• IMMUNE NETWORK
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• 제16권1호
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• pp.52-60
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• 2016

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of their maturation and effector functions. Furthermore, DCs take up and process antigens as a form of peptide loaded on the major histocompatibility complex (MHC) and present them to T cells, which are responsible for the adaptive immune response. Conversely, DCs can also play a role in inducing immune suppression under specific circumstances. From this perspective, the role of DCs is related to tolerance rather than immunity. Immunologists refer to these special DCs as tolerogenic DCs (tolDCs). However, the definition of tolDCs is controversial, and there is limited information on their development and characteristics. In this review, we discuss the current concept of tolDCs, cutting-edge methods for generating tolDCs in vitro, and future applications of tolDCs, including clinical use.

• 무역학회지
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• 제46권5호
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• pp.13-30
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• 2021

The government of Vladimir Putin, which has been ruling Russia for a long period since 2000, has recently strived for the balanced development of underdeveloped regions and sustainable economic growth. Therefore, along with energy development in the Far East and Siberian regions, the government is promoting development projects on logistics and distribution infrastructure. It is also expanding the construction of innovative districts to develop cutting-edge technologies in the outskirts of Moscow. Amid these moves, South Korea is pushing for the New Northern Policy aimed at widening economic cooperation with European and North Asian countries to expand the scope and influence of the country's trade market. The previous year of 2020, marked the 30th anniversary of establishment of diplomatic relations between South Korea and Russia. In this context, this study was initiated to propose various measures for promoting economic cooperation and expanding trade between South Korea and Russia. Therefore, this study examined Russia's political and economic environment and explored its major industrial environment with a focus on the energy industry, innovative districts and infra facility. The study also examined the progress of a FTA between the Eurasian Economic Union, in which Russia currently takes the lead, and South Korea and recommended several measures to upgrade and accelerate economic cooperation between the two countries through research on a range of topics.

• 한국엔터테인먼트산업학회논문지
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• 제13권3호
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• pp.333-342
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• 2019

본 연구의 목적은 CJ CGV, 롯데시네마, 메가박스의 멀티플렉스 영화산업에 관한 사례를 비교분석하여 경영전략관점에서 CJ CGV만의 혁신적인 핵심역량이 무엇인지 연구하는 데 있다. 이를 통해, 컬쳐플렉스의 확대과정을 바탕으로 주요 성공요소가 무엇인지 도출하고자 핵심역량 전략인 VRIO(Value, Rareness, Inimitability, Organization)모델 분석하였다. 분석결과, CJ CGV의 차별화된 가치로는 영화관의 문화놀이터인 컬쳐플렉스이고, 희소성에서는 영화관의 기술적 혁신을 통한 종합생활문화공간으로의 변신이며, 모방불가능성에는 사회공헌으로써 CGV의 사회적 브랜드파워 확립하였으며, 조직화하는데 전 세계의 CGV 글러벌화 등이 CJ CGV의 핵심역량으로 나왔음을 알 수 있다. 기존 영화관의 활용도를 넓혀 파격적이고 혁신적인 개발에 앞장서 CJ CGV는 문화 체험영화관의 브랜드 가치를 높이고 고객의 만족도를 높이는데 기여하고 있다. CJ CGV는 끊임없는 경쟁 지배력을 높여 CGV만의 핵심역량 기업 가치를 상승시키고 있는 것이다.

