• Biomedical Science Letters
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• v.26 no.3
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• pp.164-169
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• 2020

Atherosclerosis is a cardiovascular disease in which plaque builds up inside of an artery and can lead to various complications such as myocardial infarction, stroke, and thrombosis. Recently, hypertriglyceridemia has attracted significant attention as contributors to development of atherosclerosis. However, molecular mechanism of its contribution to atherosclerosis is poorly understood. Here we proposed a potential link between triglyceride (TG) and atherosclerosis. TG treatment promoted downregulation of certain scavenger receptor, macrophage scavenger receptor-1 (MSR-1) in phorbol myristate acetate (PMA)-derived human macrophages. TG treatment caused reduction of MSR-1 mRNA expression in a time- and dose-dependent manner. Using chemical inhibitors, we found that inhibition of signaling pathways associated with PI3K and PLC enhances TG-induced reduction of MSR-1 expression in THP-1 macrophages implying that PI3K and PLC is implicated in the expression of MSR-1 in macrophages. Since MSR-1 is associated with uptake and clearance of atherogenic lipoprotein, oxidized low density lipoprotein (oxi-LDL), our data suggest that increase of oxi-LDL due to TG-mediated reduction of its receptor MSR-1 can promote atherosclerosis.

• BMB Reports
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• v.44 no.4
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• pp.256-261
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• 2011

PEP-1 peptide has been used for transduction of native protein into mammalian cells. This work describes the findings that the fusion of PEP-1 to target proteins led to protein truncation likely in a non-protein-specific manner. Approximately 75% of PEP-1-MsrA fusion protein was truncated in the N-terminal region of MsrA between Lys-27 and Val-28 during expression in Escherichia coli and purification. This large protein truncation was also observed in another PEP-1 fused protein, PEP-1-MsrB2, in the N-terminal region of MsrB2. The full-length PEP-1-MsrA protein was rapidly transduced into keratinocyte cells within 15 min. The transduced PEP-1-MsrA was functionally active and could protect skin cells against oxidative stress- and ultraviolet radiation-induced cell death. Collectively, our data demonstrated the protective roles of MsrA in skin cells and, moreover, may raise a concern of protein truncation caused by fusion of PEP-1 about the general use of this peptide for protein transduction.

• Journal of KIISE:Information Networking
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• v.31 no.1
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• pp.20-26
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• 2004

A congestion control algorithm to prevent buffer overflow in MSR(Mobility Support Router) for I-TCP is proposed. Due to high bit error rate and frequent hand-offs over wireless environment, the current congestion control scheme in TCP Reno over mixed(wired and wireless) network exhibits lower throughput than the throughput achieved over wired only network. I-TCP has been proposed to address this by splitting a TCP connection into two TCP connections over wired section and wireless section, respectively. However, buffer overflow in MSR may occur whenever there are excessive bit errors or frequent hand-offs. This may lead to the loss of packets acked by MSR(resident in buffer) to the sender, but not received by the receiver, breaking TCP end-to-end semantics. In this Paper, a new scheme is proposed to prevent the MSR buffer from overflow by introducing “flow control” between the sender and the MSR. Advertised window for the TCP connection between the sender and the MSR is tied to the remaining MSR buffer space, controlling the flow of packets to the MSR buffer before overflow occurs.

• Journal of Welding and Joining
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• v.5 no.2
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• pp.1-8
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• 1987

MSR 처리를 실제구조물에 적용하기 위해서 잔류응력과 기계적성질에 대하여 조사해 본 결과 다음의 결론을 얻었다. (1) MSR 처리는 소성변형을 유발시켜 높은 인장잔류응력을 감소시키는데 유효하며, 잔류응력이 낮은 부위에 대해서는 잔류응력 재배치에 따른 응력치의 변화가 수반된다. (2) 잔류응력 감소량은 MSR 하중에 비례하여 증가 한다. (3) 모재의 항복응력보다 낮은 하중으로 MSR 처리를 하면 충격치의 감소는 무시할 정도이지만 모재의 항복응력보다 높은 하중으로 행하면 응착금속에서 충격치의 감소가 현저하다. (4) MSR 처리를 하게되면 항복응력이 높아지고, 잔류응력이 감소해서 선형의 응력-스트레인의 관계를 가지는 범위가 넓어져서 구조적으로 안전한 상태가 된다.

