• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3293-3298
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• 2012

The present study was conducted to evaluate in vivo anticancer activity of two novel mononuclear ruthenium(II) compounds, namely Ru(1,10-phenanthroline)$_2$(2-nitro phenyl thiosemicarbazone)$Cl_2$(Compound $R_1$) and Ru (1,10-phenanthroline)$_2$(2-hydroxy phenyl thiosemicarbazone)$Cl_2$(Compound $R_2$) against Ehrlich ascites carcinoma (EAC) mice and in vitro cytotoxic activity against IEC-6 (small intestine) cell lines and Artemia salina nauplii using MTT [(3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide)] and BLT [brine shrimp lethality] assays respectively. The tested ruthenium compounds at the doses 2 and 4 mg/kg body weight showed promising biological activity especially in decreasing the tumor volume, viable ascites cell counts and body weights. These compounds prolonged the life span (% ILS), mean survival time (MST) of mice bearing-EAC tumor. The results for in vitro cytotoxicity against IEC-6 cells showed the ruthenium compound $R_2$ to have significant cytotoxic activity with a $IC_{50}$ value of $20.0{\mu}g/mL$ than $R_1$ ($IC_{50}=78.8{\mu}g/mL$) in the MTT assay and the $LC_{50}$ values of $R_1$ and $R_2$ compounds were found to be 38.3 and $43.8{\mu}g/mL$ respectively in the BLT assay. The biochemical and histopathological results revealed that there was no significant hepatotoxicity and nephrotoxicity associated with the ruthenium administration to mice.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.5
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• pp.159-171
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• 2011

This paper suggests an algorithm that obtains the Minimum Spanning Tree for directed graph (DMST). The existing Chu-Liu/Edmonds DMST algorithm has chances of the algorithm not being able to find DMST or of the sum of ST not being the least. The suggested algorithm is made in such a way that it always finds DMST, rectifying the disadvantage of Chu-Liu/Edmonds DMST algorithm. Firstly, it chooses the Minimum-Weight Arc (MWA) from all the nodes including a root node, and gets rid of the nodes in which cycle occurs after sorting them in an ascending order. In this process, Minimum Spanning Forest (MST) is obtained. If there is only one MSF, DMST is obtained. And if there are more than 2 MSFs, to determine MWA among all MST nodes, it chooses a method of directly calculating the sum of all the weights, and hence simplifies the emendation process for solving a cycle problem of Chu-Liu/Edmonds DMST algorithm. The suggested Sulee DMST algorithm can always obtain DMST that minimizes the weight of the arcs no matter if the root node is set or not, and it is also capable to find the root node of a graph with minimized weight.

• Journal of the Korea Society of Computer and Information
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• v.21 no.9
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• pp.79-84
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• 2016

In this paper we consider the problem of finding the triplet (S,${\pi}$,f), where $S{\subseteq}V$, ${\pi}$ is a sequence of nodes in S and $f:V{\backslash}S{\rightarrow}S$ for a given complete graph G=(V,E). In particular, there exist two costs, $c^V_{uv}$ and $c^D_{uv}$ for $(u,v){\in}E$, and the cost of triplet (S,${\pi}$,f) is defined as $\sum_{i=1}^{{\mid}S{\mid}}c^V_{{\pi}(i){\pi}(i+1)}+2$ ${\sum_{u{\in}V{\backslash}S}c^D_{uf(u)}$. This problem is motivated by the integrated routing of the vehicle and drone for urban delivery services. Since a well-known NP-complete TSP (Traveling Salesman Problem) is a special case of our problem, we cannot expect to have any polynomial-time algorithm unless P=NP. Furthermore, for practical purposes, we may not rely on time-exhaustive enumeration method such as branch-and-bound and branch-and-cut. This paper suggests the simple heuristic which is motivated by the MST (minimum spanning tree)-based approximation algorithm and neighborhood search heuristic for TSP.

