International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Effects of immune-challenged domestic silkworm hemolymph on the regulation of SIRT5 and PRDx1 expression

  • Jin Ha Yun (Department of Biomedical Science, Daegu Catholic University) ;
  • Seong Ryul Kim (Sericultural and Apicultural Materials Division, National Academy of Agricultural Science, RDA) ;
  • Seung-Won Park (Department of Biomedical Science, Daegu Catholic University)
  • Received : 2023.10.31
  • Accepted : 2023.12.04
  • Published : 2023.12.31
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Abstract

SIRT5 and PRDx1 play crucial roles in cancer and are involved in the basic mechanisms of reactive oxygen species detoxification. In our previous studies, we showed that hemolymph extracts of immune-challenged Bombyx mori have antioxidant properties. Following H2O2 stimulation, immune-challenged B. mori hemolymph extracts elicited SIRT5 downregulation activity, reaching effective activity at the highest concentration of 100 ppm. Additionally, cells treated with immune-challenged B. mori hemolymph extracts demonstrated increased PRDx1 mRNA expression compared to that of PBS-treated cells. Therefore, immune-challenged B. mori hemolymph extracts offer a potential auxiliary means of treating drug-resistant tumors through downregulation of SIRT5 and upregulation of PRDx1 expression. Nevertheless, further studies on the effects of B. mori hemolymph on SIRT5 and PRDx1 regulation are pertinent for using it as a food or pharmaceutical material and understanding its therapeutic effect on tumors, including those that are drug-resistant.

Keywords

Acknowledgement

I express sincerely my former research assistants from the Department of Biomedical Science, at the Daegu Catholic University and gratitude to the participants who were involved in the study. This work was supported by the National Research Foundation of Korea (NRF) grant founded by the Korea Government (MSIT) (No. 2021R1F1A1062456).

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