• Mass Spectrometry Letters
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• v.13 no.4
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• pp.115-124
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• 2022

Emerging evidence has shown that RNA-binding proteins (RBPs) dynamically regulate all aspects of RNA in cells and involve in major biological processes of RNA, including splicing, modification, transport, transcription and degradation. RBPs, as powerful and versatile regulatory molecule, are essential to maintain cellular homeostasis. Perturbation of RNA-protein interactions and aberration of RBPs function is associated with diverse diseases, such as cancer, autoimmune disease, and neurological disorders. Therefore, it is crucial to systematically investigate the RNA-binding proteome for understanding interactions of RNA with proteins. Thanks to the development of the mass spectrometry, a variety of proteome-wide methods have been explored to define comprehensively RNA-protein interactions in recent years and thereby contributed to speeding up the study of RNA biology. In this review, we systematically described these methods and summarized the advantages and disadvantages of each method.

• The Bulletin of The Korean Astronomical Society
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• v.24 no.2
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• pp.19-19
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• 1999

• Journal of Korean Tunnelling and Underground Space Association
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• v.6 no.3
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• pp.183-197
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• 2004

The introduction of geodetic methods of absolute displacement monitoring in tunnels has significantly improved the value of the measurements. Structurally controlled behavior and influences of an anisotropic rock mass can be determined, and the excavation and support adjusted accordingly. Three-dimensional finite element simulations of different weakness zone properties, thicknesses, and orientations relative to the tunnel axis were carried out and the function parameters were evaluated from the results. The results were compared to monitoring results from Alpine tunnels in heterogeneous rock. The good qualitative correlation between trends observed on site and numerical results gives hope that by a routine determination of the function parameters during excavation the prediction of rock mass conditions ahead of the tunnel face can be improved. Implementing the rules developed from experience and simulations into the monitoring data evaluation program allows to automatically issuing information on the expected rock mass quality ahead of the tunnel.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.2
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• pp.288-296
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• 1997

Curved beam elements with two nodes based on shallow beam geometry and strain interpolations are employed in eigenvalue analysis. In these elements, the displacement interpolation functions and mass matrices are consistent with strain fields. To assess the quality of the element mass matrix in free vibration problems, several numerical experiments are performed. In these analysis, both the inconsistent mass matrices using linear displacement interpolation function and the consistent mass matrices are used to show the difference. The numerical results demonstrate that the accuracy is closely related to the property of the mass matrix as well as that of the stiffness matrix and that the mass matrix consistent with strain fields is very beneficial to eigenvalue analysis. Also, it is proved that the strain based elements are very efficient in a wide range of element aspect ratios and curvature properties.

• Journal of The Korean Astronomical Society
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• v.32 no.1
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• pp.17-39
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• 1999

We investigate dynamical evolution of globular clusters with multi-mass component under the Galactic tidal field. We compare the results with our previous work which considered the cases of single-mass component m the globular clusters. We find the followings: 1) The general evolutions are similar to the cases of single-mass component. 2) There is no evidence for dependence on the orbital phase of the cluster as in the case of single-mass component. 3) The escape rate in multi-mass models is larger than that in the single-mass models. 4) The mass-function depends on radius more sensitively in anisotropic models than in isotropic models.

• Journal of The Korean Astronomical Society
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• v.48 no.4
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• pp.213-228
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• 2015

The Horizon Run 4 is a cosmological N-body simulation designed for the study of coupled evolution between galaxies and large-scale structures of the Universe, and for the test of galaxy formation models. Using 6300³ gravitating particles in a cubic box of L_box = 3150 h⁻¹Mpc, we build a dense forest of halo merger trees to trace the halo merger history with a halo mass resolution scale down to M_s = 2.7 × 10¹¹h⁻¹M_⊙. We build a set of particle and halo data, which can serve as testbeds for comparison of cosmological models and gravitational theories with observations. We find that the FoF halo mass function shows a substantial deviation from the universal form with tangible redshift evolution of amplitude and shape. At higher redshifts, the amplitude of the mass function is lower, and the functional form is shifted toward larger values of ln(1/σ). We also find that the baryonic acoustic oscillation feature in the two-point correlation function of mock galaxies becomes broader with a peak position moving to smaller scales and the peak amplitude decreasing for increasing directional cosine μ compared to the linear predictions. From the halo merger trees built from halo data at 75 redshifts, we measure the half-mass epoch of halos and find that less massive halos tend to reach half of their current mass at higher redshifts. Simulation outputs including snapshot data, past lightcone space data, and halo merger data are available at http://sdss.kias.re.kr/astro/Horizon-Run4.

