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Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty

  • Kim, Eun Young
    • Clinical and Experimental Pediatrics
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    • v.58 no.1
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    • pp.1-7
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    • 2015
  • Gonadotropin-releasing hormone analogs (GnRHa) are widely used to treat central precocious puberty (CPP). The efficacy and safety of GnRHa treatment are known, but concerns regarding long-term complications are increasing. Follow-up observation results after GnRHa treatment cessation in female CPP patients up to adulthood showed that treatment (especially <6 years) was beneficial for final adult height relative to that of pretreated or untreated patients. Puberty was recovered within 1 year after GnRHa treatment discontinuation, and there were no abnormalities in reproductive function. CPP patients had a relatively high body mass index (BMI) at the time of CPP diagnosis, but BMI standard deviation score maintenance during GnRHa treatment seemed to prevent the aggravation of obesity in many cases. Bone mineral density decreases during GnRHa treatment but recovers to normal afterwards, and peak bone mass formation through bone mineral accretion during puberty is not affected. Recent studies reported a high prevalence of polycystic ovarian syndrome in CPP patients after GnRHa treatment, but it remains unclear whether the cause is the reproductive mechanism of CPP or GnRHa treatment itself. Studies of the psychosocial effects on CPP patients after GnRHa treatment are very limited. Some studies have reported decreases in psychosocial problems after GnRHa treatment. Overall, GnRHa seems effective and safe for CPP patients, based on long-term follow-up studies. There have been only a few long-term studies on GnRHa treatment in CPP patients in Korea; therefore, additional long-term follow-up investigations are needed to establish the efficacy and safety of GnRHa in the Korean population.

Productivity Changes by Public Transport Reforms in the Seoul's Urban Bus Industry (서울의 대중교통체계 개편에 따른 시내버스업체의 생산성 변화)

  • Oh, Mi-Young;Kim, Sung-Soo
    • Journal of Korean Society of Transportation
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    • v.23 no.7 s.85
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    • pp.53-61
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    • 2005
  • The Seoul City Government recently reformed the entire public transport system in an effort to prevent further deterioration in urban bus system's performance and service level. To analyze into impact on the productivity of Seoul's urban bus firms, this paper measures firm-level technical efficiency and productivity change with data envelopment analysis and Malmquist index approach. The paper then conceptualizes that these forms produce three kinds of output (bus-kilometers, passengers, or bus-kilometers and passengers) using five inputs (driver, maintenance, management, vehicle and fuel). The findings show that most (over one half) firms experienced a decline (an improvement) in productivity in the case of specifying only bus-kilometers (passengers) as output. As a result, it is discovered that an average firm had no change in productivity in the case of combining bus-kilometers and passengers as output. This is because the efficiency of an average firm declined due to increase in employees per bus and to an decrease in kilometers per bus. while its effectiveness improved due to an increase in passengers per bus which was caused by an increase in routes and a change in fare structure.

The Dietary Characteristics of Middle-aged People by BMI and food Habits (체질량 지수와 식습관에 따른 중 .장년층의 식생활 특성)

  • 박지연;구난숙
    • Korean Journal of Community Nutrition
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    • v.6 no.1
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    • pp.43-50
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    • 2001
  • This study was conducted to compare the dietary characteristics of middle-aged people with different obesity index or food habits. Questionnaires were collected from 480 subjects in Daejon. The data were analyzed by $X^2$-test and ANOVA. The subjects were distributed into the normal weight group(66.3%), overweight group(18.3%) and underweight(15.4%) based on BMI. Twenty-five percent of males and 23.0% of females in the 50's belonged to the overweight group. The least consumed food was milk or milk products among the five basic food groups. The frequency of exercise was low in their daily life. The had better food habits than the males. The overweight group had worse food habits than the normal weight or underweight group. The underweight group ate light meal and ate slowly. The better the subjects had, the more regularly they took breakfast(p<0.001). The good food habits group were more interested in their dietary life and were more careful in selecting foods for their health than the bad food habits group(p<0.001). Based on the results of this study, the practical education programs should be focused on more intake of milk or products and on daily exercise for the self-health maintenance of middle-aged people. Also, proper education programs should be developed for males and females in their 50's to practice weight control and regularity of meals in their life, and to utilize nutrition knowledge in dietary life. Further research on the comparision of dietary characteristics are needed with consideration of the subjects ratio according to BMI.

