessed by the flow cytometric analysis of hypodiploid nuclei stained with propodium iodide. In addition, ascorbic acid increased intracellular Ca$\^$2+/ concentration, whereas the level of reactive oxygen species was not significantly changed, suggesting that ascorbic acid may not alter cellular redox potential in the cells. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.258.2-258.2
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• 2002

In our previous study. we reported that PG. a polysaccharide isolated from Plyatycodon grandiflorum, activated macrophages and B cells. but not T cells. Here. we investigated in more detail the mechanism of action of PG in macrophage activation. Since PG cannot penetrate cells due to the large molecular mass, it should bind to membrane receptors of macrophages. We showed that some antibodies to cell surface molecules (CD14, CD11b. TLR2, and TLR4) inhibited RAW264.7 macrophage activation, suggesting the possible binding sites of PG. (omitted)

• YAKHAK HOEJI
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• v.28 no.3
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• pp.149-160
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• 1984

In order to certify the diuretic mechanism of dopamine, this study was performed in dog. The following results were obtained. Dopamine, when given intravenously, produced diuresis, and increased glomerular filtration rate (GFR), renal plasma flow (RPF), and amount of sodium excreted in urine. When infused directly into a renal artery, dopamine elicited a marked diuresis confined only to the infused side, with concomitant rises in osmolar clearance and sodium excretion as well as a slight increase in free water clearance. Simultaneously total renal plasma flow and medullary plasma flow increased markedly with a increase of glomerular filtration rate and renal plasma flow. Medullary concentration gradient of sodium also markedly lowered in the infused kidney. These changes were not observed during mannitol diuresis and renal action of dopamine were not apparent in dog pretreated with haloperidol. From the above experimental results, it is thought that dopamine, when given into a vien or infused directly into a renal artery, induces diuresis, and the mechanism of its action is due to dual actions which are hemodynamic effect along with glomerular filtraction rate, and the increased response in the medullary blood flow.

• YAKHAK HOEJI
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• v.45 no.4
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• pp.397-406
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• 2001

It has been demonstrated previously that R(-)-2,10,11-trihydroxy-N-n-propylnora porphine (TNPA), a dopamine D$_2$receptor agonist, produced the antidiuresis through changes of central friction in dog. This study was investigated about effects of renal denervation and raclopride, a dopamine D$_2$receptor antagonist, on the antidiuresis of TNPA in order to elicidate the mechanism involved in this central antidiuresis induced by TNPA. Antidiresis exhibited by TNPA given into the vein or into carotid artery was not influenced by renal denervation, whereas antidiuresis of TNPA administered into carotid artery was blocked almost perfectly by raclopride pretreated into carotid artery. From these observations it is concluded that central antidiuresis induced by TNPA is brought about through activation of dopamine D$_2$receptor localized in brain, not related to renal nerve activity.

• Proceedings of the IEEK Conference
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• 2009.05a
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• pp.264-266
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• 2009

A skill is defined as the special ability to do something well, especially as acquired by learning and practice. To learn a skill, a Bayesian network model for representing the skill is first learned. We will regard the Bayesian network for a skill as an affordance. We propose a soft Behavior Motivation(BM) switch as a method for ordering affordances to accomplish a task. Then, a skill is constructed as a combination of an affordance and a soft BM switch. To demonstrate the validity of our proposed method, some experiments were performed with GENIBO(Pet robot) performing a task using skills of Search-a-target-object, Approach-a-target-object, Push-up-in front of -a-target-object.

• Journal of Local Government Studies
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• v.25 no.1
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• pp.91-116
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• 2013

The purpose of this paper is to find out the set of the factors influencing on the successful voluntary consolidation among local governments. This paper considers the voluntary consolidation as a kind of coordination mechanism and institutional collective action process between local governments, and identifies the configurations of the causal factors influencing the voluntary consolidations by applying the fuzzy-set analysis. It is found that the sets of the causal factors which include political and economic homogeneity factors in the region, and interlocal political, economic, and social homogeneity factors, and prior consolidation experience between regions have positive effects on the consolidations. Also, it turns out that interlocal homogeneity and conformity between regions should be considered significantly for institutionalization which supports the consolidation between local entities.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2006.05a
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• pp.391-394
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• 2006

In this paper, a criterion on enclosed die forging with a double action link type hydraulic die set is presented. Operational principle of the die set in enclosed die forging is introduced with emphasis on force transfer from the press and the hydraulic system to the material through links, die components and punches. Force transfer mechanism is examined and three different modes are introduced. Requirements on force equilibrium are applied to the three force transfer modes and a criterion on enclosed die forging with a double action link type hydraulic die set is drawn. The criterion is discussed to minimize forming load.