• 전자공학회논문지SC
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• 제44권1호
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• pp.94-99
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• 2007

협심증과 급성 심근 경색증 등 관상동맥 질환이 급증함에 따라 병원 밖이나 응급실 중환자실 심도자 검사실 등에서 급성 심장 쇼크에 빠지거나 심장마비가 발생하는 경우가 많이 발생하고 있다. 이러한 심혈관 질환에는 정류성 체외생명보조장치가 널리 사용되고 있으나 이러한 장치는 그 무게와 크기로 인해 응급상황에 대처할 수 있는 능력이 작고, 막형 산화기의 전단에 인가되는 압력이 크며, 시스템 구성상 혈액이 공기에 노출된다. 박동성 혈류를 공급하기 위하여 단일 구동펌프를 이용한 시도가 있었으나 회로내의 순간 압력 상승 등으로 인한 여러 가지 단점들이 발생한다. 이러한 기존의 체외생명보조장치의 단점을 극복하고자 한국형 인공심장의 원리를 이용한 이중 박동식 혈액펌프를 개발하였다. 이 시스템의 구동원리는 막형산화기를 중심으로 전.후에 혈액펌프를 위치하여 혈액펌프를 Actuator가 한번씩 짜주는 것이다. 이런 방법으로 구동할 경우 막형산화기 후단에 있는 펌프가 음압을 동시에 일으킴으로, 막형산화기에 인가되는 큰 양압을 줄인다는 가정 하에 시스템을 개발한 것이다. 생체외 실험을 통하여 각 부분의 압력을 측정하고, 총 12건의 동물실험을 통하여 그 장점을 검증하였다

• 한국음향학회지
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• 제19권1호
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• pp.78-83
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• 2000

디지털 이동통신 단말기에서 사용되는 보코더는 통화 품질을 높이기 위하여 새로운 알고리즘들을 채택함에 따라 서로 다른 알고리즘을 사용하는 단말기간의 통신이 문제가 된다. 본 논문에서는 8kbps QCELP 및 13kbps QCELP 보코더 알고리즘을 하나의 DSP 칩에 효율적으로 구현함으로써 이러한 단말기 사이의 통신 문제를 해결하였다. 또한 QCELP 보코더 알고리즘을 실시간 구현하는데 있어 계산량 감소를 위한 단계별 최적화 방법에 대하여 기술하였다. 알고리즘 레벨, 수식 레벨, 코딩 레벨 등의 단계별 최적화 과정을 통하여 계산량이 가장 큰 부분인 코드북 검색 루프에서 약 50% 정도의 계산량을 감소하여 8kbps QCELP는 25 MIPS, 13kbps QCELP는 33 MIPS에 각각 구현하였다. 실시간 구현에 사용한 DSP는 자체 설계한 16 비트 고정소수점 DSP로써 보코더 알고리즘의 구현에 적합하도록 설계되었고, 저전력을 실현하기 위하여 범용의 DSP에 비해 매우 간단한 구조를 가지고 있다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제2권1호
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• pp.23-35
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• 2008

Mobile IP (MIP) is the solution supporting the mobility of Mobile Nodes (MNs), however, it is known to lack the support for NEtwork MObility (NEMO). NEMO manages situations when an entire network, composed of one or more subnets, dynamically changes its point of attachment to the Internet. NEMO Basic Support (NBS) protocol ensures session continuity for all the nodes in a mobile network, however, there exists a serious pinball routing problem. To overcome this weakness, there are many Route Optimization (RO) solutions such as Bi-directional Tunneling (BT) mechanism, Aggregation and Surrogate (A&S) mechanism, Recursive Approach, etc. The A&S RO mechanism is known to outperform the other RO mechanisms, except for the Binding Update (BU) cost. Although Improved Prefix Delegation (IPD) reduces the cost problem of Prefix Delegation (PD), a well-known A&S protocol, the BU cost problem still presents, especially when a large number of Mobile Routers (MRs) and MNs exist in the environment such as train, bus, ship, or aircraft. In this paper, a solution to reduce the cost of delivering the BU messages is proposed using a multicast mechanism instead of unicasting such as the traditional BU of the RO. The performance of the proposed multicast-based BU scheme is examined with an analytical model which shows that the BU cost enhancement is up to 32.9% over IPDbased, hence, it is feasible to predict that the proposed scheme could benefit in other NEMO RO protocols.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.1044-1051
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• 2002

