• Title/Summary/Keyword: MR, experimental

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Facile Fabrication of Animal-Specific Positioning Molds For Multi-modality Molecular Imaging (다중 분자 영상을 위한 간편한 동물 특이적 자세 고정틀의 제작)

  • Park, Jeong-Chan;Oh, Ji-Eun;Woo, Seung-Tae;Kwak, Won-Jung;Lee, Jeong-Eun;Kim, Kyeong-Min;An, Gwang-Il;Choi, Tae-Hyun;Cheon, Gi-Jeong;Chang, Young-Min;Lee, Sang-Woo;Ahn, Byeong-Cheol;Lee, Jae-Tae;Yoo, Jeong-Soo
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.5
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    • pp.401-409
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    • 2008
  • Purpose: Recently multi-modal imaging system has become widely adopted in molecular imaging. We tried to fabricate animal-specific positioning molds for PET/MR fusion imaging using easily available molding clay and rapid foam. The animal-specific positioning molds provide immobilization and reproducible positioning of small animal. Herein, we have compared fiber-based molding clay with rapid foam in fabricating the molds of experimental animal. Materials and Methods: The round bottomed-acrylic frame, which fitted into microPET gantry, was prepared at first. The experimental mice was anesthetized and placed on the mold for positioning. Rapid foam and fiber-based clay were used to fabricate the mold. In case of both rapid foam and the clay, the experimental animal needs to be pushed down smoothly into the mold for positioning. However, after the mouse was removed, the fabricated clay needed to be dried completely at $60^{\circ}C$ in oven overnight for hardening. Four sealed pipet tips containing $[^{18}F]FDG$ solution were used as fiduciary markers. After injection of $[^{18}F]FDG$ via tail vein, microPET scanning was performed. Successively, MRI scanning was followed in the same animal. Results: Animal-specific positioning molds were fabricated using rapid foam and fiber-based molding clay for multimodality imaging. Functional and anatomical images were obtained with microPET and MRI, respectively. The fused PET/MR images were obtained using freely available AMIDE program. Conclusion: Animal-specific molds were successfully prepared using easily available rapid foam, molding clay and disposable pipet tips. Thanks to animal-specific molds, fusion images of PET and MR were co-registered with negligible misalignment.

Sloshing of liquids in partially filled tanks - a review of experimental investigations

  • Eswaran, M.;Saha, Ujjwal K.
    • Ocean Systems Engineering
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    • v.1 no.2
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    • pp.131-155
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    • 2011
  • Liquid sloshing constitutes a broad class of problems of great practical importance with regard to the safety of liquid transportation systems, such as tank trucks on highways, liquid tank carriages on rail roads, ocean going vessels and propellant tanks in liquid rocket engines. The present work attempts to give a review of some selected experimental investigations carried out during the last couple of decades. This paper highlights the various parameters attributed to the cause of sloshing followed by effects of baffles, tank inclination, magnetic field, tuned liquid dampers, electric field etc. Further, recent developments in the study of sloshing in micro and zero gravity fields have also been reported. In view of this, fifteen research articles have been carefully chosen, and the work reported therein has been addressed and discussed. The key issues and findings have been compared, tabulated and summarized.

Interleaved Spiral Scan Imaging (Interleaved 나선 주사 영상)

  • Ahn, C.B.;Kim, H.J.;Shin, J.K.
    • Proceedings of the KOSOMBE Conference
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    • v.1998 no.11
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    • pp.98-99
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    • 1998
  • In this paper, an interleaved spiral scan imaging is investigated for an ultra fast MR imaging. The interleaved spiral technique has relative advantage over single shot spiral imaging with improved resolution and less inhomogeneity-related artifact. An improved reconstruction algorithm is devised with DC-offset correction. Some preliminary experimental results are shown at 1.0 Tesla and 3.0 Tesla whole body MRI system.

