• The Journal of Pediatrics of Korean Medicine
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• v.22 no.1
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• pp.13-24
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• 2008

Objectives This study was designed to analyze the clinical studies on Mental retardation(MR) in traditional Chinese medicine(TCM). Methods For this study, we searched the clinical studies on MR, which had been published from 2003 to 2007, through web site CNKI(中國知識基礎設施工 http://www.cnki.net). There were 17 clinical studies and we focused on those studies. Results 1. In those Chinese studies, they used following words to describe Mental retardation; 小人弱智($xi\check{a}o\acute{e}rru\grave{o}zh\grave{i}$), 智能發育不全($zh\grave{i}n\acute{e}ngf\bar{a}y\grave{u}buqu\acute{a}n$), 智力低下($zh\grave{i}l\grave{i}d\bar{i}xi\grave{a}$), 精神發育遲滯($j\bar{i}ngsh\acute{e}f\bar{a}y\grave{u}ch\acute{i}zh\grave{i}$), 智能落后($zh\grave{i}n\acute{e}nglu\grave{o}h\grave{o}u$), 智能落后($zh\grave{i}n\acute{e}ngch\acute{i}hu\check{a}n$), 失天愚型患人($xi\bar{a}nti\bar{a}ny\acute{u}x\acute{i}nghu\grave{a}n'\acute{e}r$). 2. There were many kinds of TCM treatment methods for MR, such as herbal medicine, acupuncture, electroacupunture, acupoint injection, Chuna therapy, and special education. And those TCM treatments methods showed higher efficacies in the treatment of MR compared with Western medicine. 3. Mental retardation was related with the deficiency of heart, kidney, liver, spleen(心虛, 腎虛, 肝虛, 脾虛) and the pathological mechanism of Phlegm(絹) and Blood stasis(慫沂)in the studies about the Bian Zheng-the types of differential diagnosis- of MR. 4. Most of studies used Intelligence Quotient(IQ) to assess the efficacy of TCM treatment of MR. And the duration of treatment, the degree of illness, the age of patient, and the cause of illness affected the prognosis of MR. Conclusions These results suggest that traditional medicine could be one of the useful treatments on MR. And these results could be used in the clinical practices and studies on MR in Korea.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.2
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• pp.151-157
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• 2010

This paper presents the modelling of an MR damper system through extensive experimental studies. The hysteresis of the MR damper is modelled by using the improved Bouc-wen model. A test bed for experimental studies of measuring parameters of the MR damper is designed and implemented. Based on the experimental data, the Bouc-Wen Model is modified for the MR damper system. To check the modelling property, a vehicle suspension system is controlled using a PID controller for the verification of the MR damper model.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.127-134
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• 2018

Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB ($NF-{\kappa}B$) signaling pathway, and atherosclerotic lesion macrophage content. In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. In vitro studies demonstrated similar changes in Ang II-treated vascular smooth muscle cells (VSMCs) and macrophages: siRNA-MR-1 inhibited the expression levels of proinflammatory factor. These studies uncover crucial proinflammatory mechanisms of Ang II and highlight actions of silencing MR-1 to inhibit Ang II signaling, which is atheroprotective.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.511-518
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• 2006

In this study, seismic response mitigation effect of an MR damper generating response-dependent frictional force is investigated. It has been reported in previous studies that passively operated MR damper with constant input current doesn't show better control performance than semi-active MR damper with varying input current calculated by control algorithms such as linear quadratic regulator and sliding mode control. However, in order to operate the MR damper semi-actively, other control systems besides the damper itself such as sensors for measuring structural responses and controller for calculating optimal input current are necessary, which deteriorate the economical efficiency. This study presents a MR damper generating frictional force of which magnitude is controlled in accordance to the displacement and velocity transferred to the damper. Numerical analyses results indicate that the performance of the response dependent MR damper is closely related with the range of the friction force and it can be designed to short better control performance than the passive MR damper.

• Proceedings of the KIEE Conference
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• 2008.10b
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• pp.163-164
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• 2008

본 논문에서는 MR(Magneto-rheological)댐퍼의 특성을 파악하고 모델링하기 위해 실험 장치를 설계 및 제작을 하였다. 그리고 MR댐퍼의 특성 중 전항복(pre-yieid) 영역에서의 속도가 증가하거나 및 감소할 때의 감쇠력의 차이를 보이는 이력현상을 모델링하기 위해 개선된 Bouc-Wen 모델을 이용하였다. 다양한 실험을 통해 Bouc-Wen 모델의 변수들을 이용하여 구하였다.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.109-111
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• 2003

Compared to the present clinical field strengths, MR at 47 and above promises to improve anatomic imaging quality by factors, and to bring metabolic and functional imaging to the forefront of research and diagnostic modalities. While human bore sized magnets as high as 9.4T are now installed, realization of the potential benefit of these magnets will require more of the MR system than a simple field, frequency or power scaling from technologies used at lower fields. New constraints on the high field MR studies, both physical and physiological, will require new technical developments to be considered for the highest field systems.

