• Title/Summary/Keyword: Matched-pair analysis

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Detection and Analysis of DNA Hybridization Characteristics by using Thermodynamic Method (열역학법을 이용한 DNA hybridization 특성 검출 및 해석)

  • Kim, Do-Gyun;Gwon, Yeong-Su
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.51 no.6
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    • pp.265-270
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    • 2002
  • The determination of DNA hybridization reaction can apply the molecular biology research, clinic diagnostics, bioengineering, environment monitoring, food science and application area. So, the improvement of DNA hybridization detection method is very important for the determination of this hybridization reaction. Several molecular biological techniques require accurate predictions of matched versus mismatched hybridization thermodynamics, such as PCR, sequencing by hybridization, gene diagnostics and antisense oligonucleotide probes. In addition, recent developments of oligonucleotide chip arrays as means for biochemical assays and DNA sequencing requires accurate knowledge of hybridization thermodynamics and population ratios at matched and mismatched target sites. In this study, we report the characteristics of the probe and matched, mismatched target oligonucleotide hybridization reaction using thermodynamic method. Thermodynamic of 5 oligonucleotides with central and terminal mismatch sequences were obtained by measured UV-absorbance as a function of temperature. The data show that the nearest-neighbor base-pair model is adequate for predicting thermodynamics of oligonucleotides with average deviations for $\Delta$H$^{0}$ , $\Delta$S$^{0}$ , $\Delta$G$_{37}$ $^{0}$ and T$_{m}$, respectively.>$^{0}$ and T$_{m}$, respectively.

Effect of Artificial Aeration System on Water Quality of Yeoncho Lake (연초호의 인공 순환 장치 운영에 의한 수질 개선 효과 분석)

  • Seo, Dong-Il;Hwang, Hyun-Dong;Lee, Eun-Hyoung;Heo, Woo-Myung
    • Journal of Korean Society of Water and Wastewater
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    • v.18 no.3
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    • pp.357-365
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    • 2004
  • Effect of artificial circulation on amelioration of water quality in Yeoncho Lake was analyzed using summer data between 1991-2002. Two sites, intake tower area where aeration systems are concentrated in and near the inlet of reservoir were selected for comparison in this study. Summer averages between may and september Showed that aeration system might be beneficial in the improvement of water quality of BOD5, COD, and TN while Chl-a concentration and transparency did show opposite pattems. Wilcoxon's singed rank test for matched pair indicated slight increase of BOD5 and COD concentrations in the vicinity of intake tower while other variables did not show any significant differences from data of inlet of reservoir. During the study, it was found that the following subjects need to be investigated for more detailed analysis. 1) Dynamic pollutant loading from outside and inside the lake, 2) Biological, Chemical and Physical lake data when aeration systems are in and not in operation and 3) Radius of influence of aeration system.

Noise Analysis of Common Source CMOS Pair for Dual-Band LNA (이중밴드 저잡음 증폭기 설계를 위한 공통 소스 접지형 CMOS쌍의 잡음해석)

  • Cho, Min-Soo;Kim, Tae-Sung;Kim, Byung-Sung
    • Proceedings of the Korea Electromagnetic Engineering Society Conference
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    • 2003.11a
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    • pp.168-172
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    • 2003
  • This paper analyzes the output noise and the noise figure of common source MOSFET pair each input of which is separately driven in the different frequencies. This analysis is performed for concurrent dual band cascode CMOS LNA with double inputs and single output fabricated in $0.18{\mu}m$ CMOS process. Since both inputs and output are matched to near $50{\Omega}$ using on-chip inductors, the measured noise figures are much higher than those of usual CMOS LNA. But, the main concern of this paper is focused on the added noise features due to the other channel common source stage. The dual-band LNA results in noise figure of 4.54dB at 2.14GHz and 6.03dB at 5.25GHz for selectable operation and 7.44dB and 6.58dB for concurrent operation. The noise analysis explains why the added noise at each band shows so large difference.

