• International Journal of Precision Engineering and Manufacturing
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• 제6권3호
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• pp.24-28
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• 2005

Stress state of chip formation zone is one of the main problems in metal cutting mechanics. In two-dimensional case this process is usually considered as consistent shears of work material along one of several shear surfaces, separating chip from workpiece. These shear planes are assumed to be trajectories of maximum shear stress forming corresponding slip-line field. This paper suggests a new approach to the constriction of slip-line field, which implies uniform compression in chip formation zone. Based on the given model it has been found that imaginary shear line in orthogonal cutting is close to the trajectory of maximum normal stress and the problem about its determination has been considered as well. It has been shown that there is a second central slip-line field inside chip, which corresponds well to experimental data about stress distribution on tool rake face and tool-chip contact length. The suggested model would be useful in understanding mechanistic problems in machining.

• Journal of Ginseng Research
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• 제45권6호
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• pp.683-694
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• 2021

Background: Ginsenoside Rg1 (Rg1) has been well documented to be effective against various cardiovascular disease. The aim of this study is to evaluate the effect of Rg1 on mechanical stress-induced cardiac injury and its possible mechanism with a focus on the calcium sensing receptor (CaSR) signaling pathway. Methods: Mechanical stress was implemented on rats through abdominal aortic constriction (AAC) procedure and on cardiomyocytes and cardiac fibroblasts by mechanical stretching with Bioflex Collagen I plates. The effects of Rg1 on cell hypertrophy, fibrosis, cardiac function, [Ca²⁺]_i, and the expression of CaSR and calcineurin (CaN) were assayed both on rat and cellular level. Results: Rg1 alleviated cardiac hypertrophy and fibrosis, and improved cardiac decompensation induced by AAC in rat myocardial tissue and cultured cardiomyocytes and cardiac fibroblasts. Importantly, Rg1 treatment inhibited CaSR expression and increase of [Ca²⁺]_i, which similar to the CaSR inhibitor NPS2143. In addition, Rg1 treatment inhibited CaN and TGF-b1 pathways activation. Mechanistic analysis showed that the CaSR agonist GdCl₃ could not further increase the [Ca²⁺]_i and CaN pathway related protein expression induced by mechanical stretching in cultured cardiomyocytes. CsA, an inhibitor of CaN, inhibited cardiac hypertrophy, cardiac fibrosis, [Ca²⁺]_i and CaN signaling but had no effect on CaSR expression. Conclusion: The activation of CaN pathway and the increase of [Ca²⁺]_i mediated by CaSR are involved in cardiac hypertrophy and fibrosis, that may be the target of cardioprotection of Rg1 against myocardial injury.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2285-2290
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• 2012

동맥경화는 혈관 안에서 콜레스테롤의 침착 때문에 혈관이 좁아지거나, 딱딱해 지거나, 두꺼워 지게 되는데, 이런 현상이 심해지게 되면 동맥은 단단해져서 혈액이 원활히 통과하지 못하게 되고 심하면 사망 까지 이르게 되는 것이다. 본 연구에서는 복대동맥에서의 동맥경화가 진행되는 것을 탄성 혈관 일 때와 강성 혈관 일 때 각각 협착률이 혈관 직경의 20과 45%로 설정하고 속도와 압력 변화를 살펴보기 위하여 유한 요소 해석을 이용하여 모델링을 하였다. 혈관이 탄성 혈관일 때 속도와 압력 값은 협착률이 혈관 직경의 20%일 때 보다 45%일 때 더 높게 나타났으며, 강성 혈관에서 속도와 압력 값은 협착률이 혈관 직경의 20%일 때보다 45%에서 더 높았다. 협착률이 혈관 직경의 20과 45%인 탄성 혈관에서 재순환영역이 나타났다. 본 연구결과 혈관 협착에 따른 혈류역학적 특징을 이해하는데 도움이 될 것으로 판단된다.

