• The Journal of the Korea Contents Association
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• v.21 no.1
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• pp.352-362
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• 2021

This study was conducted to investigate the relationship between major satisfaction, depression, self esteem and life stress among college dental hygiene students. This study targeted 227 dental hygiene student in one school. Data were analyzed using descriptive analyses, t-tests, ANOVA, Pearson's correlation, and Hierarchical multiple regression with the SPSS WIN 21. program. The results of this study were as follows: The average score of major satisfaction was 3.65±.59, the score of depression was 1.74±.43, the score of self esteem was 3.59±.70, the score of life stress was 1.50±.33. Life stress was negatively related to major satisfaction and self esteem, and positively related to depression. The factors influencing the life stress of dental hygiene students were grade, economic status, major satisfaction, depression. Overall, to decrease life stress among dental hygiene student, it is necessary to develop educational method and program that can prevent and mitigate depression and can increase major satisfaction.

• Journal of Korean Public Health Nursing
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• v.32 no.2
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• pp.263-274
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• 2018

Purpose: This study examined the correlation of insomnia, sleep quality, depression, and circadian rhythm in nursing students. Methods: A total of 213 subjects completed a questionnaire consisting of their general characteristics, Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression (CES-D), and Composite Scale of Morningness (CSM). The collected data were analyzed by descriptive statistics, t-test, ANOVA, and Pearson's correlation coefficient using the SPSS 23.0 program. Results: The subjects' mean scores were ISI 7.18; PSQI 11.18; CES-D 16.00; and CSM 30.18. In insomnia, there were significant differences according to caffeine, perceived health status and major satisfaction. In sleep quality, there were significant differences according to perceived health status and major satisfaction. Significant differences in depression were observed according to gender, caffeine, subjective health status, major satisfaction, and circadian rhythm by drinking and exercise. A significant positive correlation was observed among ISI, PSQI, and CES-D. ISI and CES-D were negatively correlated. Conclusion: Tailored health care programs should be developed and applied to prevent and manage sleep-related and emotion-related problems in nursing students by considering the health status, major satisfaction, and gender.

• Sleep Medicine and Psychophysiology
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• v.11 no.2
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• pp.100-105
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• 2004

Objectives: Major depression is associated with an increased risk of cardiovascular mortality. One possible explanation for this association is that major depression influences autonomic neurocardiac regulation. However, previous studies on the relationship between heart rate variability (HRV) and major depression have revealed conflicting results. The purpose of this study is to clarify that major depressive patients compared to healthy controls show a reduction in HRV as an expression of reduced modulation of vagal activity to the heart. Methods: According to DSM-IV, the time and frequency domain HRV indices (5-min resting study) of 30 patients with major depressive disorder were compared with those of 30 healthy controls. Standardized HRV tests enable quantitative estimation of autonomic nervous system function. Results: After controlling for age and gender, subjects with major depression showed a higher heart rate and significantly lower modulation of cardiovagal activity compared to controls. The total power (TP) band, very low frequency (VLF: 0.003-0.04 Hz) band, low frequency (LF: 0.04-0.15 Hz) band, and high frequency (HF: 0.15-0.4 Hz) band were significantly reduced in subjects with major depression compared to control subjects. Conclusion: Patients with major depression may suffer from functional disturbances in the interaction between the sympathetic and parasympathetic autonomic systems.

• Korean Journal of Biological Psychiatry
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• v.15 no.3
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• pp.175-185
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• 2008

Accumulating evidence has suggested the existence of reciprocal communication between immune, endocrine, and neurotransmitter system. Cytokine hypothesis of depression implies that increased pro-inflammatory cytokine such as -1, IL-6, IL-12, TNF-${\alpha}$, and IFN-${\gamma}$ in major depression, acting neuromodulators, play a key role in the mediation of behavioral, neuroendocrine, and neurochemical disturbances in depression. Concerning the relation between cytokines and serotonin metabolism, pro-inflammatory cytokines have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase(IDO) that metabolizes tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. The neurodegeneration process is reinforced by the neurotoxic effect of the hypercortisolemia during depression. From this perspective, it is possible that efficacy of antidepressants in the treatment of depression may, at least in part, rely on downregulation of pro-inflammatory cytokine synthesis. So, the use of cytokine synthesis inhibitors or cytokine antagonists may be a new treatment approach in depression. However, at present the question whether cytokines play a causal role in the onset of depression or are mere epiphenomena sustaining depressive symptoms remains to be elucidated. Nevertheless, cytokine hypothesis has created new perspectives in the study of psychological and pathophysiological mechanism that are associated with major depression, as well as the prospect for developing a new generation antidepressants.

• Journal of Korean geriatric psychiatry
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• v.18 no.2
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• pp.86-91
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• 2014

Objective : The aims of this study were to investigate the prevalence of co-morbid depression and related factors of depression in mild cognitive impairment (MCI) patients. Methods : Nine hundred and six MCI individuals were included in this study. Depression was defined as major and minor depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Depression-related demographic and clinical factors were also explored through multivariate logistic regression analysis. Results : In MCI patients, the prevalence of depression as defined according to the DSM-IV diagnostic criteria was 1.8% for major depressive disorder, 11.4% for minor depressive disorder, and overall 13.2% for both. Multivariate logistic regression showed that increased prevalence of overall depression was associated with female gender and non-amnestic subtype of MCI. Conclusion : Our findings based on a large number of MCI subjects who visited memory clinic indicated that more than ten percent of MCI patients have comorbid depression. In addition, female and non-amnestic subtype of MCI patients seems to be more vulnerable to depression.

