• The Journal of Korean Physical Therapy
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• v.21 no.4
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• pp.89-96
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• 2009

Purpose: This study examined the effects of manual lymph drainage (MLD) on edema and the quality of life (QOL) of lymphedema patients in the maintenance phase. Method: Forty five lymphedema patients, who had completed intensive decongestive therapy, were enrolled in this study. All subjects were assigned randomly to two groups: Experimental (MLD) group (n=23) and control (self-MLD) group (n=22). MLD by a specialist was applied with a comfortable pressure for 40~60 minutes in the experimental group and self-MLD was carried out by the control group 5 times a week for 2 weeks. The % edema and a SF-36 questionnaire were used to measure the decrease in edema and the QOL. A paired t-test was used to compare the period, and an independent T-test was used to compare experiment and control groups. Result: The % edema was significantly lower in the experimental group after MLD (p<0.05). The physical, vitality, and mental health scores of the experimental group was significantly higher than those of the control group (p<0.05). Conclusion: TMLD by a specialist in the maintenance phase is effective in reducing the % edema and enhancing the QOL of lymphedema patients. Further studies will be needed to determine if there are differences in the effects of many types of treatment methods in the lymphedema treatment.

• ETRI Journal
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• v.38 no.1
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• pp.100-111
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• 2016

This paper presents a low-complexity channel-adaptive reconfigurable $4{\times}4$ QR-decomposition and M-algorithm-based maximum likelihood detection (QRM-MLD) multiple-input and multiple-output (MIMO) detector. Two novel design approaches for low-power QRM-MLD hardware are proposed in this work. First, an approximate survivor metric (ASM) generation technique is presented to achieve considerable computational complexity reduction with minor BER degradation. A reconfigurable QRM-MLD MIMO detector (where the M-value represents the number of survival branches in a stage) for dynamically adapting to time-varying channels is also proposed in this work. The proposed reconfigurable QRM-MLD MIMO detector is implemented using a Samsung 65 nm CMOS process. The experimental results show that our ASM-based QRM-MLD MIMO detector shows a maximum throughput of 288 Mbps with a normalized power efficiency of 10.18 Mbps/mW in the case of $4{\times}4$ MIMO with 64-QAM. Under time-varying channel conditions, the proposed reconfigurable MIMO detector also achieves average power savings of up to 35% while maintaining a required BER performance.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.51 no.1
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• pp.107-112
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• 2018

One-dimensional numerical model is implemented to investigate temperature variations in the mixed layer depth (MLD) with the passage of typhoons. In the model, we assume a non-divergent, infinite ocean and consider wind effects only, excluding isostatic effects (inverse barometric effects) and upwelling with vertical movement of the water column. Numerical experiments investigate the effects of typhoon tracks on temperature variations, including their dependence on vertical resolutions in the MLD and these results are compared with those in a three-dimensional primitive equation model (POM). The model reproduces features of the observed temperature variations in the MLD fairly well, and implies that wind effects, rather than isostatic effects, play a predominant role in temporal and spatial temperature variations in the MLD. After the passage of typhoons, however, the model does not reproduce well the temperature variations observed in the MLD, because a limitation of the model is its inability to reproduce events such as cyclonic eddy formation (Hong et al., 2011; Masuda and Hong, 2011). The model also shows well the so called 'rightward bias' (Price, 1981) of sea surface cooling which is the most predominant in the right hand side of typhoon's track.

• Journal of Educational Research in Mathematics
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• v.26 no.3
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• pp.543-563
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• 2016

This study was designed as a meta-analysis to investigate the research trends in mathematics learning disabilities(MLD) area. The results of this study were as follows: The 201 researches targeted for the analysis can be categorized 4: characteristic of students with MLD, screening students with MLD, interventional teaching for students with MLD, and et cetera. Also, the outcomes of researches regarding intervention in MLD determined to have a large effect resulted in a total average of 0.958. Especially, as a result of analysing the effect size in accordance with teaching method variables in group-case designed researches, the effect was largest when direct instruction and strategy instruction was given. The effect was largest when the frequency of intervention was over 16 and under 20. The results in this study be summed up as follows. MLD can be served as a foundation in setting a direction for further research to improve in Korea.

• Investigative Magnetic Resonance Imaging
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• v.25 no.2
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• pp.101-108
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• 2021

Purpose: To identify characteristic magnetic resonance imaging (MRI) features to differentiate between Krabbe disease and metachromatic leukodystrophy (MLD) in young children. Materials and Methods: We collected all confirmed cases of Krabbe disease and MLD between October 2004 and September 2020 at Seoul National University Children's Hospital. Patients with initial MRI available were included. Their initial MRIs were retrospectively reviewed for the following: 1) presence of white matter signal abnormality involving the periventricular and deep white matter, subcortical white matter, internal capsule, brainstem, and cerebellum; 2) presence of volume decrease and signal alteration in the corpus callosum and thalamus; 3) presence of the tigroid sign; 4) presence of optic nerve hypertrophy; and 5) presence of enhancement or diffusion restriction. Results: Eleven children with Krabbe disease and 12 children with MLD were included in this study. There was no significant difference in age or symptoms at onset. Periventricular and deep white matter signal alterations sparing the subcortical white matter were present in almost all patients of the two groups. More patients with Krabbe disease had T2 hyperintensities in the internal capsule and brainstem than patients with MLDs. In contrast, more patients with MLD had T2 hyperintensities in the splenium and genu of the corpus callosum. No patient with Krabbe disease showed T2 hyperintensity in the corpus callosal genu. A decrease in volume in the corpus callosum and thalamus was more frequently observed in patients with Krabbe disease than in those with MLD. Other MRI findings including the tigroid sign and optic nerve hypertrophy were not significantly different between the two groups. Conclusion: Signal abnormalities in the internal capsule and brainstem, decreased thalamic volume, decreased splenial volume accompanied by signal changes, and absence of signal changes in the callosal genu portion were MRI findings suggestive of Krabbe disease rather than MLD based on initial MRI. Other MRI findings such as the tigroid sign could not help differentiate between these two diseases.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.2
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• pp.178-186
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• 2003