• Journal of Korean Society of Archives and Records Management
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• v.16 no.4
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• pp.121-148
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• 2016

MSR identifies that records are key factors in achieving the goals of an organization and that records management is part of the business administration. Therefore, organizations could secure accountability and continuity of works through the activities of production and management records. This study explored what should be prepared to adopt MSR in public institutions based on the analysis of the requirements of the ISO 30301. which is prepared to be utilized as a certificate system. It focuses on 1) how laws could be supplemented to adopt MSR by comparing the requirements of MSR and the Public Records Management Act; 2) what should be prepared by organizations in terms of their rules and procedures; and 3) how the evaluation system of public institutions and the records management evaluation system could be revised to ensure that MSR will be sufficiently implemented in the organizations. In conclusion, the part to be supplemented by the law, the area to be operated as the internal rules of the organizations, and the way to be reflected in the evaluation of the public institutions were suggested.

• Journal of Microbiology and Biotechnology
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• v.18 no.1
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• pp.59-62
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• 2008

The peptide methionine sulfoxide reductases (Msrs) are enzymes that catalyze the reduction of methionine sulfoxide back to methionine. Because of two enantiomers of methionine sulfoxide (S and R forms), this reduction reaction is carried out by two structurally unrelated classes of enzymes, MsrA (E.C. 1.8.4.11) and MsrB (E.C. 1.8.4.12). Whereas MsrA has been well characterized structurally and functionally, little information on MsrB is available. The recombinant MsrB from Bacillus subtilis has been purified and crystallized by the hanging-drop vapor-diffusion method, and the functional and structural features of MsrB have been elucidated. The crystals belong to the trigonal space group P3, with unit-cell parameters a=b=136.096, $c=61.918{\AA}$, and diffracted to $2.5{\AA}$ resolution using a synchrotron-radiation source at Pohang Light Source. The asymmetric unit contains six subunits of MsrB with a crystal volume per protein mass $(V_M)\;of\;3.37{\AA}^3\;Da^{-1}$ and a solvent content of 63.5%.

• Journal of Korean Society of Archives and Records Management
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• v.12 no.1
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• pp.95-115
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• 2012

The purpose of this study is to analyze the 7 principles of ISO 30300 and the requirements of ISO 30301 to provide the conceptual frame of MSR for various organizations providing a comprehensive understanding of the standard series. To achieve the aim of this study, we analyzed the relationship between 'ISO/FDIS 30300 MSR-Fundamentals and Vocabulary' and 'ISO/FDIS 30301 MSR- Requirements' using the Matrix Diagram approach. The results show that there exist some level of relationships between principles and requirement either directly or indirectly, however, 'Process approach' principle seems the closest relationship among them.

• Journal of Korea Multimedia Society
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• v.13 no.11
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• pp.1621-1629
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• 2010

This paper presents an improved fast MSRCR algorithm that MSRs are commonly adopted at tone mapping in color vision. Conventional MSRs consist of three SSRs, which use three Gaussian functions with different scales as those surround ones. This convolution processes require much computation load. Therefore, the proposed algorithm adopts a hierarchical discrete correlation which is equivalent to Gaussian function and the Retinex process is only applied to the luminance channel in order to get a fast processing. A simple color preservation scheme is applied to the Retinex output from the luminance channel in the proposed MSRCR algorithm. Experimental results show that the proposed algorithm required less number of oprations and computation time about 1/9.5 and 1/3.5 times, respectively, than those of the simplest MSR and was equivalent to conventional MSRs.

