• BMB Reports
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• v.53 no.1
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• pp.56-63
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• 2020

The ubiquitin-proteasome system (UPS) and autophagy are two major degradative pathways of proteins in eukaryotic cells. As about 30% of newly synthesized proteins are known to be misfolded under normal cell conditions, the precise and timely operation of the UPS and autophagy to remove them as well as their tightly controlled regulation, is so important for proper cell function and survival. In the UPS, target proteins are labeled by small proteins called ubiquitin, which are then transported to the proteasome complex for degradation. Alternatively, many greatly damaged proteins are believed to be delivered to the lysosome for autophagic degradation. Although these autophagy and UPS pathways have not been considered to be directly related, many recent studies proposed their close link and dynamic interconversion. In this review, we'll focus on the several regulatory molecules that function in both UPS and autophagy and their crosstalk. Among the proposed multiple modulators, we will take a closer look at the so-called main connector of UPS-autophagy regulation, p62. Last, the functional role of p62 in the mitophagy and its implication for the pathogenesis of Parkinson's disease, one of the major neurodegenerative diseases, will be briefly reviewed.

• Structural Engineering and Mechanics
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• v.8 no.1
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• pp.85-102
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• 1999

With the advent of computer, the finite element method has become a most powerful numerical method for structural analysis. However, bridge designers are reluctant to use it in their designs because of its complex nature and its being time consuming in the preparation of the input data and analyzing the results. This paper describes the development of a computer based finite element model using the idea of eccentric beam elements for the analysis of slab-on-girder bridges. The proposed method is supported by a laboratory test using a reinforced concrete bridge model. Other bridge analytical schemes are also introduced and compared with the proposed method. The main aim of the comparison is to prove the effectiveness of the shell and eccentric beam modelling in the studies of lateral load distribution of slab-on-girder bridges. It is concluded that the proposed finite element method gives a closer to real idealization and its developed computer program, SHECAN, is also very simple to use. It is highly recommended to use it as an analytical tool for the design of slab-on-girder bridges.

• Wind and Structures
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• v.22 no.6
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• pp.685-701
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• 2016

Downbursts are of great harm to transmission lines and many towers can even be destroyed. The downburst wind field model by Chen and Letchford was applied, and the wind loads of two typical transmission towers in inland areas and littoral areas were calculated separately. Spatial finite element models of the transmission towers were established by elastic beam and link elements. The wind loads as well as the dead loads of conductors and insulators were simplified and applied on the suspension points by concentrated form. Structural analysis on two typical transmission towers under normal wind and downburst was completed. The bearing characteristics and the failure modes of the transmission towers under downburst were determined. The failure state of tower members can be judged by the calculated stress ratios. It shows that stress states of the tower members were mainly controlled by 45 degree wind load. For the inland areas with low deign wind velocity, though the structural height is not in the highest wind velocity zone of downburst, the wind load under downburst is much higher than that under normal wind. The main members above the transverse separator of the legs will be firstly destroyed. For the littoral areas with high deign wind velocity, the wind load under downburst is lower than under normal wind. Transmission towers are not controlled by the wind loads from downbursts in design process.

• Phonetics and Speech Sciences
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• v.2 no.4
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• pp.109-118
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• 2010

Using a speeded classification task (Garner, 1978), we investigated the perceptual interaction of distinctive features in Korean consonants. The main questions of this study were whether listeners can perceptually identify the component features that make up complex consonant sounds, whether these features are processed independently or dependently and whether there is a systematic hierarchy in their dependency. Participants were asked to classify syllables based on their difference in distinctive features in the task. Reaction times for this task were also gathered. For example, participants classified spoken syllables /ta/ and /pa/ as one category and /$t^ha$/ and /$p^ha$/ as another in terms of aspiration condition. In terms of articulation, participants classified /ta/ and /$t^ha$/ as one category and /pa/ and /$p^ha$/ as another. We assumed that the difference between their RTs represents their interdependency. We compared the laryngeal features and place features (Experiment 1), resonance features and place features (Experiment 2), and manner features and laryngeal features (Experiment 3). The results showed that distinctive features were not perceived in a completely independent way, but they had an asymmetric and hierarchical interdependency. The laryngeal features were found to be more independent compared to place and manner features. We discuss these results in the context of perceptual basis in phonology.

• KIEAE Journal
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• v.10 no.5
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• pp.71-76
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• 2010

Recently, the construction and plan of super-tall building is attention link of new town development or urban core regeneration. Super-tall Buildings have many advantages and a lot of affects in urban contexts. Also, construction of super-tall building is will be able to social problem like urban core's decline, loss of openspace, incompatible urban scape, traffic congestion of urban core. But, compares to super-tall buildings affects in urban contexts, there was not extra ordinary study about super-tall building by the urban scale approaches. Therefore, need about study materplan planning of the site which is made to meet super-tall building and urban contexts. There are two main processes in this study. First, to analyze the factors affect to masterplan planning of the super-tall building's site. Through the analyzed factors, classify type of super-tall buildings and identify the type's state. Second, to classify and set the elements of masterplan planning factor in the site. Identify the masterplan planning factor's state by deployment materplan planning factor set the current applied to the constructed super-tall buildings. Through this process, identified the recent trend and providied the basic elements of materplan planning of super-tall building's site.

