• Title/Summary/Keyword: MR studies

검색결과 312건 처리시간 0.022초

사이클로스포린 신경독성에 의한 가역성 뇌관류 저하 : 증례보고 (Reversible Cerebral Hypoperfusion in Cyclosporine Neurotoxicity : A Case Report)

  • 안병철;이재태;강도영;이상우;천경아;손상균;이규보
    • 대한핵의학회지
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    • 제34권4호
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    • pp.360-365
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    • 2000
  • We experienced a case of cerebral hypoperfusion due to cyclosporine neurotoxocity confirmed only by Tc-99m ECD brain SPECT. A 53-year-old female had received allogenic peripheral blood stem cell transplantation due to refractory plasmacytoid lymphoma. Cyclosporine and steroid had been administrated to prevent graft versus host disease. Twenty days after transplantation, she became delirious and suffered from generalized tonic-clonic seizure. Immediately, brain MRI and MR angiography were performed and these studies did not show any abnormal findings. However, Tc-99m ECD brain SPECT showed diffuse hypoperfusion in the left cerebral hemisphere and blood cyclosporine level was 962.6 ng/ml. Cyclosporine administration was stopped and discontinuation of cyclosporine resulted in disappearance of all neurological symptoms. The same neurological symptoms recurred with cyclosporine re-administration for management of exacerbated graft versus host disease. In this case, Tc-99m ECD brain SPECT proved very helpful in the diagnosis of cycloporine neurotoxicity.

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Relation of Multiple Neurogenic Tumors in the Spinal Canal to Neurofibromatosis

  • Seol, Ho-Jun;Chung, Chun-Kee;Kim, Hyun-Jib;Lee, Yoon-Kyung;Park, Sung-Hye
    • Journal of Korean Neurosurgical Society
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    • 제38권1호
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    • pp.16-22
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    • 2005
  • Objective : The authors characterize a syndrome of multiple neurogenic tumors in the spinal canal, which is unclassifiable by the current National Institute of Health[NIH] criteria for neurofibromatosis. Methods : We retrospectively examined cases in which two or more spinal neurogenic tumors were detected by magnetic resonance[MR] imaging and which had been pathologically confirmed. Eighteen patients were recruited between February 1986 and March 2002. According to NIH criteria, eight cases were neurofibromatosis type 1[NF1], four were type 2[NF2], and six were neither type 1 nor type 2 [Unclassifiable : UC]. The locations of lesions, clinical presentations, radiological findings, and pathological results with immunohistochemistry were reviewed. Results : In the case of NF2, three of four cases were intradural tumors. Pathological examinations revealed neurilemmomas in two of four NF2 and all of the UC cases. In the case of NF1, pathological examinations showed seven neurofibromas and one neurilemmoma. Concerning UC, the age at presentation was middle-aged to late [mean age 48.5, range 35 to 64], which contrasted with ordinary NF2, where patients tended to become symptomatic before 20years of age. The pathological examinations of UC cases revealed neurilemmoma similar to most of NF2 and the immunohistochemical study showed characteristic of NF1. Conclusion : Multiple neurogenic tumors in the spinal canal are an under-recognized disease entity. Further studies for genetic aberration in multiple spinal neurogenic tumors are needed.

Prediction and visualization of CYP2D6 genotype-based phenotype using clustering algorithms

