• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2002년도 생물공학의 동향 (X)
• /
• pp.381-384
• /
• 2002

Response surface methodology (RSM) was successfully applied to optimize for the production of Ganoderma lucidum in batch fermentations using the whey (40,000 mg latose/L) as substrate. This study was performed according to the central composite design (CCD) with respect to pH and temperature, where the designed intervals were 3.3$22.9^{\circ}C$$37.1^{\circ}C$, respectively. A second-order factorial design of the experiments was used to build empirical models providing a quantitative interpretation of the relationships between the two variables. The optimum conditions to maximize the production of G. lucidum were pH 4.2 and $28.3^{\circ}C$. At optimum conditions, the mycelial dry weight (MDW) and residual soluble COD (SCOD) were simultaneously used to evaluate the biokinetic coefficients assocoated with substrate inhibition model by nonlinear least squares method with 95% confidence interval. The. maximum microbial growth rates (${\mu}m$), half saturation coefficient ($K_s$), and the inhibition substrate concentration ($K_{is}$) were determined to be 0.095 l/hr, 128,000 mg SCOD/L and 49,000 mg SCOD/L, respectively. And the microbial yield coefficient (Y), biomass decay rate coefficient ($K_d$), and the maintenance energy coefficient ($m_s$) were determined to be 0.37 mg MDW/mg SCOD, 0.001 1/hr, and 0.0015 1/hr, respectively.

• 한국산학기술학회논문지
• /
• 제11권1호
• /
• pp.67-72
• /
• 2010

본 논문에서는 기존의 궤도회로(Track Circuit)를 이용하는 FBS의 설비측면에서 단락감도 및 선로변 설비(지상설비)의 규모에 따른 유지보수의 증가 등의 문제점을 극복하고, 차량간 간격을 근접시키기 위한 열차제어 개념인 MBS의 구현에 따른 무인운전기술의 가능성을 검증하였다. MBS에 의한 열차 운전은 중앙국에서 열차의 위치를 실시간으로 알 수 있어 선행열차의 정보를 후속열차에 직접 전달할 수 있으므로 시격(Headway)단축이 가능해지고 그에 따라 수송수요 증대와 불필요한 가.감속을 방지할 수 있다. 이와 더불어 지상설비를 대폭적으로 감소시킬 수 있으며, 승객서비스 향상 및 승차감 향상 등의 이점을 제공한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제46권4호
• /
• pp.220-227
• /
• 2020

Objectives: Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder. These patients lose their teeth at a young age and are in need of prosthetic rehabilitation. The aim of this systematic review was to assess the success of dental implant placement in these patients. Materials and Methods: An electronic search was performed in PubMed Central, Scopus, and Web of Science using the keyword "Papillon-Lefèvre syndrome" AND "dental implant" OR "prosthodontics". Articles reporting implant placement in patients with PLS until July 2019 were included. Results: Assessment of the included 11 articles reporting 15 cases showed 136 implant placements in these patients. Implant failure occurred in 3 patients (20 implants). The peri-implantitis and failure rate was higher in the maxilla. Meta-analysis showed the probability of failure to be 7% (95% confidence interval [CI] 0%-31%) for maxillary implants and 2% (95% CI 0%-9%) for mandibular implants. The follow-up time ranged between 1 and 20 years. Healing after bone graft and implant placement in these patients was uneventful. Conclusion: Dental implants may be a viable treatment option for PLS patients. Implantation can help preserve alveolar bone if the patients' immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued.

• 한국통신학회논문지
• /
• 제42권4호
• /
• pp.939-949
• /
• 2017

고장 예지 및 건전성 관리 기술(Prognostics and Health Management; PHM)은 시스템의 현재 상태를 진단하고 향후 발생 가능한 고장 시점을 신뢰성 있게 예지하는 기술로써 유지 보수 비용의 절감 및 시스템의 안정성 향상을 꾀하고자 하는 다양한 산업분야에서 활발하게 이용되고 있다. 스마트 그리드의 에너지 저장장치, 전기차, 스마트폰, 항공우주산업 등 광범위한 사용처에서 중요한 에너지원으로 사용되고 있는 배터리 또한 성능 저하 및 폭발의 위험성으로부터 자유로울 수 없기 때문에 이러한 고장 예지 및 건전성 관리 기술이 반드시 적용되어야 할 어플리케이션이다. 본 논문에서는 PHM의 기본적인 개념을 소개함과 동시에 배터리의 잔존 유효 수명(Remaining Useful Life; RUL)을 예측하는 각종 알고리즘 및 성능 평가 지표 서술에 초점을 맞추도록 한다. 더불어 배터리의 기능적 동작 원리 및 전기화학 기반의 모델링에 대한 설명을 통해 향후 잠재적인 가능성을 지닌 배터리의 전반적인 특성에 대한 깊은 이해 및 응용 기술에 대한 통찰력을 제시하고자 한다.

