• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.8 no.2
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• pp.141-149
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• 2013

Objectives : The Purpose of this study is to investigate the clinical application of conservative treatment including hip joint MST for lumbar HIVD(Herniated Intervertebral Disc) and early developed avascular necrosis of femur head. Methods : Patient is hospitalized at Dept. of Oriental Internal Medicine, Jaseng Oriental Medicine Hospital, diagnosed as lumbar HIVD(Herniated Intervertebral Disc) and early developed Avascular Necrosis of Femur Head and treated by herbal medicine, acupuncture, moxibustion and hip joint MST. This study was measured by NRS(Numeric Rating Scale), ODI(Oswestry Disability Index) and ROM(range of motion). Results : After conservative treatment, the patient's pain was controlled and NRS score was decreased. ODI and ROM also were improved. Conclusions : As seen in this one case, Oriental conservative treatment including hip joint MST has a positive effect to control pain with lumbar HIVD(Herniated Intervertebral Disc) and early developed avascular necrosis of femur head.

• Journal of International Academy of Physical Therapy Research
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• v.2 no.1
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• pp.193-200
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• 2011

This study is intended to examine the tDCS and Montoya stair task(MST) on sensorimotor recovery and glial scar expression in MCAo induced stroke model of rat. To achieve this goal, this study selected 80 SD rats of 8 weeks. The experiment groups were divided them into four groups, and assigned 20 rats to each group. Group I was a experimental control group; GroupII was a tDCS application group after MCAo; Group III was a MST application group after MCAo; Group IV was a tDCS and MST application group after MCAo. In each group, neurological function test measurement, motor behavior test, montoya stair task test, immunohistochemistric finding of GFAP expression finding were analyzed. In motor behavior test, the outcome of group I was significantly difference than the other group, especially from 14days. In montoya stair task test, the outcome of group I was significantly lower than the other group especially, group II were significantly different on 14days and group IV was most significantly difference than the other group. In immunohistochemistric finding, group II, III, IV were decrease GFAP expression on depend on time stream. These results throughout the MCAo due to focal ischemic brain injury rat model four weeks tDCS and MST was applied, when the neurobehavioural, upper extremity function and ability, histopathologic data suggest that sensorimotor function recovery and a positive influence on glial scar decrease and confirmed that.

• The Korean Journal of Applied Statistics
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• v.31 no.4
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• pp.517-528
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• 2018

We provide R scripts to detect outliers in multivariate data and visualization. Detecting outliers is provided using three approaches 1) Robust Mahalanobis distance, 2) High Dimensional data, 3) density-based approach methods. We use the following techniques to visualize detected potential outliers 1) multidimensional scaling (MDS) and minimal spanning tree (MST) with k-means clustering, 2) MDS with fviz cluster, 3) principal component analysis (PCA) with fviz cluster. For real data sets, we use MLB pitching data including Ryu, Hyun-jin in 2013 and 2014. The developed R scripts can be downloaded at "http://www.knou.ac.kr/~sskim/ddpoutlier.html" (R scripts and also R package can be downloaded here).

• Toxicological Research
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• v.34 no.2
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• pp.133-141
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• 2018

Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that $10{\mu}M$ cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.

• Journal of applied mathematics & informatics
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• v.7 no.2
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• pp.629-640
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• 2000

this paper present an efficient line-drawing algorithm that reduces the amount of space required, Because of its efficiency , this line-drawing algorithm is faster than the Bresenham algorithm or the recursive bisection method. this efficiency was achieved through a new data structure; namely , the modified segment tree (MST). Using the modified segment tree and the distribution rule suggested in this paper, we dra lines without generating the recursive calls used in [3] and without creating the binary operation used in [4]. we also show that line accuracy improves in proportion to the display resolution . In practice, we can significantly improve the algorithm's performance with respect to time and space, This improvement offer an increase in speed, specially with lines at or near horizontal, diagonal. or vertical ; that is, this algorithm requires the time complexity of (n) and the space complexity O(2k+1), where n is the number of pixels and k is a level of the modified segment tree.

• BMB Reports
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• v.51 no.3
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• pp.126-133
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• 2018

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate activities of YAP/TAZ. Because YAP and TAZ are transcriptional coactivators that lack DNA-binding activity, both proteins must interact with DNA-binding transcription factors to regulate target gene's expression. To activate target genes involved in cell proliferation, TEAD family members are major DNA-binding partners of YAP/TAZ. Accordingly, YAP/TAZ were originally classified as oncogenes. However, YAP might also play tumor-suppressing role. For example, YAP can bind to DNA-binding tumor suppressors including RUNXs and p73. Thus, YAP might act either as an oncogene or tumor suppressor depending on its binding partners. Here, we summarize roles of YAP depending on its DNA-binding partners and discuss context-dependent functions of YAP/TAZ.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.13 no.4
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• pp.107-116
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• 2013

