• Genomics & Informatics
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• 제3권4호
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• pp.166-171
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• 2005

Background: Smoking effects are relatively well-documented, especially on cancers and cardiovascular diseases. However, the direction and magnitude of association between smoking and obesity remain unclear. Conflicting results so far are thought to stem from the multiple confounding structure of smoking and other obesogenic life style characteristics. Methods: Cotwin control study is a genomic epidemiology design, in which the other twin (=cotwin) serves as a control of the twin. Cotwin control study, discordant for smoking habits can provide powerful evidence of association between smoking and obesity by completely matching genomic information, intrauterine environment, and almost all environmental factors. We selected 3,697 like-sex twin pairs (2,762 male and 935 female pairs) out of 63,666 pairs of adult twins in the existing Korea Twin and Family Register, whose smoking habits are discordant. We used the information of obesity as body mass index (BMI, $kg/m^2$) blood pressure, and blood cholesterol level at the time or later than the smoking information. Paired t-test was done to compare the smoking effects. Results: Lifetime smoking rate was 80.1 % (47.9 current smoker) for men and 10% (1.7% current smoker) for women. Among 2,762 and 935 male and female like-sex twin pairs, 363 male pairs and 20 female pairs correspond to the definition of smoker-nonsmoker pair. The male smokers demonstrated increase in BMI by 0.47, while female smokers show slight decrease (by 0.13), which were not statistically significant. Diastolic and systolic blood pressure, and cholesterol level were slightly increased among smokers by 1.85 mmHg, 0.62 mmHg, and 1.28 mg/dl for men. For women, the results show increase in diastolic blood pressure (3.42mmHg) and cholesterol level (1.25 mg/dl), and systolic pressure (8.17 mmHg). Conclusion: The results refute the possibility that smoking can reduce BMI. Considering the direct adverse effect of smoking, it should be emphasized that smoking do not decrease obesity and thus increase overall metabolic syndrome.

• Journal of Preventive Medicine and Public Health
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• 제49권2호
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• pp.108-117
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• 2016

Objectives: Smoking is known to be associated with nephropathy in patients with diabetes. The distinct effects of smoking before and after diabetes has been diagnosed, however, are not well characterized. We evaluated the association of cigarette smoking before and after a diagnosis of diabetes with the presence of diabetic nephropathy. Methods: We analyzed data from the 2011-2013 editions of the Korea National Health and Nutrition Examination Survey. A total of 629 male patients diagnosed with diabetes were classified as non-smokers (90 patients), former smokers (225 patients), or continuing smokers (314 patients). A "former smoker" was a patient who smoked only before receiving his diagnosis of diabetes. A "continuing smoker" was a patient who smoked at any time after his diabetes had been diagnosed. Diabetic nephropathy was defined as the presence of albuminuria (spot urine albumin/creatinine ratio ${\geq}30mg/g$) or low estimated glomerular filtration rate ($<60mL/min/1.73m^2$). Multiple logistic regression models were used to assess the independent association after adjusting for age, duration of diabetes, hemoglobin A1c, body mass index, systolic blood pressure, medication for hypertension, and medication for dyslipidemia. Female patients were excluded from the study due to the small proportion of females in the survey who smoked. Results: Compared to non-smokers, continuing smokers had significantly higher odds ratio ([OR], 2.17; 95% confidence interval [CI], 1.23 to 3.83) of suffering from diabetic nephropathy. The corresponding OR (95% CI) for former smokers was 1.26 (0.70 to 2.29). Conclusions: Smoking after diagnosis of diabetes is significantly associated with the presence of diabetic nephropathy in the Korean male population.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6819-6822
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• 2014

