• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.659-664
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• 2008

The Railroad Safety Act's regulation reads as follows. "The Minister of Construction and Transportation may qualify and authorize the product to guarantee performance and safety of parts, machine, and device used in Railway fields." Another regulation reads as follows."“The guidelines about targets, standards, and procedures of Quality and Authority in first provision are decided as Ministry of Construction and Transportation Decree." The software used in rail cars and facilities is considered as a railway product. Therefore, it is qualified and authorized for acquiring the safety of rail cars and facilities. The software businesses shall again a Quality and Authority for applying a software to the rail cars and facilities. This paper regulates some guidelines that are needed to develop a software. The procedures that a software developer performs are divided by plan, requirement, design, implementation, and maintenance. The procedures that a software verification person performs are classified by verification plan, requirement verification, design verification, implementation verification, testing verification, maintenance verification, and safety activity. The entire processes and detailed activities to develope and verify a software are described as new guidelines.

• Molecules and Cells
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• 제43권2호
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• pp.198-202
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• 2020

Comprehensive inhibition of RUNX1, RUNX2, and RUNX3 led to marked cell suppression compared with inhibition of RUNX1 alone, clarifying that the RUNX family members are important for proliferation and maintenance of diverse cancers, and "cluster regulation of RUNX (CROX)" is a very effective strategy to suppress cancer cells. Recent studies reported by us and other groups suggested that wild-type RUNX1 is needed for survival and proliferation of certain types of leukemia, lung cancer, gastric cancer, etc. and for their one of metastatic target sites such as born marrow endothelial niche, suggesting that RUNX1 often functions oncogenic manners in cancer cells. In this review, we describe the significance and paradoxical requirement of RUNX1 tumor suppressor in leukemia and even solid cancers based on recent our findings such as "genetic compensation of RUNX family transcription factors (the compensation mechanism for the total level of RUNX family protein expression)", "RUNX1 inhibition-induced inhibitory effects on leukemia cells and on solid cancers through p53 activation", and "autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells". Taken together, these findings identify a crucial role for the RUNX cluster in the maintenance and progression of cancers and suggest that modulation of the RUNX cluster using the pyrrole-imidazole polyamide gene-switch technology is a potential novel therapeutic approach to control cancers.

• 한국산업융합학회 논문집
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• 제26권4_2호
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• pp.649-656
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• 2023

Recently, global warming has become severe, and regulation is established for carbon savings each field. its regulation is applied to various fields using IC engine such as automobile, ship, agricultural machine. Therefore engine block applied Common Rail Direct Injection(CRDI) technology, that carry out thermal-structure analysis to examine design. The thermal load about 900℃ by explosion was applied in cylinder. And pressure about 9 MPa(90 Bar) was applied to structure analysis. As a result, it was the highest at 185.99℃ at the top of cylinder. Static-structure analysis applied thermal load, that was shown maximum equivalent stress at 142.59 Mpa and Maximum principal stress 145.03 MPa, Minimum principal stress -149 MPa. When compare analysis results to material property, it design is safety structurally.

• 한국건축시공학회지
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• 제22권6호
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• pp.673-680
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• 2022

모듈러 건축은 시공 기간의 단축, 건축비용 절감 등의 여러 가지 장점에도 불구하고 국내 건설시장에서 좀처럼 탄력을 받지 못하고 있다. 이러한 원인에는 모듈러 내화 기술 적용의 한계도 있으나 무엇보다 내화구조 제도에 대한 접근성이 쉽지 않은 것이 주요 요인으로 간주되고 있다. 따라서 모듈러 건축 활성화를 위해 주요 저해요인인 내화구조 제도 현황과 문제점에 대해 고찰하였으며, 내화구조 제도적 개선 및 연구개발 방향에 대해 제시하고자 한다.

• 한국동물생명공학회지
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• 제38권3호
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• pp.89-98
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• 2023

Background: The regulation of maternal immunity is critical for the establishment and maintenance of successful pregnancy. Among many cell types regulating the immune system, innate lymphoid cells (ILCs) are known to play an important role in innate immunity. Although some reports show that ILCs are present at the maternalconceptus interface in humans and mice, the expression and function of ILCs in the endometrium have not been studied in pigs. Methods: Thus, we determined the expression, localization, and regulation of ILC markers, CD127 (a common marker for ILCs), BCL11B (a ILC2 marker), and RORC (a ILC3 marker) at the maternal-conceptus interface in pigs. Results: The expression of BCL11B and RORC, but not CD127, in the endometrium changed during pregnancy in a stage-specific manner and the expression of CD127, BCL11B, and RORC was greatest on Day 15 during pregnancy. CD127, BCL11B, and RORC were also expressed in conceptus tissues during early pregnancy and in chorioallantoic tissues during the later stage of pregnancy. BCL11B and RORC proteins were localized to specific cells in endometrial stroma. The expression of CD127 and BCL11B, but not RORC, was increased by the increasing doses of interferon-γ (IFNG) in endometrial explants. Conclusions: These results suggest that ILCs present at the maternal-conceptus interface may play a role in the establishment and maintenance of pregnancy by regulating the innate immunity in pigs.