  • Kim, Eun-Young;Shin, Sang-Goo;Shin, Jae-Gook
    • Translational and Clinical Pharmacology
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    • 제25권3호
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    • pp.147-152
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    • 2017
  • This study focused on the role of cytochrome P450 2D6 (CYP2D6) genotypes to predict phenotypes in the metabolism of dextromethorphan. CYP2D6 genotypes and metabolic ratios (MRs) of dextromethorphan were determined in 201 Koreans. Unsupervised clustering algorithms, hierarchical and k-means clustering analysis, and color visualizations of CYP2D6 activity were performed on a subset of 130 subjects. A total of 23 different genotypes were identified, five of which were observed in one subject. Phenotype classifications were based on the means, medians, and standard deviations of the log MR values for each genotype. Color visualization was used to display the mean and median of each genotype as different color intensities. Cutoff values were determined using receiver operating characteristic curves from the k-means analysis, and the data were validated in the remaining subset of 71 subjects. Using the two highest silhouette values, the selected numbers of clusters were three (the best) and four. The findings from the two clustering algorithms were similar to those of other studies, classifying $^*5/^*5$ as a lowest activity group and genotypes containing duplicated alleles (i.e., $CYP2D6^*1/^*2N$) as a highest activity group. The validation of the k-means clustering results with data from the 71 subjects revealed relatively high concordance rates: 92.8% and 73.9% in three and four clusters, respectively. Additionally, color visualization allowed for rapid interpretation of results. Although the clustering approach to predict CYP2D6 phenotype from CYP2D6 genotype is not fully complete, it provides general information about the genotype to phenotype relationship, including rare genotypes with only one subject.

Integrated cable vibration control system using Arduino

  • Jeong, Seunghoo;Lee, Junhwa;Cho, Soojin;Sim, Sung-Han
    • Smart Structures and Systems
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    • 제23권6호
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    • pp.695-702
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    • 2019
  • The number of cable-stayed bridges has been increasing worldwide, causing issues in maintaining the structural safety and integrity of bridges. The stay cable, one of the most critical members in cable-stayed bridges, is vulnerable to wind-induced vibrations owing to its inherent low damping capacity. Thus, vibration mitigation of stay cables has been an important issue both in academia and practice. While a semi-active control scheme shows effective vibration reduction compared to a passive control scheme, real-world applications are quite limited because it requires complicated equipment, including for data acquisition, and power supply. This study aims to develop an Arduino-based integrated cable vibration control system implementing a semi-active control algorithm. The integrated control system is built on the low-cost, low-power Arduino platform, embedding a semi-active control algorithm. A MEMS accelerometer is installed in the platform to conduct a state feedback for the semi-active control. The Linear Quadratic Gaussian control is applied to estimate a cable state and obtain a control gain, and the clipped optimal algorithm is implemented to control the damping device. This study selects the magnetorheological damper as a semi-active damping device, controlled by the proposed control system. The developed integrated system is applied to a laboratory size cable with a series of experimental studies for identifying the effect of the system on cable vibration reduction. The semi-active control embedded in the integrated system is compared with free and passive mode cases and is shown to reduce the vibration of stay-cables effectively.

Compressed sensing을 이용한 TOF MRA 검사에서 Flow rate와 CS factor의 변화에 따른 영향 (Effects of Flow Rates and CS Factors on TOF MRA using Compressed Sensing)

  • 김성호;정현근;유세종
    • 한국방사선학회논문지
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    • 제15권3호
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    • pp.281-291
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    • 2021
  • 본 연구는 자기공명영상을 이용한 TOF MRA 검사에서 flow rate 2.0 ml 이하의 유속을 표현함에 있어 Compressed sensing의 사용에 따른 영상의 변화를 정량적으로 측정하고자 하였다. Auto-injector와 Flow phantom을 이용하여 각각의 혈류속도 구간을 설정하고 CS를 사용하지 않은 TOF without CS 기법과 CS를 이용한 TOF with CS 기법에서 CS factor의 변화에 따른 SNR, CNR, SSIM, RMSE 등을 측정하여 비교하였다. CS factor의 증가에 따라 나타나는 영상의 영향을 검증하고자 일원배치 분산분석(One-way ANOVA)을 시행하였다. 실험 결과 CS를 사용한 TOF MRA는 CS를 사용하지 않은 TOF MRA와 비교하여 SNR 및 CNR의 유의한 차이 없이 scan time이 현저하게 감소하였다. 반면 CS factor의 증가에 따라 SSIM 및 RMSE는 TOF without CS 영상과의 차이가 증가함을 나타내었다. 따라서 TOF MRA 검사 시 CS 기법을 통해 scan time을 효율적으로 감소시키되 적절한 CS factor의 범위를 충분히 고려해야 한다. 또한 CS factor와 영상의 유사도, 정밀성에 대한 지속적인 연구가 필요할 것으로 사료된다.

