• Analytical Science and Technology
• /
• v.34 no.2
• /
• pp.78-86
• /
• 2021

The objective of this study was to investigate urinary cut-off concentrations of quetiapine and risperidone for distinction between normal and abnormal/non-takers who were being placed on probation. Liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was employed for determination of antipsychotic drugs in urine from mentally disordered probationers. The optimal cut-off values of antipsychotic drugs were calculated using receiver operating characteristic (ROC) curve analysis. The sensitivity and specificity of the method for the detection of antipsychotic drugs in urine were subsequently evaluated. The area under the ROC curve (AUC) was 0.927 for norquetiapine and 0.791 for 9-hydroxyrisperidone, respectively. These antipsychotic drugs are classified readily in the ROC curve analysis. The cut-off values for distinguishing regular and irregular/non-takers were 39.1 ng/mL for norquetiapine and 67.9 ng/mL for 9-hydroxyrisperidone, respectively. The results of this study suggest the cut-off values of quetiapine and risperidone were highly useful to distinguish regular takers from irregular/non-takers.

• Journal of Positioning, Navigation, and Timing
• /
• v.9 no.4
• /
• pp.293-304
• /
• 2020

In this paper, various modulation techniques, including the legacy Global Navigation Satellite System (GNSS) signal modulation techniques, are introduced and the spectral characteristics and correlation characteristics of signals with various modulation techniques are analyzed based on numerical simulation. With the development of various GNSS services, the limited frequency band has become increasingly saturated, and issues of interoperability and compatibility have emerged in the new GNSS design. Since the efficient allocation of frequency resources is closely related to spectrum design, modulation techniques are one of the important signal design parameters of new signal design. Signal modulation techniques are closely related to various figure of merits (FoMs) as well as spectrum characteristic, and in some cases there is a complicated trade-off between FoMs. Thus, the FoMs associated with modulation technology should be analyzed and the best signal candidates should be chosen carefully via the trade-off analysis for FoMs. In this paper, we define the modulation technique based on Phase Shift Keying (PSK), Binary Offset Carrier (BOC) and Continuous Phase Modulation (CPM) for the design of KPS signals, and the FoMs of signals in terms of spectrum and correlation function are evaluated. Signals with various modulation techniques are implemented through a numerical simulation, and the relevant FoMs are analyzed.

• Biomolecules & Therapeutics
• /
• v.31 no.1
• /
• pp.68-72
• /
• 2023

Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there is an urgent need to develop novel therapies. In this study, we investigated the antitumor activity of MS-5, a naphthalene derivative, on BxPC-3, a human pancreatic cancer cell line. We observed that MS-5 was cytotoxic to BxPC-3 cells, as well as inhibited the growth of cells in a concentration- and time- dependent manner. Flow cytometry analysis revealed that the percentage of annexin V-positive cells increased after MS-5 treatment. We also observed cleavage of caspases and poly (ADP-ribose) polymerase, and downregulation of Bcl-xL protein. Flow cytometry analysis of intracellular levels of reactive oxygen species (ROS) and mitochondrial superoxide suggested that MS-5 induced the generation of mitochondrial superoxide while lowering the overall intracellular ROS levels. Thus, MS-5 may be potential candidate for pancreatic cancer treatment.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
• /
• 2011.04a
• /
• pp.37-40
• /
• 2011

화재현장에서는 화재의 원인으로 간주되는 여러 가지 증거물이 발생한다. 이러한 증거물을 분석하기 위한 수단으로 GC/MS의 역할은 아주 크며, 이를 이용한 증거물의 분석에 관한 표준으로 ASTM 1618-10과 전처리법을 소개한다. 또한 전처리법에 따른 여러 가지 종류의 유류의 특성을 알아보고 유류 성분을 포함한 화재증거물의 실제 사례를 들어 보겠다. 아울러 화재현장에서의 가연물로 추정되는 물질에 대하여 열분해를 통한 GC/MS 분석 사례도 제시하여 본다.

• 한국약용작물학회:학술대회논문집
• /
• 2008.05a
• /
• pp.162-163
• /
• 2008

• Journal of Positioning, Navigation, and Timing
• /
• v.11 no.4
• /
• pp.341-349
• /
• 2022

When designing a new RNSS signal, the performance analysis for the legacy signal providing the same service, is required to determine the performance requirements. However, there are few studies on the secured service (SS) signal performance analysis, and the waveform is the only published information on the signal design component of the SS signal. Therefore, in this paper, we introduce several figures-of-merit (FoMs) that can be used for performance analysis in terms of the waveform. And then, we calculate the FoMs, such as autocorrelation main peak to secondary peak ratio (AMSR), spectral efficiency, Gabor bandwidth, multipath error, and jamming resistance quality factor, for the existing SS signals and discuss the analysis results. Finally, we conclude that the superior waveform for each FoM is different, and that the consideration of the trade-off relationship between the FoMs is required for waveform design.

