• Aerospace Engineering and Technology
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• v.1 no.2
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• pp.75-82
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• 2002

This paper presents a summary of the input data, requirements and notch prediction analysis for sinusoidal excitation test of a satellite. In the notch prediction analysis, the loads at excitation points and internal loads at the important locations on satellite structure were obtained. After checking of limit loads and margin of safety for each location, the notched sinusoidal test inputs were generated using the results of the notch prediction analysis.

• Aerospace Engineering and Technology
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• v.7 no.2
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• pp.117-122
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• 2008

Acoustic test was performed to verify the ability of KSLV-I PLF acoustic protection system (Acoustic blanket) to reduce the acoustic load. The test results showed that the acoustic protection system has +3 dB safety margin compared with design requirement. This paper also illustrates the increase of insertion loss by the acoustic protection system by comparing that of the bare PLF structure.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.754-757
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• 2004

This study was performed to propose design bending moment formula for long-span slab on a composite two-girder bridge. FEM models representing slab spaning between 4m and 12m were analyzed, and parameters such as girder flexibility and orthotropy of slab were considered. By regression of the parametric analyses results, the moment formula that can predict the design moment with reasonable margin of safety and correctness was developed. The research also showed that the design bending moment from Korean Bridge Design Code overestimated the design moment for the span length under gm, and underestimated for the span length over 9m.

• The Journal of the Korean dental association
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• v.11 no.1
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• pp.45-52
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• 1973

Ketamine HC1(Phencyclidine derivative) is a white, crystalline substance with melting point 259℃. It is soluble in water to a 20% clear, colorless solution. a 10% aqueous solution has a pH 3.5. The chemical structure is 2-(O-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is a rapid acting, nonhypnotic, nonbarbiturate drug with a wide safety margin. The author used the anesthetic ketamine hydrochloride for oral surgery procedure in 16 patients(2 to 33 years). Anesthesia was achieved with a single intramuscular injection by introduction of manufacture. Result obtained as follows : 1. It was easily administered. 2. Onset time was rapid and duration was short. 3. The mild cardiac stimulation resulted in moderate increase in the blood pressure and pulse. 4. There was no significant respiratory depression. 5. The airway can be maintained without artificial support or endotracheal intubation. 6. All protective reflex maintained, which was important in oral surgery. 7. The best results were achieved in pediatric patients than adults.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.15 no.3
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• pp.70-76
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• 2007

The benefits for using reduced takeoff thrust are many, ranging from lower maintenance and operating costs to improved engine and dispatch reliabilities. Some pilots, however, are apprehensive about using reduced thrust. They are particularly reluctant to use the maximum permissible level of reduced thrust. Two common arguments are (1)If reduced thrust is used, then the airplane will not be able to clear the obstacles if an engine fails during takeoff, and (2)If the maximum allowable assumed temperature is used, then there will be no stopping margin left if the takeoff is aborted. There is the notion that using reduced thrust sacrifices safety. The intent of this discussion is to: (1)Show that reduced thrust performance meets all regulatory requirements (2)Show that the Assumed Temperature method includes inherent extra performance margins (3)Show how to maximize performance margins while maximizing thrust reduction.

• Journal of Gastric Cancer
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• v.22 no.2
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• pp.135-144
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• 2022

Purpose: This study aimed to compare the surgical and oncological outcomes between totally laparoscopic pylorus-preserving gastrectomy (TLPPG) with intracorporeal anastomosis and laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG) with extracorporeal anastomosis. Materials and Methods: A retrospective analysis was performed in 258 patients with cT1N0 gastric cancer who underwent laparoscopic pylorus-preserving gastrectomy using two different anastomosis methods: TLPPG with intracorporeal anastomosis (n=88) and LAPPG with extracorporeal anastomosis (n=170). The following variables were compared between the two groups to assess the postoperative surgical and oncological outcomes: proximal and distal margins, number of resected lymph nodes (LNs) in total and in LN station 6, operation time, postoperative hospital stay, and postoperative morbidity including delayed gastric emptying (DGE). Results: The average length of the proximal margin was similar between the TLPPG and LAPPG groups (2.35 vs. 2.73 cm, P=0.070). Although the distal margin was significantly shorter in the TLPPG group than in the LAPPG group (3.15 vs. 4.08 cm, P=0.001), no proximal or distal resection margin-positive cases were reported in either group. The average number of resected LN was similar in both groups (36.0 vs. 33.98, P=0.229; LN station 6, 5.72 vs. 5.33, P=0.399). The operation time was shorter in the TLPPG group than in the LAPPG (200.17 vs. 220.80 minutes, P=0.001). No significant differences were observed between the two groups in terms of postoperative hospital stay (9.38 vs. 10.10 days, P=0.426) and surgical complication rate (19.3% vs. 22.9%), including DGE (8.0% vs. 11.8%, P=0.343). Conclusions: The oncological safety and postoperative complications of TLPPG with intracorporeal anastomosis are similar to those of LAPPG with extracorporeal anastomosis.