• The Korean Journal of Pain
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• 제25권4호
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• pp.213-220
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• 2012

Background: It has been demonstrated that the expression of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and apoptotic cell death in the dorsal root ganglion (DRG) following spinal nerve constriction injury play a role in the initiation and continuation of hyperalgesia and allodynia. The present study was designed to investigate the effects of ethyl pyruvate (EP) on mechanical and cold allodynia, TNF-${\alpha}$ expression, and apoptosis in DRG after spinal nerve ligation injury. Methods: Rats were divided into 3 groups: control, pre-EP, and post-EP. EP (50 mg/kg) was intraperitoneally injected 30 minutes before (pre-EP) or after (post-EP) surgery. Behavioral tests to determine mechanical and cold allodynia were conducted before surgery and 4 and 7 days after surgery. Seven days after surgery, TNF-${\alpha}$ protein levels in DRG were evaluated by enzyme-linked immunosorbent assay, and DRG apoptosis was determined by immunohistochemical detection of activated caspase-3. Results: Treatment with EP significantly reduced mechanical and cold allodynia following spinal nerve ligation injury. TNF-${\alpha}$ protein levels in the pre-EP ($4.7{\pm}1.2$ pg/200 ${\mu}g$; P < 0.001) and post-EP ($6.4{\pm}1.8$ pg/200 ${\mu}g$; P < 0.001) groups were 2-3 times lower than the control group ($14.4{\pm}1.2$ pg/200 ${\mu}g$). The percentages of neurons and satellite cells that co-localized with caspase-3 were also significantly lower in the pre-EP and post-EP groups than the control group. Conclusions: These results demonstrate that EP has a strong anti-allodynic effect that acts through the inhibition of TNF-${\alpha}$ expression and apoptosis in DRG after spinal nerve ligation injury.

• International Journal of Oral Biology
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• 제42권3호
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• pp.129-135
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• 2017

The present study investigated the role of spinal glutamate recycling in the development of orofacial inflammatory pain or trigeminal neuropathic pain. Experiments were carried out on male Sprague-Dawley rats weighing between 230 and 280 g. Under anesthesia, a polyethylene tube was implanted in the atlanto-occipital membrane for intracisternal administration. IL-$1{\beta}$-induced inflammation was employed as an orofacial acute inflammatory pain model. IL-$1{\beta}$ (10 ng) was injected subcutaneously into one vibrissal pad. We used the trigeminal neuropathic pain animal model produced by chronic constriction injury of the infraorbital nerve. DL-threo-${\beta}$-benzyloxyaspartate (TBOA) or methionine sulfoximine (MSO) was administered intracisternally to block the spinal glutamate transporter and the glutamine synthetase activity in astroglia. Intracisternal administration of TBOA produced mechanical allodynia in naïve rats, but it significantly attenuated mechanical allodynia in rats with interleukin (IL)-$1{\beta}$-induced inflammatory pain or trigeminal neuropathic pain. In contrast, intracisternal injection of MSO produced anti-allodynic effects in rats treated with IL-$1{\beta}$ or with infraorbital nerve injury. Intracisternal administration of MSO did not produce mechanical allodynia in naive rats. These results suggest that blockade of glutamate recycling induced pro-nociception in na?ve rats, but it paradoxically resulted in anti-nociception in rats experiencing inflammatory or neuropathic pain. Moreover, blockade of glutamate reuptake could represent a new therapeutic target for the treatment of chronic pain conditions.

• The Korean Journal of Pain
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• 제34권4호
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• pp.394-404
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• 2021

Background: We aimed to investigate the effect of epidural polydeoxyribonucleotide (PDRN) on mechanical allodynia and motor dysfunction in a rat model of lumbar foraminal stenosis (LFS). Methods: This study was conducted in two stages, using male Sprague-Dawley rats. The rats were randomly divided into eight groups. In the first stage, the groups were as follows: vehicle (V), sham (S), and epidural PDRN at 5 (P5), 8 (P8), and 10 (P10) mg/kg; and in the second stage, they were as follows: intraperitoneal PDRN 8 mg/kg, epidural 3,7-dimethyl-1-propargilxanthine (DMPX) (0.1 mg/kg), and DMPX (0.1 mg/kg). The LFS model was established, except for the S group. After an epidural injection of the test solutions, von Frey and treadmill tests were conducted for 3 weeks. Subsequently, histopathologic examinations were conducted in the V, S, P5, and P10 groups. Results: A total of 65 rats were included. The P8 and P10 groups showed significant recovery from mechanical allodynia and motor dysfunction at all time points after drug administration compared to the V group. These effects were abolished by concomitant administration of DMPX. On histopathological examination, no epineurial inflammation or fibrosis was observed in the epidural PDRN groups. Conclusions: Epidural injection of PDRN significantly improves mechanical allodynia and motor dysfunction in a rat model of LFS, which is mediated by the spinal adenosine A_2A receptor. The present data support the need for further research to determine the role of epidural PDRN in spinal stenosis treatment.