• Journal of Fisheries and Marine Sciences Education
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• v.18 no.2
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• pp.77-84
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• 2006

This research evaluates thermal comfort by comparing the case of maintain cooing temperature of room with the case of raising it at the point of time that human body begins to adapt. An experiment uses constant temperature & humidity chamber 2 places. Pretesting room make up summer season environment, the testing room control by air-conditioner. In condition that maintain temperature of $33^{\circ}C$. The subjects stay in the pretesting room during the 30 minute for the heat storage amount of the normal summertime. The subjects stay in the testing room under each case (case 1: maintaining $24^{\circ}C$, case 2: maintaining $26^{\circ}C$, case 3: up $1^{\circ}C$ after maintaining $24^{\circ}C$ during 30 minute, case 4: up $1^{\circ}C$ after maintaining $26^{\circ}C$ during 40 minute). 1. Result of comparison of case 1 and case 2 appears that thermal sensitive vote examine from slight cool to cool and thermal comfort examine slight comfort by temperature rise at human body adaptation point of time.2. Test of case 3 and case 4 appear similar value at thermal sensitive vote and thermal comfort.3. Through the case 2 and case 4, continuous thermal comfort maintain at $24^{\circ}C$, if raise $26^{\circ}C$, same thermal comfort maintain after a human body adaptation temperature rising effect bring energy saving.

• Journal of Acupuncture Research
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• v.17 no.1
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• pp.189-219
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• 2000

To study the effects of anti-cancer, anti-metastasis and immune response improvement effects of aqua-acupuncture with Rubi Fructus infusion solution, we used Rubi Fructus infusion solution(taken by water-alcohol method) put into Chung-wan (CV12) and Chok-Samni(ST36) of BALB/c or C57BL/6 which are corresponding to humanbody. We observed the cytotoxicity, the effect on the expression of MMP-9 gene, the ability to control cancer cell proliferation, change of body weight, surviving number, median surviving time, increase of life span, changes in amount of leukocyte, erythrocyte, platelet, total protein, creatinine, glucose and LDH, weight of spleen, number of pulmonary colony, histological analysis on tissue metastasis of lung and liver, splenic cell proliferation, the expression of cytokine gene, the number of $CD4^+$, $CD8^+$, $CD19^+$ and NK cell, and concluded like this. The results were obtained as follows : 1. Effects of Anti-cancer 1) The cytotoxicity about B16-F10 cell line of $2^0$, $2^{-1}$, $2^{-2}$, $2^{-3}$, $2^{-5}$, $2^{-6}$, $2^{-7}$, $2^{-8}$ diluent groups in Rubi Fructus infusion solution treatment was inhibited significantly, compared with control group. 2) The cytotoxicity about HT1080 cell line of $2^0{\sim}2^{-8}$ diluent groups in Rubi Fructus infusion solution treatment was inhibited significantly, compared with control group. 3) The effect on expression of MMP-9 gene was inhibited significantly in all the sample groups, compared with control group. 4) The effect on the control-ability on the cancer cell proliferation showed cytotoxicity significantly in $2^0$, $2^{-1}$, $2^{-2}$, $2^{-3}$, $2^{-4}$, $2^{-5}$, $2^{-6}$, $2^{-7}$, diluent groups. 2. Effects of Anti-metastasis 1) S-180 cancer cell line transplants in BALB/c mice were inhibited significantly in weight increase in all the sample groups, compared with control group. The surviving number increased in almost sample groups, except one group put into Chok-Samni(ST36) with 20% Rubi Fructus infusion solution treatment group that showed same number of the control group. 2) S-180 cancer cell line transplants in BALB/c mice showed high MST significantly in almost sample groups, compared with control group. But one group put into Chok-Samni(ST36) with 20% Rubi Fructus infusion solution showed low MST than control group. 3) The group injected in vein with B16-F10 cancer cell line in C57BL/6 mice showed increased ILS than control group significantly in anti-metastasis test. 3. Effects of Immune response improvement 1) The group injected in vein with B16-F10 cancer cell line in C57BL/6 mice were increased significantly in the number of leukocyte and glucose, and decreased significantly in the amount of platelet and LDH, compared with control group. However, there's no significant increase or decrease in number of erythrocyte, total protein and creatinine. 2) We couldn't find any significant relation in spleen weight of the sample group. 3) In pulmonary colony, sample group was decreased significantly, compared with control group. 4) Histological analysis of sample group inhivited compared with that of control group in both of lung and liver. 5) In immune system, all the sample groups showed having more relevancy to the effect on splenic cell proliferation than normal group. 6) Cytokine gene increased in almost sample groups, except one group treated with $50{\mu}g/m{\ell}$ Rubi Fructus infusion solution on IL-12. 7) In flow cytometry there's no significant relation in number of $CD8^+$ cell, however, the number of $CD4^+$, $CD19^+$ cell and NK cell in sample group had more relation than in control group. Above the results showed that aqua-acupuncture of Rubi Fructus solution has effects of anti-cancer, and-metastasis and immune response improvement.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.4
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• pp.307-312
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• 2007

