• Progress in Medical Physics
• /
• v.32 no.4
• /
• pp.130-136
• /
• 2021

Purpose: The Halcyon radiotherapy platform at Groote Schuur Hospital was delivered with a factory-configured analytical anisotropic algorithm (AAA) beam model for dose calculation. In a recent system upgrade, the Acuros XB (AXB) algorithm was installed. Both algorithms adopt fundamentally different approaches to dose calculation. This study aimed to compare the dose distributions of cervical carcinoma RapidArc plans calculated using both algorithms. Methods: A total of 15 plans previously calculated using the AAA were retrieved and recalculated using the AXB algorithm. Comparisons were performed using the planning target volume (PTV) maximum (max) and minimum (min) doses, D95%, D98%, D50%, D2%, homogeneity index (HI), and conformity index (CI). The mean and max doses and D2% were compared for the bladder, bowel, and femoral heads. Results: The AAA calculated slightly higher targets, D98%, D95%, D50%, and CI, than the AXB algorithm (44.49 Gy vs. 44.32 Gy, P=0.129; 44.87 Gy vs. 44.70 Gy, P=0.089; 46.00 Gy vs. 45.98 Gy, P=0.154; and 0.51 vs. 0.50, P=0.200, respectively). For target min dose, D2%, max dose, and HI, the AAA scored lower than the AXB algorithm (41.24 Gy vs. 41.30 Gy, P=0.902; 47.34 Gy vs. 47.75 Gy, P<0.001; 48.62 Gy vs. 50.14 Gy, P<0.001; and 0.06 vs. 0.07, P=0.002, respectively). For bladder, bowel, and left and right femurs, the AAA calculated higher mean and max doses. Conclusions: Statistically significant differences were observed for PTV D2%, max dose, HI, and bowel max dose (P>0.05).

• Journal of the Korean Operations Research and Management Science Society
• /
• v.22 no.2
• /
• pp.13-29
• /
• 1997

This paper considers a new routing problem, successive max-min connection ratio problem (SMCRP), arised in circuit telecommunication networks such as SONET and WDM optical transport network. An optimization model for SMCRP is established based on link-flow formulation. It's first optimization process is an integral version of maximum concurrent flow problem. Integer condition does not give the same connection-ratio of each node-pair at an optimal solution any more. It is also an integral multi-commodity flow problem with fairness restriction. In order to guarantee fairness to every node-pair the minimum of connection ratios to demand is maximized. NP- hardness of SMCRP is proved and a heuristic algorithm with polynomial-time bound is developed for the problem. Augmenting path and rerouting flow are used for the algorithm. The heuristic algorithm is implemented and tested for networks of different sizes. The results are compared with those given by GAMS/OSL, a popular commercial solver for integer programming problem.n among ferrite-pearlite matrix, the increase in spheroidal ratio with increasing fatigue limitation, 90% had the highest, 14.3% increasing more then 70%, distribution range of fatigue.
ife was small in same stress level. (2) $\sqrt{area}_{max}$ of graphite can be used to predict fatigue limit of Ductile Cast Iron. The Statistical distribution of extreme values of $\sqrt{area}_{max}$ may be used as a guideline for the control of inclusion size in the steelmaking.

• YAKHAK HOEJI
• /
• v.43 no.6
• /
• pp.834-842
• /
• 1999

The metabolism and pharmacokinetics of M-l, which is metabolite of pentoxifylline, have been studied in human liver microsomes. Biphasic kinetics was observed from the Eadie-Hofstee plot for the formation of both metabolites of M-l. For the kinetics of pentoxifylline, mean values of $V_{max1}{\;}and{\;}V_{max2}$ were 1,648 and 5,622 nmol/min/mg protein, and the estimated values of $K_{ml}{\;}and{\;}K_{m2}$ were 0.180 and 4.829 mM, respectively. For M-3, mean values of $V_{max1}{\;}and{\;}V_{max2}$ were 0.062 and 0.491 nmol/min/mg protein, and estimated values of $K_{ml}{\;}and{\;}K_{m2}$ were 0.025 and 1.216 mM. The formations of pentoxifylline and M-3 from M-1 were indentified by using several selective inhibitors of cytochrome P450 isoformes at 0.05-5 mM concentration of M-1 in human liver microsomes. For the analysis of low (0.05 mM) concentration of M-1, where the affinity was expected as low, indicated that CYPlA2 and CYP3A4 were major P450 isoforms responsible for pentoxifylline and M-3 formation. CYP3A4 and CYP2A6 appeared to be P450 isoforms responsible for M-3 formation at high (5 mM) concentration of M-1.

