• Journal of Pharmaceutical Investigation
• /
• v.30 no.3
• /
• pp.213-218
• /
• 2000

Ondansetron is a potent, highly selective 5-hydroxytryptamine3(5-HT3) receptor- antagonist, for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiography, and the treatment of post-operative nausea and vomiting. The purpose of the present study was to evaluate the bioequivalence of two ondansetron tablets, $Zofran^{TM}$, (Glaxo Wellcome Korea Ltd.) and Hana ondansetron (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.56{\pm}1.79$ year in age and $67.35{\pm}8.35\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 8 mg of ondansetron was orally administered, blood was taken at predetermined time intervals and the concentrations of ondansetron in serum were determined using HPLC with UV detector. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were 7.53%, -0.23% and -3.92%, respectively when calculated against the $Zofran^{TM}$, tablet. The powers $(1-{\beta})$ for $AUC_t,\;C_{max}\;and\;T_{max}$ were above 99.00%, above 99.00% and 84.99%, respectively. Minimum detectable differences $(\Delta)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ were all less than 20% (e.g., 12.25%, 10.88% and 18.37% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively). The 90% confidence intervals were all within ${\pm}20%$ (e.g., $-0.70{\sim}15.76,\;-7.53{\sim}7.08\;and\;-16.27{\sim}8.42\;for\;AUC_t,\;C_{max}\;and\;T_{max}$, respectively). All of the above parameters met the criteria of KFDA for bioequivalence, indicating that Hana ondansetron tablet is bioequivalent to $Zofran^{TM}$, tablet.

• Journal of Korean Society of Environmental Engineers
• /
• v.22 no.4
• /
• pp.661-669
• /
• 2000

This research was carried out to evaluate effect of metallic release and change of water corrosive indices by the pH and alkalinity adjustment using the SDLS (Simulated Distribution Loop System) which consist of six types of pipe loop with DCIP, PVC, PE, STS304, CP, GSP, respectively, and its effects on water quality changes which were microbes quality(SPC), residual chlorine. THMs and other parameters. And it was to propose optimal criteria of water quality control for the field application. According to the results, water control system by pH and alkalinity adjustment showed the changing of corrosive water and reducing of metallic release rate and it was not affects of THMs formation, microbes regrowth and variation of other parameters. Water quality stability and corrosion control were due to calcium carbonate precipitation film formation of pipe inner by water quality control. Therefore, corrosive water control system by pH and alkalinity adjustment can be attributed to effective water quality management in water distribution system according to water quality stability of pH and TIC(Total Inorganic Carbonate concentration) that affect the precipitation and dissolution of solids.

• Journal of Korean Society of Forest Science
• /
• v.85 no.2
• /
• pp.195-209
• /
• 1996

The purpose of this study is to suggest objective basic data for the national park development through the quantitative analysis of the visual quality included in the physical environment of the Dukyu National Park. For this, spatial images structure of physical elements have been analyzed by factor analysis algorithm and degree of visual quality have been measured mainly by questionnaires. Result of this thesis can be summarized as follows. Factors covering the spatial image of the Dukyu National Park landscape have been found to be the overall synthetic evaluation spatial, appeal, natural quality and physical factors such as the overall the synthetic evaluation, spatial and appear yield high factor scores. Thus, these factors can be considered to represent the site spatial image of Dukyu Korean-National Park. By using the control method for the number of factors, Total variance explained by the factors has been obtained as 45.46% and 45.45%. Principal variables of main factors explained above may be the scaling containing the functional criteria of quantitative approach for landscape management of national park development. According to difference of special image from each place, for these variables that decided the visual quality can be differed, and even the same place due to landscape control point change the visual quality can be affected affirmately or negatively, according to recognized by the landscape control point.