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Soybean Wastewater Treatment by Activated Sludge Process (고농도 대두가공폐수의 처리를 위한 개선 활성슬러지법)

  • Cho, Kwon-Ik;Lee, Jeoung-Su;Lee, Tae-Kyoo;Kim, Jong-Hwa
    • Applied Biological Chemistry
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    • v.45 no.1
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    • pp.25-29
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    • 2002
  • The kernel of wastewater treatment by activated sludge is elimination of organic substances and maintenance of well-flocculated sludge sedimentation. By the conventional activated sludge treatment, the optimum F/M ratio of soybean wastewater treatment was 0.24 (kg-BOD/kg-MLVSS day) and sludge bulking was generated at 0.48 (kg-BOD/kg-MLVSS day). To improve the treatment capacity and operation quality in higher loading of soybean wastewater, influent pH was constantly controlled by 9.0 using NaOH as a coagulant agent. In this process, higher loading up to 2.88 (kg-BOD/kg-MLVSS day) was possible and SVI was maintained under 150 without bulking. This was equivalent to 7.2 times higher than maximum permissible load of the conventional activated sludge process.

Analyses on the Factors Related to Stages of Dietary Behavioral Changes among Child Bearing Aged Women (가임여성에서 식행동 변화단계에 따른 식생활 요인 분석)

  • 권성옥;오세영
    • Journal of Nutrition and Health
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    • v.36 no.7
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    • pp.759-768
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    • 2003
  • This study examined the factors related to stages of dietary behavioral changes among 1449 child bearing aged women (mean age $\pm$ SD = 25.6 $\pm$ 5.3 years) residing in large cities. A self administered questionnaire was used to assess stages of dietary behavioral change, meal balance and regularity, food availability, nutrition knowledge, body mass index, nutrient intake, and psycho-social factors including self efficacy, perceived benefits and barriers, social modeling. Undesirable dietary behaviors (precontemplation and contemplation) were shown among 45.1-57.4% of the participants, among those, 33.4-43.0% were precontemplators. Participants' self efficacy scores associated with dietary changes were higher in specific situations (3.42) as compared to general situations (2.86). Similarly, they appeared to perceive more benefits (3.86) rather than barriers (2.76) by changing their inappropriate eating habits. Perception and accuracy scores of nutrition knowledge were relatively high, indicating 90.9 and 80.1, respectively. In terms of food availability at home, fresh fruits received the highest score, followed by milk and milk products, vegetables, meat, alcoholic beverages and soft drinks. In social modeling assessment, family members, as compared to friends, appeared to have better dietary habits. Stages of dietary behavioral change assessed in terms of meal regularity were associated with nutrient intake, showing higher energy and carbohydrate intakes but lower fat intake among those who belonged to the action and maintenance stage. They also presented higher self efficacy and perceived more benefits and less barriers regarding the change of undesirable eating habits. Fresh meat and vegetables were more available among those maintaining desirable dietary habits. Results of this study presented the significant relations of motivational and reinforcing social factors with stages of dietary behavioral changes and a need for the development of tailored nutrition education program considering these factors for child-bearing aged Korean women.

Effects of calcium intake, milk and dairy product intake, and blood vitamin D level on osteoporosis risk in Korean adults: analysis of the 2008 and 2009 Korea National Health and Nutrition Examination Survey

  • Hong, Heeok;Kim, Eun-Kyung;Lee, Jung-Sug
    • Nutrition Research and Practice
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    • v.7 no.5
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    • pp.409-417
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    • 2013
  • This study was performed to determine the effects of dietary calcium (Ca) intake, milk and dairy product intake, and serum vitamin D level on bone mineral density. The survey data from the 2008-2009 Korea National Health and Nutrition Examination Survey (KNHANES) for adults (3,819 males, 5,625 females) aged > 20 years were examined; osteoporosis was defined according to the standards for Asian populations (T-score < -2.5). The risk for osteoporosis significantly decreased as Ca intake increased; this effect persisted (quartile 4 vs. quartile 1 of Ca intake: odds ratio [OR] 0.66; 95% confidence interval [CI]: 0.50-0.87) even after adjustment for gender, age, and other factors (body mass index, serum vitamin D, menstruation, female hormone intake, menopausal status, and the number of days per week of muscular strength exercise). Additionally, the risk for osteoporosis significantly decreased as the Ca/P ratio increased (quartile 4 vs. quartile 1: OR 0.76; 95% CI: 0.58-0.98). The degree of risk was 0.96 (0.66-1.38) in those who consumed < 1 portion of milk or dairy products daily, and 0.71 (0.53-0.96) in those who consumed > 1 portion per day, compared with those who had zero intake. The risk for osteoporosis significantly decreased as the serum 25(OH) vitamin D level increased. From these results, we advocate an increase in Ca, milk, and dairy product intake, and that serum 25(OH) vitamin D levels be maintained within the normal range, for the maintenance of bone health and the prevention of osteoporosis in adults.

