• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.347-350
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• 2012

TP53 is the mostly commonly mutated gene in many cancers and the P53 tumor suppressor protein is involved in multiple cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control and apoptosis. A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis. The aim of this study was to understand the association of the 72 codon polymorphism with acute leukemia development and prognosis. A total of 288 acute leukemia cases comprising 147 acute lymphocytic leukemia (ALL) and 141 acute myeloid leukemia (AML), as well as 245 controls were recruited for analysis of the TP53 72 polymorphism using PCR-RFLP method. Significant association of homozygous arginine genotype with AML was observed (${\chi}^2$- 133.53; df-2, p < 0.001. When data were analyzed with respect to clinical variables, elevation in mean WBC, blast %, LDH levels and slight reduction in DFS in ALL cases with the arginine genotype was observed. In contrast, AML patients with Pro/Pro had elevated WBC, Blast%, LDH levels with slightly reduced DFS. Our study indicates that Arg/Arg genotype might confer increased risk to development of acute myeloid leukemia.

• The Journal of Korean Academy of Prosthodontics
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• v.41 no.5
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• pp.551-564
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• 2003

Statement of problem : Magnesium oxide may increase pH of alginate, and supply magnesium ions to the polymerization reaction of alginate. Purpose : This study was designed to evaluate the influence of incorporation of magnesium oxide to alginate composition. Material and Method : Seven kinds of experimental alginates were prepared and used for the experiments. Components with unchanging concentrations were sodium alginate 15%, calcium sulfate 14%, sodium phosphate 2%, and zinc fluoride 3%. Contents of magnesium oxide were varied as 0%, 1%, 2%, 3%, 4%, 5%, 6%. Diatomaceous earth were added to each experimental groups as balance to be 100%. Control group was a MgO 0% group. Working time, setting time, elastic recovery strain in compression, compressive strength and tear resistance were measured were measured. Sample size for each groups were 10. Arithmetic means were used as each groups representative values. Regression test between MgO contents and results, Duncan's multiple range test, and One-way ANOVA test were done between groups at level of 0.05. Results : 1 Magnesium oxide made the working time and setting time as longer(p<0.0001). 2 Magnesium oxide did not alter the elastic recovery(p>0.05). 3. Magnesium oxide contents between 2% and 4% exhibited the lowest strain in compression on alginates(p<0.0001). 4. Magnesium oxide made the compressive strength and the tear resistance stronger(p<0.0001). Conclusion : These results mean that setting time of alginate maybe controlled and that mechanical properties maybe improved by the incorporation of magnesium oxide into alginate, without any reduction of elasticity.

• Journal of Electrochemical Science and Technology
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• v.6 no.3
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• pp.95-105
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• 2015

In the present work, Carbon supported Pt₁₀₀, Pt₈₀Sn₂₀, Pt₈₀Ni₂₀ and Pt₈₀Sn₁₀Ni₁₀ electrocatalysts with different atomic ratios were prepared by ethylene glycol-reduction method to study the electro-oxidation of ethanol in membraneless fuel cell. The electrocatalysts were characterized in terms of structure, morphology and composition by using XRD, TEM and EDX techniques. Transmission electron microscopy measurements revealed a decrease in the mean particle size of the catalysts for the ternary compositions. The electrocatalytic activities of Pt₁₀₀/C, Pt₈₀Sn₂₀/C, Pt₈₀Ni₂₀/C and Pt₈₀Sn₁₀Ni₁₀/C catalysts for ethanol oxidation in an acid medium were investigated by cyclic voltammetry (CV) and chronoamperometry (CA). The electrochemical results showed that addition of Ni to Pt/C and Pt-Sn/C catalysts significantly shifted the onset of ethanol and CO oxidations toward lower potentials. The single membraneless ethanol fuel cell performances of the Pt₈₀Sn₁₀Ni₁₀/C, Pt₈₀Sn₂₀/C and Pt₈₀Ni₂₀/C anode catalysts were evaluated at room temperature. Among the catalysts investigated, the power density obtained for Pt₈₀Sn₁₀Ni₁₀/C (37.77 mW/cm² ) catalyst was higher than that of Pt₈₀Sn₂₀/C (22.89 mW/cm² ) and Pt₈₀Ni₂₀/C (16.77 mW/ cm² ), using 1.0 M ethanol + 0.5 M H₂SO₄ as anode feed and 0.1 M sodium percarbonate + 0.5 M H₂SO₄ as cathode feed.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.2
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• pp.157-166
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• 2007

