• Earthquakes and Structures
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• v.10 no.2
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• pp.463-482
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• 2016

Air Traffic Control (ATC) towers play significant role in the functionality of each airport. In spite of having complex dynamic behavior and major role in mitigating post-earthquake problems, less attention has been paid to the seismic performance of these structures. Herein, seismic response of an existing ATC tower with a wall-frame structural system that has been designed and detailed according to a local building code was evaluated through the framework of performance-based seismic design. Results of this study indicated that the linear static and dynamic analyses used for the design of this tower were incapable of providing a safety margin for the required seismic performance levels especially when the tower was subjected to strong ground motions. It was concluded that, for seismic design of ATC towers practice engineers should refer to a more sophisticated seismic design approach (e.g., performance-based seismic design) which accounts for inelastic behavior of structural components in order to comply with the higher seismic performance objectives of ATC towers.

• Archives of Craniofacial Surgery
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• v.9 no.1
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• pp.38-40
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• 2008

Purpose: Lymphangioma circumscriptum is a rare, congenital benign hamartous malformation, caused by the saccular dilatation of lymph channels lines by normal, single cell, lymphatic endothelia that present as local eruptions of persistent, grouped, translucent vesicles. The lymphangioma circumscriptum lesions may occur on axillary fold shoulder, neck proximal limbs and buccal mucosa. We reported a rare case of lymphangioma circumscriptum on the scalp. Methods: A 15-year-old girl with a $5{\times}3cm$ sized lymphangioma circumscriptum on scalp was examined. It was defined a boundry by ultrasound. And then, a tissue crescent type expander with 120 cc normal saline was inserted on occipital area for a month. After confirmed safety margin of the excised lymphangioma circumscriptum on frozen biopsy and the scalp flap was elevated and covered with empty space. Results: A histopathologic finding revealed that lymphangioma circumscriptum. During 11 months follow up, no relapse was found. Conclusion: We described a rare case of lymphangioma circumscriptum on scalp. By using a tissue expander and excision, we achieved no recurrence and aesthetically satisfactory outcome.

• Journal of Korean Association for Spatial Structures
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• v.18 no.2
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• pp.121-128
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• 2018

The push-out tests have been conducted on the specimens which consist of the steel beam with U-shape section and the cap-type shear connectors with constant intervals. Existing equations for the evaluation of shear connector strength have been investigated on the basis of test results. The reinforcing bars for longitudinal reinforcement and the penetrative bars for transverse reinforcement didn't have much effect on the shear capacity of the cap-type shear connector. The larger the width of cap-type shear connector was profiled, the greater the shear strength turned. The shear capacities of cap-type shear connectors with constant intervals were evaluated on the basis of push-out test results, and those were possible to be determined with proper safety margin using the Eurocode 4. The slip capacity of cap-type shear connector was shown to exceed the limit value of 6mm for sufficiently ductile behavior.

• Archives of Craniofacial Surgery
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• v.20 no.3
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• pp.203-206
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• 2019

Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroectodermal carcinoma arising from mechanoreceptor Merkel cells. Multiple MCCs are even rarer. We report a case of two independent MCCs simultaneously present in the cheek of a patient, which were effectively and esthetically treated using a cheek flap. Punch biopsy performed in a 60-year-old woman admitted with a chief complaint of two skin-colored hard nodules in her left cheek, accompanied by an itching sensation, was suggestive of MCC. Accordingly, we performed sentinel lymph node biopsy through the modified Blair incision under general anesthesia, in cooperation with the head and neck surgery department. The defect was covered with a cheek flap by slightly extending the existing incision following wide excision with a safety margin of 1 cm. This paper is significant in that it introduces an effective reconstruction technique that maintains function using a cheek flap for the management of this rare case. In addition, this paper is the first to classify multiple MCCs according to the time of onset. We believe that this paper presents an effective alternative reconstruction technique with sentinel node biopsy through the modified Blair incision.

• Nuclear Engineering and Technology
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• v.54 no.9
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• pp.3422-3428
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• 2022

The prompt gamma imaging (PGI) technique is considered as one of the most promising approaches to estimate the range of proton beam in the patient and unlock the full potential of proton therapy. In the PGI technique, a dedicated algorithm is required to estimate the range of the proton beam from the prompt gamma (PG) distribution acquired by a PGI system. In the present study, a new range estimation algorithm was developed for a multi-slit prompt-gamma camera, one of PGI systems, to estimate the range of proton beam with high accuracy. The performance of the developed algorithm was evaluated by Monte Carlo simulations for various beam/phantom combinations. Our results generally show that the developed algorithm is very robust, showing very high accuracy and precision for all the cases considered in the present study. The range estimation accuracy of the developed algorithm was 0.5-1.7 mm, which is approximately 1% of beam range, for 1×10⁹ protons. Even for the typical number of protons for a spot (1×10⁸), the range estimation accuracy of the developed algorithm was 2.1-4.6 mm and smaller than the range uncertainties and typical safety margin, while that of the existing algorithm was 2.5-9.6 mm.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.399-401
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• 2014