Extended R-Tree with Grid Filter for Efficient Filtering (효율적인 여과를 위한 그리드 필터를 갖는 R-Tree 의 확장)

  • 김재흥
    • Spatial Information Research
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    • v.8 no.1
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    • pp.155-170
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    • 2000
  • When we use R-Tree,a spatial index, to find objects matches some predicate, it often leads to an incorrect result of perform filtering step only with MBR. And , each candidates need to be inspected to conform if it really satisfies with given query, so called, 'refinement step'. In refinement step. we should perform disk I/O and expansive spatial operations which is the cause of increasing retrieval costs. Therefore, to minimize the number of candidate after filtering step, two-phase filtering methods were studied, but there was many problems such as inefficiency of filtering,maintenance of additional informations and reconstruction of data resulted from the loss of original information. So , in this paper, I propose an Extended R-Tree which provides ability to retrieve spatial objects only with some simple logical operations using Grid Table, truth table strong the information about the existence of spatial objects, in second filtering step. Consequently , this Extended R-Tree using Grid Filter has low cost of operation for filtering because of efficient second filtering step, and better filtering efficiency caused by high quality of approximation.

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Mobile Client-Server System for Realtime Continuous Query of Moving Objects (이동 객체의 실시간 연속 질의를 위한 모바일 클라이언트-서버 시스템)

  • Joo, Hae-Jong;Park, young-Bae;Choi, Chang-Hoon
    • Journal of the Korea Society of Computer and Information
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    • v.11 no.6 s.44
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    • pp.289-298
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    • 2006
  • Many researches are going on with regard to issues and problems related to mobile database systems, which are caused by the weak connectivity of wireless networks, the mobility and the portability of mobile clients. Mobile computing satisfies user's demands for convenience and performance to use information at any time and in any place, but it has many problems to be solved in the aspect of data management. The purpose of our study is to design Mobile Continuous Query Processing System(MCQPS) to solve problems related to database hoarding, the maintenance of shared data consistency and the optimization of logging, which are caused by the weak connectivity and disconnection of wireless networks inherent in mobile database systems under mobile client server environments. We proved the superiority of the proposed MCQPS by comparing its performance to the C I S(Client-Intercept-Slaver) model. In Addition, we experiment on proposed index structure and methodology in various methods.

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Performance Measurement of ISO Quality Management System in the Construction Industry (건설산업 ISO 품질경영시스템의 성과측정에 관한 연구)

  • Lee Woo-Chang;Kim Kyung-Rai;Shin Dong-Woo
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2004.11a
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    • pp.414-418
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    • 2004
  • Quality system of construction industry in Korea was a means to prevent unqualified construction work. But lately, it has became an essential requirement. So, lots of construction companies acquire ISO quality management system which provides fundamental management criteria. Now, most of the Korean construction companies have got IS0 quality management system. So, getting ISO quality management system doesn't mean advantage in public competition of construction bidding and that causes increase in the maintenance cost. That's why some construction companies abandon the 150 certificate. Therefore, the authors need to check the effect of ISO quality management system. For this, the authors provide the performance measurement index of ISO quality management system.

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Prevalence and Risk Factors of Fatty Liver among Industrial Male Workers (산업장 남성 근로자의 지방간 유병율 및 위험요인 연구)

  • Paek, Yun-Mi;Choi, Tae-In;Kim, Yun-Jeong;Choi, Eun-Ok
    • The Korean Journal of Rehabilitation Nursing
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    • v.10 no.2
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    • pp.141-146
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    • 2007
  • Purpose: This study was conducted to estimate the prevalence rate, and related factors,of fatty liver in male industrial workers. Method: Fatty liver was diagnosed using ultrasonography. The data for abdominal ultrasonography, BMI, smoking, alcohol drinking, exercise, liver enzymes, and lipid profiles were collected in 4,604 male who were examined with a health screening program in 2005. Prevalence rate and associated factors of fatty liver were analyzed using SPSS v. 12.0. Results: Overall prevalence of fatty liver was 34.1% and higher in the 30-39 year male group. Age, body mass index(BMI), hypertriglyceridemia, hypercholesterolemia, HDL cholesterol, r-GTP level were independently associated factors with presence of fatty liver in logistic regression analysis. Conclusion: The prevalence of fatty liver and tendency of associated factors were similar to those in the western world. To prevent development of this hepatic disorder, which may result in end-stage liver disease, risk factors such as obesity and dyslipidemia must be monitored and controlled within normal levels. The results of this study suggested maintenance of a healthy lifestyle, including diet, exercise, and behavioral change, as fundamental rehabilitation nursing implications.

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