• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2002년도 제54차 추계 학술대회 연제집
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• pp.206-207
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• 2002

• 대한가정학회지
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• 제35권3호
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• pp.139-150
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• 1997

The purpose of this study was (1) to explore the difference in parental satisfaction regarding personal/family, work, and psychological variables of employment characteristics, and (2) to investigate the most effecting variables on the parental satisfaction. For this study, the working mother with children aged under 10 year were surveyed. The results of this study were as follow; (1) There were significant differences in the parental satisfaction according to work time, job preference, income, the difficulty of work life. However, working mother's personal and family variable were not found as the related variable. Psychological variables were correlated with parental satisfaction. (2) Maternal role efficiency, dual role conflict, flexibility of work, marriage year, income, psychological stress, expanded family, durations of occupation, spouse support significantly predicted parental satisfaction. Psychological variables were important in parental satisfaction of working mothers.

• Child Health Nursing Research
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• 제8권4호
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• pp.414-421
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• 2002

The purpose of this study is to analyze the concept of caretaking behavior for children. This study adopts the methode of Walker and Avant in analysis. Based on the results of the study, the attributes, precedents, and consequences of caretaking behavior for children are follows ; 1. The affirmative attributes of caretaking behavior are affection binding, nutritional guidance, education, caring, protection moral training and acquisition of parents' role. The negative attributes of caretaking behavior are inconsistent moral training, incapability of affection binding and overprotection. 2. The precedent of caretaking behavior are postpartum contact with their babies, cognizance capacity of child-caretaking, economic support, level of preparation for child-caretaking and self-consciousness as parents. 3. The affirmative consequences of caretaking behavior are promotion of child growth and development, formation of maternal-infantile attachment, development of children sociality, satisfaction of parental role and reinforcement of relationship between the members of family. The negative consequences of caretaking behavior are burden and conflict to parental role, children's illness, role conflict and role stress among the members of the family and family breaking up.

• 부모자녀건강학회지
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• 제9권1호
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• pp.17-32
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• 2006

The purpose of this study was to understand mother's experience of caring child with a severe atopic dermatitis. Twelve participants were selected and collected on their caring difficulties using in-depth interview. Data were analyzed according to the method of Colaizzi. Significant statements were extracted from the data. From the significant statement, 18 clusters of themes and 7 categories were emerged. Eighteen cluster of themes formed 7 categories : Thinking of atopic dermatitis during 24 hour, Mom would cure you, You are atopic, I'm depressive, I need 12 or more bodies to take care of him/her, Great conversion of daily life, From a bitterness to a frailness, In peace with an atopic dermatitis. In this study, it was implicated that mothers were suffered from caring children with an atopic dermatitis and nurses need to have more interests in the maternal stress and their quality of life as well as provision of information.

• 여성건강간호학회지
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• 제5권1호
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• pp.80-95
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• 1999

The purpose of this study was to investigate the characteristics of low birth-weight infants and their's mothers, and to identify the factors which influenced to delivery of L.B.W infants. The data derived from K. General Hospital and J. obs & gyn clinic in pusan from January, 1998 to August, 1998, which were from mothers of having B. W infants. The factors used for this study were characteristics of general, obstetrical, environmental aspects and physical and psychological life experiences during pregnancy. Analysis of data obtained were computerized statistically by using SPSS 7.5 WIN program. the data were analysed as number, frequency, percentage, t-test and ANOVA. The major results obtained of this study were as follows : 1) Gender that L.B.W infants were male in 47.2% and female in 52.8%, body weight of 2001~2500gm was above 8 in 68.5%, and below 5 in 1.8%. The L.B.W infants with complications were 7, which were 6.5%. The kinds of malformations were the Cleft palate & lip, Hyper-kalemia, Hypoglycemia, Meningocele, CHD, Down syndrome and each of them marked 0.9%. 2) In the general characteristics of pregnant women, the age group of 25~29 years was the most common as 46.3%. Over 35 years of age, elderly gravidas were in 7.5%. the height of 156~160cm was the most common as 52.8%. pregnant women of below 150cm height was in 3.7%. body weight of 51~55kg was the most common as 38%. pregnant women of below 45kg were in 19.4%. The women with smoking and drinking episodes during pregnancy were 1.9% and 25%. In the status of marriage, married women were in 95.4%, unmarried ones were in 1.9%, and unmarried couples were in 2.8%. Iin he obstetrical characteristics of pregnant women, pregnant women with gestational age under 37wks were in 45.4%, and the ones over 38wks were 54.6%. At the methods of delivery, normal spontaneous vaginal deliveries were in 51.9%, which were the most common, cesarian section deliveries were in 47.2%, and breech deliveries were in 0.9%. In the environmental characteristics of pregnant women, 40.8% of pregnant women lived in house or apartments with stairs, 23.1% of them lived in the high altitude. the pregnant women who ran a household without a helper were in 65.7%. In the pregnant women who had underwent life experiences of physical and psychological stress during pregnancy. life experiences of physical stresses were described as persistent fatigue due to lifestyle, traumatic experience, illness, move away with an effort, physical impact caused by discord. life experiments of psychological stresses were describeded as trouble with their husbands, discord with one's husband family, family problems, and conflicts due to environmental factors, etc. The number of the pregnant women who had complications during pregnancy was 32, which was 29.6% totally. Among them, pre-eclampsia was in 12.1% and the premature rupture of membrane in 7.4%. 3) In the analysis of the general, obstetrical, and circumstantial characteristics and L.B.W infants. There were statistical difference significantly between the gestational age of pregnant women(F=12.035, P=.000), and the status of marriage(F=3.207, P=.044), and maternal complication(t=2.344, P=.021) etc.