• 국제초고층학회논문집
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• 제6권3호
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• pp.261-269
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• 2017

Designed by star architect of Moshes Safdie, Raffles City Chongqing includes a total of 6 mega high-rise towers 250 to 380 m tall, a sky conservatory, a 5-storey high shopping mall and a 3-storey basement car parking. Located at the confluence of the Yangtze and Jailing Rivers, the site for the project is imbued with a significance that is immediately symbolic, both as a sign of Chongqing's important past and as a vivid indicator of the city's thriving present and future. The design for the project to be situated at this gateway takes as its governing idea the image of powerful sails upon the water. The outer facades of the project's eight towers - the transparent surfaces that will face the water to the north - are meant to recall a fleet of ancient Chinese ships, with their huge rectangles of white canvas filled by the wind. This is a $1.13million\;m^2$ mega scale integrated project of office, retail, hotel, service residence and high-end residence with the transportation hub and traffic circulation at various levels of the project. This paper presents the multi-dimensional hybrid design, engineering and construction of this mega scale project. The innovations and the cutting-edge technology used in this project are introduced and discussed benchmarking the design and construction of the skyscraper cluster in a major city like Chongqing of China.

• 융합보안논문지
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• 제15권3_2호
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• pp.77-82
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• 2015

IT 융합은 IT의 자체 고도화를 바탕으로 다른 분야의 기술개발과 산업발전을 견인하거나 새로운 산업창출을 목표로 국가전략적 차원에서 접근을 하고 있으며 연구자원을 집중 투자하고 있다. 이에 IT 융합은 주력산업을 고부가가치화하고, IT 신산업을 창출할 뿐만 아니라, 범부처적으로 추진하는 신성장동력 육성에 기여하는 첨단융합 산업분야로 부상하게 되었다. 건강관련 융합서비스는 기존의 질병 예방과 관리 중심의 치료기술 산업에서 운동/스포츠 및 재활 중심의 엔터테인먼트체험 산업으로 확장되는 추세이다. 따라서 본 논문에서는 IT 융합에 대하여 그 중요성을 지니는 것만큼 건강운동과 관련된 IT 융합기술개발 동향을 파악하고 기존에 진행되었던 주요 기술개발과 융합산업 발전을 위한 방향에 관한 제언을 하고자 한다.

• BMB Reports
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• 제43권6호
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• pp.383-388
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• 2010

The number of cancer patients has increased due to longer life spans and treatment has become a universal problem. Since molecular-targeted therapies were introduced as a new developmental strategy, certain targets have been examined hundreds of times, with developers overlapping their research efforts. We need to focus our energy and resources on novel drug candidate identification and optimization, in order to enhance the entry of early-stage drug candidates into the therapeutics pipeline. This presents a major opportunity for Korea to jump the decades-old development gap between our programs and those that are more advanced in other countries. Although this country does not have a specific center for validation and development of cancer therapeutics, we do have cutting-edge scientists performing research in many institutions. In this paper, I will review cancer drug development in Korea and suggest future directions, while urging colleagues to utilize their networking expertise so we can move toward a new paradigm of novel therapeutics development. An example of such efforts has begun with the Drug Development Consortium, which was described in the KSBMB chapter. This consortium was launched in 2010 by biochemists, chemists, cell and molecular biologists and pharmacologists. It is clear that effective cancer therapeutics will be developed more efficiently when we all strive for the same goal.

• 복식문화연구
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• 제7권5호
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• pp.122-139
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• 1999

Paco Rabanne, who has created experimental and prophetic avant-garde fashion by cutting edge techniques and revolutionary new materials, is known as one of the most influential fashion designer of modern times. The purpose of this study is to analyze the various factors, including some major artistic movements, which influenced on the formative characteristics of Paco Rabanne\`s fashion design. First, Paco Rabanne\`s fantastic new materials is also influenced by his study in architecture and his own fantasies -which other people can hardly imagine- during his early childhood. Second, light one of the most important element in Paco Ranbanne\`s fashion design, shows some influence of medieval symbols of love and salvation. Third, the artistic trends which influenced on Paco Rabanne\`s fashion include surrealism, opart, and kinetic art. His use of new materials and avant -garde style represents the influence of surrealism. his experimental use of waving plastics and glittering metal during his early period is especially related with opart and kinetic art in the early 1960s which emphasize the artistic effect of light and movement. Fourth, the geometrical figures like triangles, rectangles, and circles represent the influence of Egyptian architecture like pyramids and the geometrical characteristics of Eguptian art. Fifth, Paco Rabanne\`s distinctive use of metal chains in his fashion shows the influence of the chain mail hauberk, the medieval knightly armour. By using the medieval material Paco Rabanne properly expressed the modern person\`s pain and suffering. Sixth, the ethnic elements of Egypt, Africa, Spain, and Japan reflect the experience in his former lives he insists he lived. The ethnic elements of his dresses emphasize the natural vitality and inheritance from the past.

