• Investigative Magnetic Resonance Imaging
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• 제25권4호
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• pp.338-344
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• 2021

Solitary fibrous tumors (SFT) are rare mesenchymal tumors that most commonly develop in the pleura; they rarely involve the diaphragm. MRI has not been widely used to evaluate SFTs of the thoracic cavity, though it may be highly useful in assessing local invasion, predicting malignant potential, and helping in the differential diagnosis. However, MRI findings of malignant SFTs of the diaphragmatic pleura have been described in only two cases. We report a rare case of a malignant solitary fibrous tumor of the diaphragmatic pleura in an 82-year-old man. We describe the clinical and characteristic imaging features, including computed tomography, conventional MRI, and diffusion-weighted imaging. Contrast-enhanced MRI is more accurate than is CT in identifying the origin of SFTs, predicting whether they ae benign or malignant, and assessing local invasion. This imaging modality proved helpful in deciding on the treatment strategy for these rare tumors.

• Journal of Chest Surgery
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• 제46권4호
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• pp.295-298
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• 2013

Solitary fibrous tumor is a rare spindle cell mesenchymal tumor entity, with either benign or malignant behavior that cannot be accurately predicted by histological findings. An intrapulmonary site of origin is even rarer. We report a case of a 51-year-old woman in whom an abnormal nodule in the lower right lung was detected during staging for sigmoid adenocarcinoma. The nodule was excised and pathological examination revealed an intrapulmonary solitary fibrous tumor.

• Journal of Korean Neurosurgical Society
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• 제54권3호
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• pp.246-249
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• 2013

A solitary fibrous tumor (SFT) is a rare neoplasm originated from the pleura, but they can occur in a variety of extrathoracic regions. Although many cases of primary SFT have been reported, there are extremely rare repots to date of a malignant SFT in the spine or skull. A 54-year-woman visited our hospital due to low back pain and both leg radiating pain. Several imaging studies including magnetic resonance imaging and computed tomography revealed expansive enhanced lesions in the occipital bone, T8, S1-2, and ilium, with neural tissue compression. We performed surgical resection of the tumor in each site, and postoperative radiosurgery and chemotherapy were performed. However, after six months, tumors were recurred and metastasized in multiple regions including whole spine and lung. The authors report here the first case of patient with malignant SFT of tandem lesions in the various bony structures, including skull, thoracic spine, and sacral spine, with a rapid recurrence and metastasis. Although malignant SFT is extremely rare, it should be considered in the differential diagnosis and carful follow-up is needed.

• Journal of Chest Surgery
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• 제29권12호
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• pp.1385-1391
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• 1996

흉막의 고립성 섬유성 종양은 과거 중피종의 한 형태로 알려져 있으며 중피종과 흔돈하여 쓰여 왔으나 최근에는 중피하에 존재하는 미분화 중배엽성 기원의 섬유세포에서 기원하고 있는 종양으로 해석된다. 환자는 65세 여자로 우측흉통과기침 및 호흡곤란을 주소로 본원에 입원하여 흉부 방사선 및 전산화 단층 촬영상 우측 흉강내에 고형성 종괴가 발견되었다. 수술소견상 종괴의 크기와 무게는 12$\times$12$\times$6mm, 400mm 이었으며, 폐 실질내로 침윤하였고 세기관지 내강을 따라 성장한 부분이 관찰되었다. 또한 종괴는 횡경막과 벽측 흉막 및 폐실질에 다발성으로 전이 되어 있었다. 병리학적으로, 종괴는 세포밀도가 높았고, 판상배열을 보이는 등글거나 난원형 또는 짧은 방추형의 세포로 이루어졌으며, 10배의 고배율 시야에서 3개의 유사분열이 관찰되었다. 면역조직화학 염색상 vimentin과 actin에 미만성 강양성 반응을 보였고 전자현미경적으로 조면 세포질내세망이 풍부하며 세포접합부나 미세응모는 관찰되지 않아서 악성 고립성 섬유성 종양에 합당하였다. 본 교실에서는 흉막에 발생한 악성 고립성 섬유성 종양을 경험하였기에 문헌 고찰과 함께 보고한다.

• 대한세포병리학회지
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• 제12권2호
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• pp.111-115
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• 2001

Solitary fibrous tumor on the pleura is rare but should be included in the differential diagnosis on a peripheral pulmonary nodule. Cytologic features of solitary fibrous tumor of the pleura is not familar to the pathologist and may be misdiagnosed as malignancy. We report fine needle aspiration cytologic(FNAC) findings of a case of solitary fibrous tumor misdiagnosed as adenocarcinoma in a 48-year-old woman. The FNAC displayed a mixture of bland-looking spindle cells and clusters of epithelioid cells, which have hyperchromatic nuclei with prominent nucleoli. The helpful finding to distinguish It from other circumscribed benign and malignant lesions is the presence of fibromyxoid matrix admixed with blood vessels and thin collagen fibers. Familiarity with these features is essential to avoid misdiagnosis and overtreatment.

