• Archives of Pharmacal Research
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• v.25 no.5
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• pp.697-703
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• 2002

We investigated that the role of nitric oxide (NO) on ischemic rats in brain and heart. Ischemia was induced by both common carotid arteries (CCA) occlusion for 24h following reperfusion. Then tissue samples were removed and measured NOx. In brain, NOx was increased by about 40% vs. normal and it was significantly inhibited by aminoguanidine, selective iNOS inhibitor. This result showed that NOx concentration was increased by iNOS. We investigated the role of $Ca^{2+}$ during ischemia. Nimodipine, L-type calcium channel blocker, didn't inhibit the increases of NOx concentration during ischemia. It suggested that increased NOx was due to calcium-independent NOS. MK-801, which N-methyl-D-aspartate (NMDA) receptor antagonist, didn't significantly prevent the increases of NOx. In heart, ischemia caused NOx decrease and it is inconsistent with NOx increase in brain. Aminoguanidine and nimodipine didnt affect on NOx decrease. But MK-801 more lowered NOx concentration than those of ischemia control group. It seemed that $Ca^{2+}$ influx in heart partially occurred via NMDA receptor and inhibited by NMDA receptor antagonist. The mean arterial pressure (MAP) in ischemic rats after 24h of CCA occlusion was decreased when compared to normal value, whereas the heart rates (HR) was not different between two groups. Aminoguanidine or MK801 had no effect on MAP or HR, but nimodipine reduced MAP. There was no difference the effects of aminoguanidine, nimodipine, or MK-801, on MAP and HR between normal rats and ischemic rats. In summary, ischemic model caused an increase of NOx concentration, suggesting that this may be produced via iNOS, which is calcium independent in brain. However in heart, ischemia decreased NOx concentration and NMDA receptor was partially involved. The basal MAP was decreased in ischemic rats but HR was not different from normal control, suggesting that increased NOx in brain of ischemic rat may result in the hypotension.

• Journal of Veterinary Clinics
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• v.29 no.5
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• pp.368-371
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• 2012

The present study evaluated the outcome of use of thoracostomy tube tunneling technique under the latissimus dorsi muscle for the evacuation of postoperative pneumothorax induced by thoracotomy in 11 dogs. A stab incision was made through the skin and the latissimus dorsi muscle over the rib in the fifth intercostal space caudal to a surgical window. The thoracostomy tube with a Kelly hemostat was advanced into the thoracic cavity in a cranioventral direction through the sublatissimal tunnel. After tube placement, a # 1 nylon horizontal mattress suture was placed around the skin incision. The thoracostomy tube was removed after creating a negative pressure in the thoracic cavity. Dogs were monitored after surgery for pneumothorax, subcutaneous emphysema, clinical signs including dyspnea, and tube kinking in a muscle tunnel using physical examination and postoperative radiography. There was no tube kinking in the sublatissimal tunnel in 11 dogs on introducing the tubes into the thoracic cavity. The mean (${\pm}SD$) follow-up period was $19{\pm}10$ months. On postoperative radiography, there was no evidence of pneumothorax in 11 dogs. Subcutaneous emphysema was identified around the stab incision in a dog postoperatively. The subcutaneous emphysema disappeared spontaneously within 3 days. On postoperative physical examination, there was no evidence of dyspnea in 11 dogs. Our results suggest that the sublatissimal tunneling technique for thoracostomy tube placement is effective to prevent air leakage around the thoracostomy tube while the tube remains in the thoracic cavity and along the thoracostomy tunnel after tube removal. Tunneling under the latissimus dorsi muscle should be considered the thoracostomy tube placement technique to prevent iatrogenic pneumothorax with first priority.

• Journal of Veterinary Clinics
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• v.27 no.5
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• pp.540-545
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• 2010

Changes of electroencephalogram (EEG), mean arterial blood pressure (MAP) and heart rate under surgical anesthesia were investigated in medetomidine (MED) and tiletamine/zolazepam (ZT)-anesthetized dogs. To determine the level of surgical anesthesia, pedal withdrawal reflex was regularly tested after ZT injection. The first time point without pain response was regarded as the beginning of surgical anesthesia (SSA). After SSA, the first time point showing positive pain response was considered the end of surgical anesthesia (ESA). Comparing the control, an additional significant decrease of ${\delta}2$ and ${\alpha}2$ was observed at SSA. Comparing the control, ${\delta}2$ was significantly decreased at ESA. Significant reductions of MAP were observed at pre-ESA and ESA. Heart rate significantly decreased in all stages. These results suggest that ${\delta}2$ band power is a valuable parameter for correlating surgical anesthesia in dogs anesthetized with MED and ZT.

