• Advances in Traditional Medicine
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• 제7권1호
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• pp.34-40
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• 2007

The present study was carried out to elucidate the potential of Muntingia (M.) calabura leaves chloroform extract (MCCE) as antinociceptive, anti-inflammatory and antipyretic agents using various animal models. The dried powdered leaves of M. calabura (20 g) were soaked in chloroform for 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (0.912 g), dissolved in dimethyl sulfoxide (1:20; w/v) and considered as a stock solution (100% concentration/strength), was then diluted to the concentrations of 10 and 50% and used together in all experimental models. The MCCE was found to show significant (P < 0.05) antinociceptive and antipyretic activities, but less remarkable anti-inflammatory activity. Only the antinociceptive activity of MCCE measured using the abdominal constriction test and in the first phase of the formalin test occurred in a concentration-dependent manner. The anti-inflammatory activity of 50 and 100% concentrations MCCE was observed only at the range of time interval of 60 - 120 and 60 min, respectively. Based on the results, we conclude that the M. calabura leaves chloroform extract possessed remarkable antinociceptive and antipyretic, but less effective anti-inflammatory, activities and thus justifies the Peruvian folklore claims of its medicinal values.

• 대한전자공학회논문지SP
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• 제40권1호
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• pp.43-50
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• 2003

오늘날 멀티미디어의 응용이 크게 늘면서 영상 취득 장치의 수요가 증대되고 있다. 그중 필름 스캐너는 고해상도와 고화질의 디지털 영상을 취득할 수 있는 장치이다. 그러나 필름 스캐너에서는 광원 및 센서의 비선형적 특성으로 인해 원 필름 영상의 컬러와 스캔된 영상의 컬러가 정확히 일치하지 않는 문제가 발생한다. 따라서, 필름 스캐너에서는 스캔된 디지털 영상에 대한 색보정이 필수적이다. 본 논문에서는 스캔된 RGB 색공간의 데이터를 CIE L/sup */a/sup */b/sup */ 색공간으로 변환한 후 다항회귀를 이용하여 색보정한다. 또한, TMS320C32 DSP 칩과 고해상도 라인 센서를 사용하여 R, G, B 각각 12 비트의 색분해도와 2400 dpi 급의 해상도를 갖는 스캐너 하드웨어를 구현하였다. 제작한 스캐너의 색보정 성능을 평가하기 위한 실험 결과, 색보정 전에는 평균색차 (ΔE/sup *//sub ab/)가 13.48 이었던 것이 색보정 후에는 8.46으로 감소함을 확인하였다.

• 한국자기공명학회논문지
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• 제10권2호
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• pp.126-140
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• 2006

Purpose: Contrary to the human study, it has rarely investigated metabolic alterations in the dorsolateral prefrontal cortex (DLPFC) of depressed rats versus age and sex-matched controls using proton magnetic resonance spectroscopy (MRS). Thus, the purpose of this research was to verify the feasibility of metabolic differences between the normal rat and the depression model rat. Materials and Methods: A homogeneous group of 20 SD male rats was used for MRI and in vivo 1H MRS. To induce a depressed status in SD rats, we performed the forced swimming test (FST). Using image-guide, water suppressed in vivo 1H MRS with 4.7 T MRI/MRS system, NAA/Cr and Cho/Cr ratios were mainly measured between depressed rats and normal subjects. Results: In depressed rats, increased Cho/Cr ratio was measured versus control subjects. However, no significant group effect for NAA/Cr was observed between case-control pairs. Discussion and Conclusions: The present 1H MRS study shows significant brain metabolic alterations of dorsolateral prefrontal cortex with experimental depressed status of SD rat induced by FST compared to normal subjects. This result provides new evidence that in vivo 1 H MRS may be a useful modality for detecting localized functional neurochemical markers alterations in left DLPFC in SD rats.

• 한국전기전자재료학회논문지
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• 제13권5호
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• pp.451-457
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• 2000

Experimental investigations on the effect of two kinds of additives ; aqueous NaOH solution and ammonia(NH$_3$) for removal of NOx and SO$_2$ simultaneously by corona discharge were carried out. The simulated combustion flue gas was[NO(0.02[%])-SO$_2$(0.08[%])-$CO_2$-Air-$N_2$] Volume percentage of aqueous NaOH solution used was 20[%] and $N_2$flow rate was 2.5[$\ell$/min] for bubbling aqueous NaOH solution Ammonia gas(14.81[%]) balanced by argon was diluted by air. NH$_3$ molecular ratios(MR) based on [NH$_3$] and [NO+SO$_2$] were 1, 1.5 and 2.5 The vapour of aqueous NaOH solution and NH$_3$was introduced to the main simulated combustion flue gas duct through injection systems which were located at downstream of corona discharge reactor. NOx(NO+NO$_2$) removal rate by injecting the vapour of aqueous NaOH solution was much better than that by injecting NH$_3$however SO$_2$removal rate by injecting NH$_3$was much better than that by injecting the vapour of aqueous NaOH SO$_2$removal rate slightly increased with increasing applied voltage. When the vapour of aqueous NaOH solution and NH$_3$were simultaneously injection NOx and SO$_2$ removal rate were significantly increased.