• 여성건강간호학회지
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• 제25권1호
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• pp.112-123
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• 2019

Purpose: The objective of this study was to investigate the prevalence of antenatal depression in pregnant women and its influencing factors. Methods: With a cross-sectional survey design, a total of 396 pregnant women were recruited from a local obstetrics and gynecology clinic. Measurements included antenatal depression, perceived stress, predictors of depression during pregnancy, and demographic and obstetric characteristics. Results: Mean antenatal depression score was 8.20 (standard deviation=4.95) out of 30, falling into its normal range. However, the prevalence of antenatal depression was 35.9% when cut-point of 9/10 was used. The prevalence of antenatal depression among women in the first trimester was 31.4%. It was slightly increased to 34.9% in the second trimester but significantly increased to 40.5% in the third trimester. In multiple logistic regression analysis, experiencing prenatal anxiety (odds ratio [OR], 4.16), having no job (OR, 2.90), lower self-esteem (OR, 1.62), and higher perceived stress (OR, 1.32) were significant factors influencing antenatal depression. Conclusion: Negative feeling such as feeling anxious, lower self-esteem, and higher perceived stress during pregnancy are key factors affecting antenatal depression. Thus, antenatal nursing intervention focusing on pregnant women's feeling upon their job status is necessary to improve their antenatal psychological well-being.

• 융합정보논문지
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• 제8권6호
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• pp.1-7
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• 2018

본 연구는 산욕기 산모의 삶의 질 에 영향을 미치는 요인을 파악하기 위해 시도 되었다. 본 연구는 D광역시 지역에 거주하는 출산 후 6-8주 이내의 여성 113명을 대상으로 한 서술적 조사연구이며 자료는 SPSS 21.0 프로그램을 이용하여, 기술통계, ANOVA, t-test, Pearson's correlation coefficient 및 Multiple regression analysis를 실시하였다. 자료수집은 2018년 8월부터 2018년 9월까지 하였다. 본 연구결과는 다음과 같다. 삶의 질에 가장 큰 영향요인은 양육스트레스(${\beta}=-.646$, p<.001), 피로(${\beta}=-.329$, p=.009)순으로 확인되었다. 양육스트레스(r=-.647, p<.01), 산후우울(r=-.826, p<.01), 피로(r=-.760, p<.01)는 삶의 질과 유의미한 상관관계를 보였다. 출산 후 산모는 공허감, 산후우울감 등 정서적 기분변화를 느끼는 경우 삶의 질 저하로 이어지기 때문에 산욕 기간 동안 신체적, 정신적 건강관련 간호중재 프로그램을 개발하는 것이 필요할 것이다.

• 한국수정란이식학회지
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• 제32권4호
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• pp.287-295
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• 2017

Mitochondrial dysfunction is found in oocytes and transmitted to offspring due to maternal obesity. Treatment of obese mothers with endoplasmic reticulum (ER) stress inhibitors such as salubrinal (SAL) can reverse the mitochondrial dysfunction and result in normal embryonic development. Pig oocytes have also shown ER stress mostly in metaphase II stage. ER stress in oocytes may hinder the in vitro production of pig embryos. This study investigated the effect of ER stress inhibition by SAL treatment during in vitro maturation (IVM) of porcine oocytes at 1, 10, 50 and 100 nM concentrations. Firstly, we tested various concentrations of SAL. SAL at 10 nM showed higher (P < 0.05) developmental competence to the blastocyst stage (55.6%) after parthenogenesis (PA) than control (44.2%) while not different from other concentrations (49.2, 51.6, and 50.8% for 1, 50, and 100 nM, respectively). Secondly, we performed time-dependent treatment at 10 nM of SAL for IVM of oocytes. It revealed that treatment with SAL during 22 to 44 h of IVM significantly improved PA embryonic development to the blastocyst stage compared to control (40.5, 46.3, 51.7 and 60.2% for control, 0 to 22 h, 22 to 44 h and 0 to 44 h of IVM, respectively, P < 0.05). Glutathione (GSH) content is an indicator of cytoplasmic maturation of oocytes. Reactive oxygen species (ROS) have a harmful effect on developmental competence of oocytes. For this, we determined the intraoocyte levels of GSH and ROS after 44 h of IVM. It was found that SAL increased intraoocyte GSH level and also decreased ROS level (P < 0.05). Finally, we performed somatic cell nuclear transfer (SCNT) after treating oocytes with 10 nM SAL during IVM. SAL treatment significantly improved blastocyst formation of SCNT embryos compared to control (39.6% vs. 24.7%, P < 0.05). Our results indicate that treatment of pig oocytes with ER stress inhibitor SAL during IVM improves preimplantation development PA and cloned pig embryos by influencing cytoplasmic maturation in terms of increased GSH content and decreased ROS level in IVM pig oocytes.