• 한국노년학
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• v.31 no.3
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• pp.653-672
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• 2011

The present study empirically confirmed Korean elder's four major pains consisted of poverty, disease, role loss, loneliness and investigated the mediating role of depression between the four major pains and the elder's suicidal thought. To investigate the cause and effect of factors, we conveniently collected 309 samples from 16 Gyungrodangs evenly located in Jeonju and 291 samples, survived the data cleaning such as missing values, outliers, normality and covariance conditions, were analyzed by frequency, factor analysis, reliability, confirmatory factor analysis and structural model analysis. Followed were the selected contributions of the present study. First, the constructs of four major pains such as poverty, disease, role loss, loneliness were predictors of suicidal thought mediated by depression. Second, the elder's poverty, that was the heaviest factor of the four major pain constructs, was a predictor of role loss leading to loneliness. Third, four major pains were predictors of the elder's depression. Note that poverty were not direct but indirect predictor of depression. The present study confirmed the concept of four major pains. Also those who practice in the area of the elderly care should consider the four major pains as well as depression while intervening in the elderly's suicidal thought.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.19 no.2
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• pp.150-161
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• 2012

Purpose: This study was performed to investigate the influencing factors of cognitive function and depression in elderly. Method: From 3 provinces, 282 elders who resided in community and facilities completed structured questionnaires, including cognitive functions, depression, self-esteem, ADL, and IADL. Data were analyzed by applying ${\chi}^2$-test, ANOVA, partial correlation coefficient, and stepwise multiple regression analysis with SAS 8.12. Results: Community dwelling aged people showed higher scores in MMSE-K, self-esteem, ADL and IADL, and showed lower scores in depression than facility elders. MMSE-K was positively correlated in self-esteem, ADL, and personal cognition of health, except depression. Major factors that affect cognitive function of elderly were residual type, age, and IADL. In addition, major factors that affect depression of elderly were self-esteem, personal cognition of health, and marital status. Conclusions: Based on the results above, it is necessary to identify the status of cognition and depression in the elderly, and to develop nursing intervention programs, which improve cognitive function and reduce depression for aged, especially for the facility admitted aged.

• Anxiety and mood
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• v.12 no.1
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• pp.1-6
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• 2016

Objective : This study was performed to confirm the hypothesis that the more one applies positive thinking, the less severe the symptoms of stress and the better the therapeutic responsein panic disorder and major depressive disorders. Methods : The study included 50 subjects with confirmed diagnoses of panic disorder or major depressive disorders. Positive thinking was assessed using Positive thinking scale. Beck Depression Inventory was used as a subjective measure for depression, and to ensure an objective measure for depression and anxiety, the Hamilton Depression and Hamilton Anxiety rating scales were implemented. Results : The positive thinking scale measured at the initial visit had shown a strong negative correlation with objective depression. Although patients with a high level of positive thinking had shown a tendency to respond better to the treatment, as compared with those with a lower level, the differences were not statistically significant. Conclusion : Positive thinking is likely to ameliorate major depressive disorder, panic disorder-induced depression, and anxiety. Nevertheless, it was not possible to confirm the effects of positive thinking on the patients' treatment responses.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.17-30
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• 1994

Several different classes of antidepressants(ADs) with newer drugs becoming available have been used for the phamacological management of a broad spectrum of mental disorders, among which depressive disorder is most commonly indicated. Successful clinical use of ADs requires a complete understanding of the psychopharmacological properties of ADs and on accurate knowledge of patients, characteristics based on clinical experience and theoretical framework. This paper aims at providing some practical information on the clinical use of ADs to assist clinicians in treating patients with major depression. The author describes (1) different classes of ADs and their presumed mechanisms of action, (2) clinical characteristics of ADs focusing on side-effect profiles, (3) some issues arising during the treatment course such as : a) pretreatment tasks, b) choice of ADs, c) therapeutic drug dose and monitoring of drug concentration, d) three stages of treatment and e) strategies in refractory depression and (4) ADs in special patient groups.

• Archives of Obesity and Metabolism
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• v.1 no.1
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• pp.39-42
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• 2022

Obesity is a chronic disease associated with severe complications. A major complication of obesity is depression, which can worsen obesity and vice versa. In addition, most antidepressants or antipsychotics cause weight gain, and the relationship between obesity and depression is clinically critical. However, treatment of obese patients with major depressive disorder is complicated. Bariatric physicians should provide appropriate behavioral interventions alongside pharmacological treatment, considering psychiatric symptoms, drug side effects, and drug interactions. Two successful cases of moderate-to-severe obese patients with major depressive disorder who had been treated for obesity using behavioral intervention therapy along with liraglutide will be discussed. This report highlights the safety and efficacy of liraglutide treatment of obesity in patients with depression who take antidepressants and antipsychotics.