• Proceedings of the KIEE Conference
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• 1999.07g
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• pp.3064-3066
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• 1999

The existing equipment with wire communication can expect the stability of data transmission. However, according to increasing a number of DTE (Data Terminal Equipment), wiring work becomes a heavy burden. Restriction to application about portable DTE and the lack of flexibility are another drawback of wire communication. This paper presents the design and implementation of a RF (Radio Frequency) based wireless communication system. The RF based module is designed to the multi communication between DTEs. The RF based module consists of RF circuit and microprocessor. The main properties of RF circuit are maximum 5Kbps transmission rate, maximum 90m transmission distance and 433MHz frequency band. The microprocessor rearrange the data into AHDLC(Advanced High level Data Link Control) format and then instructs RF circuits to transmit/receive the data. The RF module have a wide application field such as fire/security alarm, remote control/measurement etc..

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.633-634
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• 2006

The aim of present work is to link geometrical parameter of maximum area of structural defect $\sqrt{area}\;_{max}$ (proposed by Y. Murakami, 1983) with surface fatigue mechanisms. Determined relations allow making predictions of surface fatigue properties of cemented carbides (WC-Co hardmetal - H15 - 85wt% WC and 15wt %Co, TiC-based cermets - T60/8 - 60wt %TiC and Fe/8wt% Ni and T70/14 - 70wt %TiC and Fe/14wt% Ni) in conditions of rolling contact and impact cycling loading. Pores considered being equivalent to small defects. Three comparative defects conditions are distinguished: surface pore, just below free surface and interior pores. The Vickers hardness of binder (as main responsible for the fracture mechanism of hardmetal and cermets) assumed to be the basis of such assumption. The estimate of this prediction has been done by analyzing the pore sizes using the statistics of extremes. The lower bound of fatigue properties can be correctly predicted by considering the maximum occurring pore size.

• Korean Institute of Interior Design Journal
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• v.18 no.6
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• pp.176-183
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• 2009

This study was intended to define the spatial concept of the boundary structure of the architectural space as well as evaluate the Hyangdan which well represents the features of Korean traditional building in such a way of reviewing the building structure of Korean traditional residential space. The boundary is categorized into visible boundary and invisible boundary which was also functionally classified into the features of isolating, passing, mediating and overlapping. The major elements comprising the boundary structure was analyzed by the characteristic of the pattern so as to define them as the concept of surrounding, duality, hierarchism, continuity and overlapping. Based on such concepts, a boundary structural characteristics of Hyangdan were reevaluated and outlined as follows. The surrounding feature was seen through the outer side of the structure surrounded, two courtyards and eaves, and a duality showing both the closure of main house and openness of detached house was seen through the characteristics of surrounding structure. And the continuous activities toward the inner room and the empty space to link them in a systematic way and repeatedly aligned rooms reveal the overlapping as continuous and transitional space. And finally, an elevated stylobate demonstrates the hierarchical features of the structure.

• IE interfaces
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• v.23 no.1
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• pp.35-47
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• 2010

This paper presents a structured framework for developing the embedded subsystem, called ESDMP (Embedded Subsystem Development Methodology for POP), which is one of core components at the development of POP (Point Of Production) system. It is essential that embedded subsystem development methodology must be closely related to the general information system development methodology from the early stage of system development. Therefore, this paper investigates the PDSM (Production System Development Methodology) that is developed by Korea Technology and Information Promotion Agency for SMEs and widely utilized at the fields of POP system development, and proposes the embedded subsystem development methodology aligned with each step of PSDM. The main characteristics of proposed methodology are as follows : First, it is developed to link each step of embedded subsystem development with relating steps of PSDM from the early stage of feasibility study. Second, it provides the procedure for designing and implementing hardware and software simultaneously. Third, it includes the method of reusability for developed products and modules.

• Journal of Power Electronics
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• v.3 no.4
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• pp.230-238
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• 2003

Electric vehicles (EV) demands for greater acceleration, performance and vehicle range in pure electric vehicles plus mandated requirements to further reduce emissions in hybrid electric vehicles (HEV) increase the appeal for combined on-board energy storage systems and generators. And the power electronics plays an important role in providing an interface between fuel cells (FC) and loads. This paper deals with a multiple input DC-DC power converter devoted to combine the power flowing of multi-source on energy systems. The multi-source is composed of (i) FC system as a prime power demands, (ii) super capacitor banks as energy storage devices for high and intense power demands, (iii) superconducting magnetic energy storage system (SMES), (iv) multiple input DC-DC power converter and (v) a three phase inverter-fed permanent magnet synchronous motor as a drive. In this system, It is used super capacitor banks and superconducting magnetic energy replaces from the battery system. The modeling and transient performance simulation is effective for reducing transient influence caused by sudden charge of effective load. The main purpose of power electronic converters is to convert the DC power output from the fuel cell and other to a suitable AC voltage, which can be connected to electric loads directly (PMSM). The fuel cell and other output is connected to the DC-DC converter, which regulates the DC link voltage.