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Adaptive Matching Method of Rigid and Deformable Object Image using Statistical Analysis of Matching-pairs (정합 쌍의 통계적 분석을 이용한 정형/비정형 객체 영상의 적응적 정합 방법)

  • Won, In-Su;Yang, Hun-Jun;Jang, Hyeok;Jeong, Dong-Seok
    • Journal of the Institute of Electronics and Information Engineers
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    • v.52 no.1
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    • pp.102-110
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    • 2015
  • In this paper, adaptive matching method using the same features for rigid and deformable object images is proposed. Firstly, we determine whether the two images are matched or not using the geometric verification and generate the matching information. Decision boundary which separates deformable matching-pair from non-matching pair is obtained through statistical analysis of matching information. The experimental result shows that the proposed method lowers the computational complexity and increases the matching accuracy compared to the existing method.

Forces and Displacements of Outrigger-Braced Structures with a Pair of Coupled Cores (병렬코아를 갖는 아웃리거구조물의 응력과 변위)

  • 정동조;이태희
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.16 no.3
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    • pp.291-299
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    • 2003
  • Based on the continuum approach, an investigation is made to get the forces and displacements of laterally loaded outrigger braced structures with a pair of coupled cores, and to show the effect of stiffening outriggers on the behavior of the structure. From the condition that the rotation of the core at the outrigger level is matched with the rotation of the corresponding outrigger, the outrigger restraining moment is derived analytically. From this, the core moment diagram, the column axial forces, and the horizontal displacements of the structure may be determined. Comparisons with the results by the program MIDAS-GEN for the structural models, have shown that this analysis can give reasonably accurate results for outrigger-braced structures with a pair of coupled cores. And a lateral displacement at the top of the structure is influenced by the outrigger location than the core location. Although the formulae are accurate only for idealized outrigger braced structures, they have a useful practical purpose in providing a guide to the behavior, and for making approximate estimates of the forces and displacements, in practical outrigger braced structures with a pair of coupled cores.

First Record of an Abnormal Bathyraja brachyurops (Rajiformes: Arhynchobatidae) Collected from the Southwest Atlantic Ocean (남서대서양에서 채집된 Bathyraja brachyurops (Rajiformes: Arhynchobatidae) 기형의 첫 보고)

  • Min-Gyoon Park;Eunjung Kim;Jin-Koo Kim
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.56 no.6
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    • pp.916-922
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    • 2023
  • An abnormal shape of Bathyraja brachyurops was first reported from the catch of a bottom trawl in the southwest Atlantic Ocean in June 2022. Both pectoral fins of the specimen did not fuse with the head, resulting in a horn-like structure separated from the sides of the eyes. Analysis of mitochondrial DNA cytochrome c oxidase subunit I sequences showed that our specimen was perfectly matched to Bathyraja brachyurops registered with the National Center for Biotechnology Information. Our specimen possessed the following morphological features: a pair of flexible but elongated and pointed horns on the head; rough dorsal disc, densely covered with numerous small denticles on the head, anterior margin of pectoral fins and median line of the disc; a thorn between the first and second dorsal fins; and a pair of large ocelli at the base of pectoral fins. Unlike the normal B. brachyurops, our specimen had a slender clasper and no nuchal thorns, which may be related to the morphological abnormality. The horn-like structure on the head may be owing to the lack of fusion between the pectoral fins and head during early embryonic development.

Multi-Point Sheet Forming Using Elastomer (탄소중합체를 이용한 다점 박판 성형)

  • 박종우
    • Transactions of Materials Processing
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    • v.13 no.2
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    • pp.129-136
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    • 2004
  • Recently, instead of a matched die forming method requiring a high cost and long delivery term, a multi-point dieless forming method using a pair of matrix type punch array as flexible dies has been developed. Since the conventional multi-point dieless forming method has some disadvantages of difficulty in precise punch control and high-cost of equipment, a new concept of multi-point dieless forming method combined with an elasto-forming method has been suggested in this study. For optimal selection of elastomers, compression tests of rubbers, polyethylene and foams were carried out together with FEM analysis of the deformation behavior during sheet forming process using a rigid punch and elastomers. Compressive strain was concentrated on the upper central area of the elastomer under the punch, and the rubber exhibited higher concentration of the compressive strain than foams. Two-dimensional curved surface was formed successfully by the multi-point elasto-dieless forming method using an optimal combination of rubber and foam materials.