• Analytical Science and Technology
• /
• v.26 no.1
• /
• pp.80-85
• /
• 2013

The sixty nine accident preparedness substances (APS) having high probability of chemical accident are controlled under the Toxic Chemicals Control Act (TCCA). Around the world, there has been a growing interest in the analysis of chemical warfare agent (CWAs). When a chemical accident occurs, it is generally required to detect and identify APS. However, the quantitative analytical data remain limited in Korea. In this study, an analytical method using GC/MS for volatile organic chemicals was established and a quantitative analysis method was studied. The calibration curve for 25 chemicals were obtained and 21 chemicals showed higher coefficient of determination ($r^2$ >0.998).

• Journal of the Korean Wood Science and Technology
• /
• v.46 no.1
• /
• pp.1-9
• /
• 2018

Nowadays, synthetic resin varnish such as cashew nut shell liquid (CNSL) is being used as well as traditional lacquer. The code of ethics states that material must be identical to the original when preserving cultural heritage. Therefore, lacquer should be used. However, problem is that even experts have difficulties differentiating lacquer and CNSL as they have similar components. Therefore, this study was carried out to identify the difference between lacquer and CNSL using IR and Py-GC/MS. As a result of IR, in lacquer, $720cm^{-1}$ peak was detected and in CNSL, $750cm^{-1}$, $720cm^{-1}$ and $700cm^{-1}$ peaks were detected. The results of Py-GC/MS detect benzene compounds and alkyl chains for both varnishes. However, hexanoic acid was detected from CNSL but not lacquer. Using these analytical methods, the differences between lacquer and CNSL can be identified on the scene. This is expected to be applied to the authentic conservation and restoration of lacquerware.

• Herbal Formula Science
• /
• v.21 no.1
• /
• pp.177-185
• /
• 2013

Objectives : Leejung-tang (Lizhong-tang) has been used for treatment of gastrointestinal disorders in Korea. In this study, we performed quantification analysis of five marker components, liquiritin, ginsenoside Rb1, ginsenoside Rg1, glycyrrhizin, and 6-gingerol in Leejung-tang using a ultra performance liquid chromatography- electrospray ionization-mass spectrometer (UPLC-ESI-MS). In addition, we evaluated antioxidant activity of Leejung- tang. Methods : The column for separation of five constituents used a UPLC BEH C18 ($100{\times}2.1mm$, $1.7{\mu}m$) maintained at $45^{\circ}C$. The mobile phase consisted of two solvent systems, 0.1% (v/v) formic acid in H2O (A) and CH3CN (B) by gradient flow. The flow rate was 0.3 mL/min with detection at mass spectrometer. The antioxidative activities conduct an experiment on 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities of Leejung-tang. Results : Calibration curves of five marker compounds were acquired with r2 values > 0.99. The amount of the five compounds in Leejung-tang were 0.07 - 0.84 mg/g. The concentration required for 50% reduction (RC50) against ABTS radical was 119.02 ug/mL. In addition, the scavenging against DPPH radical of Leejung-tang was 11.4%, 14.5%, 19.8%, 29.6%, and 49.2% at 25 ug/mL, $50{\mu}g/mL$, $100{\mu}g/mL$, $200{\mu}g/mL$, and $400{\mu}g/mL$, respectively. Conclusions : The established LC-MS/MS method will be helpful to improve quality control of Leejung-tang. In addition, Leejung-tang is a potential antioxidant therapeutic agent.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.14 no.4
• /
• pp.719-725
• /
• 2011

To apply TMAH-based Py-MS to a field biological detection system for real-time classification of cell-type, reproducible patterns of the TMAH-based Py-MS spectra was known as a critical factor for classification but was seriously disturbed by quantity of cells injected into pyro-tube. This factor is an exterior variable that could not be complemented by improving the performance of the TMAH-based Py-MS instrument. One of idea to solve the knotty problem has been flashed from "Top-down proteomics for identification of intact microoganisms". That is, biomarker peaks are selected from complicate Py-MS spectra for intact microoganisms by tracing out their origins, based on Py-MS spectra for the featured components of different cell-types, in Top-down approach. This idea has been tested in classification of different Gram-type microoganisms. Through the analyses of spectra for the featured components - peptidoglycan and lipoteichoic acid for Gram-positive cells and lipopolysaccharide and lipid A for Gram-negative cells - with comparing to the spectra the corresponding Gram-type cells in the Top-down approach, biomarker peaks were selected to carry out PCA(Principal Component Analysis) in order to see classification of different Gram-types, resulting in significant improvement of their classification. Furthermore, weighting biomarker peaks on intact cell's spectra, based on the data for the featured components of the Gram-types, contributed to elevate classification performance.