• Smart Structures and Systems
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• 제23권6호
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• pp.695-702
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• 2019

The number of cable-stayed bridges has been increasing worldwide, causing issues in maintaining the structural safety and integrity of bridges. The stay cable, one of the most critical members in cable-stayed bridges, is vulnerable to wind-induced vibrations owing to its inherent low damping capacity. Thus, vibration mitigation of stay cables has been an important issue both in academia and practice. While a semi-active control scheme shows effective vibration reduction compared to a passive control scheme, real-world applications are quite limited because it requires complicated equipment, including for data acquisition, and power supply. This study aims to develop an Arduino-based integrated cable vibration control system implementing a semi-active control algorithm. The integrated control system is built on the low-cost, low-power Arduino platform, embedding a semi-active control algorithm. A MEMS accelerometer is installed in the platform to conduct a state feedback for the semi-active control. The Linear Quadratic Gaussian control is applied to estimate a cable state and obtain a control gain, and the clipped optimal algorithm is implemented to control the damping device. This study selects the magnetorheological damper as a semi-active damping device, controlled by the proposed control system. The developed integrated system is applied to a laboratory size cable with a series of experimental studies for identifying the effect of the system on cable vibration reduction. The semi-active control embedded in the integrated system is compared with free and passive mode cases and is shown to reduce the vibration of stay-cables effectively.

• 한국콘텐츠학회논문지
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• 제21권10호
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• pp.508-519
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• 2021

본 연구의 목적은 사람돌봄이론(Interpersonal Caring Theory; ICT)의 이해와 적용의 확장을 위하여 영화를 활용한 ICT 교육프로그램을 개발하는 것이었다. 본 연구는 2020년 2월부터 10월까지 수행되었다. ICT 10개 요소를 분석해 영화를 선정하였고, Kolb(1984)의 경험학습모형에 따라 프로그램을 개발하였다. 영화 선정의 타당성은 간호사 11명이 임상전문가로서 프로그램의 시범 운영에 참여한 후 평가하였다. 선정된 영화는 블라인드 사이드(알아봐 줌), 바베트의 만찬(동참함), 굿 윌 헌팅(공유함), 킹스 스피치(경청함), 굿바이 마이프렌드(동행함), 홀랜드 오퍼스(칭찬함), 패치 아담스(안위 제공함), 쇼생크 탈출(희망 불어넣음), 미션(용서함), 사도(수용함)이었다. 프로그램은 총 12회기로 구성되었으며 각 회기에는 경험학습모형의 단계를 위한 토의질문이 포함되었다. 프로그램을 시범 운영한 후 ICT의 요소에 따른 영화 선정의 타당성을 평가한 결과 선정된 영화는 모두 적절한 것으로 평가되었다(I-CVI=0.98). 영화를 활용한 ICT 교육프로그램은 간호사와 간호대학생을 대상으로 돌봄의 역량을 증진시키기 위해 사용될 수 있을 것이다.

• 한국컴퓨터정보학회논문지
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• 제26권7호
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• pp.37-44
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• 2021

뇌 MRI 영상의 자동 분류는 뇌종양의 조기 진단을 하는 데 있어 중요한 역할을 한다. 본 연구에서 우리는 심층 특징 앙상블을 사용한 MRI 영상에서의 딥 러닝 기반 뇌종양 분류 모델을 제안한다. 우선 사전 학습된 3개의 합성 곱 신경망을 사용하여 입력 MRI 영상에 대한 심층 특징들을 추출한다. 그 이후 추출된 심층 특징들은 완전 연결 계층들로 구성된 분류 모듈의 입력 값으로 들어간다. 분류 모듈에서는 우선 3개의 서로 다른 심층 특징들 각각에 대해 먼저 완전 연결 계층을 거쳐 특징 차원을 줄인다. 그 이후 3개의 차원이 준 특징들을 결합하여 하나의 특징 벡터를 생성한 뒤 다시 완전 연결 계층의 입력값으로 들어가서 최종적인 분류 결과를 예측한다. 우리가 제안한 모델을 평가하기 위해 웹상에 공개된 뇌 MRI 데이터 셋을 사용하였다. 실험 결과 우리가 제안한 모델이 다른 기계학습 기반 모델보다 더 좋은 성능을 나타냄을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.