• 생명과학회지
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• 제29권9호
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• pp.1002-1009
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• 2019

생애 초기 유해 경험은 우울증의 위험성을 높이며, 성인기 스트레스의 민감성에 영향을 미칠 수 있다. 출생 후 모성 분리(MS)로 인한 성인기 스트레스(장기간 예측 불가능한 스트레스; CUS)의 취약성에 p11 유전자의 후성유전기전이 영향을 미치는 지를 확인하였다. 출생 직후부터 21일 동안 하루 3시간 동안 새끼 생쥐를 어미 생쥐로부터 분리시켜 새끼 생쥐가 성체가 되었을 때 CUS를 3주 동안 매일 적용하였다. Real time PCR기법으로 해마의 p11 발현 양을 측정하였고, 염색질 면역 침전 분석법으로 p11 promoter의 히스톤 H3 아세틸화 및 메틸화 양을 측정하였다. 강제수영검사에서 우울 유사 행동을 측정하였다. MS군 및 CUS군은 p11 mRNA 발현 양을 유의하게 감소시켰으며, MS+CUS군은 CUS군에 비해 p11 발현 양을 유의하게 증가시켰다. 또한 MS+CUS군은 CUS군에 비해 H3 아세틸화를 감소시켰다. 이러한 감소는 HDAC5 mRNA 발현 증가와 일치하였다. MS+CUS군은 CUS군에 비해 H3K4 메틸화를 감소시켰으며, H3K27 메틸화를 증가시켰다. 강제수영검사에서 p11 발현이 가장 많이 감소된 MS+CUS군이 대조군에 비해 더 긴 부동 시간을 나타내었다. 출생 후 모성 분리를 경험하고 성체 기간에 스트레스를 함께 받은 생쥐는 성체기간에만 스트레스를 받은 생쥐보다 훨씬 더 큰 후성유전 변화를 보여주었다. 생애 초기 유해 경험은 해마에서 p11 유전자의 히스톤 변형을 통해 성체 스트레스 효과를 더 악화시키는 것으로 생각된다.

• 한국발생생물학회지:발생과생식
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• 제12권2호
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• pp.117-124
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• 2008

지구상의 모든 생명체들은 자신의 생존과 종의 영속성을 보장하기 위해 우호적이지 않은 환경 변화에 대응하기 위한 효과적인 전략을 발전시켜왔다. 그 결과, 생명체들은 환경요인들의 변화에도 불구하고 체내 생리적 환경의 역동적인 평형, 즉 항상성(homeostasis)을 유지해 나간다. 스트레스는 항상성을 위협하는 정서적 그리고 물리적 반응이다. 스트레스는 일시적일 뿐만 아니라 거의 영구적인 영향을 개체에 줄 수 있는데, 특히 출생전 스트레스는 유전 코드의 변경없이 성체의 기능과 구조를 바꿀 수 있는 '후생학적 프로그래밍'을 할 수 있음이 최근의 연구들에 의해 알려졌다. 본 논문에서는 출생 전 스트레스를 받은 수컷 흰쥐에서 나타나는 생식과 연관된 일련의 사건들, 예를 들어 성적 이형현상을 보이는 뇌 지역의 변화, 신경전달물질 대사의 수정, 생식내분비 상태의 변화, 그리고 마지막으로 성행동의 이상들을 소개한다. 태아의 뇌는 출생전 프로그래밍에 극히 민감한데, 특히 글루코코티코이드는 강력한 뇌-프로그래밍 능력을 갖고 있다. 모체 스트레스에 의해 유도된 글루코코티코이드 입력에 의한 태아 뇌의 지속적인 과도 활성은 신경 가소성을 증가시키는 새로운 프로그램을 제공할 것이다. 그리고 증가한 신경 가소성은 환경 도전 속에서 개체가 더 잘 적응하도록 하는 증가된 표현형의 가소성에 대한 기초가 될 것이다. 결론적으로, '혹독한' 환경을 태아기에 경험한 개체는 미래에 자신의 생존 가능성을 높이기 위해 번식능력을 일부 포기하도록 후생학적으로 (재)프로그램하는 것으로 추정된다.