• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.196-201
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• 1996

The N-methyl-D-aspartate (NMDA) receptor-ion channel complex is activated by the simultaneous presence of L-glutamate and glycine, allowing the binding of MK-801 to the phencyclidine (PCP) site of the receptor. The $[^3H]$MK-801 binding assay system was established for determination of pharmacological functions of test compounds acting at the glycine site of the receptor. The binding in the presence of 0.1 $\mu$M L-glutamate was increased by an agonist (glycine) in a dose-dependent fashion, while decreased by either partial agonist (R-(+)-HA-966) or antagonist (5,7-dichlorokynurenic acid: 5,7-DCKA). To distinguish partial agonism from antagonism, various concentrations of 7-chlorokynurenic acid (7-CKA) were added in the assay to eliminate the interference of the endogenous glycine present in the membrane preparations. The bindings in the presence of L-glutamate (0.1$\muM$) and 7-CKA (1, 5, or 10$\muM$) were increased by R-(+)-HA-966. Being a weak partial agonist, the extent of potentiation was much less than that by the agonist. These binding profiles were clearly distinguishable from those by the antagonist, 5,7-DCKA, which exhibited no intrinsic activity. The binding assays established in the present study are a useful system to classify ligands acting at the glycine site of the NMDA receptor by their pharmacological functions.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.120-125
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• 2004

Fatigue life of welded joints are governed by the propagation of multiple collinear surface cracks distributed randomly along weld bead. These cracks propagate in mutual interaction and coalescence of them. To estimate the fatigue life, the influences of above two mechanisms on the fatigue life should be taken into account. These two mechanisms appear through the stress intensity factors disturbed mutually. However, it is difficult to calculate the stress intensity factors of multiple surface cracks located in vicinity of weld toe. The stress intensity factors are calculated normally by using the Mk-factors, but such Mk-factors are very rare in literature. In this study, the Mk-factors were obtained from a parametric study on crack length and depth, in which a finite element method is used. A fatigue test for a cruciform welded joint was conducted. The fatigue life of the tested specimen was estimated through present method with the informations obtained from the test, e.g. the number, size and locations of the cracks. The estimated and measured fatigue life showed a good agreement.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.123.2-123.2
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• 2010

본 논문에서는 2008년 4월 이후 지열원 열펌프가 설치되어지는 현장에 시험공의 지중열전도도를 현장열응답법을 이용하여 측정하였으며, 그간에 측정된 지중열전도도를 이용하여 전국의 지중온도 및 지중열전도도의 산포도를 정리하였다. 지중열교환기의 심도가 150m일 때 지중온도 분포는 약 $12.0{\sim}19^{\circ}C$의 넓은 분포를 보였으나 대부분의 지중온도가 $15.0{\sim}17.0^{\circ}C$의 범위에 분포하였으며, 지중열전도도의 경우도 마찬가지로 1.50 ~ 9.00 W/mk 값으로 아주 넓은 분포를 보였으나 2.30 ~ 2.90W/mk 값이 가장 많이 나타냈다.

• Proceedings of the KWS Conference
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• 2005.06a
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• pp.34-36
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• 2005

Copper wire bonding is an alternative interconnection technology that serves as a viable and cost saving alternative to gold wire bonding. In this paper, ultrasonic wedge bonding with $25{\mu}m$ copper wire on Au/Ni/Cu metallization of a PCB substrate was performed at ambient temperature. The central composite design of experiment (DOE) approach was applied to optimize the copper wire wedge bonding process parameters. After that, pull test of the wedge bond was performed to study the bond strength and to find the optimum bonding parameters. SEM was used to observe the cross section of the wedge bond. The pull test results show good performance of the wedge bond. Additionally, DOE results gave the optimized parameter for both the first bond and the second bond. Cross section analysis shows a continuous interconnection between the copper wire and Au/Ni/Cu metallization. The diffusion of Cu into the Au layer was also observed.

• East Asian Journal of Business Economics (EAJBE)
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• v.10 no.1
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• pp.95-108
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• 2022

Purpose - This study attempts a multifaceted analysis utilizing the Chinese test takers' results of the Economy & Business Aptitude Test. Since Chinese students study socialist theories of economics along with market-based ones, comparing Chinese university students' basic knowledge of economics and business and its application to those of Korean test takers is also very meaningful from the perspective of economics education research. Research design, data, and methodology - This study investigates the results on the test of economy and business understanding between Korea and China. For comparison of the result, we conducted MK-TEST for two universities in China. Result - This study finds that the average correct answer rate of Korea is higher than one of China according to the overall results. The average difference rate is about 15% between Korea and China. More concretely, the correct answer rate of business area is higher than one of economy area, identifying them by subject area. Conclusion - According to the results, this study can infer that there are no or little differences in the ability of examinee to solve applied questions between Korea and China and the differences of the scope and emphasis point in an academic curriculum between both countries might bring these kinds of results. Finally, Chinese students shows higher correct answer rate to the questions about the economy issues and policies related to China than one of Korea examinee.