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Adhesion Characteristics between Stamp and Polymer Materials Used in Thermal Nanoimprint Lithography (열 나노임프린트 리소그래피에서 사용되는 스탬프와 폴리머 재료 사이의 점착 특성)

  • Kim Kwang-Seop;Kang Ji-Hoon;Kim Kyung-Woong
    • Tribology and Lubricants
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    • v.22 no.4
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    • pp.182-189
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    • 2006
  • In this paper, the adhesion characteristics between a fused silica without or with an anti-sticking layer and a thermoplastic polymer film used in thermal NIL were investigated experimentally in order to identify the release performance of the anti-sticking layer. The anti-sticking layers were derived from fluoroalkylsilanes, (1H, 1 H, 2H, 2H-perfluorooctyl)trichlorosilane ($F_{13}-OTS$) and (3, 3, 3-trifluoropropyl)trichlorosilane (FPTS), and coated on the silica surface in vapor phase. The commercial polymers, mr-I 7020 and 8020 (micro resist technology, GmbH), for thermal NIL were spin-coated on Si substrate with a rectangular island which was fabricated by conventional microfabrication process to achieve small contact area and easy alignment of flat contact sur- faces. Experimental conditions were similar to the process conditions of thermal NIL. When the polymer film on the island was separated from the silica surface after imprint process, the adhesion force between the silica surface and the polymer film was measured and the surfaces of the silica and the polymer film after the separation were observed. As a result, the anti-sticking layers remarkably reduced the adhesion force and the surface damage of polymer film and the chain length of silane affects the adhesion characteristics. The anti-sticking layers derived from FPTS and $F_{13}-OTS$ reduced the adhesion force per unit area to 38% and 16% of the silica sur-faces without an anti-sticking layer, respectively. The anti-sticking layer derived from $F_{13}-OTS$ was more effective to reduce the adhesion, while both of the anti-sticking layers prevented the surface damages of the polymer film. Finally, it is also found that the adhesion characteristics of mr-I 7020 and mr-I 8020 polymer films were similar with each other.

Clinical and Experimental Applications of $^1$H MRS (양성자 자기공명분광법의 임상과 실험응용)

  • Choe, Bo-Young;Lee, Hyoung-Koo;Suh, Tae-Suk;Shinn, Kyung-Sub
    • Progress in Medical Physics
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    • v.7 no.1
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    • pp.37-52
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    • 1996
  • Image-guided localized, water-suppressed in vivo $^1$H MR spectroscopic studies were performed on the patients with brain tumors, acute cerebral infarction and schizophrenia, and dogs. GE Signa 1.5 T whole-body MRI/MRS system using STEAM pulse sequence was used. Proton metabolite ratios relative to creatine (Cr) were obtained using a Marquart algorithm. In vivo $^1$H MR spectra in brain neoplastic tissues revealed the changes of signal intensities of N-acetylaspartate (NAA), choline (Cho) and lactate (Lac) resonances. The present results suggest that the observed metabolite alterations from localized, water-suppressed in vivo $^1$H MR spectroscopy can be useful as an index of brain tumors, cerebral infarction and schizophrenia, and provide good quality metabolic information of cerebral tissue in the field of thanato-chronology.

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Numerical Study on Propeller Cavitation and Pressure Fluctuation of Model and Full Scale ship for a MR Tanker (MR Tanker 실선 및 모형선 프로펠러 캐비테이션 및 변동압력 수치해석 연구)

  • Park, Il-Ryong;Kim, Ki-Sup;Kim, Je-In;Seol, Han-shin;Park, Young-Ha;Ahn, Jong-Woo
    • Journal of the Society of Naval Architects of Korea
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    • v.57 no.1
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    • pp.35-44
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    • 2020
  • Propeller cavitation extent, pressure fluctuation induced by cavitation, pressure distribution on propeller blade, total velocity distribution and nominal wake distribution for a MR Taker were computed in both conditions of model test and sea trial using a code STAR-CCM+. Then some of the results were compared with model test data at LCT and full-scale measurement (Ahn et al (2014); Kim et al (2014)] in order to confirm the availability of a numerical prediction method and to get the physical insight of local flow around a ship and propeller. The nominal wake distributions computed and measured by LDV velocimeter on the variation of on-coming velocity show the wake contraction characteristics proposed by Hoekstra (1974). The numerical prediction of propeller cavitation extent on a blade angular position and pressure fluctuation level on each location of pressure sensors are very similar with the experimental results.