The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Reversible Cerebral Hypoperfusion in Cyclosporine Neurotoxicity : A Case Report

사이클로스포린 신경독성에 의한 가역성 뇌관류 저하 : 증례보고

  • Ahn, Byeong-Cheol (Department of Nuclear Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Jae-Tae (Department of Nuclear Medicine, Kyungpook National University School of Medicine) ;
  • Kang, Do-Young (Department of Nuclear Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Sang-Woo (Department of Nuclear Medicine, Kyungpook National University School of Medicine) ;
  • Chun, Kyung-Ah (Department of Nuclear Medicine, Kyungpook National University School of Medicine) ;
  • Sohn, Sang-Kyun (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Kyu-Bo (Department of Nuclear Medicine, Kyungpook National University School of Medicine)
  • 안병철 (경북대학교 의과대학 핵의학교실) ;
  • 이재태 (경북대학교 의과대학 핵의학교실) ;
  • 강도영 (경북대학교 의과대학 핵의학교실) ;
  • 이상우 (경북대학교 의과대학 핵의학교실) ;
  • 천경아 (경북대학교 의과대학 핵의학교실) ;
  • 손상균 (경북대학교 의과대학 내과학교실) ;
  • 이규보 (경북대학교 의과대학 핵의학교실)
  • Published : 2000.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

We experienced a case of cerebral hypoperfusion due to cyclosporine neurotoxocity confirmed only by Tc-99m ECD brain SPECT. A 53-year-old female had received allogenic peripheral blood stem cell transplantation due to refractory plasmacytoid lymphoma. Cyclosporine and steroid had been administrated to prevent graft versus host disease. Twenty days after transplantation, she became delirious and suffered from generalized tonic-clonic seizure. Immediately, brain MRI and MR angiography were performed and these studies did not show any abnormal findings. However, Tc-99m ECD brain SPECT showed diffuse hypoperfusion in the left cerebral hemisphere and blood cyclosporine level was 962.6 ng/ml. Cyclosporine administration was stopped and discontinuation of cyclosporine resulted in disappearance of all neurological symptoms. The same neurological symptoms recurred with cyclosporine re-administration for management of exacerbated graft versus host disease. In this case, Tc-99m ECD brain SPECT proved very helpful in the diagnosis of cycloporine neurotoxicity.

Keywords