• Journal of Photoscience
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• v.3 no.2
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• pp.49-60
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• 1996

Preparative features of photoinduced single electron transfer (SET) reactions of selected N-silylmethallyl-iminium salts have been probed in the context of strategies for functionally complex spirocyclic amine synthesis.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 1998.11a
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• pp.17-19
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• 1998

• Defense and Technology
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• no.1 s.179
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• pp.22-37
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• 1994

이글은 Maryland대학의 George H. Quester 교수가 제7회 화랑대 국제학술 심포지엄에서 발표한 기조연설 내용이다. 세계의 군사적 동향, 특히 탈 냉전이후 아시아 지역의 국지분쟁 가능성 증대에 따른 각 국의 군비경쟁을 객관적 시각에서 심도있게 다뤄 주목을 받았다.

• Molecules and Cells
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• v.40 no.7
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• pp.466-475
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• 2017

Dietary supplements have exhibited myriads of positive health effects on human health conditions and with the advent of new technological advances, including in the fields of proteomics, genomics, and metabolomics, biological and pharmacological activities of dietary supplements are being evaluated for their ameliorative effects in human ailments. Recent interests in understanding and discovering the molecular targets of phytochemical-gene-protein-metabolite dynamics resulted in discovery of a few protein signature candidates that could potentially be used to assess the effects of dietary supplements on human health. Persimmon (Diospyros kaki) is a folk medicine, commonly used as dietary supplement in China, Japan, and South Korea, owing to its different beneficial health effects including anti-diabetic implications. However, neither mechanism of action nor molecular biomarkers have been discovered that could either validate or be used to evaluate effects of persimmon on human health. In present study, Mass Spectrometry (MS)-based proteomic studies were accomplished to discover proteomic molecular signatures that could be used to understand therapeutic potentials of persimmon leaf extract (PLE) in diabetes amelioration. Saliva, serum, and urine samples were analyzed and we propose that salivary proteins can be used for evaluating treatment effectiveness and in improving patient compliance. The present discovery proteomics study demonstrates that salivary proteomic profile changes were found as a result of PLE treatment in prediabetic subjects that could specifically be used as potential protein signature candidates.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1999-2004
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• 2013

Asian Americans experience disproportionate incidence and mortality rates of certain cancers, compared to other racial/ethnic groups. Primary care physicians are a critical source for cancer screening recommendations and play a significant role in increasing cancer screening of their patients. This study assessed primary care physicians' perceptions of cancer risk in Asians and screening recommendation practices. Primary care physicians practicing in New Jersey and New York City (n=100) completed a 30-question survey on medical practice characteristics, Asian patient communication, cancer screening guidelines, and Asian cancer risk. Liver cancer and stomach cancer were perceived as higher cancer risks among Asian Americans than among the general population, and breast and prostate cancer were perceived as lower risks. Physicians are integral public health liaisons who can be both influential and resourceful toward educating Asian Americans about specific cancer awareness and screening information.

• Korean Journal of Child Studies
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• v.31 no.1
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• pp.179-195
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• 2010

미국의 한국계 이민가정이 해마다 증가하고 있으나 부모의 문화적응과 자녀양육에 관한 연구는 미흡한 실정이다. 본 연구는 미국 동부지역의 88명의 한인 이민어머니와(M=35.9세 SD=3.77) 2-6세 유아를(M=4.29세 SD=1.06; 49.4% 여아) 대상으로 실시되었다. 어머니의 문화적응 유형에 따라 1) 양육실제에 어떠한 차이가 있는지, 2) 유아의 사회 정서적 행동에는 어떠한 차이가 있는지, 3) 양육실제와 아동의 사회 정서적 행동간에 어떠한 상관이 있는지를 살펴보았다. 연구결과, 한국과 미국문화를 균형지게 통합한 어머니들이 미국문화에서 고립되거나, 두 문화에서 모두 소외된 어머니들보다 자녀에게 더욱 긍정적인(애정표현, 합리적 문제해결, 자율성 격려) 양육실제를 사용하였으며 자녀들 또한 정서적 문제행동은 적은 반면 친사회적 행동은 높은 것으로 나타났다.