• 한국항공운항학회지
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• 제30권4호
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• pp.33-44
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• 2022

As the majority of Korean MRO demand is outsourced overseas, AMO by major foreign authorities is required to promote the Korean MRO industry to keep Korean MRO demand on shore. This study aims to promote consulting for AMO (obtaining repair station certification) by U.S. Federal Aviation Administration (FAA) for Korean maintenance companies. We analyzed AMO process, studied various industry cases, developed a model for AMO consulting, and identified core competencies for consultants. We suggested a five-step modified Milan model to apply AMO consulting process. We identified seven core competencies (ethics, communications, problem-solving, technical, relationship, resource management, organizational understanding) both social and technical for consultants. Additionally, we text analyzed more than 260 FAA AMO consultant resumes on Linkedin and interpreted frequent words (airline, audit, inspector, DER, regulation, ISO, system) to their competencies. This study contributes to promote consulting for the Korean MRO industry to be recognized by FAA and to develop the Korean MRO industry.

• 한방비만학회지
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• 제19권2호
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• pp.119-136
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• 2019

Objectives: People often fail to maintain their weight even though they have succeeded in weight loss. The purpose of this study was to review previously published study results with regards to the predictive factors associated with weight loss maintenance after successful weight loss. Methods: The authors searched for the articles related to weight loss maintenance after successful weight loss, published up until June 2019 on PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, Research Information Sharing Service (RISS), and Koreanstudies Information Service System (KISS). A total of 76 articles were finally selected. From the study results, changeable and unchangeable predictors were extracted, and these predictors were examined according to detailed categories. Results: The changeable predictors of weight loss maintenance included behavioral factors, psychological factors and treatment process-related factors, whereas the unchangeable predictors included genetic and physiological factors, demographic factors, history of treatment on obesity-related factors. The main factors of weight loss maintenance were changeable predictors such as healthy eating habits, dietary intake control, binge eating control, regular exercise and physical activity, depression and stress control, social supports, self-regulation, self-weighing and initial weight loss and unchangeable predictors such as low initial weight and maximum lifetime weight. Conclusions: The results of our review results suggest that changeable and unchangeable predictors of weight loss maintenance should be carefully examined during treatments of obesity.

• 대한토목학회논문집
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• 제34권6호
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• pp.1901-1910
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• 2014

현재 국내외 BIM을 도입한 사회기반시설 적용 사례는 BIM 시각화를 기반으로 하는 설계 및 시공단계에 제한되며 효율적 운영을 위한 설계, 시공 정보 활용 방안에 대한 연구는 매우 미미하다. 본 연구는 최근 국내 경제 발전에 많은 기여를 하고 있는 산업설비군 중 운영 및 유지관리 능력 향상이 필요한 하수처리시설을 대상으로 BIM 기반 통합 유지관리 프로토타입 시스템을 개발하였다. 본 연구에 사용된 주요 연구 방법으로는 시스템 개발 순서에 따라 진행하였으며, 최종적으로 개발된 프로토타입 시스템의 현업 적용 가능성을 판단하기 위하여 4가지의 대표적 유지관리 시나리오를 제안하고 산출물을 통해서 문제 해결이 가능함을 보여준다. 최근 상하수도시설의 자산관리 개념 도입 노력과 유역기반 운영 및 유지관리의 정책 및 제도 적 변화, 그리고 국내 상하수도 기술력의 해외시장 진출 필요에 따른 운영 및 유지관리 능력 고도화를 위해 본 연구결과가 일조할 수 있기를 기대해 본다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 춘계학술대회 논문집
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• pp.1092-1096
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• 2011

The "standard regulation" of the vehicles from "urban transit law" are being adopted to electric multiple unit in domestic. In the standard regulation, there are two types for EMU. One is heavy EMU for Seoul. The other is large EMU for Pusan, Daegu, Gwangju, Daejeon, Incheon. Korea Railroad Research Institute, with the assistance of the Ministry of Land, Transport and Maritime Affairs, "advanced EMU development project" are progressed, and 6th year started at September, one unit to six cars is completed. Now "urban transit vehicle performance tests are on the current progress. The main characteristics of AUTS(Advanced Urban Transit System) are as follows. One inverter control one motor, DDM(Dircet Drive Motor), no driving gear, plug door and steps, mounting and maintenance costs down, passenger convenience improvement. This paper describes the key features the next generation EMU, and performance test results, and the commercial success method of national R&D business.

• 아동학회지
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• 제22권3호
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• pp.31-48
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• 2001

This study was designed to examine various patterns of developmental change in children's recall, strategic behaviors, and meta-memory with a sort-recall task in relation to utilization deficiencies. Memory tasks consisting of 18 pictures were presented individually to 48 seven-year-old children in each of 7 sessions. Sessions 1 and 2 were baseline; Sessions 3 and 4 were for strategy training, including the organization group, the self-regulation group, the organization/self-regulation group and control group. Sessions 5, 6, and 7 were unprompted tests of strategy maintenance. Results showed significant differences between the 4 groups in their recall, strategy repertories and strategy evaluation. Findings were discussed in terms of the analysis of memory strategy and memory development.