• Current Research on Agriculture and Life Sciences
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• 제24권
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• pp.1-8
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• 2006

When tea trees were introduced to Korea peninsular from China? Historically, Mr. Taeryum, an envoy of Shilla dynasty brought tea seeds from China during Tang dynasty and the seeds were planted at Jiri Mt. by the order of King Heungduk at AD828. During Koryo Dynasty(918 1392), Buddhism spread rapidly all over the country and the tea culture reached its highest stage of prosperity. At the Chosun Dynasty, however, the ceremonial drinking of tea vanished almost completely due to the flourishing Confucian tradition, a kind of substitution of Buddhism. But a few people have supported the traditional tea culture by themselves. Since the independence of Korea soon after the World War II at 1945, Korean War have been exploded at 1950. After economic evolution have been succeeded at 1980, the cultivation area of tea trees has been increased about 2,000ha and the cultural tradition of tea drinking has become popular again at a tea consume quantities amounted to 100g per capita at 2004. The northern limited area of tea plant is lined on the southern part of Korea peninsular. It is very small region compared to China about one million ha and to Japan over 60 thousand ha. It is problem not only the area of tea fields but also the methodology of tea cultivation, for examples without clonal cultivars and mechanical systems. WTO treatments was discussing with Korea, China and Japan government at 2005. Green tea custom is very high at 514% in Korea. If three countries will be agreed the imported tax will be cut off, the Korean tea farmers will be confused because of unstable situation of tea markets. All most of tea farmers should be made the tea fields by seeding not clonal propagation. Because of clonal cultivars have not developed in Korea, there have not been the research institutes for tea plants and manufactures before 1992. Now there are three research institute of tea in Korea; Tea Experiment Station at Bosung of Jeonnam Agricultural Research & Extension Services, Mokpo Experimental Station of National Institute of Crop Science, and Green Tea Cluster Institute of Hadong. Mokpo and Hadong Research Station were established at 2004 and at 2005 but Bosung Station was established at 1992. Seven clonal tea cultivers were selected at Bosung Station; Bohyang, Myngsun, Chanlok, Sunhyang, Mihyang, Jinhyang and Ohsun until 2004. Mokpo Experimental Institute was started the tea provenance testing about 4 provenances: Kangwon-do, Jeonlabuk-do, Jeonlanam-do, and Kyungsangnam-do. Korean new tea cultivers should be selected because Koran wild tea population have been high genetic variation. If tea breeding research will be successful to select new clonal cultivers, the tea farmers of Korea will be stable after WTO treatment with each country.

• 한국의학물리학회지:의학물리
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• 제15권1호
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• pp.54-58
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• 2004

목적: 인체에 비해 크기가 작은 동물의 자기공명영상을 획득하기 위하여 현재 사용되고 있는 Head 코일보다 원통 반지름이 작은 Low-pass Filter 형태의 Birdcage Resonator를 제작하여 보다 큰 신호대잡음비(Signal-to-Noise Ratio: SNR)를 획득함으로써 고해상도의 영상을 얻고자 하였다. 방법: 원통형의 아크릴과 구리테이프를 사용하여 각각 내경 지름이 13 cm, 15 cm이고, 길이 30 cm, 12개의 element를 가진 동물용 Low-pass Filter 형태의 Birdcage Resonator를 각각 제작하였고, 자기공명영상을 얻기 위하여 Spin Echo Pulse Sequence와 Fast Spin Echo Pulse Sequence를 사용하였다. 제작된 Birdcage Resonator는 실험적 수치와 팬톰과 동물에 대한 MR영상으로 그 가치를 평가하였다. 결과: 대상물의 크기에 따른 SNR을 비교하기 위하여 다양한 크기의 코일을 이용하여 각각의 팬톰 영상을 획득하였다. 팬톰 영상으로부터 측정된 SNR의 값을 통해 코일의 크기에 대한 대상물의 크기를 알 수 있었다. 토의 및 결론: 본 연구를 통하여 같은 형태의 Birdcage Resonator일 경우 대상물의 크기에 따라 SNR이 다르며, 특히 대상물의 크기가 코일 크기의 40∼80% 정도일 때 SNR이 더 크다는 것을 알 수 있었다. 따라서 코일의 크기에 비해 촬영하고자 하는 대상물의 부피가 작은 경우 대상물의 부피에 맞추어 코일을 제작하면 SNR이 보다 뛰어난 영상을 얻을 수 있을 것으로 사료된다.