Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models

  • Zakaria, ZA (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Kumar, G Hanan (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Zaid, Siti NH Mohd (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Ghani, Marwiza A (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Hassan, MH (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Hazalin, Nurul AMN (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Khamis, Mahirah M (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Devi, G Rathna (Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor) ;
  • Sulaiman, MR (Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia)
  • Published : 2007.03.31
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Abstract

The present study was carried out to elucidate the potential of Muntingia (M.) calabura leaves chloroform extract (MCCE) as antinociceptive, anti-inflammatory and antipyretic agents using various animal models. The dried powdered leaves of M. calabura (20 g) were soaked in chloroform for 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (0.912 g), dissolved in dimethyl sulfoxide (1:20; w/v) and considered as a stock solution (100% concentration/strength), was then diluted to the concentrations of 10 and 50% and used together in all experimental models. The MCCE was found to show significant (P < 0.05) antinociceptive and antipyretic activities, but less remarkable anti-inflammatory activity. Only the antinociceptive activity of MCCE measured using the abdominal constriction test and in the first phase of the formalin test occurred in a concentration-dependent manner. The anti-inflammatory activity of 50 and 100% concentrations MCCE was observed only at the range of time interval of 60 - 120 and 60 min, respectively. Based on the results, we conclude that the M. calabura leaves chloroform extract possessed remarkable antinociceptive and antipyretic, but less effective anti-inflammatory, activities and thus justifies the Peruvian folklore claims of its medicinal values.

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References

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