• Journal of the Korean Geophysical Society
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• v.6 no.4
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• pp.269-276
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• 2003

Sub-bottom profile were conducted in Chungju Regulation Lake by use of ground penetrating radar(GPR). The survey area covers approximately 1,000,000 $m^2$ and total survey line length is about 5km and more. GPR surveys with GPS system were made across and transverse direction of the lake. From the survey results of GPR, it could be possible to distinguish the gravel and/or sand dominant bed from silt and/or clay material dominant bed.

• International Journal of Industrial Entomology and Biomaterials
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• v.47 no.2
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• pp.134-139
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• 2023

SIRT5 and PRDx1 play crucial roles in cancer and are involved in the basic mechanisms of reactive oxygen species detoxification. In our previous studies, we showed that hemolymph extracts of immune-challenged Bombyx mori have antioxidant properties. Following H₂O₂ stimulation, immune-challenged B. mori hemolymph extracts elicited SIRT5 downregulation activity, reaching effective activity at the highest concentration of 100 ppm. Additionally, cells treated with immune-challenged B. mori hemolymph extracts demonstrated increased PRDx1 mRNA expression compared to that of PBS-treated cells. Therefore, immune-challenged B. mori hemolymph extracts offer a potential auxiliary means of treating drug-resistant tumors through downregulation of SIRT5 and upregulation of PRDx1 expression. Nevertheless, further studies on the effects of B. mori hemolymph on SIRT5 and PRDx1 regulation are pertinent for using it as a food or pharmaceutical material and understanding its therapeutic effect on tumors, including those that are drug-resistant.

• Journal of Radiation Protection and Research
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• v.49 no.1
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• pp.19-28
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• 2024

Background: This study aims to analyze radiation safety management and regulatory perceptions, focusing on companies that must report radiation sources. The intent is to reduce the gap between regulation measures and addressing real concerns while improving practical safety management measures and regulations for all stakeholders. Materials and Methods: Radiation safety officers at a total of 244 reporting companies using radiation generators (79.8%) and sealed radioisotopes (15.1%) were surveyed using a questionnaire. Results and Discussion: The perception that regulation is stronger than the actual risk of the radiation source used was 3.47 points (out of 5 points), indicating a score above average. The most important factors and considerations were education and training (48%) as a human factor, safety devices of the radiation source (71.3%) as a hazardous material factor, the use of radiation (50.8%) as an organizational environment, and the radiation effect of nearby facilities (67.2%) as a physical environment. Radiation safety management educational experience (F= 5.030, p< 0.01), the group with high subjective knowledge (t= 6.017, p< 0.001), and the group with high objective knowledge (t= 1.989, p< 0.05) was found to be better at radiation safety management. Conclusion: It is necessary to standardize the educational experience regarding radiation safety management because each staff member has individual differences in educational experience. It is necessary to provide more information on how to solve radiation accidents via educational content. Applying radiation safety regulations based on the factors that significantly affect radiation safety management shown in this survey will help improve safety.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1533-1539
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• 2007

It is mainly due to the toxic gases, produced from the material combustion, threatens human body in case of urban railway car like subway which passes through underground tunnel. In the field of railway industry, fire accidents was not frequent but occurs in each country and, the causes was investigated. The advanced country established the test standard (e.g., BS, EN) to measure the toxic gases quantitatively and, have applied to enhance the fire safety of railway car. We must also follow the procedures to use gangway material for railway car as stated the Safety regulation for the urban railway car. In this study, various gangway materials(silicon, synthtic rubber, soaltapulin) are used to investigate element of toxic gases when the fire occurs. The amount of toxic gases measured from the ISO 5659 chamber using cone heater was measured and compared the results for each materials.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.4031-4036
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• 2012

Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.07b
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• pp.1127-1130
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• 2003

In the last several centuries, humankind have been experienced the material abundance with a development of technical civilization and being industrialized quickly. During the process of this, environmental pollutant have occurred naturally so that humankind have more interests for environment pollutant. Air pollution caused by exhaust from a car is very harmful for human. Most of exhaust from a gasoline engine are $CO_x(CO+CO_2),\;NO_x(NO+NO_2)$, and THC(Total Hydrocarbon). The method to remove these kinds of noxious gases are so many thing such as the three catalysts, $NO_x$ catalysts, Filter and so on. However, although air pollution caused by exhaust from motorcycle have also occurred very much, there is no regulation for motorcycle. In this paper, we studied to remove $CO_x(CO+CO_2),\;NO_x(NO+NO_2)$, THC exhaust from a motorcycle using non-thermal plasma In the result, $NO_x(NO+NO_2)$ concentration was decreased approximately 70% and THC(Total Hydrocarbon) was removed about 40%.

