• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 추계학술대회 논문집
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• pp.198-203
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• 2003

Unsteady two-dimensional nonlinear waves which are generated by the numerical wavemaker of plunging type are numerically simulated using a finite difference method in rectangular grid system. Two-dimensional Navier-Stokes equations and the continuity equation are used for the computations. Irregular leg lengths and stars are employed near the boundaries of body and free surface to satisfy the boundary conditions. Marker-density function method is adopted for the simulation of wave breaking phenomena, and the computations are carried out with various wave amplitudes and two section shapes of wavemaker. The computation results are compared with other existing computational and experimental results, and the agreement between the experimental data and the computation results is good.

• 한국해양공학회지
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• 제19권3호
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• pp.18-24
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• 2005

Wave overtopping is one of the most important processes for the design of seawalls. The term "wave overtopping" is used here to refer to the processes where waves hit a sloping structure run up the slope and, if the crest level of the slope is lower than the highest run up level, overtop the structure. Wave overtopping is dependent on the processes associated with breaking wave. A numerical model based on Navier-Stokes equation and the Marker-density function for predicting wave overtopping of coastal structures is developed in this paper. In order to evaluate the present model, two simulations are tested. One is overflow without waves at vertical seawall, and the other is wave overtopping at sloping seawalls.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2004년도 학술대회지
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• pp.90-95
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• 2004

During the past 50 years methods for predicting wave overtopping of coastal structures have coastal structures have continuously been developed Wave overtopping is one of the most important processes for the design of seawalls. The term 'wave overtopping' is used here to refer to the processes where waves hit a sloping structure run up the slope and, if the crest level of the slope is lower than the highest run up level, overtop the structure. Wave overtopping is dependent on the processes associated with breaking wave. The Numerical model is based on Navier-Stokes equation and Marker-Density Function of method for nonlinear free-surface flow by Miyata & Park(1995). The influence of how the slopes of seawalls, wave type and crest freeboard affect overtopping discharges has been investigated. The research of study using the new development nonlinear free-surface flow numerical model SOLA-VOF are presented.

• 한국해양공학회지
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• 제17권6호
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• pp.7-15
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• 2003

A Digital Wave Tank simulation technique, based on a finite-difference method and a modified marker-and-cell (MAC) algorithm, is applied in order to investigate the characteristics of nonlinear Tsunami propagations and their interactions with a 2D sloping beach, Ohkushiri Island, and to predict maximum wove run-up around the island. The Navier-Stokes (NS) and continuity equation are governed in the computational domain, and the boundary values are updated at each time step, by a finite-difference time-marching scheme in the frame of the rectangular coordinate system. The fully nonlinear, kinematic, free-surface condition is satisfied by the modified marker-density function technique. The near shore Tsunami is assumed to be a solitary wave, and is generated from the numerical wave-maker in the developed Digital Wave Tank. The simulation results are compared with the experiments and other numerical methods, based on the shallow-water wave theory.

• 한국전산유체공학회지
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• 제11권4호
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• pp.90-100
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• 2006

A digital wave tank (DWT) simulation technique has been developed by authors to investigate the interactions of fully nonlinear waves with 3D marine structures. A finite-difference/volume method and a modified marker-and-cell (MAC) algorithm have been used, which are based on the Navier-Stokes (NS) and continuity equations. The fully nonlinear kinematic free-surface condition is implemented by the marker-density function (MDF) technique or the Level-Set (LS) technique developed for one or two fluid layers. In this paper, some applications for various engineering problems with free-surface are introduced and discussed. It includes numerical simulation of marine environments by simulation equipments, fully nonlinear wave motions around offshore structures, nonlinear ship waves, ship motions in waves and marine flow simulation with free-surface. From the presented simulations, it seems that the developed DWT simulation technique can handle various engineering problems with free-surface and reliably predict hydrodynamic features due to the fully-nonlinear wave motions interacting with such marine structures.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 춘계학술대회 논문집
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• pp.231-239
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• 2003

A Digital Wave Tank simulation technique based on a finite-difference method and a modified marker-and-cell (MAC) algorithm is applied to investigate the characteristics of nonlinear Tsunami propagations and their interactions with a 2D sloping beach and Ohkushiri island, and to predict maximum wave run-up around the island. The Navier-Stokes (NS) and continuity equation are governed in the computational domain and the boundary values updated at each time step by a finite-difference time-marching scheme in the frame of rectangular coordinate system. The fully nonlinear kinematic free-surface condition is satisfied by the modified marker-density function technique. The Nearshore Tsunami is assumed to be a solitary wave and generated from the numerical wavemaker in the developed Digital Wave Tank. The simulation results are compared with the experiments and other numerical methods based on the shallow-water wave theory.