• Progress in Superconductivity
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• v.9 no.1
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• pp.45-49
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• 2007

We have investigated the optimum combination of the environmental noise condition and type of SQUID pickup coil in order to obtain maximum signal-to-noise ratio (SNR). The measurement probe consists of 1st order gradiometer with pickup coils of 100 mm, 70 mm, and 50 mm baseline length, a 2nd order gradiometer with 50 mm baseline, and a magnetometer. The pickup coils are fabricated by winding Nb wire on a bobbin with 200 mm diameter. Noise and heart signal of a healthy male were measured by various SQUID sensors with different types of pickup coils in various magnetically shielded rooms (MSR), and compared to each other. The shielding factors were found to be 43 dB, 35 dB and 25 dB at 0.1 Hz for MSR-AS, MSR-BS, MSR-CS, respectively. White noises were $3.5\;fT/Hz^{1/2}$, $4.5\;fT/Hz^{1/2}$ and $3\;fT/Hz^{1/2}$ for the 1st order gradiometers, the 2nd order gradiometers, and magnetometer for all MSRs. SNR of the magnetometer was up to 56 dB in MSR-AS, while the 1st order axial gradiometer with 70 mm baseline length was up to 54 dB in MSR-BS. The 2nd order axial gradiometer with 50 mm baseline length of pickup coil was found to be up to 40 dB in MSR-CS.

• Journal of Chest Surgery
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• v.21 no.2
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• pp.351-365
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• 1988

During one year[1987], 110 cases of open heart surgeries were performed in the department of Thoracic and Cardiovascular Surgery, Pusan Paik Hospital, Inje Medical College. And the results were summarized as follows. 1. Among the 110 cases, there were 77 cases of congenital heart diseases and 33 cases of acquired heart diseases. Age range of the congenital patients was 8 months to 30 years with the mean age of 8 years, and acquired patients was 16 to 56 years with the mean age was 32 years. 2. The heart lung machine used for cardiopulmonary bypass was Sarns 7000, 5-head roller pump, and the number and type of oxygenators were 50 of membrane type and 60 of bubble type. For all cases GIK[glucose-insulin-potassium] solution was used as cardioplegic solution for myocardial protection during operation. 3. Among the 77 congenital anomalies, there were 67 cases of acyanotic patients[ASD: 12, VSD: 50, PS: 1, AP window: 1, Gerbode defect: 1, ECD: 2] and 10 cases of cyanotic patients[TOF: 10], and to all of which the appropriate radical operations were applied. 4. Among the 33 acquired diseases, there were one case of left atrial myxoma, one of annuloaortic ectasia, 20 of mitral valve diseases[MS: 2, MSr: 8, MR: 2, MRs: 8], 9 of double valve diseases[MRs+AR: 1, MRs+ARs: 2, MRs+TR: 1, MSr+TR: 3, MSr+ASr: 1, MSr+ARs: 1], 2 of triple valve diseases[MSr+AR+TR: 1, MSr+ASr+TR: 1]. The left atrial myxoma was removed well with right atriotomy and atrial septal approach. And to the annuloaortic ectasia, Bentall operation was applied with good result. Mitral valve replacement[MVR] was applied to 20 cases of mitral valve diseases, double valve replacement[MVR+AVR] was applied to 6 cases of double valve diseases, MVR & tricuspid annuloplasty[TVA] was applied to 3 cases of mitral 5. The number of replaced valve were 39 in 31 cases. In MVR, 5 of mechanical valves[St. Jude Medical Valve] and 26 of tissue valves[Carpentier-Edward valve] were used. In AVR, 3 of mechanical valves and 5 of tissue valves were used. 6. Postoperative complications were occurred in 23 cases, and among them 21 cases were recovered with intensive cares, but 2 cases were expired[mortality: 1.8%].