• Journal of Chest Surgery
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• v.44 no.6
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• pp.399-405
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• 2011

Background: Left ventricular (LV) hypertrophy caused by aortic valve stenosis (AS) leads to cardiovascular morbidity and mortality. We sought to determine whether aortic valve replacement (AVR) decreases LV mass and improves LV function. Materials and Methods: Retrospective review for 358 consecutive patients, who underwent aortic valve replacement for degenerative AS between January 1995 and December 2008, was performed. There were 230 men and 128 women, and their age at operation was $63.2{\pm}10$ years (30~85 years). Results: There was no in-hospital mortality, and mean follow-up duration after discharge was 48.9 months (2~167 months). Immediate postoperative echocardiography revealed that LV mass index and mean gradient across the aortic valve decreased significantly (p<0.001), and LV mass continued to decrease during the follow-up period (p<0.001). LV ejection fraction (EF) temporarily decreased postoperatively (p<0.001), but LV function recovered immediately and continued to improve with a significant difference between preoperative and postoperative EF (p<0.001). There were 15 late deaths during the follow-up period, and overall survival at 5 and 10 years were 94% and 90%, respectively. On multivariable analysis, age at operation (p=0.008), concomitant coronary bypass surgery (p<0.003), lower preoperative LVEF (<40%) (p=0.0018), and higher EUROScore (>7) (p=0.045) were risk factors for late death. Conclusion: After AVR for degenerative AS, reduction of left ventricular mass and improvement of left ventricular function continue late after operation.

• Journal of The Korean Astronomical Society
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• v.48 no.6
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• pp.343-355
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• 2015

There is much observational evidence that active star formation is taking place in the Hii regions Sh 2-255 – 257. We present a photometric study of this star forming region (SFR) using imaging data obtained in passbands from the optical to the mid-infrared, in order to study the star formation process. A total of 218 members were identified using various selection criteria based on their observational properties. The SFR is reddened by at least E(B −V ) = 0.8 mag, and the reddening law toward the region is normal (R_V = 3.1). From the zero-age main sequence fitting method it is confirmed that the SFR is 2.1 ± 0.3 kpc from the Sun. The median age of the identified members is estimated to be about 1.3 Myr from a comparison of the Hertzsprung-Russell diagram (HRD) with stellar evolutionary models. The initial mass function (IMF) is derived from the HRD and the near-infrared (J, J −H) color-magnitude diagram. The slope of the IMF is about Γ = −1.6 ± 0.1, which is slightly steeper than that of the Salpeter/Kroupa IMF. It implies that low-mass star formation is dominant in the SFR. The sum of the masses of all the identified members provides the lower limit of the cluster mass (169M_⊙). We also analyzed the spectral energy distribution (SED) of pre-main sequence stars using the SED fitting tool of Robitaille et al., and confirm that there is a significant discrepancy between stellar mass and age obtained from two different methods based on the SED fitting tool and the HRD.

• Journal of The Korean Astronomical Society
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• v.47 no.4
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• pp.137-145
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• 2014

The astrophysical parameters of four unstudied open star cluster candidates; Ivanov 2, 7, 9, and Harvard 9; are estimated for the first time using the PPMXL database. The stellar density distributions and color-magnitude diagrams for each cluster are used to determine the geometrical structure (cluster center, limited radius, core and tidal radii, the distances from the Sun, from the Galactic center and from the Galactic plane). Also, the main photometric parameters (age, distance modulus, color excesses, membership, total mass, relaxation time, luminosity and mass functions) are estimated.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.3
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• pp.256-262
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• 2007

In mass customization, the focus is variety and customization through flexibility and quick responsiveness. Mass customizers seek to provide personalized, custom-designed products at low prices to give customers exactly what they want and to provide sufficient variety in products and services. The idea of the product family is the most adequate approach to realize mass customization. An understanding of customer needs using functional decomposition becomes necessary to enhance the performance of the product family. This paper focuses on functional architecture modeling based on customer need regarding sub-functions for the product family. A quantitative functional model captures product functionality and customer need. Based on customer need ratings and sub-function, a product-function matrix was created. Additionally, a product-product matrix was generated to provide a similarity index among product families. A case study for implementing the functional architecture modeling was performed on the single use cameras.