• 농업과학연구
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• 제44권3호
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• pp.318-324
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• 2017

With the development of next-generation sequencing (NGS), a cutting-edge technology, genotype-by-sequencing (GBS) became available at a low cost per sample. GBS makes it possible to customize the process of library preparation to obtain high-quality single nucleotide polymorphisms (SNPs) in the most efficient way. However, a GBS library is hard to construct due to fine-tuning of concentration of each reagent and set-up. The major reason for this is the presence of undigested genomic DNA (gDNA) owing to the efficiency of different restriction enzymes for different species with unknown reasons. Therefore, this proof-concept study is to demonstrate the unpredictable patterns of enzyme digestion from various plants in order to make the reader aware of the caution needed when choosing restriction enzymes for their GBS library preparations. Indeed, no pattern was found for the digestibility of gDNA samples and restriction enzymes in the current study. We suggest that more data should be accumulated on this matter to help researchers who want to apply GBS technologies in a variety of genetic approaches.

• 정보처리학회논문지D
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• 제17D권1호
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• pp.67-76
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• 2010

CRM 시스템 도입이 성공하지 못했다는 회의론으로 인해 막대한 IT투자에 대한 비관론이 대두되어 왔다. 그럼에도 불구하고, 많은 기업들이 향후 CRM에 대한 신규 및 추가적인 투자를 계획하고 있는 기이한 현상이 벌어지고 있다. 하지만, 조직의 사업목표 달성에 있어서 CRM의 실질적인 역할이나 효과의 명확한 규명을 위한 연구는 미미한 실정이다. 본 연구의 목적은 CRM시스템을 도입하고 활용하여 사업목적을 달성하기까지의 과정 (CRM Chain Reaction)을 파악하여 연구모형을 설정하고, CRM이 사업목적 달성에 있어서의 역할과 효과를 제시하는데 있다. 본 논문의 연구결과는 CRM시스템 실행으로 향상된 정보 활용 역량과 경쟁역량이 CRM 전략성과를 유도하고, 이는 결국 재무적 성과를 충족한다는 의미를 함축하고 있다.

• International Journal of Computer Science & Network Security
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• 제21권8호
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• pp.196-202
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• 2021

DNA sequencing provides fundamental data in genomics, bioinformatics, biology and many other research areas. With the emergent evolution in DNA sequencing technology, a massive amount of genomic data is produced every day, mainly DNA sequences, craving for more storage and bandwidth. Unfortunately, managing, analyzing and specifically storing these large amounts of data become a major scientific challenge for bioinformatics. Those large volumes of data also require a fast transmission, effective storage, superior functionality and provision of quick access to any record. Data storage costs have a considerable proportion of total cost in the formation and analysis of DNA sequences. In particular, there is a need of highly control of disk storage capacity of DNA sequences but the standard compression techniques unsuccessful to compress these sequences. Several specialized techniques were introduced for this purpose. Therefore, to overcome all these above challenges, lossless compression techniques have become necessary. In this paper, it is described a new DNA compression mechanism of pattern matching extended Compression algorithm that read the input sequence as segments and find the matching pattern and store it in a permanent or temporary table based on number of bases. The remaining unmatched sequence is been converted into the binary form and then it is been grouped into binary bits i.e. of seven bits and gain these bits are been converted into an ASCII form. Finally, the proposed algorithm dynamically calculates the compression ratio. Thus the results show that pattern matching extended Compression algorithm outperforms cutting-edge compressors and proves its efficiency in terms of compression ratio regardless of the file size of the data.