• Journal of architectural history
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• v.13 no.4 s.40
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• pp.125-138
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• 2004

Open-rectangular plan Hanok is one of the major types that compose the urban tissues of Bukchon, a typical traditional residential area in Seoul. Through the comparison of the cadastral map of 1912 and the aerial photograph of 1962, the paper has given the outline of the and the distribution of Open-rectangular plan Hanok at Bukchon. And the paper defines the characteristics of Open-rectangular plan Hanok at Bukchon as followings. First, Open-rectangular plan Hanok at Bukchon is the mutated type of Open-rectangular plan Hanok in Kyong-gi Province. Second, the composition and characteristics of Bakat-chae and outer-courtyard have been changed through the adaptation itself to the compact lots of urban neighborhood. Third, the composition and characteristics of An-chae has not been changed except the inner corner bay, that gives the lights and view to An-bang through the window. And the comparison and observation of four examples, the paper defines the identities of Open-rectangular plan Hanok at Bukchon. The partial transformation comes from the conflicts and adjustments with the structure of alley and the topographical condition of lots.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.431-431
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• 2015

일반적으로 유량을 계산하는 수문모형은 강우에서부터 유출에 이르는 수문현상을 해석하는 방법에 따라 하나 이상의 매개변수가 이용된다. 이러한 수문모형의 보정은 계산된 유량과 관측 유량을 비교하고, 계산된 유량이 관측유량을 잘 재현할 수 있도록 모형의 매개변수를 반복적으로 수정하는 과정을 통해서 이루어진다. 수문모형의 매개변수는 수문학적으로 의미가 있는 값을 가지며, 매개변수를 수정하기 위해서는 대상 매개변수가 모형내에서 수문학적으로 어떠한 의미를 가지에 대한 이해가 필요하다. 또한 하나의 매개변수는 다른 매개변수와 함께 복합적으로 유량계산에 작용하므로, 다수의 매개변수를 함께 추정하여 최적 계산결과를 도출하는 과정은 일반적으로 전문성과 함께 많은 시간이 소요된다. 본 연구에서는 범용 매개변수 추정모형인 PEST와 GRM 모형을 연계하여 GRM 모형의 매개 변수를 자동으로 추정할 수 있는 모듈을 개발하였다. 개발된 모듈에서는 GRM 모형의 보정을 위한 PEST 모형의 입력파일을 자동으로 생성하고, PEST 혹은 병렬 PEST를 실행할 수 있다. 사용자는 GRM 모형의 추정대상 매개변수 선택, 관측자료 설정, 자동으로 생성된 PEST 입력파일을 확인 및 수정하며, 병렬 PEST를 실행할 경우에는 slave PEST 개수 등을 설정한다. 본 연구에서 개발된 모듈은 OpenGIS인 MapWindow GIS의 Plug-in으로 개발된 GRM(MW-GRM)에서 메뉴로 제공되며, GUI를 통해서 편리하게 활용될 수 있다. 본 연구에서는 물리적 분포형 모형인 GRM의 보정시 다수의 매개변수를 편리하게 추정할 수 있는 방안을 마련하였다. 본 연구의 결과는 강우-유출 해석 분야에서 GRM 모형이 좀 더 쉽게 활용되는 데 기여할 수 있을 것이다.

• Current Optics and Photonics
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• v.3 no.1
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• pp.54-65
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• 2019

To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.

• Journal of the Korean Society of Visualization
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• v.22 no.1
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• pp.79-84
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• 2024

As microchips' degree of integration is getting higher, its cooling problem becomes important more than ever. One of the promising methods is using fractal microchannel heat sink by mimicking nature's Murray networks. However, most of the related works have been progressed only by numerical analysis. Perhaps such lack of direct experimental studies is due to the technical difficulty of the temperature and heat flux measurement in complex geometric channels. Here, we demonstrate the direct visualization of in situ temperature profile in a fractal microchannel heat sink. By using the temperature-sensitive fluorescent dye and a transparent Polydimethylsiloxane window, we can map temperature profiles in silicon-based fractal heat sinks with various fractal scale factors (a=1.5-3.5). Then, heat transfer rates and pressure drops under a fixed flow rate were estimated to optimize hydrodynamic and thermal characteristics. Through this experiment, we found out that the optimal factor is a=1.75, given that the differences in heat transfer among the devices are marginal when compared to the variances in pumping power. This work is expected to contribute to the development of high-performance, high-efficiency thermal management systems required in various industrial fields.

