• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.56-56
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• 1993

새로운 cell cycle 특이적 억제제의 스크리닝 방법의 확립과 이를 이용하여 cell cycle 억제제의 검색 및 세포분열 및 성장을 억제하는 작용의 분석과 이들의 항암작용 및 세포성장 및 분열 억제 작용의 signal transduction mechanism을 규명한다. 이상의 연구를 수행하기 위해 흰쥐 재생간 조직 및 흰쥐 일차 배양 간세포를 연구 모델로 하여 스크리닝 방법을 확립하고, 세포 분열 및 성장 억제제의 연구 대상 약물로는 기존의 천연물 및 미생물의 2차 대사 산물을 분리 정제한 물질등을 사용하여 그 작용 효능을 연구한다. 1) 흰쥐 부분 간 절제 수술 26시간 후 핵 단백질을 분리 2) MPF activity 측정 3) MPF 활성 저해제 생산 균주의 1차 탐색

• Journal of Power Electronics
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• v.17 no.2
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• pp.476-489
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• 2017

Under partial shading conditions (PSCs), multiple maximums may be exhibited on the P-U curve of string inverter photovoltaic (PV) systems. Under such conditions, heuristic methods are invalid for extracting a global maximum power point (GMPP); intelligent algorithms are time-consuming; and model-based methods are complex and costly. To overcome these shortcomings, a novel hybrid MPPT (MPF-IP&O) based on a model-based peak forecasting (MPF) method and an improved perturbation and observation (IP&O) method is proposed. The MPF considers the influence of temperature and does not require solar radiation measurements. In addition, it can forecast all of the peak values of the PV string without complex computation under PSCs, and it can determine the candidate GMPP after a comparison. Hence, the MPF narrows the searching range tremendously and accelerates the convergence to the GMPP. Additionally, the IP&O with a successive approximation strategy searches for the real GMPP in the neighborhood of the candidate one, which can significantly enhance the tracking efficiency. Finally, simulation and experiment results show that the proposed method has a higher tracking speed and accuracy than the perturbation and observation (P&O) and particle swarm optimization (PSO) methods under PSCs.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.1 s.41
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• pp.25-32
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• 2005

Seismic load is distributed to modes of a structure through the modal participation factor(MPF). The modal participation factor is essential to analyze structural response under earthquake load. MPF of a real structure differs from that of analytical mathematical model due to the error induced from analytical assumptions and during the construction. In this study, an identification method is proposed to calculate the 1st MPF of real structure based on $H^{\infty}$ optimal model reduction. The MPF is obtained from the relationship between observability and controllability matrices realized from system identification and those of a prototype 2-degree state space model. The proposed method is verified thorough numerical examples.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.5
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• pp.491-499
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• 1999

This study was designed to evaluate the efficacy of dynamic parameters, such as correlation dimension $D_2,$ by comparing spectral electroencephalographic (EEG) parameters. These parameters are used to estimate the depth of halothane anesthesia as defined by the presence of body movement in response to a tail clamp. Six rats were used and each of them was exposed to halothane sequentially at the concentrations of 0%, 0.5%, 1.0% and 1.5% for 30 min. A tail clamp was applied every five min and the movements were recorded at each concentration level. The spectral parameters and the dynamic parameters were derived from 20-sec and 10-sec segments, respectively, from the last 5-mins of EEG recording at each concentration level. Correlation coefficients between the parameters and the movements were calculated. Standardized values of three parameters, betaL power, median power frequency (MPF), and $D_2$ were derived by calculation based on the number of animals showing the movement in response to a tail clamp. The betaL power had the largest correlation coefficient to spontaneous movement and to the response to a tail clamp than any other band parameter. MPF had a better correlation with the movement than 90% spectral edge frequency. Among the dynamic parameters, $D_2$ on the parietal cortex had a better correlation with the movement. The level of deviation and variation of standardized $D_2,$ MPF, and betaL were significant (p<0.01). The order of deviation and variation was; betaL power > MPF > $D_2.$ The correlation dimension serves as a better index for the depth of halothane anesthesia defined in forms of a response to external stimulation.

• Animal cells and systems
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• v.2 no.1
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• pp.87-91
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• 1998

The present study investigated the involvement of the phospholipase C (PLC) and protein kinase C (PKC) signaling pathways during progesteroneinduced meiotic maturation in amphibian (Rana dybowskii) oocytes. Prosesterone-induced germinal vesicle breakdown (GVBD) of oocytes was significantly inhibited by a PKC inhibitor, staurosporine and a PLC inhibitor, U73122, in a dose-dependent manner. In contrast, U73343, an inactive analogue of U73122, was ineffective in suppressing GVBD. PKC activity in oocytes reached a maximum level at 30 min after progesterone stimulation and this elevated PKC activity was effectively suppressed by U73122 or staurosporine, suggesting that the activation of PKC enzyme is closely linked to PLC signaling during oocyte maturation. In addition, these inhib itors blocked the maturation promoting factor (MPF) activity which appeared in oocytes in response to progesterone, suggesting that PKC activation is an important signal for MPF activity. Therefore, this study demonstrates that the activation of PKC via PLC signaling is directly linked to an intracellular protein kinase cascade related to the appearance of MPF activity during meiotic maturation in amphibian (Rana dybowskii) oocytes.