Multi-point sheet forming using elastomer (탄소중합체를 이용한 다점 박판 성형)

  • Park Jong-Woo
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2003.08a
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    • pp.21-28
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    • 2003
  • Recently, instead of a matched die forming method requiring a high cost and long deliverly ten a multi-point dieless forming method using a pair of matrix type punch array as flexible dies has been developed. As this multi-point dieless forming method has some disadvantage of difficulty in precise punch control and high-cost of equipment, a new concept of multi-point dieless forming method combined with elastomer forming was suggested in this study. For optimal selection of elastomers, compression tests of rubbers, polyethylene and foams were carried out together with FEM analysis of the deformation behavior during sheet forming process using a rigid punch and elastomers. Compressive strain was concentrated on the upper central area of the elastomer under the punch, and the rubber exhibited higher concentration of the compressive strain than foams. Two-dimensional curved surface was formed successfully by the multi-point elasto-dieless forming method using an optimal combination of a rubber and foam.

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Linkage Disequilibrium of Dopamine D2 Receptor Gene in the Korean Population

  • Kang, Byung-Yong;Oh, Sang-Duk;Lee, Kang-Oh
    • Toxicological Research
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    • v.20 no.1
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    • pp.49-53
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    • 2004
  • The genetic basis of hypertension is complex, and has been considered to be associated with the dopamine D2 receptor gene (DD2R). Because association studies using the candidate gene approach may provide important clues regarding the pathogenesis of hypertension and establish basis for further study, we performed the association study on the relationship between genetic polymorphisms in the DD2R gene and hypertension in Koreans. Eighty nine patients with hypertension and 86 age-matched subjects with normal blood pressure were enrolled. Genomic DNA was extracted from peripheral blood leukocytes. PCR-RFLP analysis was performed to detect the three polymorphic Taq I sites in the DD2R gene. There were no significant differences in genotype, allele and haplotype distributions of any polymorphisms in the DD2R gene between two groups, respectively (P>0.05), although significant linkage disequilibriums among these polymorphic sites were detected by pair-wise analysis (P<0.05). Therefore, our negative result suggest that the three Taq I RFLPs in the DD2R gene were not significantly associated with hypertension in Koreans.

Texture Comparison with an Orientation Matching Scheme

  • Nguyen, Cao Truong Hai;Kim, Do-Yeon;Park, Hyuk-Ro
    • Journal of Information Processing Systems
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    • v.8 no.3
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    • pp.389-398
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    • 2012
  • Texture is an important visual feature for image analysis. Many approaches have been proposed to model and analyze texture features. Although these approaches significantly contribute to various image-based applications, most of these methods are sensitive to the changes in the scale and orientation of the texture pattern. Because textures vary in scale and orientations frequently, this easily leads to pattern mismatching if the features are compared to each other without considering the scale and/or orientation of textures. This paper suggests an Orientation Matching Scheme (OMS) to ease the problem of mismatching rotated patterns. In OMS, a pair of texture features will be compared to each other at various orientations to identify the best matched direction for comparison. A database including rotated texture images was generated for experiments. A synthetic retrieving experiment was conducted on the generated database to examine the performance of the proposed scheme. We also applied OMS to the similarity computation in a K-means clustering algorithm. The purpose of using K-means is to examine the scheme exhaustively in unpromising conditions, where initialized seeds are randomly selected and algorithms work heuristically. Results from both types of experiments show that the proposed OMS can help improve the performance when dealing with rotated patterns.