• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권2호
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• pp.196-201
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• 1994

One case of an unusual form of carcinoma involving the submucosal gland and duct of tongue was reported and reviewed. According to Gerughty et al(1968) four distinct component parts were classified : ductal carcinoma in situ(involvement of the ductal epithelium by in situ carcinomatous changes), squamous cell carcinoma, and a mixed carcinoma(combination of glandular and squamous characteristics and occasionally consisted of large nests composed of "glassy" cell). This tumor was fond to be extremely aggressive and highly malignant. The histopathologic features and the clinical behavior of this tumor were sufficiently distinctive to warrant the designation adenosquamous carcinoma : exhibit concomitant glandular and squamous neoplasm. The mode of therapy was evaluated and the treatment of choice appears to be radical surgery. So, we has done the radical neck dissection and partial glossectomy. However, the limited number of cases indicated that collection and subsequent analysis of additional cases must be performed before any definitive conclusion can be drawn.

• 한국임상수의학회지
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• 제36권6호
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• pp.358-363
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• 2019

An 11-year-old, female Miniature Schnauzer dog was presented with recurrent skin ulcer of the second metatarsal region in the right hindlimb following metatarsal resection. Physical examination revealed an ulcerated and bleeding lesion of the second metatarsal region in the right hindlimb. Impression smears of the ulcerative lesion confirmed numerous degenerated neutrophils and mixed bacterial infection. Initially, the dog was treated with antibiotics and povidone-iodine flushing for the control of deep pyoderma. Because the skin lesion had been deteriorated over time despite of topical and systemic treatments, skin biopsy was performed. Histopathologic examination indicated squamous cell carcinoma based on the features of multiple nests of squamous neoplastic cells and mitotic figures. Although amputation of the right hindlimb was performed, the dog was expired five months later because of tumor metastasis to the lung and the popliteal lymph node. This is the first case report describes malignant digital squamous cell carcinoma in Korea.

• International Journal of Oral Biology
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• 제44권3호
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• pp.77-80
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• 2019

Clear cell odontogenic carcinoma (CCOC), a very rare neoplasm located mostly in the mandible, has been regarded as a benign tumor. However, due to the accumulation of case reports, CCOC has been reclassified as a malignant entity by the World Health Organization. Patients with CCOC present with regional swelling and periodontal indications with variable pain, often remaining misdiagnosed for a long period. CCOC has slow growth but aggressive behavior, requiring radical resection. Histologic analysis revealed the monophasic, biphasic, and ameloblastic types of CCOC with clear cells and a mixed combination of polygonal and palisading cells. At the molecular level, CCOC shows the expression of cytokeratin and epithelial membrane antigen, along with markers that assign CCOC to the sarcoma family. At the genetic level, Ewing sarcoma breakpoint region 1-activating transcription factor 1 fusion is regarded as the key feature for identification. Nevertheless, the scarcity of cases and dependence on histological data delay the development of an efficient therapy. Regarding the high recurrence rate and the potential of distant metastasis, further characterization of CCOC is necessary for an early and accurate diagnosis.

• Journal of Yeungnam Medical Science
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• 제5권2호
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• pp.189-193
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• 1988

저자들은 최근 영남대학교 의과대학 부속병원에서 경험한 위에 발생한 원발성 선편평세포암종 3예를 경험하고 문헌고찰과 함께 보고하는 바이다.

• Advances in pediatric surgery
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• 제14권2호
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• pp.153-163
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• 2008

Inflammatory myofibroblastic tumor (IMT) is a rare reactive lesion characterized by the feature of myofibroblasts and a mixed inflammatory infiltrate that rarely undergoes malignant transformation. Extrapulmonary IMTs in children have been described involving the mesentery, omentum, retroperitoneum, abdominal soft tissues, liver, bladder, mediastinum, head and neck, extremity, appendix, and kidney. Medical records of children treated with abdominal IMT between 1985 and 2005 were reviewed retrospectively. Seven children were treated for IMT with the mean age of 3 y 2 m (range, 1 y 1 m to 14 y). Tumors were located in transverse mesocolon (n=2), omentum (n=1), porta hepatis (n=2), complex site (antrum, duodenum, common bile duct, porta hepatis) (n=2). The symptoms included abdominal mass, fever, jaundice, abdominal pain and anemia. The masses were excised totally in transverse mesocolon, omentum IMT and there is no evidence of recurrence (follow-up periods: 6 y 8 m, 8 y 9 m, 4 y 10 m). In porta hepatis IMT, liver transplantations were performed and there is no evidence of recurrence (follow period: 6 y 8 m, 8 y 7 m). In one case of complex site IMT, partial excision of mass was performed and he still survived with no change of the residual tumor during follow-up period. The other one of complex site IMT denied further treatment after the biopsy. In conclusion, complete surgical excision including liver transplantation and close follow-up are mandatory for the abdominal IMT in child.