This study was performed to evaluate sleep efficiencies and conditions for comfortable sleep based on the analysis of sleep efficiency and MST under four thermals conditions ($22^{\circ}C,\;24^{\circ}C,\;26^{\circ}C,\;30^{\circ}C$). Five female subjects who have similar life cycle and sleep patterns were participated for the sleep experiment. Their age was from 20 to 22 years old. They were healthy, and had regular sleep with consistent bed and wakeup time. It was checked whether they had a good sleep before the night of experiment. Experiments were performed in an environmental chamber using thermo-hygrostat. The physiological signal (EEG) for sleep stage were obtained from C3-A2 and C4-Al electrode sites. Sleep stages were classified, then SWS latency and SWS/TST were calculated for the evaluation for sleep efficiencies on thermal conditions. As results, mean skin temperature for comfort sleeping was $34.5{\sim}35.4^{\circ}C$. Considering sleep efficiency and mean skin temperature, indoor room temperature of upper limit was $28.1^{\circ}C$.

• Journal of Sensor Science and Technology
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• v.21 no.3
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• pp.198-203
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• 2012

In this paper, the driving information system of the bicycle has been studied by using the 3-axis acceleration sensor. The sensor module composed of 3-axis acceleration sensor and MCU(Microcontroller Unit) was mounted onto the handle of bicycle and the experiments were conducted on the flatland, uphill and downhill of bicycle road. Three axis acceleration values were converted to the pitch and roll angles, then four major compensation methods have been applied to achieve meaningful data for driving information system. The experimental results of pitch angles showed 2.46, -1.26, 7.79 degrees in case of flatland, uphill, downhill, respectively. When the steering handle turned to the left direction, roll angles showed -29.35, -41.67, -36.98 degrees at each road condition. With the right-turn, roll angles presented 20.05, 33.75, 24.44 degrees in case of flatland, uphill, and downhill, respectively. The pitch angle has been increased more than 40 degrees at stop mode. By using the change of pitch and roll angles, we could obtain the driving information system of bicycle successfully.

• Radiation Oncology Journal
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• v.25 no.2
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• pp.101-108
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• 2007