• Transactions of Materials Processing
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• v.22 no.5
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• pp.243-249
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• 2013

The multi-point forming (MPF) process for three-dimensional curved sheet metal has been developed as an alternative to the conventional die forming process since MPF allows the manufacturing of various shapes using one die set and reduce the cost of production. However, the MPF process cannot provide high quality products yet due to defects occurring in the sheet such as dimples and wrinkles. It can also lead to economic loss because of long tool setup time and additional machining required outside of the sheet formed area. In this study, a new sheet metal forming method, called flexible roll forming (FRF), is proposed to solve the problems of existing processes for three-dimensional curved sheet metal. This progressive process utilizes adjusting rods, as well as upper and lower flexible rollers as forming tools. In contrast with the existing processes, FRF can reduce the additional production costs because of the possible blank size for the part longitudinal direction, which is unrestricted. In this research, methods and procedures of the flexible roll forming technology are described. Numerical forming simulations of representative three-dimensional curved sheet products are also carried out to demonstrate the feasibility of this technology.

• The Korean Journal of Zoology
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• v.36 no.2
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• pp.277-284
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• 1993

A possible involvement of maturation promoting factor (nfPF) in the two-cell block phenomenon was studied by fusion experiments. Germinal vesicle (GlF) ooeyte was fused with a blastomore from late or blocked 2-cell mouse embryos. and germinal vesicle breakdoum (GVBD) of fused GV oocvtes in the presence of dbcAMP (100$\mu$g/ml) was scored as an index of MPF aniviD. GnD was induced approximately 30% by fusion of a blastomere derived from late 2-cell embryos, but not from blocked 2-cell embryos. The rate of GVBD was changed when GV oocyte was fused with a blastomere from late 2-cell embryos which were treated with u-amanitin, puromvcin or colcemid before and after hsion: Treatment of late 2-cell embryos with puromycin (50 Is/mll but not with u-amanitin (100 Is/ml) clearly inhibited GVBD, indicating that do novo protein synthesis maw be required for the appearance of MPF activity in late 2-cell embryos. Treatment of late 2-cell embryos w기h colcemid (0.1 Is/mll doubled GVBD, presumably due to the maintenance of metaphase or mitotic phase. SDS-PAGE and twoiimensional electrophoresis revealed that there was no difference in protein synthetic pattern in late and blocked 2-cell embryos, but three phosphoproteins with 27, 35 and 46 M)a, presumsblv M-phase components were phosphorylated in late 2-cell embryos but not in blocked 2-cell embryos. It seems then that MPF activity is closely related to phosphorylstion of M-phase components in late 2-cell embryos.

• Journal of the Ergonomics Society of Korea
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• v.29 no.2
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• pp.183-188
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• 2010

The purpose of this study is to investigate the stationarity of the electromyographic signal in various flexion angles, loads, and window sizes, which influence the result of the mean power frequency (MPF) and median frequency (MNF) analysis. Six healthy subjects participated in the experiment. They were tested in the combination of 3-level flexion angles (0 degree, 22.5 degree, 45 degree) and 3-level loads (0Nm, 30Nm, 60Nm). Electromyographic data were collected for 20 seconds during isometric contraction. The stationarity of collected data were analyzed with four different window sizes including 250, 500, 1000 and 2000ms. Two test methods for stationarity such as Reverse Arrangements Test and Modified Reverse Arrangements Test were used. In order to show the effect of nonstationarity, the increasing/decreasing trend of MPF and MNF trend were discussed. In results, the stationarity of the electromyographic signal decreased as flexion angle increased and load decreased while window size decreased based on Reverse Arrangements Test. The highest stationarity was shown at 500 ms window in Modified Reverse Arrangements Test. The inclination of MNF and MPF indicated 3.6-6.3%, 3.8-5.1% discrepancy compared to the result from stationary data.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.1
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• pp.156-161
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• 2013

Recently, there has been a trend in the manufacturing process to focus on the durability of cable lug joint, especially in welding process due to the poor cable lug joint causes many troubles on products and workers during manufacturing process. Therefore development of high quality cable lug joint is important for successful manufacturing process and safety of worker. The Magnetic Pulse Forming(MPF) is one of efficient way to developed a high quality cable lug joint. In MPF, a high strain rate forming process, utilizes a high velocity oblique collision on the workpiece to be formed in required shape. The objective of this paper is to develop of high quality cable lug joint using electromagnetic force. To successfully accomplish this goal, section and electrical contact temperature of developed cable lug joint has been compared with various cable lug joint. Electrical contact temperature of developed cable lug joint by electromagnetic force is lower than manufactured cable lug joint by pressurer and hydraulic pressurer.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.20 no.3
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• pp.292-297
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• 2011

MPF(Magnetic pulse forming) process refers to the high velocity and high strain rate deformation of a low-ductility materials driven by electromagnetic forces that are generated by the rapid discharge current through forming coil. The goal of this study was to find the characteristics of dynamic behavior of workpiece and to find the main design process on MPF using bar forming coil. For these purposes, thin Al5053 sheet were used for the experiment. The measured strain data were analyzed by developed electromagnetic FE-model. The main design parameter is location of coil, electromagnetic force. In case of the bar forming coil, there exists the dead regions where the low electromagnetic force applied on the workpiece.