• The Korean Journal of Pain
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• v.25 no.4
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• pp.228-237
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• 2012

Background: Milnacipran is a balanced serotonin norepinephrine reuptake inhibitor with minimal side effects and broad safety margin. It acts primarily on the descending inhibitory pain pathway in brain and spinal cord. In many animal studies, intrathecal administration of milnacipran is effective in neuropathic pain management. However, there is no study for the neurological safety of milnacipran when it is administered neuraxially. This study examined the neurotoxicity of epidural milnacipran by observing behavioral and sensory-motor changes with histopathological examinations of spinal cords in rats. Methods: Sixty rats were divided into 3 groups, with each group receiving epidural administration of either 0.3 ml (3 mg) of milnacipran (group M, n = 20), 0.3 ml of 40% alcohol (group A, n = 20), or 0.3 ml of normal saline (group S, n = 20). Results: There were no abnormal changes in the behavioral, sensory-motor, or histopathological findings in all rats of groups M and S over a 3-week observation period, whereas all rats in group A had abnormal changes. Conclusions: Based on these findings, the direct epidural administration of milnacipran in rats did not present any evidence of neurotoxicity in behavioral, sensory-motor and histopathological evaluations.

• Toxicological Research
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• v.35 no.2
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• pp.119-129
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• 2019

As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2'-hydroxy-5'-methylphenyl)benzotriazole] is categorized as a sunscreen ingredient and is used in cosmetics and non-cosmetics as a UV light absorber. No significant toxicity has been observed in acute oral, inhalation, or dermal toxicity studies. In a 13-week oral toxicity study in beagle dogs, No observed adverse effect level (NOAEL) was determined as 31.75 mg/kg bw/day in males and 34.6 mg/kg bw/day in females, based on increased serum alanine aminotransferase activity. Although drometrizole was negative for skin sensitization in two Magnusson-Kligman maximization tests in guinea pigs, there were two case reports of consumers presenting with allergic contact dermatitis. Drometrizole showed no teratogenicity in reproductive and developmental toxicity studies in which rats and mice were treated for 6 to 15 days of the gestation period. Ames tests showed that drometrizole was not mutagenic. A long-term carcinogenicity study using mice and rats showed no significant carcinogenic effect. A nail product containing 0.03% drometrizole was nonirritating, non-sensitizing and non-photosensitizing in a test with 147 human subjects. For risk assessment, the NOAEL chosen was 31.75 mg/kg bw/day in a 13-week oral toxicity study. Systemic exposure dosages were 0.27228 mg/kg bw/day and 1.90598 mg/kg bw/day for 1% and 7% drometrizole in cosmetics, respectively. Risk characterization studies demonstrated that when cosmetic products contain 1.0% of drometrizole, the margin of safety was greater than 100. Based on the risk assessment data, the MFDS revised the regulatory concentration of drometrizole from 7% to 1% in 2015. Under current regulation, drometrizole is considered to be safe for use in cosmetics. If new toxicological data are obtained in the future, the risk assessment should be carried out to update the appropriate guidelines.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.4A
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• pp.323-329
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• 2011

Most current design codes of concrete structures adopt the partial safety factor format to assure the proper safety margin or reliability against various limit states as a practical design tool. The safety factors, load and resistance factors and so on, are determined based on the theory of structural reliability, which takes into account the statistical uncertainties of both loads and resistances. The establishment of statistical models for load and resistance should be preceded the application of reliability theory. In this paper, especially the influence of the statistical variations of resistance models, which are described in terms of strength of concrete, strength of reinforcements and sectional dimensions and so on, are examined and the probabilistic models for resistance of reinforced concrete members were developed. The statistical data were collected on local tests and experiments in Korea and the Monte Carlo simulation (MCS) technique was used. The results of this paper may be useful and valuable in calibration of design code in this country.

• Earthquakes and Structures
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• v.14 no.4
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• pp.349-360
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• 2018

Reinforced concrete (RC) moment frames supported on two ground levels have been widely constructed in mountainous areas with medium to high seismicity in China. In order to investigate the seismic collapse behavior and risk, a scaled frame model was tested under constant axial load and reversed cyclic lateral load. Test results show that the failure can be induced by the development of story yielding at the first story above the upper ground. The strong column and weak beam mechanism can be well realized at stories below the upper ground. Numerical analysis model was developed and calibrated with the test results. Three pairs of six case study buildings considering various structural configurations were designed and analyzed, showing similar dynamic characteristics between frames on two ground levels and flat ground of each pair. Incremental dynamic analyses (IDA) were then conducted to obtain the seismic collapse fragility curves and collapse margin ratios of nine analysis cases designated based on the case study buildings, considering amplification of earthquake effect and strengthening measures. Analysis results indicate that the seismic collapse safety is mainly determined by the stories above the upper ground. The most probable collapse mechanism may be induced by the story yielding of the bottom story on the upper ground level. The use of tie beam and column strengthening can effectively enhance the seismic collapse safety of frames on two ground levels.