럭셔리 패션 브랜드 가상패션쇼 경험에 대한 탐색적 연구 (An Exploratory Study on Experience of Luxury Brand Virtual Fashion Show)

  • 정효조;고은주
    • 패션비즈니스
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    • 제27권2호
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    • pp.70-87
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    • 2023
  • Today, VR, AR, and MR technologies that travel between real world and virtual world are rapidly developing. These technologies are adopted in luxury fashion brands for virtual fashion shows and runways, virtual retail shops and virtual fitting services. Despite its growth potential and social importance, virtual fashion space has been studies insufficiently. Therefore, this study aimed to examine the consumer experience on the virtual fashion space types, components of virtual fashion space, perceived value, and continuous usage intention. Prada, one of the most active luxury fashion brands in the VR field, was selected as the stimulus for an in-depth interview. Participants experienced virtual fashion show space through VR device (Oculus Quest 2 from Meta) before responding to the questions about their experience. Results showed that material space was more like virtual whereas perceptual space felt like reality. Participants could imagine about more virtual image from material space and more real image from perceptual space elements. Moreover, perceptual space enhanced the immersion, presence, and interactivity compared to material space. Most participants perceived that the virtual fashion show was useful and playful, leading to the continuous usage intention. It implies that improvements for some technical limitation from VR device and virtual contents can provide quality consumer experience in the future. Based on results of this study, fashion companies can establish useful marketing strategies for consumers' immersive and playful experiences when introducing virtual fashion space.

소설의 발생과 성적 계약 -국민국가 담론을 넘어 (The Rise of the Novel and the Sexual Contract: Beyond correspondence between novel and nation-state)

  • 김봉률
    • 영어영문학
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    • 제55권5호
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    • pp.793-820
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    • 2009
  • The studies of correspondence between novel and nation-state, among which The Rise of the Novel by Ian Watt is supposed to be the first book, have flourished for more than twenty years, encouraged by Benedict Anderson's and Cathy Davidson's works. According to them, the novel should come simultaneously with, or after the foundation of the nation-state, and testify to its production or the emergence of its subject/citizen. This paper questions about these prepositions, trying to introduce a new paradigmatical approach, "between global and transnational historical approach," to first novels in transatlantic areas including England and atlantic coastal areas. In its complex relation to a variety of colonial, post-colonial, and transnational geopolitics, various cultural practices such as history, traveler's tales and epistolary novels can be included in the genre of the novel. The idea of the sexual contract by Carole Pateman is very useful because it helps more clearly understand the nature of relation between men and women in the capitalist reproduction, while the social contract tells about the relation between men as citizens. Unlike Freud in Totem and Taboo, Zilboorg argues that there were primordial and violent scenes such as rape before the first sexual contract. This paper will illuminate that "the rise of the novel" corresponded with the emergence of the sexual contract. In the so-called first novel Pamela, the heroine Pamela was threatened to be violated by Mr. B., and was really even confined in his cottage. Mary Rowlandson's The Captive Narrative shows that her body was confined as an English female captive, and troubled with imaginary rape by Indians which resulted in the unequal sexual contract between her and her puritan community in America. However, Leonora Sansay's Secret History in an alternative communality, which was not a nation-state, was different from both novels mentioned above, in that it shows the possibility of emancipation from their unequal marriage, the sexual contract. Therefore, it can be argued that "between global and transnational historical approach" has a possibility to provide a new vision of global sisterhood and solidarity to recognize globalized women's violence, and free themselves from the unequal sexual contract.

Faulkner's Narrative Strategies and the Nature of History in Absalom, Absalom!