• Korean Journal of Applied Biomechanics
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• v.25 no.4
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• pp.371-381
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• 2015

Object : The purpose of this study was to investigate aging-related changes of intrinsic and extrinsic hand muscles in their strength, cross-sectional area and volume, force control, and multi-digit synergies. It was hypothesized that aging would negatively affect distal muscles (intrinsic muscles) more than proximal muscles (extrinsic muscles). Method : Nine young and eleven older right-handed participants underwent MRI scans of the hand and forearm. Muscle cross-sectional areas and volumes of the intrinsic and extrinsic hand muscles were determined. Result : Muscle volume of the intrinsic muscles were larger in the younger group than the older group while muscle volume of the extrinsic muscles did not differ. For the cross-sectional area, both the intrinsic and extrinsic muscles of the younger group were larger than the older group. The maximum strength of the intrinsic muscles of the young group was 31% greater than the older group ($399.1{\pm}26.4$ vs $270.2{\pm}22.9Ncm$, p < 0.05) while the extrinsic muscles showed no significant difference. Although the elderly group showed a trend of decreased force control and multi-digit synergies, no statistical differences were found. These findings indicate aging-related decreases in hand muscle size and strength affect intrinsic muscles more than extrinsic muscles, thus supporting the hypothesis that sarcopenia affects the muscle size and strength of distal muscles more than proximal muscles. Conclusion : The aging-related decreases in hand muscle size and function were more apparent in intrinsic hand muscles, located more distally, than extrinsic muscles, located more proximally.

• Biomolecules & Therapeutics
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• v.23 no.1
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• pp.39-44
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• 2015

Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-${\kappa}B$) is a sequence-specific transcription factor and plays a key role in the development and progression of inflammation and cancer. We performed the current study to investigate the underlying mechanisms by which TA suppresses inflammation focusing on NF-${\kappa}B$ pathway in TNF-${\alpha}$ stimulated human normal and cancer cell lines and lipopolysaccharide (LPS)-stimulated mouse macrophages. Different types of human cells (HCT116, HT-29 and HEK293) and mouse macrophages (RAW264.7) were pre-treated with different concentrations of TA and then exposed to inflammatory stimuli such as TNF-${\alpha}$ and LPS. Transcriptional activity of NF-${\kappa}B$, $l{\kappa}B-{\alpha}$-degradation, p65 translocation and mitogen-activated protein kinase (MAPK) activations were measured using luciferase assay and Western blots. Pre-treatment of TA repressed TNF-${\alpha}$- or LPS-stimulated NF-${\kappa}B$ transactivation in a dose-dependent manner. TA treatment reduced degradation of $l{\kappa}B-{\alpha}$ and subsequent translocation of p65 into nucleus. TA significantly down-regulated the phosphorylation of c-Jun N-terminal kinase (JNK). However, TA had no effect on NF-${\kappa}B$ signaling and JNK phosphorylation in HT-29 human colorectal cancer cells. TA possesses anti-inflammatory activities through suppression of JNK/NF-${\kappa}B$ pathway in different types of cells.

• Journal of the Korean Geographical Society
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• v.43 no.1
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• pp.52-70
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• 2008

Using MD Property View database on 15 counties in Maryland in the U.S., this study attempts to explore the estimation process on the housing development capacity under the Maryland's urban growth management policy known as the Smart Growth Initiatives. This study also seeks to draw the implications of the estimated development capacity by individual counties on successful implementation of the urban growth management policy. The finding shows that this region has land for residential use enough to accommodate growth for the next 30 years. However, contrary to the goal of the Smart Growth Initiatives, a majority of development capacity is located not only outside the Priority Funding Area designated by the Smart Growth Initiatives but also at counties that are located far away from the major metropolitan area. In addressing this problem, the state does not need to either abolish or immediately expand the Priority Funding Area. Rather, the state requires local governments to include housing elements in their comprehensive planning, to provide periodic estimates on housing and employment capacity, and to establish and manage database on the location and the capacity of developable land.

• Korean Journal of Applied Biomechanics
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• v.26 no.1
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• pp.93-99
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• 2016

Objective: The purpose of this study was to investigate the effect of transcutaneous electrical nerve stimulation (TENS) treatment on maximum voluntary force (MVF) production. Methods: Ten healthy, young subjects (5 males and 5 females) participated in the study. MVF was recorded after a fifteen minute session of TENS stimulation under two conditions: low frequency (4 Hz) at maximum tolerable level and high frequency (110 Hz) at maximum tolerable level. TENS was provided simultaneously via self-adhesive electrodes placed on the finger pads of the index, middle, ring and little fingers. MVF was also recorded in a baseline condition with no TENS treatment. Data were collected in three different sessions on three consecutive days at the sametime of the day. Results: Results from the study show that on an average, MVF increasesby 25% for the index, middle and little fingers for TENS treatment with 4 Hz frequency as compared to the baseline condition. However, the 110 Hz condition did not result in a significantly different MVF than the baseline condition during individual finger pressing tasks. In addition, while producing MVF with all the four finger stogether, MVF was 30% higher for the 4 Hz conditionin comparison to the baseline condition, and 15% higher for the 110 Hz condition in comparison to the baseline condition respectively. Conclusion: The results suggest that stimulation ofafferent fibers onthe glabrous skinwith TENS could have a net facilitatory effect on the maximum motoroutput.