• Journal of The Korean Society of Agricultural Engineers
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• v.53 no.6
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• pp.59-65
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• 2011

This study was performed to evaluate the compressive and flexural strength, void ratio and permeability coefficient used powdered waste glass, $CaCO_3$, recycled coarse aggregate and unsaturated polyester resin to find optimum mix design of permeable polymer concrete for pavement. The compressive and flexural strength of permeable polymer concrete for pavement using powdered waste glass were in the range of 16.8~19.7 MPa and 4.7~6.1 MPa, respectively. it was satisfied the regulation of permeable concrete for pavement (18 MPa and 4.5 MPa). The void ratio and permeability coefficient were decreased with increasing the powdered waste glass, respectively. The void ratio and permeability coefficient were satisfied national regulation of permeable concrete for pavement (8 % and $1{\times}10^{-2}$ cm/s). In addition, this study found out that required amount of binder was decreased with increasing the powdered waste glass. This fact is expected to have economical effects during the use of powdered waste glass in the manufacture of permeable polymer concrete for pavement. Accodingly, the powdered waste glass can be used for permeable concrete material.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.20 no.5
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• pp.410-414
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• 2007

To prevent degradation of battery efficiency generated by serious current variation in rechargeable batteries, we researched a hybrid battery combining a super capacitor and a rechargeable battery. The hybrid battery shows high efficiency in a lifetime and a voltage drop. The hybrid battery was composed of a rechargeable battery, a current regulator and a super capacitor that can be used with supporting power. Before the experiment, the hybrid battery was simulated for current regulation and an electric current in a super capacitor by using the Pspice program. After that, we compared the efficiency of the hybrid battery with the efficiency of the normal battery. In this result, we demonstrated that the hybrid battery has a higher efficiency and a longer lifespan than the normal battery.

• BMB Reports
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• v.43 no.1
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• pp.29-33
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• 2010

It is well known that PR/SET family members participate in transcriptional regulation via chromatin remodeling. PRDM10 might play an essential role in gene expression, but no such evidence has been observed so far. To assess PRDM10 expression at various stages of mouse development, we performed immunohistochemistry using available PRDM10 antibody. Embryos were obtained from three distinct developmental stages. At E8.5, PRDM10 expression was concentrated in the mesodermal and neural crest populations. As embryogenesis proceeded further to E13.5, PRMD10 expression was mainly in mesoderm-derived tissues such as somites and neural crest-derived populations such as the facial skeleton. This expression pattern was consistently maintained to the fetal growth period E16.5 and adult mouse, suggesting that PRDM10 may function in tissue differentiation. Our study revealed that PRDM10 might be a transcriptional regulator for normal tissue differentiation during mouse embryonic development.

• Journal of the Korean Society of Industry Convergence
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• v.26 no.4_2
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• pp.649-656
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• 2023

Recently, global warming has become severe, and regulation is established for carbon savings each field. its regulation is applied to various fields using IC engine such as automobile, ship, agricultural machine. Therefore engine block applied Common Rail Direct Injection(CRDI) technology, that carry out thermal-structure analysis to examine design. The thermal load about 900℃ by explosion was applied in cylinder. And pressure about 9 MPa(90 Bar) was applied to structure analysis. As a result, it was the highest at 185.99℃ at the top of cylinder. Static-structure analysis applied thermal load, that was shown maximum equivalent stress at 142.59 Mpa and Maximum principal stress 145.03 MPa, Minimum principal stress -149 MPa. When compare analysis results to material property, it design is safety structurally.