  • Rhee, Beau La
    • 영어영문학
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    • 제56권6호
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    • pp.1091-1103
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    • 2010
  • Absalom, Absalom! is not only about family history but also about the nature of reconstructing history. Faulkner shows us what will happen if we give too much credit to the person having the authority; he first makes us listen to Rosa, so we just listen without doubt until we arrive at the question of the objectivity of her narration, when we get to know Sutpen's design. Meanings of "facts" change depending on who perceives the facts. The incremental repetition of the narrative in the novel resembles the process of our thinking mind and the process of history being constructed. Time is a significant element in determining the meaning of an event, not only because the event cannot be understood without its social, cultural context of the contemporary, but also because only the later events make it possible for the perceiver to categorize it in its proper place in history. Furthermore, through his narrative strategy, Faulkner suggests that imagination play a large part in recreating history. He blurs the distinction between facts and imagination, making us regard Shreve's and Quentin's conjectures as facts in several ways. The conversation between father and son, and the two brothers, which is an imagination constructed through the clues Mr Compson has offered, becomes a fact willingly accepted by the readers as well as Shreve and Quentin. The people in the past, present, and future may be very much unlikely to agree on the same event, because the gap in temporality will keep widening our perceptions. Faulkner demonstrates the nature of history in such a way that we can compare our understanding of the Sutpens' history in the earlier and later part of the novel through repetitions.

오큘러스 VR (Oculus VR)를 이용한 애니메이션 콘텐츠의 새로운 모색 - VR 플랫폼과 킬러콘텐츠를 중심으로 - (The new explore of the animated content using OculusVR - Focusing on the VR platform and killer content -)

  • 이종한
    • 만화애니메이션 연구
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    • 통권45호
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    • pp.197-214
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    • 2016
  • 최근의 전 세계적으로 주목받고 있는 증감현실(增强現實, Augmented Reality, AR)과 가상현실(假想現實, virtual reality, VR), 그리고 이들을 섞은 혼합현실(mixed reality, MR)등은 과학의 테크놀로지 범주를 넘어 대중문화 전반에 큰 영향을 끼치고 있다. 구글, 애플, 삼성, 마이크로소프트, 소니, LG등 세계 굴지의 IT회사들은 대중을 위한 AR. VR 기술개발에 주력하고 있으며 크고 작은 관련 회사들도 해당 하드웨어, 소프트웨어, 콘텐츠 개발에 박차를 가하고 있다. 특정한 플랫폼이나 프로그램을 이용해 인간의 인지력을 인위적으로 조작 통해 특정한 장소나 상황을 경험하거나 보이지 않는 것을 보이게 해준다는 의미에서 AR, VR, MR은 모두 가상의 공간의 현실화라는 공통적인 기술을 포괄하고 있다. 특히, 기존의 평면적 구도의 한계성을 드러낸 입체영상에서 벗어나 180도, 360도 영상으로 객관적 시야와 감각과 같은 주관적 현상을 동시에 제공하고 참가자들이 이를 선택 할 수 있어 참가와 몰입을 크게 유도 할 수 있는 VR 기술은 업계뿐만 아니라 일반대중에게도 초유의 관심을 이끌어내고 있다. 2015년 선댄스 영화제의 뉴 프론티어 프로그램에서는 10개 이상의 관련 작품이 소개 되었고 열풍이 되어버린 게임인 '포켓몬 고(PoKetmon GO)'는 세계 게임시장을 석권하고 있으며 의료, 건축, 쇼핑, 영화, 애니메이션 등 관련 콘텐츠가 등장하고 있고 관련 모바일 어플리케이션도 이미 수천 개 이상 상용화 되어있다. 또한 시판되는 360도 카메라를 통해 개인이 VR 영상을 제작/공유 할 수 있어 유저간의 쌍방형 터널이 가능해 지고 있다. VR 기술의 적용범위 확대와 다양한 현실화로 앞으로 가능성도 희망적으로 여기고 있다. 이는 세계적인 추세며 우리나라 역시 후발주자로 그 추세를 따르고 있다. 그럼에도 불구하고 일부 학자들은 VR, 즉, 가상공간의 현실화가 주는 윤리적 퇴행과 가치관의 혼란이 내재 되어있음을 지적하고 있다. 4K혹은 HUD, 위치추적, 동작 센서, 연산능력, 그리고 뛰어난 3D그래픽, 촉감, 냄새 등의 4D기술, 3차원 오디오 기술 등이 그 어느 때 보다 발전해 리얼리티에 최대한 접근하고 있고 그에 따른다. 윤리적 퇴행, 정체성, 세대갈등, 현실도피 등이 우려되기 때문이다. 리얼리티를 추구하는 애니메이션 역시 이 범주 안에 든다. 미학적 이미지와 환영성의 특정한 구조를 살펴본다면 오히려 영상이라는 유사점을 가지고 있음에도 불구하고 순수한 애니메이션이 VR 콘텐츠 제작에 가장 뒤쳐져 있는 요인이 될 수도 있다. 하지만 VR기술과 플랫폼이 게임과 오락성에 치중 해 있지만 그 안에는 결국 시각적인 VR영상으로 구성 되어 있다는 점을 감안한다면 평면상에 머물고 있는 애니메이션에도 새로운 모색점을 맞이하게 될 것이 분명하다. 결국 어떻게 VR기술을 이용한 가상공간에서 만들어지는 리얼리티가 애니메이션에 적용 할 수 있을까? 그렇다면 방법과 수단이 무엇이 될 것인가 하는 문제에 대한 연구가 공통된 관심이 될 것이다. 그동안 평면적인 화면에 시간과 공간의 연속성에 제한을 받아온 애니메이션은 VR기술을 통해 제한에서 벗어나고자 하는 움직임이 일어나고 있다.