• Progress in Medical Physics
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• v.20 no.4
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• pp.298-307
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• 2009

By using the MR T2 map technique, this study intends, first, to measure the change of T2 values of cartilage between healthy people and patients with osteoarthritis and, second, to assess the form and the damage of cartilage in the knee-joint, through which this study would consider the utility of the T2 map technique. Thirty healthy people were selected based on their clinical history and current status and another thirty patients with osteoarthritis of the knee who were screened by simple X-ray from November 2007 to December 2008 were selected. Their T2 Spin Echo (SE hereafter) images for the cartilage of the knee joint were collected by using the T2 SE sequence, one of the multi-echo methods (TR: 1,000 ms; TE values: 6.5, 13, 19.5, 26, 32.5. 40, 45.5, 52). Based on these images, the changes in the signal intensity (SI hereafter) for each section of the cartilage of the knee joint were measured, which yielded average values of T2 through the Origin 7.0 Professional (Northampton, MA 01060 USA). With these T2s, the independent samples T-test was performed by SPSS Window version 12.0 to run the quantitative analysis and to test the statistical significance between the healthy group and the patient group. Closely looking at T2 values for each anterior and lateral articular cartilage of the sagittal plane and the coronal plane, in the sagittal plane, the average T2 of the femoral cartilage in the patient group with arthritis of the knee ($42.22{\pm}2.91$) was higher than the average T2 of the healthy group ($36.26{\pm}5.01$). Also, the average T2 of the tibial cartilage in the patient group ($43.83{\pm}1.43$) was higher than the average T2 in the healthy group ($36.45{\pm}3.15$). In the case of the coronal plane, the average T2 of the medial femoral cartilage in the patient group ($45.65{\pm}7.10$) was higher than the healthy group ($36.49{\pm}8.41$) and so did the average T2 of the anterior tibial cartilage (i.e., $44.46{\pm}3.44$ for the patient group vs. $37.61{\pm}1.97$ for the healthy group). As for the lateral femoral cartilage in the coronal plane, the patient group displayed the higher T2 ($43.41{\pm}4.99$) than the healthy group did ($37.64{\pm}4.02$) and this tendency was similar in the lateral tibial cartilage (i.e., $43.78{\pm}8.08$ for the patient group vs. $36.62{\pm}7.81$ for the healthy group). Along with the morphological MR imaging technique previously used, the T2 map technique seems to help patients with cartilage problems, in particular, those with the arthritis of the knee for early diagnosis by quantitatively analyzing the structural and functional changes of the cartilage.

• Journal of Life Science
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• v.18 no.8
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• pp.1132-1139
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• 2008

A CpG island is a short stretch of DNA in which the frequency of the CG dinucleotide is higher than other regions. CpG islands are present in the promoters and exonic regions of approximately $30{\sim}60$% of mammalian genes so they are useful markers for genes in organisms containing 5-methylcytosine in their genomes. Recent evidence supports the notion that the hypermethylation of CpG island, by silencing tumor suppressor genes, plays a major causal role in cancer, which has been described in almost every tumor types. In this respect, CpG island search by computational methods is very helpful for cancer research and computational promoter and gene predictions. I therefore developed a window program (called CpGi) on the basis of CpG island criteria defined by D. Takai and P. A. Jones. The program 'CpGi' was implemented in Visual C++ 6.0 and can determine the locations of CpG islands using diverse parameters (%GC, Obs (CpG)/Exp (CpG), window size, step size, gap value, # of CpG, length) specified by user. The analysis result of CpGi provides a graphical map of CpG islands and G+C% plot, where more detailed information on CpG island can be obtained through pop-up window. Two human contigs, i.e. AP00524 (from chromosome 22) and NT_029490.3 (from chromosome 21), were used to compare the performance of CpGi and two other public programs for the accuracy of search results. The two other programs used in the performance comparison are Emboss-CpGPlot and CpG Island Searcher that are web-based public CpG island search programs. The comparison result showed that CpGi is on a level with or outperforms Emboss-CpGPlot and CpG Island Searcher. Having a simple and easy-to-use user interface, CpGi would be a very useful tool for genome analysis and CpG island research. To obtain a copy of CpGi for academic use only, contact corresponding author.

• The Journal of Engineering Geology
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• v.12 no.1
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• pp.23-34
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• 2002

Borehole image analysis has been carried out to obtain the detailed geological data by approach of direct observation. Direct application of borehole image analysis inevitably gives rise to a few of restriction of data acquisition due to the limited information within narrow borehole space. Considering the apparent dip of discontinuity surface depending upon the direction, the visualized program of two-dimensional subsurface discontinuities is coded. Borehole image analysis can compensate the distribution of subsurface discontinuity extending into the expected area of investigation. In order to draw subsurface profile in the proposed area of subsurface construction, visualized program is coded as a window GUI (Graphic User Interface) using Fortran and Visual Basic Programming languages. It is to open publicly for the usage of whoever is in want. Discontinuity distribution map is visualized along the Proposed line of tunnel in the Janggye-ri area, Jangsu-gun. Using the visualized program, the limited information from borehole spatially applies into analysis of overall subsurface structures, and the distributional characteristics of discontinuity anticipate at the proposed area. In addition, spacing and extension of joint and depth of discontinuity effecting tunnel safety can be visualized along the direction of the proposed tunnel. These lines of visualization apply design and construction of fundanmental structures.