Background: The aim of this study was to evaluate the accuracy of a new scoring system in Korean patients with hematuria at high risk of bladder cancer. Materials and Methods: A total of 319 consecutive patients presenting with painless hematuria without a history of bladder cancer were analyzed, from the period of August 2012 to February 2014. All patients underwent clinical examination, and 22 patients with incomplete data were excluded from the final validation data set. The scoring system included four clinical parameters: age (${\geq}50$ = 2 vs. <50 =1), gender (male = 2 vs. female = 1), history of smoking (smoker/ex-smoker = 4 vs. non-smoker = 2) and nature of the hematuria (gross = 6 vs. microscopic = 2). Results: The area under the receiver-operating characteristic curve (95% confidence interval) of the scoring system was 0.718 (0.655-0.777). The calibration plot demonstrated a slight underestimation of bladder cancer probability, but the model had reasonable calibration. Decision curve analysis revealed that the use of model was associated with net benefit gains over the treat-all strategy. The scoring system performed well across a wide range of threshold probabilities (15%-45%). Conclusions: The scoring system developed is a highly accurate predictive tool for patients with hematuria. Although further improvements are needed, utilization of this system may assist primary care physicians and other healthcare practitioners in determining a patient's risk of bladder cancer.

• 한국치위생학회지
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• 제12권1호
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• pp.1-15
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• 2012

Objectives : The purpose of this study was to examine the effect between job stress in jobholders and xerostomia. Methods : 250 jobholders living in Jecheon city were the subjects of this questionnaire. The questionnaire was made up of three contents and 37 items: general characteristic(13), job stress(14), degree & behavior of xerostomia(10). The data were analyzed by two-sample t-test, one-way ANOVA to examine the subjects general characteristics, job stress and degree of xerostomia and were analyzed by Chi-square test to examine the subjects general characteristics, job stress and behavior of xerostomia. Results : Only 215 jobholders were evaluated due to inadequate responses. The results were as follow. 1. As general characteristic of jobholder, male(83.7%) were more than women(16.3%), 30~39 year-old(47%) in age variable, university graduation(63.7%) in the last educational background variable, 2~3 million won(31.2%) in the month average income variable, 1~5 year(33.5%) in tour of duty variable, non-smoker(47.9%) in smoking variable were most. Married(58.6%) were more than unmarried(39.5%). Alcoholic(69.8%) were more than non-alcoholic(30.2%). 2. As classification of job stress, high strain group was 28.4%, active group was 26%, low strain group was 24.2%, passive group was 21.4%. 3. Analysis of effect between general characteristic and degree & behavior of xerostomia showed smoker were statistical significantly higher than non-smoker on 'dry eat', 'Am-sal', 'Night awake', 'Slip-liq'and 'Gumcandy'(p<0.05) and showed alcoholic were statistical significantly higher than non-alcoholic on 'Dry PM', 'Night awake, $H_2O$-bed'(p<0.05). 4. Analysis of effect between job stress and degree & behavior of xerostomia showed hight strain group were statistical significantly higher than low strain group on 'Dry PM', 'Dry-day', 'Am-sal', 'Eff-life'and 'Night awake'(p<0.05). Conclusions : As high strain group were higher than other groups on degree & behavior of xerostomia, stress would be factor that have an effect on xerostomia. Thus consider and management of stress is necessary for diagnosis and treatment of xerostomia.

• Journal of Yeungnam Medical Science
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• 제7권2호
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• pp.141-149
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• 1990

The authors conducted a clinical observation of 55 cases of solitary pulmonary nodules at Yeungnam University Hospital from June 1986 to October 1990, and the following results were obtained : 1. The age distribution was ranged from 18 to 77 years, and the male-to-female ratio was 1.8:1. 2. Among 55 cases of nodules, 28 cases were benign and 27 cases were malignant nodules, and of malignant nodules, the primary lung cancer was 23 cases and of benign nodules, 18 cases were tuberculoma. 3. 23 cases (41.8%) was asymptomatic and the other 32 cases were symptomatic; chest pain 12 cases, hemoptysis; 8 cases, cough; 8 cases and dyspnea; 4 cases. 4. The non-smoker-to-smoker ratio was 1:1.04, but among 23 smoker over 20 pack years, 14 cases were malignant nodules. 5. According to nodular size, there is no striking differences between benign and malignant nodules except 3-4cm sized nodules. 6. The lobar distribution of nodules, 35 cases were in the right lung (upper lobe; 14 cases, middle lobe; 11 cases, and lower lobe; 10 cases) and 20 cases were in the left lung(upper lobe; 9 cases, lower lobe; 11 cases), and the malignant nodules were most commonly observed in the right upper lung.