• Steel and Composite Structures
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• v.51 no.5
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• pp.529-543
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• 2024

The bonding efficacy of steel I-section embedded in metakaolin-fly ash-based geopolymer concrete (MK-FA-GC) was investigated in this study. Push-out tests were conducted on nine column specimens to evaluate the influence of compressive strength of concrete, embedded length of steel I-section, thickness of concrete cover, and stirrup ratio on the bond performance. Failure patterns, load-slip relationships, bond strength, and distribution of bond stress among the specimens were analyzed. The characteristic bond strength of geopolymer concrete (GC) increased with higher compressive strength, longer embedded steel section length, thicker concrete cover, and larger stirrup ratio. Empirical formulas for bond strength at the loading end were derived based on experimental data and a bond-slip constructive model for steel-reinforced MK-FA-GC was proposed. The calculated bond-slip curves showed good agreement with experimental results. Furthermore, numerical simulations using ABAQUS software were performed on column specimens by incorporating the suggested bond-slip relationship into connector elements to simulate the interface behavior between MK-FA-GC and the steel section. The simulation results showed a good correlation with the experimental findings.

• Steel and Composite Structures
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• v.36 no.6
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• pp.657-669
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• 2020

This study investigates the fire resistance characteristics of reactive powder concrete according to changes in the cement content per unit area, mixing ratio of metakaolin (MK), and content of polypropylene fiber. A fire test was conducted, and the resulting residual strength characteristics were investigated through flexural and compressive strength measurements, as well as condition rating classification based on visual evaluation. MK effectively reduced the initial high content of calcium hydroxide, thereby reducing the water vapor pressure generated during pyrolysis and slowing spalling. Furthermore, the pore structure and loose tissue were effective for relieving the water vapor pressure in the event of a fire.

• Nuclear Engineering and Technology
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• v.41 no.3
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• pp.307-318
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• 2009

KAERI (Korea Atomic Energy Research Institute) has developed the GAMMA+ code for a thermo-fluid and safety analysis of a VHTR (Very High Temperature Gas-Cooled Reactor). A key safety issue of the VHTR design is to demonstrate its inherent safety features for an automatic reactor power trip and power stabilization during an anticipated transient without scram (ATWS) accident such as a loss of forced cooling by a trip of the helium circulator (LOFC) or a reactivity insertion by a control rod withdrawal (CRW). This paper intends to show the ATWS assessment capability of the GAMMA+ code which can simulate the reactor power response by solving the point-kinetic equations with six-group delayed neutrons, by considering the reactivity changes due to the effects of a core temperature variation, xenon transients, and reactivity insertions. The present benchmark calculations are performed by using the safety demonstration experiments of the 10 MW high temperature gas cooled-test module (HTR-10) in China. The calculation results of the power response transients and the solid core temperature behavior are compared with the experimental data of a LOFC ATWS test and two CRW ATWS tests by using a 1mk-control rod and a 5mk-control rod, respectively. The GAMMA+ code predicts the power response transients very well for the LOFC and CRW ATWS tests in HTR-10.

• Journal of the Korea Concrete Institute
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• v.17 no.3 s.87
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• pp.455-464
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• 2005

Today the application of antiwashout underwater concrete to the construction sites is increasing steadily, while its reliability is in issue. Particularly, antiwashout underwater concrete is known to have very weak durability on frost attack, and hence Japan society of civil engineers(JSCE) regulated that not to use of antiwashout underwater concrete where the freezing and thawing is suspected. This study aims the improvement of the freezing and thawing resistance for antiwashout underwater concrete. From the results of fundamental test, FA20 and SG50 showed good performance in fluidity and long term compressive strength than control concrete. Meanwhile, MK10 marked the highest compressive strength through the whole curing age but a defect on fluidity was discovered. The results from the repeated freezing and thawing test show that the large volumes of air entrapped by cellulose based antiwashout underwater admixture gave bad effects to frost durability and hence not much benefits were confirmed from the use of mineral admixtures. However there were some increasing effects on frost durability of MK10 and SG50 by securing $6{\pm}0.5\%$ of entraining air. In the meantime, there was a increasing tendency of frost durability by increasing blame's fineness of ground granulated blast furnace slag.

• Korean Journal of Radiology
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• v.20 no.5
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• pp.801-811
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• 2019

Objective: To determine whether diffusion kurtosis imaging (DKI) is effective in monitoring tumor response to neoadjuvant chemotherapy in patients with osteosarcoma. Materials and Methods: Twenty-nine osteosarcoma patients (20 men and 9 women; mean age, 17.6 ± 7.8 years) who had undergone magnetic resonance imaging (MRI) and DKI before and after neoadjuvant chemotherapy were included. Tumor volume, apparent diffusion coefficient (ADC), mean diffusivity (MD), mean kurtosis (MK), and change ratio (ΔX) between pre-and post-treatment were calculated. Based on histologic response, the patients were divided into those with good response (≥ 90% necrosis, n = 12) and those with poor response (< 90% necrosis, n = 17). Several MRI parameters between the groups were compared using Student's t test. The correlation between image indexes and tumor necrosis was determined using Pearson's correlation, and diagnostic performance was compared using receiver operating characteristic curves. Results: In good responders, MD_post, ADC_post, and MK_post values were significantly higher than in poor responders (p < 0.001, p < 0.001, and p = 0.042, respectively). The ΔMD and ΔADC were also significantly higher in good responders than in poor responders (p < 0.001 and p = 0.01, respectively). However, no significant difference was observed in ΔMK (p = 0.092). MD_post and ΔMD showed high correlations with tumor necrosis rate (r = 0.669 and r = 0.622, respectively), and MD_post had higher diagnostic performance than ADC_post (p = 0.037) and MK_post (p = 0.011). Similarly, ΔMD also showed higher diagnostic performance than ΔADC (p = 0.033) and ΔMK (p = 0.037). Conclusion: MD is a promising biomarker for monitoring tumor response to preoperative chemotherapy in patients with osteosarcoma.