• 한국임상수의학회지
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• 제26권6호
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• pp.556-562
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• 2009

피부와 유선 종양은 개에서 매우 빈번히 발생하는 종양으로, 종양 발생의 위험은 나이가 증가함에 따라 종양의 발생률은 증가하며, 발병률과 발병부위의 분포는 종양의 종류마다 다르다. 피부와 유선종양의 발생은 공기오염, 식생활 등 환경의 변화와도 관련이 있어 이들 종양들의 발생양상은 그 사회의 환경을 반영할 수 있어 시대와 지역에 따라 다양하게 다르게 나타날 수 있다. 따라서, 그 동안의 많은 보고들에도 불구하고, 피부와 유선종양발생에 대한 자료들은 종양에 대한 수의임상학적 진단과 치료를 위한 중요한 정보를 제공한다. 본 연구에서는 2005년 1월 1일부터 2006년 12월 31일까지 수의과학검역원과 강원대학교에 의뢰된 128증례의 개 피부종양과 240증례의 개 유선종양을 Goldschmidt와 Misdorp의 형태학적 기준에 의해 조직병리학적으로 진단하여, 종별, 성별 및 부위별로 각각 분류하여 국내에서 이들 종양의 발생양상을 체계적으로 분석하였다. 피부종양에서는 피부상피세포종양, 샘종양 및 간질종양이 각각 14.1%, 41.4%와 44.5%였다. Cutaneous histiocytoma가 피부종양에서 가장 빈번하게 관찰되어 전체 피부종양의 25.0%를 차지하였으며, 기름샘종 (sebaceous gland adenoma; 15.6%), 기저세포종(basal cell tumor; 8.6%), 항문둘레샘종 (perianal gland adenoma; 6.3%)와 지방종 (lipoma; 6.3%)순으로 높았다. 그 외에 비만세포종, 모낭세포종과 중층편평상피암 등이 관찰되었다. 이러한 피부종양들은 품종, 성과 나이 또는 부위에 따라 유사하거나 다른 양상을 나타내었다. 유선종양의 경우 양성과 악성이 201/240, 39/240으로 양성발생률이 현저히 높았으며, 양성혼합종 (benign mixed tumor)이 검사한 품종 모두에서 가장 높은 발생률 (35.0%)을 나타내었다. Complex adenoma는 Maltese와 Poodle에서 특히 높았으며, 악성종양에서는 simple carcinoma와 complex carcinoma가 각각 6.7%로, 악성 중 41.0%를 차지하여 가장 높은 발생률을 나타내었다. 본 연구결과는 최근 우리나라에서 여러 품종의 반려견에서 발생한 피부와 유선종양의 발생양상을 조직병리학적으로 진단 분석한 것으로, 임상수의사들이 지속적으로 증가추세에 있는 개의 피부와 유선종양을 진단하고 치료하는데 유용하게 활용될 수 있기를 기대한다.

• Journal of Yeungnam Medical Science
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• 제15권2호
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• pp.275-285
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• 1998

영남대학교 의과대학 부속병원에서 1991년 1월부터 1998년 6월까지 20례의 자궁육종을 경험한 결과 자궁육종 환자의 연령별 분포는 24세에서 71세이었고 평균 연령은 50.2세였고 평균 분만 횟수는 3.7회였다. 병기는 1기가 9례(45.0%), 2기가 1례(5.0%), 3기가 6례((30.0%), 4기 가 4례(20.0%)이었으며 병기에 따른 생존율에는 유의한 차이가 없었으며, 병리조직검사상 자궁평활근육종이 13례(65.0%), 악성 혼합 뮬러씨 종양이 5례(25.5%), 기타 횡문근육종 1례, 맥관육종 1례로 조직검사에 따라서도 생존율의 차이를 보이지 않았다. 주된 임상증상으로는 부정기적 질출혈이 7례(35.0%), 하복부동통이 5례(25.0%), 비정상 복부종괴가 5례(25.0%)였다. 조직학적 소견상 10 HPF당 유사분열수가 6-10개인 경우가 2례, 10-15개인 경우가 3례, 16-20개인 경우가 2례, 20개 이상인 경우가 2례였으며 이들 유사분열수와 생존기간과의 관계는 조사할 수가 없었다. FIGO 병기 1기의 중앙생존기간은 27.0개월이었고 3기는 23.5개월, 4기는 3.0개월이었으며 2기는 산출이 불가능하였고 이들 병기와 생존기간과는 유의한 차이가 없었다. 치료 방법으로는 수술적 방법, 화학요법, 방사선 요법을 실시하였으며 수술적 방법으로는 전자궁 및 양측 부속기 절제술이 15례 (75.0%), 전자궁 및 단측 부속기 절제술이 3례(15.0%), 근치적 자궁적출술이 1례였다. 치료결과 6명이 사망하였고 7명이 생존해 있는데 모두 무병상태로 추적 관찰중이며 나머지 7명은 추적이 불가능하였다. 추적조사를 위한 지표로서 CA-125가 5례에서 사용되었는데 그중 2례(40.0%)에서 현저한 증가를 보였다.