• 대한간호학회지
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• 제35권2호
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• pp.344-352
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• 2005

Purpose: This study was conducted to examine the relationship among health-related quality of life, smoking knowledge, smoking attitude, and smoking cessation intention in male smokers. Method: The subjects were 259 male smokers in J city. The data was collected using structured questionnaires from Nov. to Dec. of 2003. The data was analyzed by the SPSS (ver. 10.0)computer program, and it included descriptive statistics, t-test, ANOVA, the Pearson correlation coefficient, and Stepwise Multiple Regression. Result: The smoking cessation intention had a significant positive correlation among health-related quality of life (r=.159), smoking knowledge (r=.161), and smoking attitude (r=.127). These variables account for $26.8\%$ of smoking cessation intention. Conclusion: These results suggested that the smoking cessation program to enhance the health-related quality of life, smoking knowledge, and smoking cessation intention and to increase a negative influence on smoking attitude need to be developed. Therefore, these findings give useful information for constructing a smoking cessation program in male smokers.

• Tuberculosis and Respiratory Diseases
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• 제39권2호
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• pp.141-149
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• 1992

등기류용량의 예측치를 구하기 위해 남자 비흡연자 78예, 남자 흡연자 108예와 여자 비흡연자 48예 합계 234예를 대상으로 80% helium과 20% 산소의 혼합가스를 잔기량 수준에서 전폐기량 수준까지 한번 마신 후(1회 폐활량법, 1VC법) 그리고 세번 연속해서 깊이 들이마신 후(3회 폐활량법, 3VC법)에 그린 최대호기류량 곡선과 실내공기를 이용하여 그린 곡선을 분석하여 등기류 용량을 구하고, 이들 등기류용량과 연령, 신장, 체중, 체표면적, 흡연력 등의 변수를 forward법에 의한 Fatio를 구하여 이들 등기류용량과 가장 상관관계가 높았던 연령(Age, A)을 택하여 흡연자 및 비흡연자에서 1회 폐활량법과 3회 폐활량법으로 구하는 등기류용량의 추정 정상치를 산출하는 회귀 방정식을 구하였다. 1회 폐활량법 남자 흡연자 : 0.614A-2.347 남자 비흡연자 : 0.374A+2.792 여자 비흡연자 : 0.588A-0.114 3회 폐활량법 남자 흡연자 : 0.467A-1.696 남자 비흡연자 : 0.288A+1.538 여자 비흡연자 : 0.367A-0.114.

• 한국식생활문화학회지
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• 제14권4호
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• pp.405-416
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• 1999

The purposes of this study were to investigate changes in serum lipid levels with age and gender, and to determine which factors affect the serum lipid profiles. The anthropometric parameters(height, weight, waist girth, hip girth) and biochemical status(cholesterol, triglyceride, HDL-chol.) were measured for clinically normal adults(male 89, female 91) in Yeongdong area. The results are as follows: 1. The obesity index was significantly higher in female($115.2{\pm}15.2%$) than in male($109.9{\pm}13.4%$), but waist/hip girth ratio(WHR) was significantly higher in male ($0.89{\pm}0.05$) than in female($0.81{\pm}0.06$). 2. Male subjects had higher triglyceride and atherogenic index and lower HDL-cholesterol and relative cholesterol than those of female subjects. 3. Prevalences of hypercholesteolemia, hypertriglyceridemia and hypoHDL-cholesterolemia were 9.0%, 9.0%, 14.6% respectively in male and 9.9%, 2.2%, 4.4% in female. 4. WHR positively correlated with serum cholesterol, TG, LDL/HDL and A.I., and negatively correlated with HDL-chol. and relative chol. Correlation analyses indicated that WHR seemed to be more closely associated with serum lipid levels(rather than obesity index). 5. Age showed positive correlations with waist girth, WHR, cholesterol, LDL-cholesterol, LDL/HDL and A.I., but negative correlations with height, body weight and relative cholesterol. 6. There was significant differences in TG concentration between drinker($169.3{\pm}130.0mg/dl$) and non-drinker($111.4{\pm}64.5mg/dl$), and smoker($165{\pm}103.6mg/dl$) and non-smoker ($110.8{\pm}39.0mg/dl$). That is to say that as risk factors for hyperlipidemia are obesity index, serum lipid concentration, life style(such as alcohol drinking and smoking) and age. Specially major risk factors are drinking, smoking and regulated exercise in male and age is an important risk factor in female.