• Korean Journal of Veterinary Research
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• v.39 no.3
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• pp.616-627
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• 1999

This study was performed to evaluate anesthetic and cardiovascular effects of xylazine/fentanyl/azaperone and medetomidine/midazolam as preanesthetics and their combinations with antagonists in halothane-anesthetized dogs. Eight clinically healthy dogs($4.54{\pm}2.16kg$) were used at the interval of more than 14 days between experiments in turn for propionyl promazine(PP 0.3mg/kg, IM), xylazine/fentanyl/azaperone(XFA 2mg/kg, 0.0137mg/kg, 0.11mg/kg, IM), medetomidine/midazolam(MM 0.02mg/kg, 0.3mg/kg, IM), combination of XFA and their antagonists (yohimbine 0.05mg/kg, naloxon 0.0005mg/kg, IV) and combination of MM and their antagonist(atipamezole 0.08mg/kg IM). The sedation induction times in XFA($2.56{\pm}1.01min$) and MM($5.44{\pm}2.07min$) groups were significantly better than that of PP group($10.75{\pm}2.38min$)(p < 0.05). The thiopental sodium dose required for tracheal intubation in XFA($2.38{\pm}3.38mg/kg$) and MM($3.91{\pm}3.47mg/kg$) groups were significantly less than that of PP group($12.57{\pm}2.13mg/kg$)(p < 0.05). All time indices expressing the recovery(pedal reflex recurrence time, extubation time, arousal time, standing time and walking time) were significantly shorter in the combination groups of XFA or MM with their antagonists than in PP, XFA and MM groups(p < 0.05). The suppressions of cardiovascular function of XFA and MM were more than that of PP. Heart rate and cardiac output were recovered by the antagonists of XFA and MM, but mean arterial pressure were not recovered by the antagonists. PP induced apnea in 4 out of 8 dogs, but XFA in none and MM in one. The present study suggested that for rapid sedation, prevention of apnea after intubation and rapid recovery after halothane cessation, combinations of xylazine/fentanyl/azaperone or medetomidine/midazolam with their antagonists are recommendable as preanesthetic method in gas anesthetised dogs with normal cardiovascular function.

• Journal of Digital Convergence
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• v.12 no.5
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• pp.353-366
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• 2014

The purpose was to describe the state of healthcare-associated infection(HAI) control. Data were collected from 134 hospitals. The questionnaire developed by Kang[8] were modified. The mean of hospital beds was 556.4, 26.9% of hospitals were less than 300 beds. 99.3% of hospitals had infection control committee(ICC). ICC met 3.4 times a year. 54.5% of hospitals had one infection control practitioner(ICP). 95.5% of ICPs were nurse, 48.7% of ICPs had more than master's degree. Hospital experience of ICPs was 13.5 years. ICP experience was 3.2 years. 30.8% of ICPs worked for less than 1 year. All hospitals investigated HAI, 75.4% performed improvement activities. There are significant differences in existence of ICD, negative pressure room, computer program, numbers of ICPs according to hospital size. Manpower, organization, and facilities lacked in less than 300 beds. This conclusions will give baseline data to establish infection control system, manpower and practice in small-medium hospitals.

• Journal of Korean Public Health Nursing
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• v.19 no.1
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• pp.41-52
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• 2005

This study was designed to provide a base for nursing intervention to help apheresis blood-donors to perform health promotion behavior effectively by surveying their health promotion behavior and by analyzing the critical factors. The study subjects were 468 participants in platelet donation at a university hospital apheresis unit in Seoul. The data for this study were collected between May and June. 2002. by questionnaire. Data were analyzed by t-test, ANOVA. Scheffe test, Pearson correlation coefficient. and stepwise multiple regression. The results were as follows. 1. The degree of performance of health promotion behavior of the subjects was a total average score of $152.9\pm21.5$ points and a mean score of 2.7 points. The highest score was 'I have a good relationship with others' in the factor of self-actualization and interpersonal support. The lowest score was 'I have my blood pressure checked regularly' in the factor of health responsibility. 2. Considering the classification according to the subjects' general characteristics. the health promotion behavior score was significantly higher for soldiers than high school students, for religious believers than atheists. and for high class economic status than mid and low class economic status. Also the health promotion behavior score was higher for those who had made more than five blood donations than those who had made zero or one donation. and for those who had made more than four blood donations than for those who had made less than four blood donations in the previous times of apheresis blood donation. The score was also higher for those not having a relationship with recipient than those having a relationship. 3. The self-efficacy related to donation. general self-efficacy and self-esteem had a significant correlation with the performance in health promotion behavior. 4. The critical factors that influenced the health promotion behavior were explained by $35.6\%$ of the general self-efficacy and by $40.2\%$ of the total of self-efficacy related to donation, and previous times of apheresis blood donation. The health promotion behavior score of apheresis blood-donors differed according to job, religion, economic status, previous times of whole blood donation, previous times of apheresis blood donation, and relationship with recipient. The health promotion behavior and self-efficacy related to donation, general self-efficacy, and self-esteem showed significant positive correlation with one another. The general self-efficacy, self-efficacy related to donation, and previous times of apheresis blood donation appeared to be the significant predictive factors of health promotion behavior. Therefore, from these study results, it is necessary to establish more effective and organized nursing intervention strategies for the health promotion behavior of apheresis blood-donors.