• Korean Journal of Ichthyology
• /
• v.31 no.4
• /
• pp.201-207
• /
• 2019

Temperature is one of the most important criteria considered in species preference for aquaculture. Acute drop in temperature during winter is a cause of disease and mass mortality in farmed fish. This study was carried out the low water temperature tolerance, oxygen consumption, hematologic and histological responses to use as basic data for the management of fish farming which frequently cause death due to winter water temperature drop. Low-lethal water temperature for 4 days of file fish Thamnaconus modestus (4day-LT₅₀) was 6.97℃ (6.69~7.27℃). Oxygen consumption rate decreased with decreasing water temperature, showing a significant difference between water temperatures. SOD activity increased significantly at 6℃ experimental group than control group (10℃) (p<0.05), but CAT did not show any significant difference between experimental temperatures (p>0.05). Cortisol increased with decreasing experimental water temperature compared to control group. Histological changes in the liver include decreased blood vessels in the blood vessels, proliferation of acid cells, condensation of the nucleus, atrophy of pancreatic exocrine gland cells, and enzyme source granules.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.16 no.3
• /
• pp.39-49
• /
• 2017

Standards suitable for local conditions on deciding one-way road are desperately required to solve traffic congestions at the backside roads in the old downtown areas which were not designated as a road by urban planning. Therefore, this study intends to re-establish a standard to decide one-way road which is regarded to be of the greatest effect among traffic system control methods in order to control one-way road system more efficiently. Also, this paper suggests a standard for such decision to improve efficiency of using backside roads and expand designation of one-way road. AHP (analytic hierarchy process) was carried out among the traffic experts to find out the factors to decide one-way road system. Its result reveals that importance of causing accident to walking quantity and traffic was high. 10,000 cases out of all the possible scenarios of accident by combining detailed evaluation items and scales were extracted to draw the outcomes of analyzing the scenarios, which were schematized in a graph. As a result, division by three sections of point of inflection was verified into $1{\leq}$ section A<1.91, 1.9$1{\leq}$ section B<2.08, and $2.08{\leq}$ section C<3. In other words, priority of deciding one-way road should be given to section C, the highest total point, while posterior to section A, where relatively low points are distributed. The standard on deciding one-way road suggested in this paper may be used for designating one-way road and basic data to re-establish the relevant system in the future.

• Journal of Digital Convergence
• /
• v.8 no.1
• /
• pp.41-53
• /
• 2010

In this paper, we discuss patent pool and a patent valuation scheme for fair royalty distribution among the patents in a pool. In the knowledge-based economy, intellectual capital-the accumulation of technology and know-how-is recognized as the most important source of company's competitive advantage and economic growth. By providing exclusive rights to patent holders, the patent system aims to encourage innovation-invention & commercialization of new technologies-in order to raise the standard of living. However, drawbacks of patent system, which occur as the number of patents issued increases rapidly and patent ownership is fragmented, may slow down the innovation efforts seriously. A promising solution is the patent pool approach, which was for instance employed by the U.S. congress during World War I to free the airplane manufacturers from the patent tangle by letting them license all the patents for a fee. It is necessary to figure out relative technological contribution of patent for fair distribution of royalty revenues among patent holders. The Rating/Ranking Method seems to fit to that valuation purpose. We examined technology valuation models from various organizations and selected a set of more influential valuation factors which can be incorporated as scoring criteria in the Rating/Ranking Method.

• Journal of Digital Convergence
• /
• v.18 no.3
• /
• pp.395-404
• /
• 2020

The purpose of this study is to analyze the research published in Korea on the live atrium of Toegye Lee Hwang and present its applicability as a health dance program.To this end, Korean academic journals, the Korean Institute of Information Scientists and Engineers, and DBpia searched Korean journal publications with the keyword 'active visit', and 24 articles published from 1974 to December 2018 were classified into the Korean Research Foundation.According to the criteria, they were classified and analyzed into subclasses. As a result, first, the research trends of academic disciplines by year tended to increase the participation of various academic disciplines in the atrium.The interests of the live atrium differed in the order of physical education.Second, in terms of research subjects, more researches attempted to identify active atria as a research topic than research suggesting a plan.Third, the trends of the research topics were in order to study academic definition of live atrium, to find out the relationship between live atrium and other disciplines, to propose ways to use them, and to develop programs.Fourth, by applying the live atrium to a dance program, we found the potential as a dance program for health promotion.It is expected that these findings will not only provide the basic data for the possibility of a health dance program integrated with various fields, but also contribute to the search for the direction of health dance program research.

