• Geomechanics and Engineering
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• 제6권1호
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• pp.1-15
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• 2014

In this study, artificial neural network (ANN) and multiple regression (MR) models were developed to predict the critical factor of safety ($F_s$) of the homogeneous finite slopes subjected to earthquake forces. To achieve this, the values of $F_s$ in 5184 nos. of homogeneous finite slopes having different slope, soil and earthquake parameters were calculated by using the Simplified Bishop method and the minimum (critical) $F_s$ for each of the case was determined and used in the development of the ANN and MR models. The results obtained from both the models were compared with those obtained from the calculations. It is found that the ANN model exhibits more reliable predictions than the MR model. Moreover, several performance indices such as the determination coefficient, variance account for, mean absolute error, root mean square error, and the scaled percent error were computed. Also, the receiver operating curves were drawn, and the areas under the curves (AUC) were calculated to assess the prediction capacity of the ANN and MR models developed. The performance level attained in the ANN model shows that the ANN model developed can be used for predicting the critical $F_s$ of the homogeneous finite slopes subjected to earthquake forces.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.229-254
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• 2004

The objective of this study was to scrutinize the rationale of SUPAC-MR and its application in processing postapproval changes to modified release solid oral dosage forms. The types of postapproval changes that were primarily covered with SUPAC-MR included variations in the components and composition, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. SUPAC-MR defined levels of postapproval changes that the industry might make. Classification of such categories was based on the likelihood of risk occurrence and potential impact of changes upon the safety and efficacy of approved drug products. In most cases, the changes could be classified into 3 levels. It described what chemistry, manufacturing, and control tests should be conducted for each change level. The important tests specified in SUPAC-MR were batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. It then suggested what type of a filing report should be submitted to the FDA for each change level. In general, level 1 changes could be reported in an annual report, whereas level 2 and/or 3 changes could be submitted in changes-being-effected or prior approval supplements. It could be understood that the purpose of SUPAC-MR was to maintain the safety and quality of approved modified release solid oral dosage forms undergoing certain changes. At the same time, it contributed to providing a less burdensome regulatory process with the manufacturers when they wanted to make postapproval changes. European regulatory agencies also implemented SUPAC-like regulations in handling such changes to drug products. Therefore, in this study a recommendation was made for KFDA and the Korean industry to evaluate thoroughly the usefulness of these guidances and regulations in dealing with postapproval changes to modified release solid oral dosage forms.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.720-725
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• 2017

본 연구에서는 멀티 해저드를 고려한 빌딩 구조물의 안전성 및 사용성에 대한 평가를 수행하였고 지진 하중 및 풍하중에 대한 안전성과 사용성이 관련된 구조 성능을 개선하기 위하여 TMD 기반 적응형 스마트 구조 제어 시스템을 제안하였다. TMD 기반 적응형 스마트 구조 제어 시스템은 MR 감쇠기를 이용하여 구성하였다. 멀티 해저드 하중을 작성하기 위하여 미국의 대표 강진 지역 및 강풍 지역을 선택 하여 해당 지역의 특성을 고려한 인공 지진 하중 및 인공 풍 하중을 작성 하였다. 작성된 하중을 사용하여 20층 예제 구조물의 안전성 및 사용성을 검토하였다. 대상 예제 구조물의 안전성 및 사용성을 개선하기 위하여 스마트 TMD를 적용 하였고 성능 개선 정도를 평가하였다. 스마트 TMD는 MR 감쇠기를 이용하여 구성하였다. 수치 해석 결과 예제 구조물은 멀티 해저드에 대하여 안전성 및 사용성 측면에서 모두 설계 기준 값을 벗어났다. 스마트 TMD가 안전성과 연관되는 지진 응답과 사용성과 연관되는 풍 응답을 모두 효과적으로 저감시키는 것을 확인하였다.

• Earthquakes and Structures
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• 제11권6호
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• pp.1001-1025
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• 2016

Building structures generally have inherent low damping capability and hence are vulnerable to seismic excitations. Control devices therefore play a useful role in providing safety to building structures subject to seismic events. In recent years semi-active dampers have gained considerable attention as structural control devices in the building construction industry. Magneto-rheological (MR) damper, a type of semi-active damper has proven to be effective in seismic mitigation of building structures. MR dampers contain a controllable MR fluid whose rheological properties vary rapidly with the applied magnetic field. Although some research has been carried out on the use of MR dampers in building structures, optimal design of MR damper and combined use of MR and passive dampers for real scale buildings has hardly been investigated. This paper investigates the use of MR dampers and incorporating MR-passive damper combinations in building structures in order to achieve acceptable levels of seismic performance. In order to do so, it first develops the MR damper model by integrating control algorithms commonly used in MR damper modelling. The developed MR damper is then integrated in to the seismically excited structure as a time domain function. Linear and nonlinear structure models are evaluated in real time scenarios. Analyses are conducted to investigate the influence of location and number of devices on the seismic performance of the building structure. The findings of this paper provide information towards the design and construction of earthquake safe buildings with optimally employed MR dampers and MR-passive damper combinations.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.101-103
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• 1997

In-vivo and in-vitro MR Microscopy has been performed to investigate any differences in-between the normal and the abnormal skin layers. Noninvasively acquired images could provide the skin histology. Also, it was found that the epidermis of the abnormal skin was thickened more than that of normal skin. MR Microscopy utilized for the present study may be applicable to the noninvasive investigation of skin pathology and this technique may be of use in the development of cosmetics.