• Journal of the Korean earth science society
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• v.30 no.6
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• pp.734-743
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• 2009

In order to examine how climatological condition can influence on urban scale particulate air pollutants, single and cross spectrum analysis have been performed to daily mean concentrations of particulate matters ($PM_{10}$) in Busan together with the climatological variables over the Asian dust source regions. Single power spectrum analysis of $PM_{10}$ concentrations in Busan shows that, aside from the typical and well-known periodicities, 3-4 year of peak periodicity of power spectrum density was identified. In cross spectrum analysis, this 3-4 year periodicity is found to have a strong positive correlation with the wind speed and pressure, and negative with the temperature and relative humidity, which is rather consistent with both characteristics of air mass during the Asian dust event whose periodicities have been recorded inter-annually over the Korean urban cities. Over the Asian dust source regions, $PM_{10}$ vs. precipitation shows no significant periodicity from the time series of precipitation data, but the periodicity of EDI (Effective Drought Index) shows some interannual variabilities ranging from 2 to 4 years over the various source regions, suggesting that, rather than precipitation itself, the EDI could be more closely associated with the occurrence frequency of Asian dust and interannual variability of urban particle concentrations in Korean cities.

• Journal of the Korean earth science society
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• v.38 no.2
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• pp.129-140
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• 2017

Global solar radiation was calculated in this research using ground-base measurement data, meteorological satellite data, and GWNU (Gangneung-Wonju National University) solar radiation model. We also analyzed the accuracy of the GWNU model by comparing the observed solar radiation according to the total cloud cover. Our research was based on the global solar radiation of the GWNU radiation site in 2012, observation data such as temperature and pressure, humidity, aerosol, total ozone amount data from the Ozone Monitoring Instrument (OMI) sensor, and Skyview data used for evaluation of cloud mask and total cloud cover. On a clear day when the total cloud cover was 0 tenth, the calculated global solar radiations using the GWNU model had a high correlation coefficient of 0.98 compared with the observed solar radiation, but root mean square error (RMSE) was relatively high, i.e., $36.62Wm^{-2}$. The Skyview equipment was unable to determine the meteorological condition such as thin clouds, mist, and haze. On a cloudy day, regression equations were used for the radiation model to correct the effect of clouds. The correlation coefficient was 0.92, but the RMSE was high, i.e., $99.50Wm^{-2}$. For more accurate analysis, additional analysis of various elements including shielding of the direct radiation component and cloud optical thickness is required. The results of this study can be useful in the area where the global solar radiation is not observed by calculating the global solar radiation per minute or time.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.6
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• pp.567-571
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• 2008

Purpose: The purpose was to assess the usefulness of midazolam in patients undergoing minor oral surgery under conscious sedation. Materials and methods: Bispectral index was examined in 20 patients receiving oral minor surgery with conscious sedation supplemented with local anesthesia. All patients included were ASA I and had no contraindications to the study medications. The patients were escorted to the day surgery operation room where, before the commencement of the sedation and surgical procedures, routine monitoring was applied, including the noninvasive monitoring of arterial blood pressure, arterial oxygen saturation, and 3-lead electrocardiogram (Electrocardiogram). Bispectral index electrodes were applied on the frontotemporal region after cleansing the skin with alcohol. Bispectral index was calculated with the Electrocardiogram monitor (A-2000; Aspect Co.). Midazolam was then titrated (initially 3mg wait 2min and 2mg). Vital sign and Bispectral index checked every 5 minute until the end of the procedure. The results were then compared. Results: The Bispectral index index values throughout the sedation study period alter many level. The index was dropped at 5 minutes after administration, but raised at injection and odontomy procedure. During the operation, mean Bispectral index index was higher than conscious sedation index range($60{\sim}80$). The amnesic effect was shown 17 cases out of 20 cases(85%). Conclusion: Conscious sedation technique using midazolma is a safe and effective method of controlling behavior in oral and maxillofacial surgery.

• Journal of Sericultural and Entomological Science
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• v.46 no.1
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• pp.1-5
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• 2004

Rutin has many beneficial effects on human health. It was established that rutin antagonizes the increase of capillary fragility associated with hemorrhagic disease, reduces high blood pressure, decreases the permeability of the vessels, and has an antiedema effect, reduces the risk of arteriosclerosis, and shows antioxidant activity. Rutin analysis with mulberry fruits was carried out by high-performance liquid chromatography (HPLC) to reveal the possibility of source of functional food. As a result, mean content of fifty accessions was 0.14±0.050% DW. Among the tested fifty accessions, 'Sabangso' was showed the highest rutin in 0.29%DW, whereas 'Simseol' was the lowest content in 0.05% DW. Also, we researched the change of rutin content according to harvested date. The rutin contents of earlier harvested groups were higher than later harvested groups. Simultaneously, fruity characteristics as well as rutin content were researched and analyzed to select the functional mulberry varieties for the production of fruit. From the six accessions which were contained high rutin content, we selected three suitable varieties such as 'Ficus', 'Kangsun', and 'Palcheongsipyung'.