• Biomedical Science Letters
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• v.11 no.4
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• pp.555-559
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• 2005

Evaluate the triolein emulsion could disrupt the barriers and to suggest as an experimental model in blood-ocular barrier studies. Triolein emulsion was infused into the carotid artery in the experimental group ten cats. Normal saline was used in another the control group ten cats. Pre contrast and postcontrast T1-weighted MR images were obtained at 30 minutes and 3 hours after embolization. Signal intensities were evaluated in the anterior, posterior chamber and in the vitreus qualitatively and quantitatively. Postembolization 30 minutes MR images were not different from those of the control group. Postembolization 3 hour MR images demonstrated delayed contrast enhancement in the anterior chamber of the ipsilateral and contralateral eyeballs and in the posterior chamber of the ipsilateral eyeball. Delayed contrast enhancement of the posterior chamber of the ipsilateral eyeball was statistically significant (P<0.05). The present study demonstrated significant contrast enhancement in the posterior chamber with infusion of triolein emulsion and can be a model in blood-aqueous barrier studies.

• Smart Structures and Systems
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• v.9 no.1
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• pp.35-53
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• 2012

Mechanical dampers have been proved to be one of the most effective countermeasures for vibration mitigation of stay cables in various cable-stayed bridges over the world. However, for long stay cables, as the installation height of the damper is restricted due to the aesthetic concern, using passive dampers alone may not satisfy the control requirement of the stay cables. In this connection, semi-active MR dampers have been proposed for the vibration mitigation of long stay cables. Although various studies have been carried out on the implementation of MR dampers on stay cables, the optimal damping performance of the cable-MR damper system has yet to be evaluated. Therefore, this paper aims to investigate the effectiveness of MR damper as a semi-active control device for the vibration mitigation of stay cable. The mathematical model of the MR damper will first be established through a performance test. Then, an efficient semi-active control strategy will be derived, where the damping of MR damper will be tuned according to the dynamic characteristics of stay cable, in order to achieve optimal damping of cable-damper system. Simulation study will be carried out to verify the proposed semi-active control algorithm for suppressing the cable vibrations induced by different loading patterns using optimally tuned MR damper. Finally, the effectiveness of MR damper in mitigating multi modes of cable vibration will be examined theoretically.

• Tribology and Lubricants
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• v.28 no.6
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• pp.333-339
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• 2012

Typical magneto-rheological (MR) elastomers consist of silicon-based material. A number of studies have been carried out to evaluate the vibration and tribological characteristics of silicon-based MR e-lastomers. However, these elastomers have quite low strength, so they have low wear resistance. In this study, polyurethane-based MR elastomers with performances better than those of MR elastomers. Experiments have been conducted on different MR elastomers (Pu MR elastomer, Pu-Si MR elastomer, and Pu-wrapped-Si MR elastomer) and different predefined magnetic directions (Non-Direction, Vertical Direction, and Horizontal Directionality) to evaluate the friction and wear performance under a magnetic field. The results show that Pu-wrapped-Si MR elastomer with a horizontal predefined magnetic field has the best performance in terms of wear.

• Structural Engineering and Mechanics
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• v.52 no.2
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• pp.291-306
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• 2014

In this paper the progressive collapse resisting capacity of steel moment frames with MR dampers is evaluated, and a preliminary design procedure for the dampers to prevent progressive collapse is suggested. Parametric studies are carried out using a beam-column subassemblage with varying natural period, yield strength, and damper force. Then the progressive collapse potentials of 15-story steel moment frames installed with MR dampers are evaluated by nonlinear dynamic analysis. The analysis results of the model structures showed that the MR dampers are effective in preventing progressive collapse of framed structures subjected to sudden loss of a first story column. The effectiveness is more noticeable in the structure with larger vertical deflection subjected to larger inelastic deformation. The maximum responses of the structure installed with the MR dampers designed to meet a given target dynamic response factor generally coincided well with the target value on the conservative side.