• Molecules and Cells
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• 제45권5호
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• 한국기계가공학회지
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• 제17권2호
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• pp.77-82
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• 2018

Track shoes improve the off-road driving ability of tanks. The strength of the track shoe body directly affects the driving ability of tanks, self-propelled artillery, and armored vehicles. In this study, the design technique for track shoe body was investigated. To select the optimal design of track shoe body, three track shoe body models were suggested and compared. Tensile strength was calculated using computer-aided engineering (CAE) analysis. Compressive tests were conducted using the original tank sprocket because sprocket compression is critical to the lifespan of the track shoe body. As a result, one track shoe body design was selected and the process of track shoe body design was described.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(5)
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• pp.211-214
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• 2002

Under a continuous manufacturing process, two dimension inspection system causes problems as blurring effect and low resolution and requires position calibration between frames. One dimension inspection system is, therefore, being researched as a substitution. In this paper, we implement mechanism of switching memory and processing data for reasonable one dimension inspection system. Redundant weft image and noise was suggested to be reduced by new method using modified morphological process and masked erosion process. From resulting image, line data and possible error information were obtained and constructed as a structure. Finally, error detecting algorithm was performed with this data structure. Processing time of error detecting was 0.625ms per line in applied system and experiment showed 94.7% of error detecting ability. This method is 20% faster in speed and 2.7% higher in error detecting ability comparing with the present method.

• Design & Manufacturing
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• 제12권1호
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• pp.26-30
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• 2018

The aluminum chassis drive gear manufacturing process improvement has been very effective in both technical and economic aspects. Technology for Shear mold design technology, mold material selection and processing technology, and press molding technology has improved greatly overall. In the meantime, it is necessary to clarify the causes of defects that occur frequently due to lack of technology, Based on this, it is meaningful that it has secured the ability to respond to new product development and molding in the future. By applying these technologies, we plan to expand not only the drive gear chassis, but also various types of press forming such as frame, handle, various fastening parts of system window. In addition, the ability to develop precision products in the future is expected to become a driving force in further enhancing the competitiveness of companies.

• 한국기계가공학회지
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• 제20권4호
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• pp.66-72
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• 2021

Since the behavior of an autonomous underwater vehicle (AUV) is influenced by disturbances and moments that are not accurately known, the depth control law of AUVs must have the ability to track the input signal and to reject disturbances simultaneously. Here, we proposed robust tracking control for controlling the depth of an AUV. An augmented closed-loop system is represented by an error dynamic equation, and we can easily show the asymptotic stability of the overall system by using a Lyapunov function. The robust tracking controller is consisted of the internal model of the command signal and a state feedback controller, and it has the ability to track the input signal and reject disturbances. The closed-loop control system is robust to parameter uncertainties. Simulation results showed the control performance of the robust tracking controller to be better than that of a P + PD controller.

• 융복합기술연구소 논문집
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• 제5권1호
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• pp.7-12
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• 2015

Sheet metal formability can be defined as the ability of metal to deform without necking or fracture into desired shape. Every sheet metal can be deformed without failure only up to a certain limit, which is normally known as forming limit curve(FLC). In this paper, the dome stretching tests and tensile tests have been performed to obtain forming limit curve of aluminum alloy. During the experiment, failure strain is measured using digital image correlation(DIC) method. DIC method is a whole-field measurement technique that acquires surface displacements and strains from images information which characterized a random speckle as intensity grey levels. Recently years, this DIC method is being developed and used increasingly in various research. DIC results demonstrated the usefulness and ability to determine a strain.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.373-376
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• 2001

In this paper to cope with the reduction of products life-cycle as the variety of products along with the various demands of consumers, a virtual simulator is developed to make the changeover of manufacturing line efficient to embody a virtual simulation similar to a real manufacturing line. The developed virtual simulator can design a layout of a factory and make the time scheduling. Every factory has one simulator so that one product can be manufactured in the factories to use them as virtual factories. We suggest a scheme that heightens the ability to the diversity of manufacturing models by making the information of manufacturing lines and products models to be shared. The developed system embodies a virtual manufacturing line on the simulation using various manipulators and work cells as manufacturing components. we develop a virtual simulator system on Window 98/NT environment of Microsoft, operating system using of the greater part of PC user. Window program have a merit making GUI environment that programmer can use without the expert knowledge about hardware. A suer with the simulator can utilize an interface that makes one to manage the separate task process for each manufacturing module, change operator components and work cells, and easily teach tasks of each task module.

• 월간산업보건
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• 제8호통권244호
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• pp.56-57
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• 2008

• 대한전기학회:학술대회논문집
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• 대한전기학회 1986년도 하계학술대회논문집
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• pp.97-109
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• 1986

The ultimate goal of an industrial robot is to make full use of its real ability to communicate with any given intelligent device, and to do so independently of hardware, architecture and languages. This paper describes the necessary functions of a robot used in an integrated manufacturing system, and the basic philosophy of organization as applied to the robot controller. An example of a machine vision system called MYVIS is reviewed in relation to MAP and LAN in a practical cell application.

• 한국기계가공학회지
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• 제1권1호
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• pp.23-28
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• 2002

Fused deposition modelling(FDM) is a rapid prototyping(RP) process that fabricates part layer by layer by deposition of molte thermoplastic material extrude from a nozzle. RP system has benefits. Benefit would be the ability to experiment with physical objects of any complexity m a relatively short period of time. But it has a matter of surface roughness and geometric accuracy. We study on Influence of tangent line angle on surface roughness at fused deposition.