• 동의생리병리학회지
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• 제36권1호
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• pp.18-22
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• 2022

To investigate effects of cognitive function improvement whether against Taegeuk ginseng on scopolamine-induced memory impairment in rats. All experiments were conducted in three groups: the control group (CTR), the scopolamine 0.4mg/kg (SCP), and the scopolamine (SCP+T) treated with Taegeuk ginseng 100 mg/kg. Taegeuk ginseng 100 mg/kg daily was orally administered for one month and treated with scopolamine was only for 7 consecutive days on the Morris water maze task. 3 weeks after oral administration of Taegeuk ginseng, subjects were performed the Morris water maze test for 8 days and then the open-field exploration test which to assessed for cognitive function improvement. After behavioral testing, subjects were sacrificed and microdissected brains for neurochemical analysis. In the cognitive-behavioral test, long-term administration of Taegeuk ginseng improved spatial navigation learning task compared with the impeded by scopolamine treatment. In neurochemistry, the expression of the synaptic marker PSD95 (postsynaptic density protein 95) was increased in the hippocampus compared to the scopolamine group. Also, brain-derived neurotrophic factor (BDNF) expression was significantly increased in the taegeuk ginseng administration group. These data suggested that long-term administration of taegeuk ginseng might improve cognitive-behavioral functions on hippocampal related spatial learning memory, and it was correlated with neurotropic and synaptic reinforcement. In conclusion, treatment with taegeuk ginseng may positive outcome on learning and memory deficit disorders.

• Genomics & Informatics
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• 제2권2호
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• pp.75-80
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• 2004

In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo­p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused by adult exposure. We report here the changes of gene expression and the identification of the marker-genes representing the dioxin exposure. The expressions of the transcripts were analyzed using the 11 K oligonucleotide­microarray from the bone marrow cells of male C57BL/6J mice after an intraperitoneal injection of $1{\mu}g$ TCDD/kg body weight at various time intervals: gestational 6.5 day(G6.5), 13.5 day(G13.5), 18.5 day(G18.5), and postnatal 3 (P3W)and 6 week (P6W). The type of self-organizing maps(SOM) representing the specific exposure dioxin could be identified as follows; G6.5D(C14), G13.5D(C0, C5, C10, C18), G18.5D(7): P3W(C2, C21), and P6W(C4, C15, C20). The candidate marker-genes were restricted to the transcripts, which could be consistently expressed greater than $\pm$2-fold in three experiments. The resulting candidates were 85 genes, the characteristics of that were involved in cell physiology and cell functions such as cell proliferation and immune function. We identified the biomarker-genes for dioxin exposure: smc -like 2 from SOM C14 for the dioxin exposure at G6.5D, focal adhesion kinase and 6 other genes from C0, and protein tyrosine phosphatase 4a2 and 3 other genes from C5 for G13.5D, platelet factor 4 from C7 for G18.5D, fos from C2 for P3W.

• 한국해양공학회지
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• 제17권4호
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• pp.1-7
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• 2003

A virtual reality technology for multipurpose numerical simulation is developed to reproduce and investigate a variety of ocean environmental problems in a 3D Numerical Wave Tank(NWT). The governing equations for solving incompressible fluid motion are Navier-Stokes equation and continuity equation. The Marker-Density function technique is adopted to implement the fully nonlinear freesurface kinematic condition. The marine environmental situations, i.e., waves, currents, etc., are reproduced by use of multi-segmented wavemakers on the basis of the so-called ″snake-principle″. In this paper, some numerical reproduction techniques for regular, and irregular waves, multi-directional waves, Bull's-eye wave. wave-current, and solitary wave are presented, and a model test in motion with large amplitude of roll angle is conducted in the developed 3D-NWT, using a overlaid grid system.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2002년도 추계학술대회 논문집
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• pp.174-180
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• 2002

A virtual reality technology for multipurpose numerical simulation is developed to reproduce and investigate a variety of ocean environmental problems in a 3D-Numerical Wave Tank. The governing equations for solving incompressible fluid motion are Navier-Stokes equation and continuity equation, and the Marker-Density function technique is adopted to implement the fully-nonlinear free-surface kinematic condition. The marine environmental situations, i.e. waves, currents, wind, etc., are reproduced by use of multi-segmented wavemaker on the basis of the so-called "snake-principle". In this paper, some numerical reproduction techniques for regular and irregular waves, multi-directional waves, Bull's-eye wave, wave-current, and solitary wave are presented, and a model test in motion with large amplitude of roll angle is conducted in the developed 3D-NWT, using a overlaid grid system.