• Journal of Advanced Navigation Technology
• /
• v.18 no.5
• /
• pp.461-467
• /
• 2014

Active queue management (AQM) algorithms run on routers and detect incipient congestion by typically monitoring the instantaneous or average queue size. When the average queue size exceeds a certain threshold, AQM algorithms infer congestion on the link and notify the end systems to back off by proactively dropping some of the packets arriving at a router or marking the packets to reduce transmission rate at the sender. Among the existing AQM algorithms, random early detection (RED) is well known as the representative queue-based management scheme by randomizing packet dropping. To reduce the number of timeouts in TCP and queuing delay, maintain high link utilization, and remove bursty traffic biases, the RED considers an average queue size as a degree of congestions. However, RED do not well in the specified networks conditions due to the fixed parameters($P_{max}$ and $TH_{min}$) of RED. This paper addresses a extended RED to be adapted in various networks conditions. By sensing network state, $P_{max}$ and $TH_{min}$ can be automatically changed to proper value and then RED do well in various networks conditions.

• Journal of Korean Society for Atmospheric Environment
• /
• v.24 no.4
• /
• pp.393-403
• /
• 2008

In an effort to estimate secondary $PM_{10}$ concentrations and their diurnal variations at different photochemical activities, $PM_{10}$, CO, and $O_3$ concentrations obtained from the ambient air quality network located in Seoul are analyzed for the period from 2000 to 2005. In order to classify the photochemical activities on a daily basis, measured ${\Delta}O_{3,\;max-min}$ (maximum $O_3$-minimum $O_3$) and ${\int}(hv)dt$ which represents accumulated daily insolation, were used to classify each day into three regimes: 1) low photochemical reactivity; ${\Delta}O_{3,\;max-min}\;{\leq}\;40\;ppb$, and ${\int}(hv)dt\;{\leq}\;4000\;W/m^2$, 2) moderate photochemical reactivity; $40\;ppb\;<\;{\Delta}O_{3,\;max-min}\;{\leq}\;60\;ppb$, and $4000\;{\leq}\;{\int}(hv)de\;{\leq}\;6000\;W/m^2$, and 3) high photochemical reactivity; ${\Delta}O_{3,\;max-min}\;>\;60\;ppb$, and ${\int}(hv)dt\;{\geq}\;6000\;W/m^2$. The ratio of ($PM_{10}$/CO) obtained at low photochemical activity regime was used as an index of tracer for the estimation of secondary $PM_{10}$ at higher photochemical activity regimes. The results show that the estimated secondary $PM_{10}$ concentrations for moderate and high photochemical regimes are found to be 18.8% ($10.9\;{\mu}g/m^3$), and 35.0% ($26.2\;{\mu}g/m^3$), respectively. Diurnal variation of secondary $PM_{10}$ for the moderate photochemical regime shows weak but noticeable patterns. However, the highly activated photochemical regime shows strong diurnal variations of secondary $PM_{10}$ concentrations with the maximum value of $35.1\;{\mu}g/m^3$ at 1300LST.

• YAKHAK HOEJI
• /
• v.40 no.4
• /
• pp.400-410
• /
• 1996

In oder to develop the controlled release of drugs from the suppositories, in vitro drug release and in vivo absorption in rabbits were investigated. Various suppo sitory forms with hollow cavities, into which drugs in the form of fine powder or solid dispersion system(SDS) could be placed, were utilized. The oleaginous Witepsol H-15 (WH-15) as a base, and indomethacin (IDM) of a very slightly soluble drug and propranolol-HCL (PPH) of a very soluble drug were employed as model drugs. The in vitro drug release showed that the cumulative release amount of PPH from PPH-(methylcellulose) MC-SDS and PPH-(ethylcellulose) EC-SDS hollow type suppositories reached 40% and 12% in 6 hrs,respectively. On the other hand, the drug release for a conventional suppository was 80% in 6 hrs. For the IDM suppositories,the cumulative drug release from IDM-(polyvinylpyrrolidone) PVP-SDS hollow type suppositories reached 99% in 24 hrs, whereas that from a conventional suppository reached 85%. An in vivo experiment with rabbits showed that IDM-PVP-SDS hollow type suppository delayed the absorption of IDM, significantly. The $t_{max},\;C_{max}\;and\;AUC_{0{\to}8}$ of IDM-PVP-SDS suppository were 60 min, 12.12${\mu}g$/ml and 2657${\mu}g$/ml/min, respectively. The $t_{max},\;C_{max}\;and\;AUC_{0{\to}8}$ of controlled group were 20 min, 15.49${\mu}g$/ml and 2190${\mu}g$/ml/min, respectively.