This paper proposes a two-phase mathematical programming approach by considering classification gap to solve the proposed credit scoring problem so as to complement any theoretical shortcomings. Specifically, by using the linear programming (LP) approach, phase 1 is to make the associated decisions such as issuing grant of credit or denial of credit to applicants. or to seek any additional information before making the final decision. Phase 2 is to find a cut-off value, which minimizes any misclassification penalty (cost) to be incurred due to granting credit to 'bad' loan applicant or denying credit to 'good' loan applicant by using the mixed-integer programming (MIP) approach. This approach is expected to and appropriate classification scores and a cut-off value with respect to deviation and misclassification cost, respectively. Statistical discriminant analysis methods have been commonly considered to deal with classification problems for credit scoring. In recent years, much theoretical research has focused on the application of mathematical programming techniques to the discriminant problems. It has been reported that mathematical programming techniques could outperform statistical discriminant techniques in some applications, while mathematical programming techniques may suffer from some theoretical shortcomings. The performance of the proposed two-phase approach is evaluated in this paper with line data and loan applicants data, by comparing with three other approaches including Fisher's linear discriminant function, logistic regression and some other existing mathematical programming approaches, which are considered as the performance benchmarks. The evaluation results show that the proposed two-phase mathematical programming approach outperforms the aforementioned statistical approaches. In some cases, two-phase mathematical programming approach marginally outperforms both the statistical approaches and the other existing mathematical programming approaches.

• Journal of Periodontal and Implant Science
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• 제26권2호
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• pp.376-395
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• 1996

The neuropeptide substance P(SP) has been recognized to modulate immune systems, with close proximity between peptidergic sensory nerve endings and immune cells. These include the macrophage and neutrophil activation, IL-2 production in T cell, augmentation of Ig synthesis, mast cell degranulation, $PGE_2$ and collagenase secretion in synoviocytes. In this study I examined SP-induced various biological activities such as antimicrobial action, cytokine production, and mast cell degranulation in the presence or absence of other inflammatory cell activators. Antimicrobial studies showed that undifferentiated HL-60 cells were not affected by SP. However, SP significantly enhanced antimicrobial action of TPA-treated or dbcAMP-treated HL-60 cells which had been differentiated into PMN or macrophage/monocyte. I could not find synergistic relationship between SP and LPS in parallel experiments of the above. SP did not induce IL-l production from murine macrophage cell line RAW264.7 whether costimulated with LPS or not. Mast cell degranulation was occured only when stimulated with high dose ($10^{-5}M$) of SP and the degree of this activation was slightly reduced by simultaneous application of $MIP-1{\alpha}$. In addition, CGRP which is known to be a common coexisting neuropeptide with SP within specific fibers did not augment the function of SP on mast cell degranulation. These results suggest that immunoregulatory activities of SP could be mediated through direct upregulation of various functions of immune cells and also upregulation of responsiveness of immune cells to other immune activators.

• 한국음향학회지
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• 제20권1호
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• pp.56-61
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• 2001

본 논문은 비동기 방식의 IMT-2000 단말기용 ASIC (주문형 집적회로)에 포함되는 음성부호화기 알고리즘인 AMR(Adaptive Multi Rate) 보코더의 실시간 구현에 관한 것이다. 구현된 AMR 보코더는 12.2kbps에서 4.75kbps까지 8가지의 다중 비트율을 가지고 있으며, 인코더와 디코더 기능 외에 VAD (Voice Activity Detection) 블록과 SCR (Source Controlled Rate operation) 블록 등의 부가기능 및 시스템과의 접속 처리를 위한 프레임 구성 기능도 구현되어 있다. AMR 보코더를 구현하기 위하여 설계된 DSP (디지털 신호처리기)는 TeakLite 코어를 기반으로 하여 메모리 블록, 직렬접속 블록, CPU와의 접속을 위한 레지스터 파일 블록, 인터럽트 제어회로 등으로 구성된 16비트 고정 소수점형 DSP이다. 실시간 구현 방법에서는 메모리의 효율적인 관리를 통하여 계산량을 최적화하여 최대 동작 계산량을 약 24MIPS로 줄였으며, 구현된 AMR 보코더는 3GPP의 표준 시험 벡터를 모두 통과하여 검증을 완료하고, 실시간 보드 시험에서도 안정적으로 동작하는 것이 확인되었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 1999년도 추계학술대회 논문집
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• pp.46-53
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• 1999

As of July 1999, i,185 lomocotives(excluding metropolitan area electric locomotives) are in Korean National Railroad(KNR). With this limited number of resources assigning locomotives to each trains of timetable is very important in the entire railway management point of view because schedule can be regarded as goods in transportation industry. On a simple rail network, it is rather easier to assign proper locomotives to trains with the experience of operating experts and get optimal assignment solution. However, as the network is getting bigger and complicated, the number of trains and corresponding locomotives will be dramatically increased to rover all the demands required to service all of the trains in timetable. There will be also numerous operational constraints to be considered. Assigning proper locomotives to trains and building optimal cyclic rotations of locomotive routings will result in increasing efficiency of schedule and giving a guarantee of more profit. The purpose of this study is two fold: (1) we consider a planning-level locomotive scheduling problem with the objective of minimizing the wasting cost under various practical constraints and (2) development of implementation prototype program of its assigning result. Not like other countries, i.e. Canada, Sweden, Korean railroad operates on n daily schedule basis. The objective is to find optimal assignment of locomotives of different types to each trains, which minimize the wasting cost. This problem is defined on a planning stage and therefore, does not consider operational constraints such as maintenance and emergency cases. Due to the large scale of the problem size and complexity, we approach with heuristic methods and column generation to find optimal solution. The locomotive scheduling prototype consists of several modules including database, optimization engine and diagram generator. The optimization engine solves MIP model and provides an optimal locomotive schedule using specified optimization algorithms. A cyclic locomotive route diagram can be generated using this optimal schedule through the diagram generator.

