• YAKHAK HOEJI
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• v.48 no.4
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• pp.247-253
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• 2004

We investigated the hypoglycemic effect of formula containing Euonymus alatus (EA) and Mori Folium (MF) in multiple low dose (MLD) streptozotocin (STZ)-induced diabetic rats. In order to iduce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treatment groups. Treatment groups were administered with either 250 mg/kg of EA and 250 mg/kg of MF (E1Ml), or 500 mg/kg of EA mixed with same dose of MF (E2M2) for 3 weeks. Blood glucose levels and body weights were measured every 5th or 6th day. E1Ml and E2M2 both significantly reduced food intake, water intake, and fasting blood and urine glucose levels as compared to those in diabetic control group in a dose dependent manner. Body weight in diabetic control group was increased slightly after 3 weeks. Treatment group, however, showed gradual increase in body weights during 3 week-period. While plasma insulin levels of the diabetic control group were decreased to the level of 387$\pm$14 pg/ml from 534$\pm$36 pg/ml, those levels in E1Ml and E2M2-treated groups were both markedly increased by 13% and 26%, respectively. Urine glucose levels in E1Ml and E2M2-treated groups were also remarkably reduced by 17 and 26% compared to the levels of diabetic control group. While expression of membrane-bound glucose transporter-4 (GLUT-4) protein in skeletal muscle was reduced by 45% in diabetic control compared to the normal control, GLUT-4 protein expressions in E1Ml and E2M2-treated groups were augmented by 2 and 3.5 times compared to the diabetic control, respectively. Pancreatic HE staining experiments showed that E2M2-treated group revealed much less infiltrated mononuclear cells, indicating that E2M2 efficiently blocked insulitis induced by multiple low dose streptozotocin. Taken together, we conclude that formula containing EA and MF may prevent or delay the development of hyperglycemia through overexpression of GLUT-4 protein in skeletal muscle and prevention of insulitis.

• 한국인삼전략화협의회:학술대회논문집
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• v.2003 no.09
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• pp.77-88
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• 2003

"Ginseng (Panax ginseng C.A. Meyer) has been a popular herbal remedy used in eastern Asian cultures for thousands of years, and a number of health claims are made for it. Modern therapeutic claims for ginseng refer to vitality, immune function, cancer, cardiovascular diseases, diabetes and sexual function. These claims are mostly based on uncontrolled or non-randomized studies. Among modern therapeutic claims, however, therapeutic effects for diabetes can reasonably be accepted. Following experiment was done recently in our lab: this study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20mg/kg i.p injection for 5 days) induced diabetic rats. In the glucose tolerance test, 500mg/kg of each ginseng ethanol extract was admoinistered intraperitoneally 30min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as for as blood parameters and diabetic symptoms such as polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenoside were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT) : proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia effects."

• 한국해양학회지
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• v.30 no.5
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• pp.512-521
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• 1995

To investigate a short-term (from 2 hours to 24 hours) variability of a mixed layer, oceanographical data (water temperature, salinity, current) and meteorological data (wind, air temperature, solar radiation) were collected at a site in the Korea Strait at the interval of one hour for 48 hours from October 12 to 14, 1993. The average rates of temporal variations of the mixed layer depth (MLD) and temperature of the mixed layer (MLT), which are very weakly correlated with the wind stress and buoyancy flux at the sea surface, are about 5.2 m/hour and 0.2$^{\circ}C$/hour, respectively. The mixed layer is relatively shallow when both MLT and MLS (salinity of the mixed layer) are low, while MLD is relatively deep when they are high. MLT shows a sudden decrease or increase. Analysis of satellite infrared images and XBT data shows that sudden increase of MLT is caused by advection of warm water. These results suggest that the short-term variation of the mixed layer in the Korea Strait in autumn, in which surface current is relatively strong and different water masses exist, is mainly determined by advection rather than air0sea interaction such as wind stress or buoyancy flux.

• Journal of the Korean Society of Safety
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• v.24 no.3
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• pp.54-58
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• 2009

A substitute energy development has been required due to the exhaust of the fossil fuel and an environmental problem. Consequently, possible technologies producing hydrogen from water that does not release carbon is a very promising technology. Also, Iodine-Sulfur(IS) thermochemical water decomposition is one of the promising processes that are used to produce hydrogen efficiently using the high temperature gas-cooled reactor(HTGR) as an energy source that is possible to supply heat over 900$^{\circ}C$. In this study, to make a initiating events identification for the IS process, Master Logic Diagram(MLD) is used and 9 initiating events that cause a leakage of the chemical material are identified. Also, 6 events are identified among 9 initiating events above and are quantified using event tree.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.32 no.3
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• pp.249-256
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• 1996

The saury stick - held dip net fishery of Korea in the Northwest Pacific Ocean began in 1985 with 3 vessels. Since then the fishery has grown so rapidly year by year that the number of vessels increased to 34 and the catch to 40 thousands Mff in 1993. In the present study, the monthly situation and the movement of the fishing ground for the pacific saury in the Northwest Pacific were investigated and the monthly optimum fIshing tempertures were estimated, from the relationship between the catch and the sea surface temperature. In the beginning of the fishing season, June to August, the fIshing ground is formed in the very wide range, mainly in the northward area of the front meandering, as the parcific saury migrate northward. In the main season, September to November, the ground is formed in the southward area of the front, off the east coast of Japan. Andd then, the fishing season ends in December with the ground coming near to the east coast of Japan. The monthly optimum fishing tempertures showed 11~$13^{\circ}C.$ in June to July, 13-$17^{\circ}C.$ in August to November, and 15~ $17^{\circ}C.$ in December in general. The profIles of water temperature were much different in accordance by net casting position in the fishing ground, regardless of season. So, the MLD and CPUE was analyzed to find out the relation between the water temperature and the catch. Then, it is found that the CPUE shows over 0.7Mtr/haul as the MLD 40~70m.40~70m.