• Journal of IKEEE
• /
• v.8 no.1 s.14
• /
• pp.33-38
• /
• 2004

A multi-valued logic(MVL) pass gate is an important element to configure multi-valued logic. In this paper, we designed the Quaternary MIN(QMIN)/negated MIN(QNMIN) gate, the Quaternary MAX(QMAX)/negated MAX(QNMAX) gate using double pass-transistor logic(DPL) with neuron $MOS({\nu}MOS)$ threshold gate. DPL is improved the gate speed without increasing the input capacitance. It has a symmetrical arrangement and double-transmission characteristics. The threshold gates composed by ${\nu}MOS$ down literal circuit(DLC). The proposed gates get the valued to realize various multi threshold voltages. In this paper, these circuits are used 3V power supply voltage and parameter of 0.35um N-Well 2-poly 4-metal CMOS technology, and also represented HSPICE simulation results.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.38A no.8
• /
• pp.644-649
• /
• 2013

For effective DC-free coding in the optical storage systems, the Guided Scrambling algorithm is widely used. To reduce digital discrepancy of the coded sequence, functions of digital sum value (DSV) are used as criteria to choose the best candidate. Among these criteria, the minimum digital sum value (MDSV), minium squared weight (MSW), and minimum threshold overrun (MTO) are popular methods for effective DC-suppression. In this paper, we formulate integer programming models that are equivalent to MDSV, MSW, and MTO GS coding. Incorporating the MDSV integer programming model in MaxMin setting, we develop an integer programming model that computes the worst case MDSV bound given scrambling polynomial and control bit size. In the simulation, we compared the worst case MDSV bound for different scrambling polynomial and control bit sizes. We find that careful selection of scrambling polynomial and control bit size are important factor to guarantee the worst case MDSV performance.

• Korean Journal of Clinical Laboratory Science
• /
• v.46 no.4
• /
• pp.117-123
• /
• 2014

Creatinine is a general marker as a screening test for renal disease. This study was conducted to provide basic data about pediatric concentration for serum and urine creatinine. The data from the 2011 Korean National Health and Nutrition Examination Survey was used. Analysis was done on 488 Children and Adolescents (boys 278, girls 210) aged 10 to 19, the Jaffe reaction method was used to gather the data. The highest serum creatinine levels were found in boys aged 19 to 20 years, the mean being 0.97 mg/dL (min 0.81 mg/dL, max 1.14 mg/dL). The levels showed increase over those in the 10 year old group. The highest urine creatinine levels were found aged 19 to 20 years, and the mean was 222.68 mg/dL (min 133 mg/dL, max 324 mg/dL). In the case of girls, the highest serum creatinine levels were found with those aged between 18 and 19, the mean being 0.71 mg/dL (min 0.49 mg/dL, max 0.84 mg/dL). The levels showed increase over the 11 to 18 year old group. The highest urine creatinine levels were found aged 14 to 15 years, and the mean was 218.44 mg/dL (min 131 mg/dL, max 321 mg/dL). The mean difference in serum creatinine in all age groups was statistically significant except for those aged 10 to 14, that of urine creatinine in all age groups was not significant statistically except for those aged 12 to 13, 17 to 18. Therefore, it is suggested that reference values for children and adolescents should be divided into different groups according to gender, further studies are needed using complementing data of the pediatrics.

• Journal of KIISE:Software and Applications
• /
• v.34 no.6
• /
• pp.572-583
• /
• 2007

This paper investigates Centering-based metrics to evaluate ordering of utterances for text structuring. We point out a problem of MIN.NOCB metric which has been regarded as the simplest and best measure to evaluate coherence of ordering within Centering framework, and propose a new Centering-based metric, MAX.CPS as an alternative or supplementary one. This paper introduces a framework which pre-estimates the effectiveness of a metric on a given input ordering, and selects an applicable metric according to the pre-estimation result. Using this framework, we propose a new policy which can generate more optimal ordering within Centering framework. Moreover, we evaluate several kinds of Cf-ranking methods in terms of Centering-based metrics, and find that simply ranking entities by their linear order is generally the most suitable because of characteristics in Korean.