• 대한한의학회지
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• 제42권3호
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• pp.56-71
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• 2021

Objectives: This study is aimed to evaluate the protective effects of GGX on lung injury of Chronic Obstructive Lung Disease (COPD) mice model. Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 mg/kg (Dexa group), gam-gil-tang 200 mg/kg (GGT group), GGX 100, 200, and 400 mg/kg (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson's trichrome staining. Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-𝛼, IL-17A, CXCL-1, MIP2 in BALF and TNF-𝛼, IL-1𝛽, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury. Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury.

• 대한방사선치료학회지
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• 제17권2호
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• pp.125-131
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• 2005

목 적 : 폐암 환자 중 호흡에 의한 종양의 움직임이 큰 폐 하엽에서 정위적 방사선수술 시 호흡에 의한 종양의 움직임을 감소시키는 방법으로 종양의 움직임이 적은 호흡 주기에서만 방사선을 조사할 수 있는 respiratory gating system을 사용함으로써 그 유용성에 대하여 알아보고자 한다. 대상 및 방법 : 폐 하엽의 정위적 방사선 수술 환자 2명을 대상으로 하였으며, 환자의 복부에 maker block (sensor)을 부착하고 tracking camera와 Real Time Position Management (RPM)를 이용하여 호흡 주기를 측정하면서 1회 호흡주기에서 10 phases로 4D-CT를 촬영하였다. 종양의 위치 변화가 급격하지 않은 호흡주기 (%)의 phases를 치료 phases로 결정하였고, 치료 phases의 CT image를 Maximum Intensity Projection (MIP) 기법으로 재구성 후 volume contouring을 하였다. Set up의 재현성 및 GTV의 위치 변화를 확인하기 위해 치료 전과 치료 중 2회의 4D-CT 촬영을 하였다. 결 과 : GTV의 움직임이 가장 큰 Y(longitudinal)축에서 A환자는 전체 호흡주기($0{\sim}90%$)에서 9.4 mm가 치료 호흡 주기 범위 ($30{\sim}60%$)에서는 2.6 mm로, B환자는 전체 호흡주기 ($0{\sim}90%$)에서 11.7 mm가 치료 호흡주기의 범위($30{\sim}70%$)에서는 2.3 mm로 감소하였다. 2회의 4D-CT 비교 결과 set up의 X, Y, Z축 오차는 모두 3 mm이내였다. 결 론 : 호흡에 의한 종양의 움직임이 큰 폐 하엽에서 정위적 방사선수술 시행 시 respiratory gating system의 사용은 종양의 움직임을 5 mm이내로 감소시킬 수 있어 유용하였다.

• Journal of Ginseng Research
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• 제47권1호
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• pp.81-88
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• 2023

Background: Air pollution has led to an increased exposure of all living organisms to fine dust. Therefore, research efforts are being made to devise preventive and therapeutic remedies against fine dust-induced chronic diseases. Methods: Research of the respiratory protective effects of KRG extract in a particulate matter (PM; aerodynamic diameter of <4 ㎛) plus diesel exhaust particle (DEP) (PM4+D)-induced airway inflammation model. Nitric oxide production, expression of pro-inflammatory mediators and cytokines, and IRAK-1, TAK-1, and MAPK pathways were examined in PM4-stimulated MH-S cells. BALB/c mice exposed to PM4+D mixture by intranasal tracheal injection three times a day for 12 days at 3 day intervals and KRGE were administered orally for 12 days. Histological of lung and trachea, and immune cell subtype analyses were performed. Expression of pro-inflammatory mediators and cytokines in bronchoalveolar lavage fluid (BALF) and lung were measured. Immunohistofluorescence staining for IRAK-1 localization in lung were also evaluated. Results: KRGE inhibited the production of nitric oxide, the expression of pro-inflammatory mediators and cytokines, and expression and phosphorylation of all downstream factors of NF-κB, including IRAK-1 and MAPK/AP1 pathway in PM4-stimulated MH-S cells. KRGE suppressed inflammatory cell infiltration and number of immune cells, histopathologic damage, and inflammatory symptoms in the BALF and lungs induced by PM4+D; these included increased alveolar wall thickness, accumulation of collagen fibers, and TNF-α, MIP2, CXCL-1, IL-1α, and IL-17 cytokine release. Moreover, PM4 participates induce alveolar macrophage death and interleukin-1α release by associating with IRAK-1 localization was also potently inhibited by KRGE in the lungs of PM4+D-induced airway inflammation model. KRGE suppresses airway inflammatory responses, including granulocyte infiltration into the airway, by regulating the expression of chemokines and inflammatory cytokines via inhibition of IRAK-1 and MAPK pathway. Conclusion: Our results indicate the potential of KRGE to serve as an effective therapeutic agent against airway inflammation and respiratory diseases.