• Journal of Digital Convergence
• /
• v.18 no.8
• /
• pp.69-83
• /
• 2020

The purpose of this study is to classify the types of street parking in low-rise residential areas. First of all, prior research was reviewed to examine the background of occurance and the process of change of low-rise residential areas. and derive factors that affect the street environment. Next, based on the selection criteria, the residential area of Bangi 2-dong, Songpa-gu was selected as the site of the case and the status analysis was conducted on streets, buildings, and on-road parking. The summary of the results is on-road parking usually occurs on residential streets where social consensus is difficult to reach, suggesting that alternatives to on-road parking in residential areas are needed. Based on the results of the previous analysis, street types were classified considering the characteristics of streets, structures and street parking. Then, the characteristics of each type of street were analyzed and implication for improving the street environment were suggested. In addition, the results of the classification of street types confirmed that different street parking occurred depending on the width of the street and the use of the lower floors, even if it was the same area, and that a solution was needed accordingly.

• Journal of Digital Convergence
• /
• v.18 no.9
• /
• pp.191-198
• /
• 2020

In this study, in order to propose an improvement plan for fire simulation training to improve fire response capability, fire simulation training is conducted for three business facilities, and changes according to whether training materials are used and whether the response time for each response stage is reflected in the training evaluation. The response posture and response ability of the training participants were observed and analyzed. As a result of the analysis, it was analyzed that most of the training participants improved their participation in training, response posture, and response ability when the use of training textbooks and response time for each response stage were reflected in the training evaluation. In the event of a fire simulation training, a number of training materials that can similarly implement the fire situation are used to improve and maintain the fire response capabilities (fire notification and fire report, initial extinguishing, and evacuation) of the training participants, and the target time for each response step. The result was that it can be used as a useful index for improving fire response capability and improving fire simulation training in the future and feedback only when quantitative training evaluation is conducted based on this setting.

• Physical Therapy Korea
• /
• v.24 no.2
• /
• pp.48-57
• /
• 2017

Background: Rounded shoulder posture (RSP), a postural abnormality, might cause shoulder pain and pathologic conditions. Although most previous research has investigated RSP focusing on the proximal structures of the shoulder, such as the scapula and pectoralis muscles, the relationship between RSP and anterior distal structures of the upper extremity, such as the biceps brachii muscle and elbow joint, is not clearly understood. Objects: This study aimed to investigate the correlations between RSP and the biceps brachii length, elbow joint angle (EJA), pectoralis minor length, general pectoralis major length, humeral head anterior translation (HHAT), glenohumeral internal rotation (IR), external rotation (ER), and horizontal adduction (HAD). Methods: Twelve subjects with RSP (6 male, 6 female) were recruited. All subjects fulfilled the RSP criteria indicated by a distance ${\geq}2.5cm$ from the posterior aspect of the acromion to the table in the supine position. The examiner measured each of the following parameters twice: RSP, biceps brachii length, EJA, pectoralis minor length, pectoralis major length, HHAT, glenohumeral IR, ER, and HAD. Pearson's correlation coefficient(r) was used to assess the correlation between RSP and all the variables. Results: There was a significant moderate positive correlation between RSP and biceps brachii length (r=.55, p=.032), moderate negative correlation between RSP and pectoralis minor length (r=-.62, p=.015), and moderate positive correlation between RSP and HHAT (r=.53, p=.038). Conclusion: The biceps brachii length, pectoralis minor length, and HHAT could be used to evaluate patients with RSP. Better understanding of the correlation between these factors and RSP could help in the development of effective methods to treat patients with this condition in clinical management.