• 치위생과학회지
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• 제9권5호
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• pp.497-506
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• 2009

흡연 청소년의 흡연형태 요인과 구강질환과의 관련성을 조사하여 10대 청소년들의 구강건강을 효율적으로 관리하는데 도움이 될 기초자료를 제공하고자 2009년 6월 1일부터 8월 31일까지 서울지역 소재하고 있는 S병원 건강교육원 5일 금연학교 프로그램에 참석한 일부 중 고등학교 학생 흡연자 156명(남자: 103명, 여자: 50명)과 흡연군과 성별, 연령을 고려하여 짝짓기 방식으로 선정한 비흡연군 176명(남자: 64, 여자: 112명)을 분석대상으로 하였다. 설문지를 이용하여 인구 사회학적 특성, 기초구강건강관리, 흡연형태요인, 자기효능감, 구강건강통제위, 구강건강지식, 구강건강증진행위에 관한 지료를 수집하였다. 구강검사를 실시하여 DMFT index, DT index, MT index, FT index, Plaque index, Calculus index를 사용하여 치아 및 구강위생상태를 평가하여 다음과 같은 결과를 얻었다. 1. 치과방문(p < 0.05), 구강건강 자각적도(p < 0.001), 구강건강관심도(p < 0.01)는 모두 흡연군보다 비흡연군에서 높게 나타나 통계적으로 유의한 차이를 보였다. 2. 자기 효능감(p < 0.05), 구강건강통제위, 구강건강증진행위(p < 0.001), 구강건강지식 모두 비흡연군에서 높게 나타났다. 3. 우식치수(p < 0.001), 치태지수(p < 0.001), 치석지수(p < 0.001)는 비흡연군보다 흡연군에서 높게 나타나 통계적으로 유의한 차이를 보였다. 4. 흡연량이 적을수록 우식치수 (p < 0.05), 치태지수(p < 0.01), 치석지수(p < 0.001)가 낮게 나타나 통계적으로 유의한 차이를 보였다. 5. 우식치수와 자기효능감, 구강건강통제위, 구강건강증진행위와는 유의한 상관성이 있었다.(p < 0.01). 6. 흡연량과 치태지수(p < 0.05), 치석지수(p < 0.05)와 유의한 상관성이 있었다. 7. 다변량 분석결과 흡연 청소년의 우식치수와 유의한 관련성이 있는 요인은 구강건강증진행위(p < 0.05), 치태지수(p < 0.01)이었다. 즉 구강건강증진행위가 높을수록, 치태지수가 낮을수록 우식치수가 적었다.

• 한국간호교육학회지
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• 제13권2호
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• pp.266-276
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• 2007

Purpose: The purpose of this study was to identify variables related to smoking behaviors (never smoked, former smoker, current smoker) among college students on the basis of the PRECEDE model. Method: Data were collected from 327 college students in Chungbuk Province from May to June 2006 using a self-reported questionnaire. Result: The rate of current smokers was 19.0%. The rate of current smokers in male students (41.1%) was significantly higher than that of female students(8.3%). Also, there were significant differences by general characteristics such as major, academic achievements, satisfaction with major and alcohol consumption. Number of smokers among five close friends was 1.72 and it showed significant differences among different gender, majors, levels of satisfaction with majors and alcohol consumption. In discriminant analysis, discriminant variables on smoking behavior were the number of smokers among close friends, the referent persons' responses about smoking and subject's belief about smoking. Conclusion: These research findings suggest that we can enhance the prevention of college students' smoking by strengthening the related factors such as enforcing a non-smoking environment and strengthening college health education strategies of non-smoking including a negative belief of smoking and the hazard of passive smoking.