• 농업과학연구
• /
• 제45권2호
• /
• pp.283-289
• /
• 2018

Agricultural gear reducers are used in a variety of agricultural machinery designs such as in agricultural tractors and transport cars, and even greenhouses. For greenhouses, a gear reducer is used to control windows on the side and the roof. Gear reducers for agricultural applications are designed using the empirical method because of the lack of a standard for experimentation. Simulation is necessary for the optimal design of an agricultural gear reducer. There are many advantages to this optimization such as low-cost maintenance, reduced size, and weight. In this study, bending and contact safety factor simulation for the gear reducer of a greenhouse was conducted by decreasing the face widths of helical gear shaft 2 and shaft 3 from 30.8 and 30 mm, respectively, at an interval of 4 mm. The bending and contact safety factors were calculated using AGMA standard. Simulation results showed that bending and contact safety factors decreased rapidly when the face width of the helical gear on shaft 2 was 30 mm and the face width of helical gear on shaft 3 decreased from 30.8 mm to 26.8 mm, suggesting that it would be safe to reduce the face width of the helical gear on shaft 3 to 26.8 mm. The reduction of the face width also reduced the weight of the agricultural gear. This study suggests that the agricultural gear reducer safety factor decreases as the face width decreases.

• 대한장애인치과학회지
• /
• 제5권1호
• /
• pp.18-22
• /
• 2009

A 26-year-old female patient with Down syndrome visited to recieve dental treatment under gnenral anesthesia 6 years ago. The patient had difficulties in oral examination, radiograph taking and laboratory test. The patient had congenital heart disease and medical consultation based on the echocardiography was provided by a cardiologist indicating that the patient could tolearte general anesthesia during dental treatment. And two times of general anesthesia were administered during a dental treament with the interval of 3 years and no postoperpative complicaton was reported. At the third dental operation, the patient had a relatively good condition and her prescreening test revealed no abnormalities. Without further consultation with a cardiologist, general anesthesia was administered to the patient. Anaesthesia was based on thiopental and ventilation of desflurane and $N_2O$ in oxygen via an endotracheal tube with an appropriate monitoring. During the maintenance of anesthesia, the blood pressure of the patient started to drop and the oxygen saturation also began to decrease. Consequently, the proceding operation was discontinued and also inhalation anesthesia was ceased. As the patient was recovered from anesthesia, her systemic conditions were alleviated. After the complete recovery of the patient, she visited the cardiologist, and the cardiologic test revealed her severe right ventricular dilatation. In the anesthesia of patients with congenital heart disease, information on their systemic conditions needs to be undated from the medical consultation, which assures the safety of treatment.

• 한국철도학회논문집
• /
• 제16권2호
• /
• pp.110-116
• /
• 2013

궤도틀림은 철도차량의 주행안전성 및 승차감에 매우 큰 영향을 미치는 중요 인자 중 하나이다. 따라서, 차량의 주행안전성과 승차감의 확보를 위해서는 주행속도, 차량의 동적특성, 궤도틀림 검측차의 검측특성, 검측주기등을 고려하여 적정한 궤도틀림 기준을 설정하고, 관련 기준에 따라 궤도틀림을 철저히 관리하여야 한다. 본 논문에서는 궤도틀림 중에서 방향틀림이 KTX 차량의 거동에 미치는 영향을 조사하기 위하여 철도차량 동특성 해석프로그램인 VAMPIRE를 이용하여 방향틀림의 파장과 진폭에 대한 매개변수해석을 수행하였다. 방향틀림 크기와 파장에 따른 KTX의 탈선계수, 대차가속도, 차체가속도 및 궤도횡압 등의 주행거동을 조사하였으며, 방향틀림이 KTX차량의 주행안전성과 승차감에 미치는 영향을 분석하였다. 방향틀림은 차량주행안전성에 미치는 영향이 크며, KTX 주행안전성 확보를 위하여 방향틀림을 엄격하게 관리하여야 함을 알 수 있었다.