• Wind and Structures
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• 제12권1호
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• pp.49-61
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• 2009

A method is presented to estimate the form drag and the base pressure on a triangular cylinder in the presence of blockage effect. The Strouhal number, which is found to increase with the flow constriction experimentally by Ramamurthy & Ng (1973), may be decoupled from the blockage effect when re-defined by using the velocity at flow separation and a theoretical wake width. By incorporating this wake width into the momentum equation by Maskell (1963) for the confined flow, a relationship between the form drag and the base pressure is derived. Independently, the experimental data of surface pressure from Ramamurthy & Lee (1973) are found to be independent of the blockage effect when expressed in terms of a modified pressure coefficient involving the pressure at separation. Using the potential flow model by Parkinson & Jandali (1970) and its subsequent development in Yeung & Parkinson (2000) for the unconfined flow, a linear relation between the pressure at separation and the form drag is formulated. By solving the two equations simultaneously with a specified blockage ratio and an apex angle of the triangular cylinder, the predictions of the drag and the base pressure are in reasonable agreement with experimental data. A new theoretical relationship for the Strouhal number, pressure drag coefficient and base pressure proposed in this study allows the confinement effect to be appropriately taken into consideration. The present approach may be extended to three-dimensional bluff bodies.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집B
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• pp.591-596
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• 2000

Flow through compliant tubes with linear taper in wall thickness is numerically simulated by finite element analysis. Two models are examined: a planar two-dimensional channel, and an axisymmetric tube. For verification of the numerical method, flow through a compliant stenotic vessel is simulated and compared to existing experimental data. Computational results for an axisymmetric tube show that as cross-sectional area falls with a reduction in downstream pressure, flow rate increases and reaches a maximum when the speed index (mean velocity divided by wave speed) is near unity at the point of minimum cross-section area, indicative of wave speed flow limitation or "choking" (flow speed equals wave speed) in previous one-dimensional studies. For further reductions in downstream pressure, flow rate decreases. Cross-sectional narrowing is significant but localized. When the ratio of downstream-to-upstream wall thickness is ${\le}$ 2 the area throat is located near the downstream end; as wall taper is increased to ${\ge}$ 3 the constriction moves to the upstream end of the tube. In the planar two-dimensional channel, area reduction and flow limitation are also observed when outlet pressure is decreased. In contrast to the axisymmetric case, however, the elastic wall in the two-dimensional channel forms a smooth concave surface with the area throat located near the mid-point of the elastic wall. Though flow rate reaches a maximum and then falls, the flow does not appear to be choked.

• 대한치과기공학회지
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• 제21권1호
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• pp.123-130
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• 1999

I attempted to suggest a better method to separate a refractory cast in order to solve the problems caused by bonding between refractory casts and ceramics in the firing-processing of all ceramic crowns as a part of dental prosthodontics. I emphasize the advantages and effectiveness of easy separation after firing by using the separating materials about the refractory cast dies. 1. We must not usse HF(55%) that is used as the chemical separating methods. 2. We decrease such methods as grinding, blasting, bur, and point 3. We can save time, costs and manual labors by using this methods. 4. This method regulates the expansion and constriction of heat because of the chemical reaction of the separating materials. 5. This method contribute to the breaking down without modification by minimizing the chemical and mechanical damages of the marginal and interior parts.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회B
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• pp.2515-2518
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• 2008

The vacuum interrupter (VI) is widely used in medium-voltage switching circuits due to its abilities and advantages as an environmental friendly circuit breaker. An understanding of the vacuum arc flow phenomena is very important for improving the performance of vacuum interrupter. In order to closely examine the vacuum arc phenomena, it is necessary to predict the magnetohydrodynamic (MHD) characteristics by the multidisciplinary numerical modeling, which is coupled with the electromagnetic and the thermal flow fields, simultaneously. In this study, we have investigated arc plasma constriction phenomena and an effect of AMF on the arc plasma with the high-current vacuum arcs for the cup-type AMF electrode by using a commercial finite element analysis (FEA) package, ANSYS. The simulation results applied with various AMFs and constant Joule heat generation show that strong axial magnetic field (AMF) permits the arc to be maintained in a diffused mode to a high-current vacuum arc. However, further studies are required on the two-way coupling method and radiation model for arc plasma in order to accomplish the advanced analysis method.