Moderns have desire likely to be further good-looking concomitant with a qulitative advancement of the life. Orthognathic surgery for the correction of dentofacial deformities is a common elective procedure. It's possible to occur many complication during the operations and especially, an excessive bleeding of those may be fatal and so a tranfusion is performing for the prevention and management of that. The most notable of these for reduction of blood loss is the utilization of induced hypotensive anesthetic technique to reduce the mean arterial pressure between 55 and 60 mmHb. Another method for dealing with blood loss following orthognathic surgery is the transfusion of blood obtained as an autologous tranfusion or from banked blood. Some of the disadvantage of banked blood are overcome with the use of predeposited autologous transfusion. But currently, surgeons try so that even autologous transfusion may not transfuse the patients. We made a comparative study of hematologic change and transfusion requirement based on a series of 200 patients who had an orthognathic surgical procedure at Chonbuk National University during the period 2001-2005. This study is to make a comparative analysis of an post-operative hematologic (Hemoglobin, Hematocrit, Red blood cell) change and duration of the procedure under induced hypotensive anesthesia in healthy orthognathic patients.

• Wind and Structures
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• v.9 no.2
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• pp.125-146
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• 2006

Stonecutters Bridge of Hong Kong is a cable-stayed bridge with two single-column pylons each 298 m high and an aerodynamic twin deck. The total length of the bridge is 1596 m with a main span of 1018 m. The top 118 m of the tower will comprise structural steel and concrete composite while the bottom part will be of reinforced concrete. The bridge deck at the central span will be of steel whilst the side spans will be of concrete. Stonecutters Bridge has adopted a twin-girder deck design with a wide clear separation of 14.3 m between the two longitudinal girders. Although a number of studies have been conducted to investigate the aerodynamic performance of twin-girder deck, the actual real life application of this type of deck is extremely limited. This therefore triggered the need for conducting the present studies, the main objective of which is to investigate the performance of Stonecutters Bridge against flutter at its in-service stage as well as during construction. Based on the flutter derivatives obtained from the 1:80 scale rigid section model experiment, flutter analysis was carried out using 3-D finite element based single parameter searching method developed by the second author of this paper. A total of 6 finite element models of the bridge covering the in-service stage as well as 5 construction stages were established. The dynamic characteristics of the bridge associated with these stages were computed and applied in the analyses. Apart from the critical wind speeds for the onset of flutter, the dominant modes of vibration participating in the flutter vibration were also identified. The results indicate that the bridge will be stable against flutter at its in-service stage as well as during construction at wind speeds much higher than the verification wind speed of 95 m/s (1-minute mean).

• Journal of Korean Neurosurgical Society
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• v.38 no.4
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• pp.281-286
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• 2005

Objective : The authors report our experience of urokinase thrombolysis in treating patients harboring nonaneurysmal spontanesous intraventricular hemorrhage[IVH] and evaluated complications, safety and feasibility of this procedure retrospectively. Methods : Fifty-three patients with nonaneurysmal IVH>15mL without underlying structural etiology or coagulopathy were recruited. The patients with Glasgow Coma Scale[GCS]<5 were excluded. A catheter was directed into the IVH. Hematoma aspiration was followed by instillation of urokinase at the ear level of drainage bag under intracranial pressure monitoring system. This was repeated every 6hours until half of its initial volume. For analysis of prognostic factors, we classified the patients into two groups by Glasgow outcome scale[GOS]; good [$GOS\;{\ge}3$] and bad [GOS<3] prognosis group, and performed comparative analysis between two groups. Results : Mean age was 60.2years. The baseline hematoma size ranged 16 to 72mL. IVH volume reduction was done by an average of 74.2%. As complications, there were 3cases of rebleeding and 2cases of ventriculitis. No intracranial adverse effects were observed during thrombolytic theraphy. At 6months after the procedure, 29patients had achieved a good recovery, 15remained vegetative. 9patients died in hospital. The main good prognostic factors were young age, small IVH volume, and high GCS. Conclusion : The results of this study suggest that this relatively easy and safe method of treatment will improve the prognosis. However, further clinical studies also must assess optimal thrombolytic dosage, frequency, and timing of urokinase instillation for safety and effectiveness and must include controlled comparisons of mortality, disability outcome, quality of life, time until convalescence, and cost of care in treated and untreated patients.