• 대한소아치과학회지
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• 제40권4호
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• pp.321-327
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• 2013

법랑모세포섬유종은 드물게 나타나는 진성 혼합 치성 종양으로 10~20대의 어린 환자의 하악에서 호발하는 경향을 보인다. 법랑모세포섬유종의 치료는 종양부위의 제거를 원칙으로 하고 있다. 종양부의 제거는 보존적 방법과 광범위한 제거를 선택할 수 있으나 이는 아직 논쟁이 되는 사항이며 저자에 따라 주장하는 바가 다르다. 이는 법랑모세포섬유종의 재발률과 악성으로의 전이 가능성 때문이다. 본 증례는 상악 우측 유구치의 미맹출을 주소로 내원한 4세 환아에서 발생한 법랑모세포섬유종에 대하여 묘사하고 있다. 법랑모세포섬유종을 적출술과 소파술을 이용하여 성공적으로 치료 하였기에 이에 대한 문헌고찰 및 증례를 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1935-1941
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• 2012

Introduction: Uterine sarcomas are a group of heterogenous and rare malignancies of the female genital tract and there is a lack of consensus on prognostic factors and optimal treatment. Objective and Methodology: To perform a retrospective evaluation of clinicopathological characteristics, prognostic factors and treatment outcomes of 93 patients with uterine sarcomas who were diagnosed and treated at 4 different centers from November 2000 to October 2010. Results: Of the 93 patients, 58.0% had leiomyosarcomas, 26.9% malignant mixed Mullerian tumors, 9.7% endometrial stromal sarcomas, and 5.4% other histological types. According to the last International Federation of Gynecology and Obstetrics (FIGO) staging, 43.0% were stage I, 20.4% were stage II, 22.6% were stage III and 14.0 % were stage IV. Median relapse free survival (RFS) was 20 months (95% confidence interval (CI), 12.4-27.6 months), RFS after 1, 2, 5 years were 66.6%, 44.1%, 16.5% respectively. Median overall survival (OS) was 56 months (95% CI, 22.5-89.5 months), and OS after 1, 2, 5 years was 84.7%, 78%, 49.4% respectively. Multivariate analysis showed that age ${\geq}60$ years and high grade tumor were significantly associated with poor OS and RFS; patients administered adjuvant treatment with sequential chemotherapy and radiotherapy had longer RFS time. Among patients with leiomyosarcoma, in addition to age and grade, adjuvant treatment with sequential chemotherapy and radiotherapy after surgery had significant effects on OS. Conclusion: Uterine sarcomas have poor progrosis even at early stages. Prognostic factors affecting OS were found to be age and grade.

• 대한두경부종양학회지
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• 제17권1호
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• pp.42-47
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• 2001

Purpose: To evaluate the usefulness of ultrasonogram as a preoperative diagnostic tool in thyroid nodular diseases, this study was carried out. Materials and Methods: From January 1998 to December 1999, 51 patients who underwent thyroidectomy were analyzed retrospectively. We compared the finally histopathological results to ultrasonographical findings such as internal consistency, multiplicity of nodules, nodular ehogenicity, nodular capsule or margin, calcification of nodules. Results: There were 47 females and 4 males with 25 benign tumor, 23 malignant tumor and 3 occult carcinoma in histopathological diagnosis. The solid tumors in ultrasonography carried a probability of malignancy as 66.7%(16/24 cases) whereas cystic or mixed tumors as 16.7%(1/6cases) or 23.8%(5/21cases) (p=0.006). The single nodular diseases carried a high probability of malignancy as 50%(13/26cases) whereas multiple diseases as 28.6%(6/21cases). The hypoechogenicity of thyroid nodular disease showed a probability of malignancy as 60%(9/15cases) whereas mixed-echogenicity as 36.4%(4/11cases). The nodules with poorly-defined margin in ultrasonographic findings showed higher probability of malignancy as 63.6% (7/11cases) than the nodules with well -defined margin as 26.5%(9/34 cases) (p=0.025). The nodules with calcification in ultrasonographic findings were represented to high probability of malignancy as 70.6%(12/17cases) compared to those without calcification as 29.4%(10/34cases) (p=0.005). The differency between ultrasonic and histopathological diagnosis was high in solid nodules(33%), 3-4cm sized nodules (28.6%) and mixed echogenecity(27.3%) whereas low in complex nodules with cystic and solid nature(4.8%), 2-3 cm sized nodules(8.3%) and pooly defined margin(9.1%). The accuracies of sonography in differentiating malignacy from benign thyroid nodules were 7.1% of false positivity, 39.1% of false negativity, 60.9% of sensitivity, 92.9% of specificity and 78.4% of accuracy. Conclusion: Sonographic examination was relatively excellent test as a preoperative diagnostic tool in thyroid nodular diseases when detailed checklists were applied such as internal consistency, multiplicity of nodules, nodular ehogenicity, nodular capsule or margin and calcification of nodules.