간과 비장의 체적을 구하기 위한 3차원 영역 확장 기반 자동 영상 분할 알고리즘의 동물팬텀을 이용한 성능검증 (Evaluation of Automatic Image Segmentation for 3D Volume Measurement of Liver and Spleen Based on 3D Region-growing Algorithm using Animal Phantom)

  • 김진성;조준식;신경숙;김진환;전호상;조규성
    • 한국의학물리학회지:의학물리
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    • 제19권3호
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    • pp.178-185
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    • 2008
  • 간경변 및간암 환자의 증가로 간이식술의 필요성이 점점 증가되고 있고, 특히 공여자의 생체 간이식은 간이식술의 주된 분야를 차지하고 있으며 간이식 수술 전 공여자에서 간체적의 정확한 측정은 수술 후 공여자와 수여자의 간기능을 예측하는데 있어 중요한 자료가 되며, 성공적인 수술과 환자의 예후에 밀접한 영향을 미친다. 그러나 현재 환자의 간체적을 구하는 과정은 환자의 모든 CT 영상위의 간을 수작업을 통해 영상분할한 후에 3차원 간체적을 구하고 있으며 많은 시간과 노력이 필요한 작업이다. 이러한 문제를 해결하기 위해서 본 논문에서는 자동으로 간과 비장을 문턱값처리, 형태학적 영상처리, 3차원 영역확장법등의 기법을 이용하여 분할하는 알고리즘을 개발하여 체적을 구하는 시간을 단축하였다. 이러한 알고리즘의 정확성을 평가하기 위해서 동물의 실제 간과 비장을 팬텀으로 제작하여 실제 측정한 체적과 알고리즘으로 분할된 영상의 결과를 비교 평가하였다. 문턱치값의 설정에 따라 다른 결과를 보이는 특성이 있지만 자동으로 문턱치를 결정했을 때 비장과 간의 체적측정 오차는 9.27%, -4.52%이었으며, 수동으로 문턱치를 결정했을 때 최소 오차가 각각 0.2%, 0.17%의 결과를 보였다. 이러한 팬텀 연구를 통해 자동 분할 알고리즘으로 얻은 체적의 결과가 정확성과 재현성을 보여주어 추후 간체적을 구하는 보조수단으로 활용될 수 있을 것이라 예상된다.

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