• Radiation Oncology Journal
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• v.27 no.4
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• pp.228-239
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• 2009

Purpose: 4DCT scans performed for radiotherapy were retrospectively analyzed to assess the possible benefits of respiratory gating in non-small cell lung cancer (NSCLC) and established the predictive factors for identifying patients who could benefit from this approach. Materials and Methods: Three treatment planning was performed for 15 patients with stage I~III NSCLC using different planning target volumes (PTVs) as follows: 1) PTVroutine, derived from the addition of conventional uniform margins to gross tumor volume (GTV) of a single bin, 2) PTVall phases (patient-specific PTV), derived from the composite GTV of all 6 bins of the 4DCT, and 3) PTVgating, derived from the composite GTV of 3 consecutive bins at end-exhalation. Results: The reductions in PTV were 43.2% and 9.5%, respectively, for the PTVall phases vs. PTVroutine and PTVgating vs. PTVall phases. Compared to PTVroutine, the use of PTVall phases and PTVgating reduced the mean lung dose (MLD) by 18.1% and 21.6%, and $V_{20}$ by 18.2% and 22.0%, respectively. Significant correlations were seen between certain predictive factors selected from the tumor mobility and volume analysis, such as the 3D mobility vector, the reduction in 3D mobility and PTV with gating, and the ratio of GTV overlap between 2 extreme bins and additional reductions in both MLD and $V_{20}$ with gating. Conclusion: The additional benefits with gating compared to the use of patient-specific PTV were modest; however, there were distinct correlations and differences according to the predictive factors. Therefore, these predictive factors might be useful for identifying patients who could benefit from respiratory-gated radiotherapy.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.558-561
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• 2004

Currently, most IP multicasting applications are implemented based on Any-Source Multicast (ASM) model that supports many to many multicast services. However, it is known that current ASM-based multicast architecture has several deployment problems such as address allocation, lack of access control, and inefficient handling of well-known multicast sources. Source-Specific Multicast (SSM) working group in IETF proposed SSM architecture to overcome the weaknesses of ASM architecture. The architecture of SSM is based on one to many multicast services. Also, in order to provide SSM service, Multicast Listener Discovery Version 2 (MLDv2) protocol should be supported. In this paper, we introduce the architecture of SSM protocol and multicast group management protocol. After that, we present the architecture and implementation of IPv6 SSM and MLDv2 protocols in Linux systems.

• Physical Therapy Korea
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• v.6 no.1
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• pp.62-73
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• 1999

The purpose of this article was to provide basic knowledge and treatment principles of patient with lymphedema, which was usually not treated at all, or the treatment given didn't work efficiently. Lmphedema is defined as an abnormal accumulation of protein-rich fluid, edema, and chronic inflammation within an extremity. Lmphedema may be classified as either primary results from defects with aplasia, hypoplasia, and hyperplasia in the lymphatic system at birth or secondary is caused by known precipitating factors such as cancer, infection, inflammation, radiation, surgery, or trauma etc. There are essentially several conservative treatment methods which has been utilized successfully to treat lymphedema in Samsung Medical Center. We used following procedures: CPT (Complex Physical therapy) or CDP (Complex Decongesitive Physical therapy) such as skin care, MLD (Manual Lymph Drainage), compression with short-stretch bandage, exercise, elevation, elastic stocking, and pneumatic compression. Our experiences shows that conservative treatments can significantly reduce lymphedema and prevent different complications.

• Advances in Traditional Medicine
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• v.8 no.3
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• pp.295-301
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• 2008

The methanolic root extract of tissue cultured Pluchea indica (L.) Less. was tested for its antibacterial potentiality against 102 different strains of bacteria belonging to both Gram positive and Gram negative groups. The bacteria could be arranged according to their decreasing order of sensitivity as follows: Staphylococcus aureus, Vibrio cholerae, Bacillus spp. Vibrio parahaemolyticus, shigellae, Salmonella spp., and Escherichia coli. The extract was found to be bacteriostatic in nature against Salmonella typhimurium NCTC 74. When administered to Swiss strain of white mice at the doses of 0.5 and 1.0 mg/kg body weight, the extract could significantly protect the animals challenged with 50 MLD of S. typhimurium NCTC 74. According to the chi-square test, the in vivo data is highly significant (P < 0.001).

• Proceedings of the Korean Information Science Society Conference
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• 2007.06d
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• pp.310-314
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• 2007

WiBro는 IEEE 802.16에 이동성을 추가한 것으로서 현재 IPv4만을 지원하는데, IPv6를 적용할 경우 발생할 수 있는 문제점들은 최근에 이르러서야 이슈가 되고 있다. WiBro MAC은 IP 프로토콜 설계시 기본이 되는 이더넷과 많은 차이점이 존재한다. 망 구성요소들의 점대다(point-to-multipoint) 연결 형태와 상향링크 멀티캐스트 불가능으로 인해 정상적인 IP 멀티캐스팅/브로드캐스팅 동작이 어렵기 때문이다. 또한 이더넷과 같이 48비트 MAC 주소를 사용하는 것이 아니라 16비트 CID를 사용하기 때문에 IPv6를 적용할 경우 IPv6 Address Auto-Configuration, Neighbor Discovery, Duplicate Address Detection, Multicast Listener Discovery 등에서 정상적인 동작이 불가능하다. 이에 본 논문은 WiBro의 IPv6에서 MLD 프로토콜 적용방안과 무선자원을 효과적으로 사용하는 방법을 제시한다.