Seasonal variation of phytoplankton was investigated with surface mixed layer ecosystem model in the East Sea. The model consisted of four compartments (phytoplankton, zooplankton, nutrient, detritus) forced by mixed layer depths, photosynthetically available radiation and nutrient concentrations. From model results we estimated entrainment rate $2.5-4.0\;m{\cdot}day^{-1}$ to reproduce the two annual blooms, and reproduced seasonal variation of phytoplankton at southern and northern regions by the difference of surface winter mixed layer depth (MLD) using the entrainment rate value $3.0\;m{\cdot}day^{-1}$. The spring blooms in the southern and northern regions closely related to deepening of a winter surface MLD. In the southern region where MLD was shallow and phytoplankton spring bloom occurs one month in advance to the northern region where MLD was deep. The amount of light increases within the MLD during the onset of stratification and water temperature increases faster in spring in the southern region than the northern region. Decrease of phytoplankton was mainly affected by zooplankton grazing in the southern region and by nutrient exhaustion in the northern region. The fall bloom in the two regions was caused by the nutrient availability and entrainment on the phytoplankton.

• Physical Therapy Korea
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• v.14 no.3
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• pp.1-8
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• 2007

The purpose of this study was to determine whether aromatherapy massages with manual lymph drainage (MLD) are significantly more effective than sham massages with MLD in reducing edematous limb volume in lymphedema. This study was performed on 46 patients who had developed unilateral upper or lower lymphedema. Twenty-three patients served as the experimental group and were treated with complex decongestive physiotherapy (CDP) applications including aroma massages with MLD, multi layered compression bandages, remedial exercises and skin care. Twenty-three patients in the control group were treated with CDP applications including sham massages with MLD, bandages, exercises and skin care. Patients undergo a therapy program once a day; 5 days a week for 2 weeks. Percentage excess volume (PEV) and body mass index (BMI) were recorded before and after treatment. PEV and BMI were significantly decreased before and after treatment in the experimental as well as in the control groups (p<.05). However, the percentage excess volume and BMI were not significantly improved after treatment between the two groups (p>.05). This study there suggests that aroma massages is not effective in the edema of patients with lymphedema.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.25 no.1
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• pp.53-61
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• 2019

Background: This study aimed to investigate the effects of manual lymph drainage (MLD) on women with breast cancer and lymph edema. Methods: This study was carried out with a total of 23 women with breast cancer and lymph edema. By drawing lots, women were assigned to either the manual drainage group (MLD, n=12), a control group (n=11). Outcomes such as the arm size, visual analogue scale, shoulder pain and disability index, and functional assessment cancer therapy-breast (FACT-B) were measured to 0 week, 2 weeks, 4 weeks, and 8 weeks intervention for both groups. Results: A significant difference was found in the arm size, pain, functional disability level, and quality of life between the two groups and time(p<.01). Significant difference in functional disability level between 2 and 8 weeks at 4 weeks and 8 weeks for pain(p<.01), and the quality for life was significantly different at all time points (p<.01). Conclusions: Applying MLD treatment to women with breast cancer proved to have a positive effect.

• 한국해양학회지
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• v.16 no.2
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• pp.49-56
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• 1981

Annual variation of the surface mixed layer depth (MLD) in the southern part of the Sea of Japan is investigated based upon the oceanographic and meteorological data taken during 1971∼1975 by the Fisheries Research and Development Agency and the Central Meteorological Office of Korea. It is found that the variation of the MLD is strongly correlated with the heat exchange between the atmosphere and sea. The MLD and heat flux vary within ranges comparable to those in the Kuroshio region found by Bathen(1972) and Wyrtki(1965)

• Archives of Pharmacal Research
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• v.23 no.6
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• pp.626-632
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• 2000

Brazilin, an active principle of Caesalprenia sappan, was examined for its immunopotentiating effects in multiple low dose streptozotocin (MLD-STZ) induced type diabetic mice. Brazilin was intraperitoneally administered for 5 consecutive days to MLD-STZ induced type 1 diabetic mice. Delayed type hypersensitivity, Con A-induced proliferation of splenocytes and mixed lymphocyte reaction, which had been decreased in diabetic mice, were significantly recovered by the administration of brazilin. Brazilin increased IL-2 production without affecting suppressor cell activity. Con A-induced and IL-2-induced expression of high affinity IL-2 receptors were also enhanced by brazilin. These results indicate that brazilin augments cellular immune responses, which are suppressed in the MLD-STZ induced type I diabetic mice, by increasing IL-2 production and responsiveness of immune cells to IL-2.