[ $\underline{Purpose}$ ]: To compare radiation therapy alone to combined modality therapy about survival rate and tolerance of elderly patients ($70=or{\geq}$) with non-small-cell lung cancer (NSCLC). $\underline{Materials\;and\;Methods}$: Between 1998 and 2002, 57 patients given radiation therapy due to NSCLC (Stage III) were analysed retrospectively. Radiation therapy alone (RT), concurrent chemoradiation (CRT), and sequential chemoradiation (SCRT) was done to 33, 16 and 8 patients, respectively. Patients' median age was 74 (range $70{\sim}85$). Male and female are 51 patients and 6 patients, respectively. 23 patients were stage IIIa and 34 were stage IIIb. Patients' characteristic distribution of RT and CRT was not significantly different except mass size that RT has a bigger than CRT. The fraction size of radiation therapy was 1.8 Gy in CRT and $1.8{\sim}3\;Gy$ in other groups. Total radiation dose was $51{\sim}63\;Gy$ according to the fraction size. If the prescribed total radiation dose was successfully irradiated, we stated that it was completion of radiation therapy. $\underline{Results}$: 52 patients were dead. Median period of radiation therapy was as follow: RT, 35 days, CRT, 60.5 days and SCRT, 35 days. Overall median survival time (MST) was 10.1 months. The 1 yr- and 2 yr-overall survival rate was 39.8% and 17.6%, respectively. MST of RT, CRT and SCRT was 8.9, 8.2 and 11.7 months, respectively. The 1 yr survival rate of RT, CRT and SCRT was 38.4%, 37.5% and 50% (not significant). Patients given incomplete radiation therapy were 12 (RT, 5 CRT, 6 SCRT, 1). N stage (p=0.081) and the difference of treatment methods (p=0.079) were the factors affecting incompletion of radiation therapy, but it was not significant. In case of combined-agents chemotherapy, 4 of 8 ceased radiation therapy. T stage ($T{\geq}3$), mass size (${\geq}5\;cm$), Karnofsky performance scale (${\leq}70$) and completion of radiation therapy were the prognostic factors in uni- and multi-variate analysis. $\underline{Conclusion}$: In elderly patients with NSCLC, radiation therapy alone was a treatment method with similar survival period compared with other methods. Generally, patients given radiation therapy alone was tolerable to a treatment. Before planning concurrent chemoirradiation in elderly patients with NSCLC, physicians pay attention to a selection of patients and chemotherapy agents considering general condition and toxicity.

• Journal of the Korea Society of Computer and Information
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• v.17 no.1
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• pp.161-169
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• 2012

In general, Euclidean minimum spanning tree is a tree connecting input nodes with minimum connecting cost. But the tree may not be optimal when applied to real world problems of three dimension. In this paper, three dimension Euclidean minimum spanning tree is proposed, connecting all input nodes of 3-dimensional space with minimum cost. In experiments for 30,000 input nodes with 100% space ratio, the tree produced by the proposed method can reduce 90.0% connection cost tree, compared with the tree by two dimension Prim's minimum spanning tree. In two dimension plane, the proposed tree increases 251.2% connecting cost, which is pointless in 3-dimensional real world. Therefore, the proposed method can work well for many connecting problems in real world space of three dimensions.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.2 no.1
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• pp.43-56
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• 1996

The sprig of Sojekbojungwhan(消積保中丸) has been used for curing as a traditional medicine without any experimental evidence to support the rational basis for their clinical use. This experiment was carried out to evaluate the possible therapeutic or antitumoral effects of Sojekbojungwhan extract against cancer, and to study some mechanisms responsible for its effect. The cytotoxic and antitumor effects were evaluated on human cell lines(A549, hep3B, Caki-1, Sarcoma 180) after esposure to Sojekbojungwhan extract using in ILS, colony forming efficiency and SRB assay which were regarded as a valuable method for cytotoxic and antitumor effects of unknown compound on tumor cell lines. The results obtained in this studies were as follows. 1. As a result of exposure to Sojekbojungwhan extract, the proliferation of A549, hep3B, Caki-1, good correlations were shown from the results of SRB assay and those of clogenetic assay. 2. The oral administration of Sojekbojungwhan extact showed significant effects of increase of MST(mean survival time) and ILS(increased life span) depending on the increasing concentration. 3. Against squamous cell carcinoma induced by MCA, Sojekbojungwhan decreased not only the frequency of tumor production but also the number and weight of tumors per tumor bearing mice(TBM). Sojekbojungwhan also significantly suppressed the development of 3LL cell-implanted tumors by frequency and their size, and some developed tumors were regressed by the continuous treatment of Sojekbojungwhan extract into TBM. 4. Sojekbojungwhan extract also increased NK cell activities. According to the above results, it could be suggested that Sojekbojungwhan extract has some antitumor effects.