This algorithm suggests a method in which a minimum spanning tree can be obtained fast by reducing the number of an algorithm execution. The suggested algorithm performs a select-and-delete process. In the select process, firstly, it performs Borůvka's first stage for all the vertices of a graph. Then it re-performs Borůvka's first stage for specific vertices and reduces the population of the edges. In the delete process, it deletes the maximum weight edge if any cycle occurs between the 3 edges of the edges with the reduced population. After, among the remaining edges, applying the valency concept, it gets rid of maximum weight edges. Finally, it eliminates the maximum weight edges if a cycle happens among the vertices with a big valency. The select-and-delete algorithm was applied to 9 various graphs and was evaluated its applicability. The suggested select process is believed to be the vest way to choose the edges, since it showed that it chose less number of big edges from 6 graphs, and only from 3 graphs, comparing to the number of edges that is to be performed when using MST algorithm. When applied the delete process to Kruskal algorithm, the number of performances by Kruskal was less in 6 graphs, but 1 more in each 3 graph. Also, when using the suggested delete process, 1 graph performed only the 1st stage, 5 graphs till 2nd stage, and the remaining till 3rd stage. Finally, the select-and-delete algorithm showed its least number of performances among the MST algorithms.

• Korean Journal of Acupuncture
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• v.21 no.1
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• pp.79-93
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• 2004

Objectives and methods : To study on the anti-cancer, anti-metastasis and immune response improvement effects of Herbal-acupuncture with Sinomenii acuti Lignum infusion solution(SAL-HAS), we injected Sinomenii acuti Lignum infusion solution into Joksamni$(ST_{36})$ of C57BL/6 mouse which is corresponding to human Joksamni(ST36). We observed its effect on the number of $CD25^+/CD4^+,\;CD8^+/CD3e^+,\;CD69^+/B220^+,\;NK1.1^+/CD3e^+$ cells in mouse PBMCs(peripheral blood mononuclear cells), the number of the pulmonary colony, and the effect on MST(mean survival time) and ILS(increase in MST over control) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. Results and Conclusions : 1. The spleen cells proliferation of the sample groups treated with SAL-HAS extract has increased significantly compared with that of the control group. 2. The percentage of the $CD25^+/CD4^+,\;CD8^+/CD3e^+,\;CD69^+/B220^+,\;NK1.1^+/CD3e^+$ cells in C57BL/6 mouse PBMCs of the sample groups treated with SAL-HAS has increased compared with that of the control group. 3. The pulmonary colony number of the sample groups SAL-HAS has decreased significantly compared with that of the control group. 4. MST and ILS of the sample groups SAL-HAS have increased significantly compared with those of the control group.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.923-927
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• 2013

Objective: This work aims to investigate the therapeutic regimen of brain metastatic cancers and the relationship between clinical features and prognosis. Methods: Clinical data of 184 patients with brain metastatic cancers were collected and analysed for the relationship between survival time and age, gender, primary diseases, quantity of brain metastatic foci, their position, extra cranial lesions, and therapeutic regimens. Results: The average age of onset was 59.1 years old. The median survival time (MST) was 15.0 months, and the patients with breast cancer as the primary disease had the longest survival time. Females had a longer survival time than males. Patients with meningeal metastasis had extremely short survival time. Those with less than 3 brain metastatic foci survived longer than patients with more than 3. The MST of patients receiving radiotherapy only and the patients receiving chemotherapy only were all 10.0 months while the MST of patients receiving combination therapy was 16.0 months. Multiple COX regression analysis demonstrated that gender, primary diseases, and quantity of brain metastatic foci were independent prognostic factors for brain metastatic cancers. Conclusions: Chemotherapy is as important as radiotherapy in the treatment of brain metastatic cancer. Combination therapy is the best treatment mode. Male gender, brain metastatic cancers originating in the gastrointestinal tract, more than 3 metastatic foci, and involvement of meninges indicate a worse prognosis.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11b
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• pp.430-433
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• 2001

The $0.96MgTiO_{3}-0.04SrTiO_{3}+xCe(x=0{\sim}1.6wt%)$ ceramics were fabricated by the conventional mixed oxide method. The sintering temperature and time were $1300^{\circ}C$, 2hr., respectively. From the X-ray diffraction patterns, it was found that the perovskite $SrTiO_{3}$ and ilmenite $MgTiO_{3}$ structures were coexisted in the $0.96MgTiO_{3}-0.04SrTiO_{3}+xCe(x=0{\sim}1.6wt%)$ ceramics. The dielectric constant$(\varepsilon_{r})$ was increased with addition of Ce. The temperature coefficient of resonant frequency$(\Gamma_{f})$ was gradually varied from positive value to the negative value with increasing the Ce. The temperature coefficient of resonant frequency of the $0.96MgTiO_{3}-0.04SrTiO_{3}+0.2Ce$ ceramics was near zero, where the dielectric constant, quality factor, and $\Gamma_{f}$ were 20.68, 50,272 and ${-0.5ppm/^{\circ}C}$, respectively.