The comprehensive vibration assessment program(CVAP) of APR+ nuclear power plant(NPP) is classified as non-prototype, category II with Palo Verde NPP as valid prototype. In this paper, CVAP for first plant of APR+ NPP is proposed. The Control Element Assembly(CEA) shroud of APR+ NPP is different from that of Palo Verde NPP. And the Core Support Barrel(CSB) outer diameter and the flow rate of normal operation of APR+ NPP are larger than those of Palo Verde NPP. Vibration and stress analysis program should be conducted to establish test acceptance criteria. Limited vibration measurement program should be implemented to establish the margin of safety, demonstrate the satisfaction of test acceptance criteria and confirm the similar vibratory response between the APR+ and Palo Verde NPP. Because of the change of normal operation condition, the nominal differences between APR+ and Palo Verde NPP in the structural and hydraulic analysis are studied to determine the measurement locations.

• Nuclear Engineering and Technology
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• v.51 no.6
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• pp.1658-1668
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• 2019

Nuclear power generates a large portion of the energy used today and plays an important role in energy development. To ensure safe nuclear power generation, it is essential to conduct an accurate analysis of reactor structural integrity. Accordingly, in this study, a methodology for obtaining accurate structural responses to the combined seismic and reactor coolant loads existing prior to the shutdown of a nuclear reactor is proposed. By applying the proposed analysis method to the reactor vessel internals, it is possible to derive the seismic responses considering the influence of the hydraulic loads present during operation for the first time. The validity of the proposed methodology is confirmed in this research by using the finite element method to conduct seismic and hydraulic load analyses of the advanced APR1400 1400 MWe power reactor, one of the commercial reactors. The structural responses to the combined applied loads are obtained using displacement-based and stress-based superposition methods. The safety of the subject nuclear reactor is then confirmed by analyzing the design margin according to the American Society for Mechanical Engineers (ASME) evaluation criteria, demonstrating the promise of the proposed analysis method.

• The Korean Journal of Applied Statistics
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• v.37 no.4
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• pp.411-444
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• 2024

The objective of Phase I clinical trials is to ascertain the maximum tolerated dose (MTD) that is safe for human administration. Accurately determining the MTD within an acceptable safety margin is imperative, necessitating evaluations up to sufficiently high doses. To estimate the MTD, a plethora of methods have been developed, encompassing algorithm-based, model-based, and model-assisted techniques. In this paper, a new dose exploration method based on continual reassessment method (CRM) is proposed to address for the shortcomings of existing dose exploration methods. Through a comprehensive simulation study, this method's efficacy was compared against that of existing methodologies across a variety of scenarios. The findings from this study underscore its enhanced precision and safety in estimating the MTD, alongside a reduction in the number of subjects required for testing.

• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.1
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• pp.65-68
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• 2004

The purpose of the present study was to examine the efficacy and mechanism of fraction IV cold ethanol fractionation and pasteurization (60$^{\circ}C$ heat treatment for 10 h), involved in the manufacture of albumin from human plasma, in the removal and/or inactivation of the hepatitis A virus (HAV). Samples from the relevant stages of the production process were spiked with HAV and the amount of virus in each fraction then quantified using a 50% tissue culture infectious dose (TCID$\_$50/). HAV was effectively partitioned from albumin during the fraction IV cold ethanol fractionation with a log reduction factor of 3.43. Pasteurization was also found to be a robust and effective step in inactivating HAV, where the titers were reduced from an initial titer of 7.60 log TCID$\_$50/ to undetectable levels within 5 h of treatment. The log reduction factor achieved during pasteurization was $\geq$4.76. Therefore, the current results indicate that the production process for albumin has sufficient HAV reducing capacity to achieve a high margin of virus safety.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1773-1779
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• 2015

Insulation coordination is a key problem in UHVDC systems in terms of safety and cost. Although high-voltage ±1100kV UHVDC projects are being planned in China, the characteristics and key points of high-voltage systems have not yet been analyzed. This study aims to improve the safe, effective operation of these high-voltage power transmission systems. First, we analyzed two typical insulation coordination schemes used in ±800kV UHVDC systems in China. Next, we used the two typical ±800kV insulation coordination schemes as a reference to analyze the ±1100kV UHVDC system. Finally, we compared these schemes and proposed an effective insulation coordination solution, as well as developing principles for ±1100kV UHVDC systems. Our findings indicate that the points enduring the highest voltage in the system should be protected separately by special arresters. Our analysis of the insulation coordination of ±800kV and ±1100kV UHVDC systems concluded that, in ±1100kV UHVDC systems, the main goal of insulation coordination is to lower the insulation level of points enduring the highest voltage. However, in a ±800kV UHVDC system, the main goal is to reduce the cost of manufacture for arresters, as well as the space occupation in the valve hall, with an acceptable insulation level.