• 한국압력기기공학회 논문집
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• 제8권2호
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• pp.26-32
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• 2012

The systems of the nuclear power plant are designed based on the User Requirement Document, and Korea Hydro & Nuclear Power Co. (KHNP) implements preventive maintenance activities to keep the specific design function of the system consistently. To monitor the preventive maintenance effectiveness, KHNP has also developed maintenance effectiveness monitoring (MR) program based on NUMARC 93-01 since 2003, and has implemented the program in all operating plants. Recently, KHNP has upgraded MR programs by reflecting implementing experiences ; reestablishing the performance monitoring level, improving analysis for standby function and performance criteria for passive components, reestablishing the availability performance criteria and the performance criteria for the same type of components. These upgraded MR programs will contribute to enhance safety and improve equipment reliability through monitoring maintenance effectiveness.

• Geomechanics and Engineering
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• 제34권6호
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• pp.649-664
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• 2023

Structural inertial interaction is a representative the effect of dynamic soil-foundation-structure interaction (SFSI), which leads to a relative displacement between soil and foundation, period lengthening, and damping increasing phenomena. However, for a system with a significantly heavy foundation, the dynamic inertia of the foundation influences and interacts with the structural seismic response. The structure-to-foundation mass ratio (MR) quantifies the distribution of mass between the structure and foundation for a structure on a shallow foundation. Although both systems exhibit the same vertical factor of safety (FS_v), the MR and corresponding seismic responses attributed to the structure and foundation masses may differ. This study explored the influence of MR on the permanent deformation and seismic response of soil-foundation-structure system considering SFSI via numerical simulations. Given that numerous dimensionless parameters of SFSI described its influence on the structural seismic response, the parameters, except for MR and FS_v, were fixed for the sensitivity analysis. The results demonstrated that the foundation inertia of heavier foundations induced more settlement due to sliding behavior of heavily-loaded systems. Moreover, the structural inertia of heavier structures evidently exhibited foundation rocking behavior, which results in a more elongated natural period of the structure for lightly-loaded systems.

• International Journal of Safety
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• 제10권1호
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• pp.22-31
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• 2011

Seismic response control method of the bridge structures with semi-active control device, i.e., magneto-rheological (MR) damper, is studied in this paper. Design of various kinds of clipped optimal controller and fuzzy controller are suggested as a semi-active control algorithm. For determining the control force of MR damper, clipped optimal control method adopts bi-state approach, but the fuzzy control method continuously quantifies input currents through fuzzy inference mechanism to finely modulate the damper force. To investigate the performances of the suggested control techniques, numerical simulations of a multi-span continuous bridge system subjected to various earthquakes are performed, and their performances are compared with each other. From the comparison of results, it is shown that the fuzzy control system can provide well-balanced control force between girder and pier in the view point of structural safety and stability and be quite effective in reducing both girder and pier displacements over the existing control method.

• 한국안전학회지
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• 제26권4호
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• pp.69-79
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• 2011

This paper proposes a GA-based optimal fuzzy control technique for the vibration control of earthquakeexcited adjacent structures interconnected with semi-active magneto-rheological(MR) dampers. Rule-based fuzzy logic controllers are designed first by implementing heuristic knowledge and the genetic algorithm(GA) is then introduced to optimally tune the fuzzy controllers for enhancing the seismic performance of semi-active control system. For practical implementation, the fuzzy controller simply uses locally measured responses of the dampers involved and directly returns the input voltage to the magneto-rheological dampers in real time through the fuzzy inference mechanism. The local measurement based fuzzy controller provides optimal damping force in a decentralized manner so that it does not require a primary central controller unlike the conventional semi-active control techniques. As a result, it can avoid the unbridgeable discrepancy between the desired control force and the actual damper force that may occur in the conventional control approaches. The validity and effectiveness of the proposed control method are shown numerically on two 20-story earthquake-excited buildings interconnected with MR dampers.

• 한국터널지하공간학회 논문집
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• 제17권4호
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• pp.441-455
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• 2015

본 연구에서는 터널 시공 중 굴진면에서의 붕괴 위험을 판단하여 작업자의 안전을 확보할 수 있는 굴진면 안전감시시스템을 개발하였다. 이 시스템은 실시간으로 측정되는 굴진면 변위를 x-MR 관리도기법으로 실시간 분석함으로써 굴진면의 이상 거동을 감시할 수 있다. 또한 관리 기준을 초과하는 측정치의 개수와 이동 범위 k를 비교하여 굴진면의 이상 거동과 작업 과정에서 발생하는 오류를 구분할 수 있도록 오경보 판단 알고리듬을 개발하였다. 본 연구결과는 위험지반 구간에서의 굴진면의 실시간 거동 감시에 적용되어 작업자의 피해를 최소화 할 수 있을 것으로 판단된다.