• Journal of Chest Surgery
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• 제43권3호
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• pp.332-335
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• 2010

악성 고립성 섬유종은 비교적 드문 종양으로 흉막, 횡격막, 후복막 및 심낭 등에서 발생할 수 있으며, 남녀 발생 빈도는 비슷하고 60~70세 사이에 호발하나 10대의 어린 나이에도 발생하는 경우가 있다. 17세 남자에서 악성 고립성 섬유종에 의해 인접한 좌측 9번째 늑골의 형태학적 변화가 있어 섬유종의 제거 및 늑골 근위부의 부분적 절제술을 시행하였다. 술 후 뇌척수액의 흉강 내로의 누출을 CT myelography로 확인 후 뇌척수액의 배액 및 부분적 반측 추궁 절제술 및 경질막 복원술을 통한 교정을 치험하여 발표하고자 한다.

• 대한영상의학회지
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• 제84권1호
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• pp.304-310
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• 2023

고립성 섬유종은 흉막에서 흔히 발생하는 양성 종양으로 알려져 있으나, 신체 어느 곳에서나 발생할 수 있고 10%-30%에서는 악성이다. 전형적으로, 고립성 섬유종은 단일성의 조영증강되는 종괴로 나타나지만, 척추 주위의 양측성 종괴로 나타나는 경우는 보고되어 있지 않다. 이 증례에서는, 등 통증과 만성 농흉의 병력이 있던 88세 남자 환자의 영상 검사에서 침습적인 양측성 척추 주위 종괴가 발견되었고, 만성 농흉과 연관된 흉부 악성 종양을 먼저 의심하였다. CT 유도하 이중구조 바늘 생검을 통해 진단된 양측성의 척추 주위 악성 고립성 섬유종의 증례를 보고한다.

• 대한두경부종양학회지
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• 제37권2호
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• pp.87-90
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• 2021

Solitary fibrous tumor (SFT) is rare mesenchymal tumor usually arising from pleura. SFT can be found at all anatomic site in our body but incidence of SFT is much lower in head and neck region especially at lower neck area. We found a case of SFT that presented as a lower neck mass in a 41-year old woman. Ultrasonography showed a 3×1cm sized hypoechoic mass in the intermuscular fat plane of left lower neck, and computed tomography showed a well circumscribed, low-density mass with contrast enhancement. Fine needle aspiration showed no malignant cells with abundant red blood cells, but it was not possible to completely rule out malignant tumors or nodules clinically. Surgery was performed to make a definitive diagnosis and histopathology showed tightly packed, round to fusiform cells with staghorn shaped vessels at microscopic examination. The tumor cell were positive for CD34 but negative for CD31 and S-100 protein.

• 대한두경부종양학회지
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• 제33권2호
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• pp.59-62
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• 2017

Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm that is usually presented as a pleural origin localized tumor. There are few cases, found in thyroid. Twenty six cases found in thyroid have been reported since 1993, and two of these were malignant. We report another malignant case in this study; a 55 years old man visited out-patient clinic due to palpable mass of anterior neck, and pathologically diagnosed as malignant SFT of thyroid after surgical resection. In this study, we focus on the clinical features of this uncommon disease along with other literature reviews.

• Tuberculosis and Respiratory Diseases
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• 제67권5호
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• pp.449-453
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• 2009

Desmoid tumor (fibromatosis) is a histologically benign fibrous neoplasm showing locally infiltrating growth. This type of tumor commonly occurs in the abdomen, but intrathoracic desmoid tumor is uncommon. To date, 12 cases of intrathoracic desmoid tumor protruding into the pleural cavity, radiologically mimicking pleural masses, have been reported. Here, we report on a case of intrathoracic desmoid tumor protruding into the pleural cavity, and partially covered by parietal pleura. The main preoperative differential diagnoses included pleural solitary fibrous tumor, inflammatory pseudotumor or malignant mesothelioma. A near-total mass excision was performed. Pathologically, the tumor was composed of a paucicellular arrangement of spindle-shaped cells with fibromyxoid stroma. The resection margin was partially involved with spindle cells present. On histochemical staining, the spindle cells were strongly positive for vimentin and negative for CD34, consistent with a desmoid tumor. The patient was stable without further adjuvant treatment during 6-years of follow-up.