• Journal of Yeungnam Medical Science
• /
• 제35권1호
• /
• pp.54-62
• /
• 2018

Background: The type and regimen of anesthesia may affect perioperative hyperglycemia following major surgical stress. This study compared the effects of sevoflurane and propofol on the incidence of hyperglycemia and clinical outcomes in diabetic patients undergoing lung surgery. Methods: This retrospective study included 176 patients with type 2 diabetes mellitus who had undergone lung surgery. Blood glucose levels and clinical outcomes from the preoperative period to the first 2 postoperative days (PODs) were retrospectively examined in patients who received sevoflurane (group S, n= 87) and propofol (group P, n=89) for maintenance of general anesthesia. The primary endpoint was the incidence of persistent hyperglycemia (2 consecutive blood glucose levels >180 mg/dL [10.0 mmol/L]) during the perioperative period. The secondary composite endpoint was the incidence of major postoperative complications and 30-day mortality rate after surgery. Results: Blood glucose levels similarly increased from the preoperative period to the second POD in both groups (p=0.857). Although blood glucose levels at 2 hours after surgery were significantly lower in group P than in group S (p=0.022; 95% confidence interval for mean difference, -27.154 to -2.090), there was no difference in the incidence of persistent hyperglycemia during the perioperative period (group S, 70%; group P, 69%; p=0.816). The composite of major postoperative complications and all-cause in-hospital and 30-day mortality rates were also comparable between the two groups. Conclusion: Sevoflurane and propofol were associated with a comparable incidence of perioperative hyperglycemia and clinical outcomes in diabetic patients undergoing lung surgery.

• International Journal of Arrhythmia
• /
• 제18권2호
• /
• pp.66-76
• /
• 2017

Background and Objectives: Although an anterior linear ablation is an effective lesion set in radiofrequency catheter ablation (RFCA) for longstanding persistent atrial fibrillation (L-PeAF), its durability for bidirectional block (BDB) is only about 60% at repeat procedure. We hypothesized that changes in electrocardiogram (ECG) may predict an anterior line block state and the clinical outcome of L-PeAF ablation. Subjects and Methods: We studied 304 L-PeAF patients (77% male, $60{\pm}10yrs$), who consistently underwent RFCA Dallas lesion set (circumferential pulmonary vein isolation, posterior box lesion, and anterior line) protocol with subsequent comparison of pre-procedural and post-procedural P wave axes, and one year follow-up (n=205) sinus rhythm (SR) ECGs. Results: 1. P wave axis shifted inferiorly at immediate post-procedure (p<0.001), and was independently correlated with BDB of anterior line (${\ss}=10.4$, 95% confidence interval [CI] 2.79-17.94, p=0.008). 2. The degree of post-procedural inferior shift of P wave axis did not reflect clinical recurrence within one-year (n=205, p=0.923), potentially due to conduction recovery of an anterior line. However, among 160 patients without clinical recurrence within one-year, P wave axis at one-year ECG was independently associated with very late recurrence of AF after one-year (n=160, hazard ratio [HR] 0.98; 95% CI 0.97-0.99, p=0.001), during $45.6{\pm}16.7$ months of follow-up. 3. Among 22 patients who underwent repeat procedures, P wave axis shift was more significant in patients with maintained BDB of an anterior line than in those without (p=0.015). Conclusion: An inferior shift of P wave axis reflects the achievement and the maintenance of an anterior line BDB, and is associated with better long-term clinical outcome after catheter ablation for L-PeAF based on Dallas lesion set.

• 한국지반신소재학회논문집
• /
• 제20권4호
• /
• pp.113-124
• /
• 2021

도시화 및 경제성장에 따라 기존 매립지 등 기피 시설로 인식되어 있는 지상 환경기초시설 및 에너지생산 시설의 지하화가 중요한 사회적 이슈로 대두되고 있다. 대규모 플랜트 시설을 지하에 안전하게 건설하기 위해서는 제한적인 공간 레이아웃의 활용성을 높이고, 불필요한 기둥을 최소화해야 한다. 본 논문에서는 플랜트 시설을 지하화 할 경우 발생하는 작업의 제약여건, 조립 및 철거, 공정 계통의 연계성, 유지 보수 등의 문제를 해결하기 위하여 플랜트 모듈화 공법(파이프랙)에 대해 검토하였다. 복합플랜트의 지하 고집적 배치, 공간 레이아웃 활용성 향상 및 구조물 안정성 확보를 위해 다양한 하중조건(지진하중, 장치하중, 토압하중 등)을 적용한 플랜트 모듈 해석을 수행하였다. 또한, 작용하중과 부재가 견딜 수 있는 설계강도비 값을 검토하고 모듈 형상에 따른 안정성을 고려한 파이프랙 소재를 추출하였다. 다양한 경계조건에서의 해석 결과를 바탕으로 지하복합플랜트 건설 시 필요한 기본모듈의 최소 설치 간격 및 모듈 배치(안)에 관한 시사점을 도출하였다.