• Journal of Korean Academy of Nursing Administration
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• v.8 no.2
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• pp.295-308
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• 2002

Purpose: The purpose of this quasi-experimental research is to develop the CP for primary THR patients and verify its effectiveness. Method: The CP is designed for both patients and medical employees to meet the 14-day-long hospitalization with an expert and clinical validity test, and the standardized orders are also created. 21 eligible subjects for the control group(with common care plan) and 27 subjects for the experimental group(with CP service) were assigned. Data were collected from questionnaires to evaluate patients' satisfaction level of nursing care and CP, investigation of physical complications, inspection of LOS(length of hospital stay) and hospital charges from April 2000 to February 2001 at K-hospital in Daegu. The collected data were analyzed by using the SAS program. Results: After implementation of CP, there was a statistically significant reduction in mean length of stay. The hospital charges have no considerable difference between two groups. Frequency of physical complications is reduced considerably. The experimental group scored much higher than the control group on the satisfaction level toward nursing care. And in the analysis of CP satisfaction questionnaires, many subjects have high satisfaction in items of 'I see the treatment process and hospital life', 'I feel that I am participating in my treatment process with health care staff'. The analysis of variances which cause a prolonged LOS supports that it's necessary to strengthen an evaluation of pre-operative outpatients' condition and link the home nursing care system in discharge for more shortening of LOS. Conclusion: The above results show that CP can have a positive impact on satisfaction level of inpatients with primary THR and the hospital.

• Computers and Concrete
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• v.19 no.4
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• pp.419-427
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• 2017

With the rising global environmental awareness on energy saving and carbon reduction, as well as the environmental transition and natural disasters resulted from the greenhouse effect, waste resources should be efficiently used to save environmental space and achieve environmental protection principle of "sustainable development and recycling". This study used recycled cement mortar and adopted the volumetric method for experimental design, which replaced cement (0%, 10%, 20%, 30%) with recycled materials (fly ash, slag, glass powder) to test compressive strength and ultrasonic pulse velocity (UPV). The hyperbolic function for nonlinear multivariate regression analysis was used to build prediction models, in order to study the effect of different recycled material addition levels (the function of $R_m$(F, S, G) was used and be a representative of the content of recycled materials, such as fly ash, slag and glass) on the compressive strength and UPV of cement mortar. The calculated results are in accordance with laboratory-measured data, which are the mortar compressive strength and UPV of various mix proportions. From the comparison between the prediction analysis values and test results, the coefficient of determination $R^2$ and MAPE (mean absolute percentage error) value of compressive strength are 0.970-0.988 and 5.57-8.84%, respectively. Furthermore, the $R^2$ and MAPE values for UPV are 0.960-0.987 and 1.52-1.74%, respectively. All of the $R^2$ and MAPE values are closely to 1.0 and less than 10%, respectively. Thus, the prediction models established in this study have excellent predictive ability of compressive strength and UPV for recycled materials applied in cement mortar.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4815-4818
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• 2013

Background: Atrophic epithelium of cervix sampled from postmenopausal women may mimic high-grade cervical intraepithelial neoplasia in Papanicolaou-stained (Pap) smears. Ki-67 (MIB-1) protein presents on proliferating cells, and percentage of cells with positive nuclei provides a reliable tool for rapid evaluation of the growth fraction. The aim of this study was to determine the diagnostic value of protein Ki67 staining in atypical pap smears of postmenopausal women. Methods: In a case-control setting, pap smears of 75 women with an atypical pap smear (case group) and 75 with normal pap smears (controls) were obtained before and after estrogen treatment. Afterward, samples were exposed to the monoclonal antibody Ki-67 (MIB-1) and the immunohistochemically demonstrated Ki-67+ cells were compared. Results: Mean ages of cases and controls were $60.4{\pm}4.5$ and $59.9{\pm}4.3$ years respectively (P=0.50). There was one (2.7%) positive Ki-67 specimen in the case group, without any positive Ki-67 specimen in the control group (P=0.50). Conclusions: Measurement of proliferative activity index in Pap smears restrained with MIB1 is a simple, reliable, and cost-effective method for excluding negatives. This would imply that it might allow a substantial reduction of diagnostic estrogen courses and subsequent Pap smears in postmenopausal women with atypical findings.

• Atmosphere
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• v.19 no.2
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• pp.127-143
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• 2009

This study investigates characteristics of wintertime simulation conducted by METRI AGCM utilizing new radiation parameterization scheme. New radiation scheme is based on the method of Chou et al., and is utilized in the METRI AGCM recently. In order to analyze characteristics of seasonal simulation in boreal winter, hindcast dataset from 1979 to 2005 is produced in two experiments - control run (CTRL) and new model's run (RADI). Also, changes in performance skill and predictability due to implementation of new radiation scheme are examined. In the wintertime simulation, the RADI experiment tends to reduce warm bias in the upper troposphere probably due to intensification of longwave radiative cooling over the whole troposphere. The radiative cooling effect is related to weakening of longitudinal temperature gradient, leading to weaker tropospheric jet in the upper troposphere. In addition, changes in vertical thermodynamic structure have an influence on reduction of tropical precipitation. Moreover, the RADI case is less sensitive to variation of tropical sea surface temperature than the CTRL case, even though the RADI case simulates the mean climate pattern well. It implies that the RADI run does not have significant improvement in seasonal prediction point of view.