• Convergence Security Journal
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• v.13 no.3
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• pp.9-15
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• 2013

Calculating of matching cost is an important for efficient stereo matching. To investigate the performance of matching process, the concepts of the existing methods are introduced. Also we analyze the performance and merits of them. The simplest matching costs assume constant intensities at matching image locations. We consider matching cost functions which can be distinguished between pixel-based and window-based approaches. The Pixel-based approach includes absolute differences (AD) and sampling-intensitive absolute differences (BT). The window-based approach includes the sum of the absolute differences, the sum of squared differences, the normalized cross-correlation, zero-mean normalized cross-correlation, census transform, and the absolute differences census transform (AD-Census). We evaluate matching cost functions in terms of accuracy and time complexity. In terms of the accuracy, AD-Census method shows the lowest matching error ratio (the best solution). The ZNCC method shows the lowest matching error ratio in non-occlusion and all evaluation part. But it performs high matching error ratio at the discontinuities evaluation part due to blurring effect in the boundary. The pixel-based AD method shows a low complexity in terms of time complexity.

• Journal of the Korean association of regional geographers
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• v.23 no.1
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• pp.136-150
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• 2017

This study analyzed the spatial change of urban green spaces in Daegu from 1989 to 2009 using cell based spatial metrics. To do so, the conversion process of land covers during the past 20 years was explored using a land cover change detection matrix. The synoptic analysis with a moving window sampling strategy was conducted to quantify cell based spatial metrics related to size, shape, cohesion, and diversity and to explain the spatial change at the local level. Difference maps were then generated by subtracting the 1989 maps of spatial metrics from the 1998 maps and the 1998 maps from the 2009 maps. The gradient analysis was performed to identify the directional change of spatial metrics along an urban development axis in Daegu. The results from this study show that urban green spaces in Daegu during the past 20 years have been gradually fragmented around the new town housing development districts such as Dalseong-gun, Seongseo, and Ansim. Forests were most prominently fragmented in the Hwawon area while most rapidly in the Chilgok area. Grasslands were largely fragmented in many areas due to the decrease in size and cohesion indices and most fragmented in the Ansim area. The spatial pattern of the decreased and fragmented urban green spaces identified by this study can be used as a base data for establishing the environment-friendly urban development strategy in Daegu.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.53-60
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• 2002

Motion of lung tumors from respiration has been reported in the literature to be as large as of 1-2 cm. This motion requires an additional margin between the Clinical Target Volume (CTV) and the Planning Target Volume (PTV). While such a margin is necessary, it may not be sufficient to ensure proper delivery of Intensity Modulated Radiotherapy (IMRT) to the CTV during the simultaneous movement of the DMLC. Gated treatment has been proposed to improve normal tissues sparing as well as to ensure accurate dose coverage of the tumor volume. The following questions have not been addressed in the literature: a) what is the dose error to a target volume without gated IMRT treatment\ulcorner b) what is an acceptable gating window for such treatment. In this study, we address these questions by proposing a novel technique for calculating the 3D dose error that would result if a lung IMRT plan were delivered without gating. The method is also generalized for gated treatment with an arbitrary triggering window. IMRT plans for three patients with lung tumor were studied. The treatment plans were generated with HELIOS for delivery with 6 MV on a CL2100 Varian linear accelerator with a 26 pair MLC. A CTV to PTV margin of 1 cm was used. An IMRT planning system searches for an optimized fluence map ${\Phi}$ (x,y) for each port, which is then converted into a dynamic MLC file (DMLC). The DMLC file contains information about MLC subfield shapes and the fractional Monitor Units (MUs) to be delivered for each subfield. With a lung tumor, a CTV that executes a quasi periodic motion z(t) does not receive ${\Phi}$ (x,y), but rather an Effective Incident Fluence EIF(x,y). We numerically evaluate the EIF(x,y) from a given DMLC file by a coordinate transformation to the Target's Eye View (TEV). In the TEV coordinate system, the CTV itself is stationary, and the MLC is seen to execute a motion -z(t) that is superimposed on the DMLC motion. The resulting EIF(x,y)is inputted back into the dose calculation engine to estimate the 3D dose to a moving CTV. In this study, we model respiratory motion as a sinusoidal function with an amplitude of 10 mm in the superior-inferior direction, a period of 5 seconds, and an initial phase of zero.